PMC:7252096 / 1361-1756 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T34088","span":{"begin":74,"end":78},"obj":"Body_part"},{"id":"T54247","span":{"begin":79,"end":82},"obj":"Body_part"},{"id":"T87410","span":{"begin":139,"end":150},"obj":"Body_part"},{"id":"T10457","span":{"begin":168,"end":173},"obj":"Body_part"},{"id":"T61252","span":{"begin":190,"end":201},"obj":"Body_part"},{"id":"T25794","span":{"begin":274,"end":289},"obj":"Body_part"},{"id":"T1805","span":{"begin":280,"end":289},"obj":"Body_part"},{"id":"T31965","span":{"begin":294,"end":298},"obj":"Body_part"},{"id":"T91512","span":{"begin":299,"end":305},"obj":"Body_part"}],"attributes":[{"id":"A92918","pred":"fma_id","subj":"T34088","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86540","pred":"fma_id","subj":"T54247","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A88962","pred":"fma_id","subj":"T87410","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A73465","pred":"fma_id","subj":"T10457","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A16921","pred":"fma_id","subj":"T61252","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A88490","pred":"fma_id","subj":"T25794","obj":"http://purl.org/sig/ont/fma/fma63140"},{"id":"A11773","pred":"fma_id","subj":"T1805","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A80352","pred":"fma_id","subj":"T31965","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A17138","pred":"fma_id","subj":"T91512","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":274,"end":289},"obj":"Body_part"},{"id":"T6","span":{"begin":280,"end":289},"obj":"Body_part"},{"id":"T7","span":{"begin":294,"end":298},"obj":"Body_part"},{"id":"T8","span":{"begin":299,"end":305},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0005384"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T18","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"T19","span":{"begin":109,"end":113},"obj":"Disease"},{"id":"T20","span":{"begin":241,"end":250},"obj":"Disease"}],"attributes":[{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T71330","span":{"begin":31,"end":36},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T5413","span":{"begin":42,"end":47},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T55369","span":{"begin":48,"end":55},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9443"},{"id":"T95456","span":{"begin":61,"end":66},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T20143","span":{"begin":74,"end":78},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T15307","span":{"begin":168,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T78412","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T40851","span":{"begin":294,"end":298},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T20839","span":{"begin":294,"end":298},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T71984","span":{"begin":309,"end":314},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":136,"end":138},"obj":"Chemical"},{"id":"T8","span":{"begin":342,"end":352},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-sentences","denotations":[{"id":"T12","span":{"begin":0,"end":10},"obj":"Sentence"},{"id":"T13","span":{"begin":11,"end":127},"obj":"Sentence"},{"id":"T14","span":{"begin":128,"end":222},"obj":"Sentence"},{"id":"T15","span":{"begin":223,"end":305},"obj":"Sentence"},{"id":"T16","span":{"begin":306,"end":395},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}

{"project":"LitCovid-PubTator","denotations":[{"id":"66","span":{"begin":31,"end":36},"obj":"Species"},{"id":"67","span":{"begin":42,"end":47},"obj":"Species"},{"id":"68","span":{"begin":61,"end":66},"obj":"Species"},{"id":"69","span":{"begin":109,"end":119},"obj":"Species"},{"id":"72","span":{"begin":206,"end":210},"obj":"Gene"},{"id":"73","span":{"begin":213,"end":220},"obj":"Gene"},{"id":"78","span":{"begin":260,"end":264},"obj":"Gene"},{"id":"79","span":{"begin":226,"end":236},"obj":"Gene"},{"id":"80","span":{"begin":268,"end":273},"obj":"Species"},{"id":"81","span":{"begin":241,"end":250},"obj":"Species"},{"id":"85","span":{"begin":315,"end":319},"obj":"Gene"},{"id":"86","span":{"begin":342,"end":352},"obj":"Gene"},{"id":"87","span":{"begin":309,"end":314},"obj":"Species"}],"attributes":[{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:9606"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:9606"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:10090"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"Tax:2697049"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"Gene:59272"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"Gene:7113"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"Gene:59272"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"Gene:3439"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"Tax:9606"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Tax:11520"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"Gene:59272"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"Gene:3439"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Tax:10090"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Highlights\n• Meta-analysis of human, non-human primate, and mouse single-cell RNA-seq datasets for putative SARS-CoV-2 targets\n• Type II pneumocytes, nasal secretory cells, and absorptive enterocytes are ACE2 + TMPRSS2 +\n• Interferon and influenza increase ACE2 in human nasal epithelia and lung tissue\n• Mouse Ace2 is not upregulated by interferon, raising implications for disease modeling"}