PMC:7252096 / 117804-118462 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T153","span":{"begin":226,"end":231},"obj":"Body_part"},{"id":"T154","span":{"begin":388,"end":392},"obj":"Body_part"}],"attributes":[{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T233","span":{"begin":226,"end":244},"obj":"http://purl.obolibrary.org/obo/UBERON_0034922"},{"id":"T234","span":{"begin":388,"end":392},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T14","span":{"begin":309,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T15","span":{"begin":317,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T843","span":{"begin":0,"end":257},"obj":"Sentence"},{"id":"T844","span":{"begin":258,"end":401},"obj":"Sentence"},{"id":"T845","span":{"begin":402,"end":658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2812","span":{"begin":196,"end":200},"obj":"Gene"},{"id":"2813","span":{"begin":343,"end":347},"obj":"Gene"}],"attributes":[{"id":"A2812","pred":"tao:has_database_id","subj":"2812","obj":"Gene:59272"},{"id":"A2813","pred":"tao:has_database_id","subj":"2813","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}

{"project":"2_test","denotations":[{"id":"32413319-24836921-20790590","span":{"begin":636,"end":640},"obj":"24836921"},{"id":"32413319-31937974-20790591","span":{"begin":652,"end":656},"obj":"31937974"}],"text":"We conducted the following statistical analysis to estimate the effects of various factors on our ability to make confident claims regarding the presence/absence of transcripts of interest (e.g., ACE2), both within individual cells and clusters (Figure S6). Specifically, we investigated the roles of capture/reverse transcription efficiency, ACE2 expression level, sequencing depth, and cell numbers. Taken together, the results of this power analysis are in agreement with other efforts to model biological and technical sources of zero-inflation within scRNA-seq data (e.g., https://satijalab.org/howmanycells and Kharchenko et al., 2014, Svensson, 2020)."}