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PMC:7252096 / 10135-21224 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T8170 0-4 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T40688 5-20 Body_part denotes Epithelial Cell http://purl.org/sig/ont/fma/fma66768
T20735 16-20 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T61053 121-126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T38580 148-155 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T4254 257-261 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T46063 376-380 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T8984 381-387 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T79059 469-471 Body_part denotes v1 http://purl.org/sig/ont/fma/fma13444|http://purl.org/sig/ont/fma/fma68614
T85470 536-540 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T2796 696-712 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T62378 707-712 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64743 735-746 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T35128 858-863 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18720 908-918 Body_part denotes pneumocyte http://purl.org/sig/ont/fma/fma62499
T83814 990-995 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23477 1006-1022 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T1445 1017-1022 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T92758 1035-1046 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T97944 1115-1126 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T72738 1189-1200 Body_part denotes Pneumocytes http://purl.org/sig/ont/fma/fma62499
T37841 1212-1217 Body_part denotes Lungs http://purl.org/sig/ont/fma/fma68877
T92961 1283-1287 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T78907 1288-1294 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T68232 1410-1412 Body_part denotes v1 http://purl.org/sig/ont/fma/fma13444|http://purl.org/sig/ont/fma/fma68614
T20260 1453-1457 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T30494 1523-1528 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T63361 1548-1552 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T10555 1740-1747 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54627 1811-1814 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T41736 1831-1834 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T81740 1887-1891 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27177 1994-1999 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15384 2036-2040 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T58974 2147-2152 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T91751 2182-2193 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T93701 2331-2342 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T72518 2409-2413 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T49230 2460-2465 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T85711 2532-2543 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T18864 2727-2738 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T91953 2758-2762 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T71090 2818-2823 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47005 2829-2834 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T92870 2950-2961 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T63508 3485-3493 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T65371 3500-3515 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T37309 3511-3515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T48346 3650-3661 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T43690 3705-3716 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T22980 3776-3787 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T28048 3878-3883 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14664 3929-3934 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51526 4062-4066 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T99760 4067-4072 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95342 4207-4211 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T92810 4212-4218 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T78289 4311-4315 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T69943 4345-4350 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T4180 4543-4554 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T896 4568-4573 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T59565 4620-4625 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T50359 4661-4672 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T31548 4720-4728 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T33475 4773-4778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71780 4917-4922 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13117 5067-5071 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T97209 5072-5088 Body_part denotes Epithelial Cells http://purl.org/sig/ont/fma/fma66768
T58447 5083-5088 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T22748 5103-5106 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T72849 5249-5253 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T51464 5254-5260 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T32804 5376-5380 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T159 5464-5469 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16248 5496-5499 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T57087 5543-5548 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T21872 5593-5597 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T163 5752-5755 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T38697 5772-5775 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T165 5828-5832 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42440 5918-5923 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17615 5931-5935 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T67803 5960-5964 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T7984 6071-6076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17779 6151-6155 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T52492 6203-6208 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94798 6288-6299 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T69556 6328-6339 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T7255 6546-6549 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T87549 6713-6718 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24659 6811-6822 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T62679 6845-6856 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T40711 6951-6956 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57895 7174-7185 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T33276 7289-7293 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T1877 7294-7310 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T28083 7305-7310 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55595 7416-7419 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T52444 7504-7507 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T61810 7596-7601 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T52569 7613-7617 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86051 7642-7645 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T50770 7733-7748 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T30659 7744-7748 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T49150 7833-7837 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25558 8119-8122 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T6790 8326-8329 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T47054 8338-8341 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T13368 8343-8359 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T50428 8354-8359 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30868 8466-8470 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T64579 8577-8593 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T18385 8588-8593 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26459 8693-8698 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74490 8725-8736 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T57427 8754-8765 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T45527 8871-8875 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T71902 8955-8966 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T62436 9078-9089 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T41832 9104-9109 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T321 9120-9124 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T76609 9143-9153 Body_part denotes pneumocyte http://purl.org/sig/ont/fma/fma62499
T23388 9168-9172 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T38118 9216-9221 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T76254 9329-9334 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T70818 9345-9350 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15181 9415-9420 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16876 9627-9631 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T10381 9698-9714 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T43874 9709-9714 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26007 9722-9727 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T98068 9750-9754 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T99509 9761-9767 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T29624 9804-9809 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T89353 9825-9830 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39897 9856-9861 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13798 9875-9880 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T19523 9893-9904 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T40933 9922-9933 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T71611 9995-10000 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T53856 10036-10041 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6586 10045-10051 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T46157 10088-10092 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T54100 10098-10102 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T47693 10118-10123 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T49420 10133-10138 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18542 10194-10199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T45700 10211-10216 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T70996 10385-10400 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T87517 10396-10400 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T76289 10460-10465 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28685 10551-10556 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55403 10597-10601 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T83597 10639-10644 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T11799 10702-10707 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14134 10732-10743 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T63492 10798-10809 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T25039 10835-10840 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14862 10935-10951 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T38033 10946-10951 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7095 11059-11064 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 0-4 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 376-380 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 381-387 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T25 1283-1287 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T26 1288-1294 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T27 4062-4066 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 4207-4211 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T29 4212-4218 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 5067-5071 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T31 5249-5253 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T32 5254-5260 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T33 7289-7293 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T34 8466-8470 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T35 8871-8875 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T36 9627-9631 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T37 9761-9767 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T38 10045-10051 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T39 10088-10092 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T81 56-64 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 56-60 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 173-181 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 173-177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 636-640 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408
T86 1567-1571 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408
T87 2800-2808 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 2800-2804 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T89 3140-3144 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T90 3470-3484 Disease denotes adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004970
T91 4368-4372 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408
T92 5137-5149 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T93 5493-5495 Disease denotes TB http://purl.obolibrary.org/obo/MONDO_0018076
T94 5508-5510 Disease denotes TB http://purl.obolibrary.org/obo/MONDO_0018076
T95 5608-5612 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408
T96 6554-6556 Disease denotes TB http://purl.obolibrary.org/obo/MONDO_0018076
T97 6723-6731 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 6723-6727 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 7392-7408 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T100 7441-7460 Disease denotes active tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T101 7475-7494 Disease denotes active tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T102 7661-7673 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T103 7998-8008 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T104 8119-8132 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T105 8123-8132 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 8645-8649 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408
T107 9553-9565 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T108 9605-9617 Disease denotes Tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T33682 0-20 http://purl.obolibrary.org/obo/CL_0000082 denotes Lung Epithelial Cell
T96977 74-79 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T63395 80-88 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes Primates
T74612 93-99 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Humans
T22651 121-126 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T95022 134-139 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6005 257-267 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T65779 308-309 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21693 360-374 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Macaca mulatta
T78816 376-380 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T69580 376-380 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T95293 430-437 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T91672 536-546 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T86810 620-621 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T29504 632-634 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T74686 696-706 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T68973 707-712 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T53098 858-863 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T93726 990-995 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T79600 1006-1016 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T66664 1017-1032 http://purl.obolibrary.org/obo/CL_0000000 denotes cells, and type
T13219 1145-1147 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T22343 1212-1217 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lungs
T70499 1225-1230 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T98814 1231-1239 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes Primates
T59631 1241-1242 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T79845 1283-1287 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T77319 1283-1287 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T56107 1324-1329 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T41263 1330-1338 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primates
T54356 1453-1463 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T37269 1523-1528 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T88766 1548-1552 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T66647 1583-1584 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T40116 1646-1647 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T55688 1872-1877 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T97901 1887-1896 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T45113 1904-1906 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T83525 1994-1999 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T86594 2028-2029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79235 2036-2040 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T82704 2147-2152 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T94942 2384-2386 http://purl.obolibrary.org/obo/CLO_0008935 denotes S9
T53007 2409-2418 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T17987 2460-2465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T36108 2471-2476 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Genes
T72036 2658-2660 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T94552 2678-2680 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97290 2758-2762 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T56304 2818-2823 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7716 2829-2834 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T75626 2838-2839 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82354 2889-2891 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T556 2900-2905 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T57307 3031-3032 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96321 3083-3086 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T26550 3285-3290 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T1107 3465-3469 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T72877 3465-3469 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T71567 3465-3469 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T57698 3465-3469 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T30638 3465-3469 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T72132 3465-3469 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T28760 3465-3469 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T31074 3465-3469 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T7152 3500-3510 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T19610 3511-3520 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T61747 3878-3883 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T97969 3900-3901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33108 3929-3934 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T34534 3989-3994 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T86334 4062-4066 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T50390 4062-4066 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T48113 4067-4072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T37100 4099-4105 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T5449 4119-4120 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31894 4207-4211 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T2015 4207-4211 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T45149 4311-4321 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T83337 4345-4350 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T80628 4360-4363 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2 A
T55319 4401-4406 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T795 4461-4463 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T51533 4461-4463 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T66909 4568-4582 http://purl.obolibrary.org/obo/CLO_0000031 denotes cells, in line
T42173 4620-4625 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T35738 4641-4643 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T95623 4773-4778 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24497 4917-4922 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T86794 5067-5088 http://purl.obolibrary.org/obo/CL_0000082 denotes Lung Epithelial Cells
T51443 5159-5164 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T63387 5201-5202 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T35956 5243-5248 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T32379 5249-5253 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T73304 5249-5253 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T7811 5376-5386 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T89005 5436-5437 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37671 5464-5469 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T53946 5543-5548 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T21733 5593-5602 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T96107 5624-5625 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T75647 5650-5651 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T62279 5813-5818 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T23408 5828-5837 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T67693 5918-5923 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T25827 5931-5940 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T4783 5952-5953 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67532 5960-5964 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T46104 6071-6076 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20388 6099-6108 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes are
T2783 6127-6129 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T54985 6127-6129 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T59240 6151-6161 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T38339 6203-6208 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T65003 6265-6270 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T49895 6362-6367 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T27452 6373-6374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55966 6453-6463 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes; the
T60530 6496-6498 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T6253 6496-6498 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T52423 6530-6535 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T18839 6595-6599 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T75828 6617-6619 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T26490 6617-6619 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T16241 6713-6718 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T78984 6772-6777 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T13184 6883-6885 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T38372 6883-6885 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T59087 6951-6956 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T25222 6991-6994 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T54419 7070-7076 http://purl.obolibrary.org/obo/CLO_0007900 denotes Murphy
T55694 7247-7248 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84889 7289-7310 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T58859 7330-7334 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T31098 7386-7391 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T51827 7409-7414 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T72175 7441-7447 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T95140 7475-7481 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T7363 7596-7601 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32543 7613-7623 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T19180 7733-7743 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T38954 7744-7754 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T89753 7789-7793 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T95742 7833-7837 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T76826 7974-7975 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15040 8058-8059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81003 8343-8353 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T39323 8354-8359 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32896 8374-8375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62302 8466-8470 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T49811 8466-8470 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T83510 8503-8522 http://purl.obolibrary.org/obo/NCBITaxon_9541 denotes Macaca fascicularis
T95036 8577-8587 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T34107 8588-8593 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2157 8630-8632 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T63441 8693-8698 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T39559 8738-8740 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T74853 8871-8875 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T2994 8871-8875 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T21425 8923-8927 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Test
T43594 9104-9109 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T81133 9120-9124 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T47932 9168-9178 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T61012 9216-9221 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T89605 9309-9314 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T35819 9329-9334 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T41200 9345-9350 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11298 9415-9420 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T39187 9430-9437 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T12030 9441-9447 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T67132 9517-9518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26933 9598-9600 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T73657 9627-9631 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T20633 9627-9631 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T61293 9675-9676 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T38285 9698-9708 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T57087 9709-9714 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T71105 9722-9727 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T63382 9750-9759 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T17198 9804-9809 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T82766 9825-9830 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19623 9840-9842 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T37996 9856-9861 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69593 9875-9880 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27809 9910-9912 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T85798 9981-9982 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T80701 9995-10000 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46135 10036-10041 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9290 10088-10092 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T95835 10088-10092 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T64574 10098-10107 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T34712 10118-10123 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T48746 10133-10138 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T82967 10194-10199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T84738 10211-10216 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T48976 10315-10319 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Test
T44586 10370-10375 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T18907 10385-10395 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T89339 10396-10405 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T66912 10460-10465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T58845 10551-10556 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54918 10597-10601 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T45497 10639-10644 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T61092 10654-10658 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T69561 10702-10707 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T90995 10835-10840 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T58071 10882-10887 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T53729 10935-10945 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T23060 10946-10951 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54660 10973-10977 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T48816 11059-11064 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68923 11080-11087 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T36 732-734 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T37 905-907 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T38 1112-1114 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T39 1186-1188 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T40 1740-1747 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 2179-2181 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T42 2328-2330 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T43 2529-2531 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T44 2724-2726 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 2947-2949 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T46 3051-3053 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T47 3130-3133 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T48 3539-3542 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T49 3549-3552 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T50 3647-3649 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T51 3702-3704 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T52 4007-4010 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T53 4243-4245 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T54 4461-4463 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T55 4540-4542 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T56 4658-4660 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T57 4709-4719 Chemical denotes surfactant http://purl.obolibrary.org/obo/CHEBI_35195
T58 4720-4728 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T59 5172-5174 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T60 5333-5335 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T61 6127-6129 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T62 6496-6498 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T63 6617-6619 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T64 6808-6810 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T65 6842-6844 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T66 6883-6885 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T67 7061-7063 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T68 7171-7173 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T69 7273-7276 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T70 8548-8550 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T71 8641-8643 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T72 8722-8724 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T73 8952-8954 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T74 9009-9022 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T75 9075-9077 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T76 9538-9541 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T77 9919-9921 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T78 9965-9967 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T79 9975-9977 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T80 10327-10329 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T81 10565-10570 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T82 10860-10862 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T83 11041-11043 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T43635 8240-8245 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T85557 9553-9565 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T57 0-99 Sentence denotes Lung Epithelial Cell Expression of Host Factors Used by SARS-CoV-2 in Non-Human Primates and Humans
T58 100-304 Sentence denotes To investigate which cells within human and NHP tissues represent likely SARS-CoV-2 targets, we analyzed new and existing scRNA-seq datasets to assess which cell types express ACE2, alone or with TMPRSS2.
T59 305-650 Sentence denotes In a previously unpublished dataset consisting of NHP (Macaca mulatta) lung tissue collected after necropsy of healthy adult animals and analyzed by using Seq-Well v1 (Gierahn et al., 2017), we recovered at least 17 distinct major cell types, including various lymphoid, myeloid, and stromal populations (Figures 1 A–1C; Table S1; STAR Methods).
T60 651-823 Sentence denotes ACE2 and TMPRSS2 were primarily expressed in epithelial cells, with 6.7% of type II pneumocytes expressing ACE2 and 3.8% co-expressing ACE2 and TMPRSS2 (Figures 1B and 1C).
T61 824-1149 Sentence denotes Notably, the only double-positive cells observed were classified within the type II pneumocyte population; however, we also identified TMPRSS2 expression within club cells, ciliated epithelial cells, and type I pneumocytes, albeit at diminished abundance and frequency compared with type II pneumocytes (Figure 1C; Table S1).
T62 1150-1239 Sentence denotes Figure 1 Expression of ACE2 in Type II Pneumocytes in Healthy Lungs of Non-human Primates
T63 1240-1490 Sentence denotes (A) Schematic of protocol for isolation of lung tissue at necropsy from healthy non-human primates (M. mulatta, n = 3), creation of scRNA-seq libraries by using Seq-Well v1, and computational analysis to identify cell types by using unbiased methods.
T64 1491-1581 Sentence denotes UMAP projection of 3,793 single cells, points colored by cell identity (see STAR Methods).
T65 1582-1775 Sentence denotes (B) Uniform manifold approximation and projection (UMAP) as in (A), points colored by detection of ACE2 (coronavirus receptor, top) or TMPRSS2 (coronavirus S protein priming for entry, bottom).
T66 1776-1844 Sentence denotes Color coding is as follows: black, RNA positive; blue, RNA negative.
T67 1845-1961 Sentence denotes (C) Dot plot of 2 defining genes for each cell type (Table S1) (Bonferroni-adjusted p < 0.001) and ACE2 and TMPRSS2.
T68 1962-2153 Sentence denotes Dot size represents fraction of cells within that type expressing a given gene, and color intensity represents binned count-based expression amount (log(scaled UMI+1)) among expressing cells.
T69 2154-2315 Sentence denotes ACE2 is enriched in type II pneumocytes (6.7% expressing, Bonferroni-adjusted p = 8.62E−33), as is TMPRSS2 (29.5% expressing, Bonferroni-adjusted p = 8.73E−153).
T70 2316-2388 Sentence denotes Of all type II pneumocytes, 3.8% co-express ACE2 and TMPRSS2 (Table S9).
T71 2389-2466 Sentence denotes Red arrow indicates cell type with largest proportion of ACE2+TMPRSS2+ cells.
T72 2467-2662 Sentence denotes (D) Genes differentially expressed among ACE2+ and ACE2− type II pneumocytes. (SCDE package, FDR-adjusted p < 0.05 for IFNGR2, NT5DC1, ARL6IP1, and TRIM27; full results can be found in Table S1).
T73 2663-2681 Sentence denotes See also Table S1.
T74 2682-2893 Sentence denotes Next, we compared ACE2 + with ACE2 − type II pneumocytes to explore broader gene programs that differentiate putative SARS-CoV-2 target cells from cells of a similar phenotype and ontogeny (Figure 1D; Table S1).
T75 2894-3059 Sentence denotes Among genes significantly upregulated in ACE2 + type II pneumocytes, we observed IFNGR2 (false discovery rate [FDR]-adjusted p = 0.022), a receptor for type II IFNs.
T76 3060-3265 Sentence denotes Notably, previous work has demonstrated limited anti-viral potency of IFN-γ for SARS-associated coronaviruses, compared with that of type I IFNs, at least in vitro (Sainz et al., 2004, Zheng et al., 2004).
T77 3266-3584 Sentence denotes Other co-regulated genes of potential interest include TRIM27 (FDR-adjusted p = 0.025), as well as NT5DC1 (FDR-adjusted p = 0.003) and ARL6IP1 (FDR-adjusted p = 0.047), which were upregulated in the A549 adenocarcinoma alveolar basal epithelial cell line after exposure to IFN-α and IFN-γ for 6 h (Sanda et al., 2006).
T78 3585-3850 Sentence denotes We found IFNAR1 consistently expressed among both ACE2 + type II pneumocytes and ACE2 + TMPRSS2 + co-expressing type II pneumocytes, but its level of upregulation compared with all remaining pneumocytes did not meet statistical significance (FDR-adjusted p = 0.11).
T79 3851-4021 Sentence denotes This analysis finds ACE2 + cells enriched within a rare fraction of secretory cells in NHPs and that ACE2 expression is co-regulated with genes involved in IFN responses.
T80 4022-4268 Sentence denotes To assess whether the findings from NHP lung cells were similarly present in humans, we analyzed a previously unpublished scRNA-seq dataset derived from surgical resections of fibrotic lung tissue collected with Seq-Well S3 (Hughes et al., 2019).
T81 4269-4465 Sentence denotes Unsupervised analysis identified multiple cell types and subtypes of immune cells (Figures 2 A–2C; STAR Methods), as defined by the genes displayed in Figure 2C (full lists available in Table S2).
T82 4466-4649 Sentence denotes Here, we found that ACE2 and TMPRSS2 were primarily expressed within type II pneumocytes and ciliated cells, in line with our analysis of the NHP-derived cells (Figures 1 and 2A, 2B).
T83 4650-4904 Sentence denotes In type II pneumocytes (identified by unique expression of surfactant proteins SFTPC, SFTPB, and SFTPA1), we found 1.4% of cells expressing ACE2 (FDR-adjusted p = 1.35E−21), 34.2% expressing TMPRSS2 (FDR-adjusted p < 1E−300), and 0.8% co-expressing both.
T84 4905-5050 Sentence denotes In ciliated cells, we found 7% were ACE2 + (FDR-adjusted p = 5E−64), 24.6% were TMPRSS2 + (FDR-adjusted p = 3.8E−30), and 5.3% co-expressed both.
T85 5051-5199 Sentence denotes Figure 2 Select Lung Epithelial Cells from Control, HIV-1-Infected, and Mycobacterium-tuberculosis-Infected Human Donors Co-Express ACE2 and TMPRSS2
T86 5200-5413 Sentence denotes (A) Schematic of protocol for isolation of human lung tissue from surgical excess, creation of scRNA-seq libraries by using Seq-Well S3, and computational analysis to identify cell types by using unbiased methods.
T87 5414-5542 Sentence denotes Shown on the right is a UMAP projection of 18,915 cells across 8 donors (n = 3 TB+HIV+; n = 3 TB+; n = 2 non-infected patients).
T88 5543-5622 Sentence denotes Cells represented by points, colored according to cell type (see STAR Methods).
T89 5623-5716 Sentence denotes (B) UMAP projection as in (A), points colored by detection of ACE2 (top) or TMPRSS2 (bottom).
T90 5717-5785 Sentence denotes Color coding is as follows: black, RNA positive; blue, RNA negative.
T91 5786-6077 Sentence denotes (C) Dot plot of 2 defining genes for each cell type (FDR-adjusted p < 0.001), and ACE2 and TMPRSS2; dot size represents fraction of cells within cell type expressing a given gene, and color intensity represents binned count-based expression amount (log(scaled UMI+1)) among expressing cells.
T92 6078-6130 Sentence denotes All cluster-defining genes are provided in Table S2.
T93 6131-6209 Sentence denotes Red arrow indicates cell types with largest proportion of ACE2+TMPRSS2+ cells.
T94 6210-6340 Sentence denotes (D) Volcano plot identifying significantly upregulated genes in ACE2+TMPRSS2+ pneumocytes compared with all remaining pneumocytes.
T95 6341-6425 Sentence denotes Red points represent genes with a FDR-adjusted p < 0.05, and log2(fold change) >1.5.
T96 6426-6499 Sentence denotes Text highlighting specific genes; the full list is available in Table S2.
T97 6500-6601 Sentence denotes (E) Expression of ACE2 across human donors by HIV and TB status (p = 0.009 by likelihood-ratio test).
T98 6602-6620 Sentence denotes See also Table S2.
T99 6621-6887 Sentence denotes As above, to assess for cellular pathways significantly co-expressed within putative target cells for SARS-CoV-2, we computed differentially expressed genes between ACE2 + TMPRSS2 + type II pneumocytes and all other type II pneumocytes (Figures 2C and 2D; Table S2).
T100 6888-7091 Sentence denotes We found significant enrichment of BATF among ACE2 + TMPRSS2 + cells (FDR-adjusted p = 3.25E−7), which has been demonstrated previously to be upregulated by type I and type II IFNs (Murphy et al., 2013).
T101 7092-7336 Sentence denotes Of note, we also observed TRIM28 co-expressed with ACE2 and TMPRSS2 among type II pneumocytes in this dataset (FDR-adjusted p = 2.34E−9), which might play a role in potentiating an IFN response in lung epithelial cells (Krischuns et al., 2018).
T102 7337-7549 Sentence denotes Within this cohort of donors, 3 individuals were human immunodeficiency virus (HIV)+ and diagnosed with active tuberculosis, 3 donors had active tuberculosis and were HIV−, and 2 were negative for both pathogens.
T103 7550-7818 Sentence denotes Surprisingly, we found that all of the ACE2 + cells across all cell types were derived from HIV+ Mycobacterium tuberculosis (Mtb)+ donors despite approximately equivalent recovery of epithelial cell types from all donors (likelihood-ratio test, p = 0.009) (Figure 2E).
T104 7819-8361 Sentence denotes Given limited cell and patient numbers combined with potential sampling biases, we caution that this observation requires much broader cohorts to validate a potential role for co-infections; still, we note our observation is suggestive of a role for chronic IFNs in the induction of ACE2, given that HIV infection is associated with persistent upregulation of ISGs, and we observed elevated amounts of IFNAR2, IFI30, and IKBKB (Utay and Douek, 2016) (FDR-adjusted p = 1.1E−6, 8.8E−9, 1.57E−7, respectively; HIV+ versus HIV− epithelial cells).
T105 8362-8659 Sentence denotes Next, using a previously unpublished scRNA-seq dataset consisting of granuloma and adjacent, uninvolved lung samples from Mtb-infected NHPs (Macaca fascicularis) collected with Seq-Well S3, we identified subsets of epithelial cells expressing ACE2 and TMPRSS2 (Figure S1 ; Table S3; STAR Methods).
T106 8660-8929 Sentence denotes The majority of ACE2 + TMPRSS2 + cells were, once again, type II pneumocytes (22%) and type I pneumocytes (9.7%) and were largely enriched within granulomatous regions compared with those in adjacent uninvolved lung (Figures S1B and S1C) (p = 0.006, Fisher Exact Test).
T107 8930-9103 Sentence denotes ACE2 + TMPRSS2 + type II pneumocytes expressed significantly higher amounts of antimicrobial effectors such as LCN2 compared with remaining type II pneumocytes (Figure S1D).
T108 9104-9373 Sentence denotes Cells with club cell/secretory, type I pneumocyte, and ciliated cell types also contained some ACE2 + TMPRSS2 + cells, but we did not have sufficient power to detect significantly differentially expressed genes between these cells and other cells within those clusters.
T109 9374-9590 Sentence denotes Altogether, we identify ACE2 + TMPRSS2 + cells in lower airways of humans and NHPs with consistent cellular phenotypes and evidence supporting a potential role for IFN-associated inflammation in upregulation of ACE2.
T110 9591-9673 Sentence denotes Figure S1 NHP Tuberculosis Infected Lung and Granuloma, Related to Figures 1 and 2
T111 9674-9678 Sentence denotes (A).
T112 9679-9810 Sentence denotes UMAP projection of epithelial cells (1,099 cells) colored by annotated cell type, tissue source, and gating as ACE2+TMPRSS2+ cells.
T113 9811-9934 Sentence denotes ACE2+TMPRSS2+ cells comprise 11% of ciliated cells, 16% of club cells, 10% type I pneumocytes, and 22% type II pneumocytes.
T114 9935-9979 Sentence denotes Data generated using Seq-Well S3 (Table S3).
T115 9980-9984 Sentence denotes (B).
T116 9985-10108 Sentence denotes Number of cells (left) and % (right) ACE2+TMPRSS2+ cells by tissue source (granuloma versus uninvolved lung) and cell type.
T117 10109-10264 Sentence denotes Ciliated cells and club cells were omitted from this analysis as we detected too few cells (< 7 total cells) belonging to these clusters in the granulomas.
T118 10265-10331 Sentence denotes Statistical significance assessed by Fisher Exact Test (Table S3).
T119 10332-10336 Sentence denotes (C).
T120 10337-10427 Sentence denotes Dot plot of top cluster defining genes for each epithelial cell type and ACE2 and TMPRSS2.
T121 10428-10602 Sentence denotes Dot size represents fraction of cells expressing, and color intensity represents average log(normalized UMI + 1) among all cells in each group scaled between 0 and 1 by gene.
T122 10603-10756 Sentence denotes ACE2 expression is enriched in club cells (Bimodal test, Bonferroni-corrected p < 0.001), ciliated cells (p < 0.005), and type I pneumocytes (p < 0.001).
T123 10757-10864 Sentence denotes TMPRSS2 expression is enriched in type I pneumocytes (p < 0.001) and ciliated cells (p < 0.001) (Table S3).
T124 10865-10869 Sentence denotes (D).
T125 10870-11089 Sentence denotes Dot plot of genes differentially expressed between ACE2+TMPRSS2+ epithelial cells versus rest (Bimodal test, Bonferroni-corrected p < 0.01, log fold change > 0.5). (Table S3, c = number of cells, n = number of animals).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 7392-7408 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 8431-8440 Phenotype denotes granuloma http://purl.obolibrary.org/obo/HP_0032252
T8 9636-9645 Phenotype denotes Granuloma http://purl.obolibrary.org/obo/HP_0032252
T9 10060-10069 Phenotype denotes granuloma http://purl.obolibrary.org/obo/HP_0032252
T10 10253-10263 Phenotype denotes granulomas http://purl.obolibrary.org/obo/HP_0032252

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
314 56-66 Species denotes SARS-CoV-2 Tax:2697049
315 74-79 Species denotes Human Tax:9606
318 1173-1177 Gene denotes ACE2 Gene:59272
319 1225-1230 Species denotes human Tax:9606
323 1567-1571 Gene denotes STAR Gene:6770
324 1324-1329 Species denotes human Tax:9606
325 1340-1350 Species denotes M. mulatta Tax:9544
330 1681-1685 Gene denotes ACE2 Gene:59272
331 1717-1724 Gene denotes TMPRSS2 Gene:7113
332 1687-1698 Species denotes coronavirus Tax:11118
333 1726-1737 Species denotes coronavirus Tax:11118
342 1944-1948 Gene denotes ACE2 Gene:59272
343 1953-1960 Gene denotes TMPRSS2 Gene:7113
344 2154-2158 Gene denotes ACE2 Gene:59272
345 2253-2260 Gene denotes TMPRSS2 Gene:7113
346 2360-2364 Gene denotes ACE2 Gene:59272
347 2369-2376 Gene denotes TMPRSS2 Gene:7113
348 2446-2450 Gene denotes ACE2 Gene:59272
349 2451-2458 Gene denotes TMPRSS2 Gene:7113
356 2508-2512 Gene denotes ACE2 Gene:59272
357 2518-2522 Gene denotes ACE2 Gene:59272
358 2586-2592 Gene denotes IFNGR2 Gene:3460
359 2594-2600 Gene denotes NT5DC1 Gene:221294
360 2602-2609 Gene denotes ARL6IP1 Gene:23204
361 2615-2621 Gene denotes TRIM27 Gene:5987
374 276-280 Gene denotes ACE2 Gene:59272
375 296-303 Gene denotes TMPRSS2 Gene:7113
376 651-655 Gene denotes ACE2 Gene:712790
377 660-667 Gene denotes TMPRSS2 Gene:715138
378 758-762 Gene denotes ACE2 Gene:712790
379 786-790 Gene denotes ACE2 Gene:712790
380 795-802 Gene denotes TMPRSS2 Gene:715138
381 959-966 Gene denotes TMPRSS2 Gene:715138
382 636-640 Gene denotes STAR Gene:699515
383 134-139 Species denotes human Tax:9606
384 173-183 Species denotes SARS-CoV-2 Tax:2697049
385 360-374 Species denotes Macaca mulatta Tax:9544
406 2700-2704 Gene denotes ACE2 Gene:59272
407 2712-2716 Gene denotes ACE2 Gene:59272
408 2935-2939 Gene denotes ACE2 Gene:59272
409 2975-2981 Gene denotes IFNGR2 Gene:3460
410 3130-3135 Gene denotes IFN-γ Gene:3458
411 3321-3327 Gene denotes TRIM27 Gene:5987
412 3365-3371 Gene denotes NT5DC1 Gene:221294
413 3401-3408 Gene denotes ARL6IP1 Gene:23204
414 3539-3544 Gene denotes IFN-α Gene:3440
415 3594-3600 Gene denotes IFNAR1 Gene:3454
416 3635-3639 Gene denotes ACE2 Gene:59272
417 3666-3670 Gene denotes ACE2 Gene:59272
418 3673-3680 Gene denotes TMPRSS2 Gene:7113
419 3871-3875 Gene denotes ACE2 Gene:59272
420 3952-3956 Gene denotes ACE2 Gene:59272
421 4007-4010 Gene denotes IFN Gene:3439
422 2800-2810 Species denotes SARS-CoV-2 Tax:2697049
423 3156-3169 Species denotes coronaviruses Tax:11118
424 3470-3493 Disease denotes adenocarcinoma alveolar MESH:D002282
425 3465-3469 CellLine denotes A549 CVCL:0023
430 5183-5187 Gene denotes ACE2 Gene:59272
431 5159-5164 Species denotes Human Tax:9606
432 5103-5117 Disease denotes HIV-1-Infected MESH:D015658
433 5123-5158 Disease denotes Mycobacterium-tuberculosis-Infected MESH:D014376
439 5608-5612 Gene denotes STAR Gene:6770
440 5243-5248 Species denotes human Tax:9606
441 5532-5540 Species denotes patients Tax:9606
442 5496-5499 Species denotes HIV Tax:12721
443 5523-5531 Disease denotes infected MESH:D007239
446 5685-5689 Gene denotes ACE2 Gene:59272
447 5699-5706 Gene denotes TMPRSS2 Gene:7113
452 5868-5872 Gene denotes ACE2 Gene:59272
453 5877-5884 Gene denotes TMPRSS2 Gene:7113
454 6189-6193 Gene denotes ACE2 Gene:59272
455 6194-6201 Gene denotes TMPRSS2 Gene:7113
458 6274-6278 Gene denotes ACE2 Gene:59272
459 6279-6286 Gene denotes TMPRSS2 Gene:7113
464 6518-6522 Gene denotes ACE2 Gene:59272
465 6530-6535 Species denotes human Tax:9606
466 6546-6549 Species denotes HIV Tax:12721
467 6554-6556 Chemical denotes TB MESH:D013725
479 4486-4490 Gene denotes ACE2 Gene:59272
480 4495-4502 Gene denotes TMPRSS2 Gene:7113
481 4729-4734 Gene denotes SFTPC Gene:6440
482 4736-4741 Gene denotes SFTPB Gene:6439
483 4747-4753 Gene denotes SFTPA1 Gene:653509
484 4790-4794 Gene denotes ACE2 Gene:59272
485 4841-4848 Gene denotes TMPRSS2 Gene:7113
486 4941-4945 Gene denotes ACE2 Gene:59272
487 4985-4992 Gene denotes TMPRSS2 Gene:7113
488 4368-4372 Gene denotes STAR Gene:6770
489 4099-4105 Species denotes humans Tax:9606
518 6786-6790 Gene denotes ACE2 Gene:59272
519 6793-6800 Gene denotes TMPRSS2 Gene:7113
520 6923-6927 Gene denotes BATF Gene:10538
521 6934-6938 Gene denotes ACE2 Gene:59272
522 6941-6948 Gene denotes TMPRSS2 Gene:7113
523 7118-7124 Gene denotes TRIM28 Gene:10155
524 7143-7147 Gene denotes ACE2 Gene:59272
525 7152-7159 Gene denotes TMPRSS2 Gene:7113
526 7273-7276 Gene denotes IFN Gene:3439
527 7589-7593 Gene denotes ACE2 Gene:59272
528 8102-8106 Gene denotes ACE2 Gene:59272
529 8221-8227 Gene denotes IFNAR2 Gene:3455
530 8229-8234 Gene denotes IFI30 Gene:10437
531 8240-8245 Gene denotes IKBKB Gene:3551
532 6723-6733 Species denotes SARS-CoV-2 Tax:2697049
533 7386-7414 Species denotes human immunodeficiency virus Tax:12721
534 7647-7673 Species denotes Mycobacterium tuberculosis Tax:1773
535 7842-7849 Species denotes patient Tax:9606
536 7416-7419 Species denotes HIV Tax:12721
537 7504-7507 Species denotes HIV Tax:12721
538 7642-7645 Species denotes HIV Tax:12721
539 7675-7678 Species denotes Mtb Tax:1773
540 8326-8329 Species denotes HIV Tax:12721
541 8338-8341 Species denotes HIV Tax:12721
542 7448-7460 Disease denotes tuberculosis MESH:D014376
543 7482-7494 Disease denotes tuberculosis MESH:D014376
544 7995-8008 Disease denotes co-infections MESH:D060085
545 8119-8132 Disease denotes HIV infection MESH:D015658
548 9601-9631 Disease denotes NHP Tuberculosis Infected Lung MESH:D012141
549 9636-9645 Disease denotes Granuloma MESH:D006099
554 9790-9794 Gene denotes ACE2 Gene:59272
555 9795-9802 Gene denotes TMPRSS2 Gene:7113
556 9811-9815 Gene denotes ACE2 Gene:59272
557 9816-9823 Gene denotes TMPRSS2 Gene:7113
562 10022-10026 Gene denotes ACE2 Gene:59272
563 10027-10034 Gene denotes TMPRSS2 Gene:7113
564 10060-10069 Disease denotes granuloma MESH:D006099
565 10253-10263 Disease denotes granulomas MESH:D006099
570 10410-10414 Gene denotes ACE2 Gene:59272
571 10419-10426 Gene denotes TMPRSS2 Gene:7113
572 10603-10607 Gene denotes ACE2 Gene:59272
573 10757-10764 Gene denotes TMPRSS2 Gene:7113
576 10921-10925 Gene denotes ACE2 Gene:59272
577 10926-10933 Gene denotes TMPRSS2 Gene:7113
597 8605-8609 Gene denotes ACE2 Gene:102130864
598 8614-8621 Gene denotes TMPRSS2 Gene:102137447
599 8676-8680 Gene denotes ACE2 Gene:102130864
600 8683-8690 Gene denotes TMPRSS2 Gene:102137447
601 8930-8934 Gene denotes ACE2 Gene:102130864
602 8937-8944 Gene denotes TMPRSS2 Gene:102137447
603 9041-9045 Gene denotes LCN2 Gene:3934
604 9199-9203 Gene denotes ACE2 Gene:102130864
605 9206-9213 Gene denotes TMPRSS2 Gene:102137447
606 9398-9402 Gene denotes ACE2 Gene:59272
607 9405-9412 Gene denotes TMPRSS2 Gene:7113
608 9538-9541 Gene denotes IFN Gene:3439
609 9585-9589 Gene denotes ACE2 Gene:59272
610 8645-8649 Gene denotes STAR Gene:102132972
611 8503-8522 Species denotes Macaca fascicularis Tax:9541
612 9441-9447 Species denotes humans Tax:9606
613 8431-8440 Disease denotes granuloma MESH:D006099
614 8484-8501 Disease denotes Mtb-infected NHPs MESH:D007239
615 9553-9565 Disease denotes inflammation MESH:D007249

2_test

Id Subject Object Predicate Lexical cue
32413319-28192419-20790459 489-493 28192419 denotes 2017
32413319-15476870-20790460 3239-3243 15476870 denotes 2004
32413319-15296649-20790461 3259-3263 15296649 denotes 2004
32413319-16800785-20790462 3578-3582 16800785 denotes 2006
32413319-23787991-20790463 7085-7089 23787991 denotes 2013
32413319-30323812-20790464 7330-7334 30323812 denotes 2018
32413319-27500281-20790465 8263-8267 27500281 denotes 2016