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PMC:7252011 / 7079-8282 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
224 34-39 Gene denotes ACE-2 Gene:59272
225 119-124 Gene denotes ACE-2 Gene:59272
226 310-315 Gene denotes ACE-2 Gene:59272
227 521-526 Gene denotes ACE-2 Gene:59272
228 675-678 Gene denotes ACE Gene:1636
229 745-748 Gene denotes ACE Gene:1636
230 749-754 Gene denotes ACE-2 Gene:59272
231 871-874 Gene denotes ACE Gene:1636
232 879-884 Gene denotes ACE-2 Gene:59272
233 975-980 Gene denotes ACE-2 Gene:59272
234 371-379 Species denotes patients Tax:9606
235 409-419 Species denotes SARS-CoV-2 Tax:2697049
236 508-516 Species denotes patients Tax:9606
237 549-557 Species denotes patients Tax:9606
238 1192-1202 Species denotes SARS-CoV-2 Tax:2697049
239 69-78 Disease denotes infection MESH:D007239
240 362-370 Disease denotes infected MESH:D007239
241 563-575 Disease denotes hypertension MESH:D006973
242 577-580 Disease denotes CVD MESH:D002318
243 582-589 Disease denotes obesity MESH:D009765
244 601-609 Disease denotes diabetes MESH:D003920
245 1058-1066 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T54 23-30 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T55 151-163 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T56 151-155 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 281-285 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T58 352-357 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T59 452-459 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T60 492-497 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T61 718-722 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 352-357 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T25 492-497 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T40 69-78 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 409-417 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 563-575 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 582-589 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T44 594-609 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T45 601-609 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T46 1192-1200 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T85 43-44 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 135-136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 151-155 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T88 191-192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 204-205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 224-226 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T91 263-270 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T92 281-285 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T93 330-331 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 352-357 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T95 352-357 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T96 430-432 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97 465-470 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 471-474 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T99 492-497 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T100 492-497 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T101 533-534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 694-700 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4
T103 770-771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 818-820 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T105 1033-1035 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T49 23-30 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T50 452-459 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T51 679-681 Chemical denotes AI http://purl.obolibrary.org/obo/CHEBI_73805|http://purl.obolibrary.org/obo/CHEBI_74007|http://purl.obolibrary.org/obo/CHEBI_74088
T54 777-786 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T50 0-103 Sentence denotes The binding of viral S Protein to ACE-2 is a critical phenomenon for infection and disease progression.
T51 104-296 Sentence denotes Interestingly, ACE-2, which is a transmembrane cell surface expressed enzyme, can form a dimer with a high affinity for S1 trimers, which increases binding of viruses and their cell entry [9].
T52 297-358 Sentence denotes In addition, ACE-2 is present in a soluble form in the blood.
T53 359-517 Sentence denotes In infected patients, it could circulate bound to SARS-CoV-2 or to the S1 subunit of viral S Protein, and virus has been detected in blood from some patients.
T54 518-835 Sentence denotes As ACE-2 plays a major role in patients with hypertension, CVD, obesity, or type 2 diabetes, by opposing the harmful effects of the RAAS, mainly through the ACE-AI [[1], [2], [3], [4], [5], [6], [7]] axis and Mas Receptor, the ACE/ACE-2 ratio could be a good indicator of disease progression [[10], [11], [12], [13]].
T55 836-935 Sentence denotes Lastly, there are polymorphisms of ACE and ACE-2 which increase the risk to develop these diseases.
T56 936-1203 Sentence denotes From these considerations, the role of ACE-2 (and impairment of its function when complexed with S1) can be important for Covid-19 clinical complications, especially those associated with comorbidities, and not only because it is the entrance receptor for SARS-CoV-2.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 563-575 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 582-589 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T19 594-609 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978

2_test

Id Subject Object Predicate Lexical cue
32387238-32125455-142271862 293-294 32125455 denotes 9
32387238-21148624-142271863 812-814 21148624 denotes 10
32387238-27081112-142271864 824-826 27081112 denotes 12