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PMC:7252011 / 6526-8282 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
182 11-16 Gene denotes ACE-2 Gene:59272
183 20-35 Disease denotes viral infection MESH:D001102
193 164-169 Gene denotes ACE-2 Gene:59272
194 227-234 Gene denotes TMPRSS2 Gene:7113
195 278-285 Gene denotes TMPRSS2 Gene:7113
196 343-348 Gene denotes ACE-2 Gene:59272
197 410-415 Gene denotes ACE-2 Gene:59272
198 58-63 Species denotes Cov-2 Tax:2697049
199 171-181 Species denotes SARS-CoV-2 Tax:2697049
200 247-253 Chemical denotes serine MESH:D012694
201 474-482 Disease denotes infected MESH:D007239
224 587-592 Gene denotes ACE-2 Gene:59272
225 672-677 Gene denotes ACE-2 Gene:59272
226 863-868 Gene denotes ACE-2 Gene:59272
227 1074-1079 Gene denotes ACE-2 Gene:59272
228 1228-1231 Gene denotes ACE Gene:1636
229 1298-1301 Gene denotes ACE Gene:1636
230 1302-1307 Gene denotes ACE-2 Gene:59272
231 1424-1427 Gene denotes ACE Gene:1636
232 1432-1437 Gene denotes ACE-2 Gene:59272
233 1528-1533 Gene denotes ACE-2 Gene:59272
234 924-932 Species denotes patients Tax:9606
235 962-972 Species denotes SARS-CoV-2 Tax:2697049
236 1061-1069 Species denotes patients Tax:9606
237 1102-1110 Species denotes patients Tax:9606
238 1745-1755 Species denotes SARS-CoV-2 Tax:2697049
239 622-631 Disease denotes infection MESH:D007239
240 915-923 Disease denotes infected MESH:D007239
241 1116-1128 Disease denotes hypertension MESH:D006973
242 1130-1133 Disease denotes CVD MESH:D002318
243 1135-1142 Disease denotes obesity MESH:D009765
244 1154-1162 Disease denotes diabetes MESH:D003920
245 1611-1619 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T44 42-49 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T45 67-74 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T46 218-225 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 247-253 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T48 286-290 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T49 309-316 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T50 357-364 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T51 483-496 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T52 483-487 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53 519-522 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T54 576-583 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T55 704-716 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T56 704-708 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 834-838 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T58 905-910 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T59 1005-1012 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T60 1045-1050 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T61 1271-1275 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 905-910 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T25 1045-1050 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T37 20-35 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T38 26-35 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 171-179 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 622-631 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 962-970 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 1116-1128 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 1135-1142 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T44 1147-1162 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T45 1154-1162 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T46 1745-1753 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T73 85-86 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 140-143 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T75 144-145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 209-217 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T77 236-237 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 238-246 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T79 286-290 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T80 398-400 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T81 421-423 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T82 421-423 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T83 483-487 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T84 488-496 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T85 596-597 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 688-689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 704-708 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T88 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 757-758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 777-779 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T91 816-823 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T92 834-838 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T93 883-884 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 905-910 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T95 905-910 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T96 983-985 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97 1018-1023 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 1024-1027 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T99 1045-1050 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T100 1045-1050 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T101 1086-1087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 1247-1253 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4
T103 1323-1324 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 1371-1373 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T105 1586-1588 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T42 42-49 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T43 67-74 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T44 218-225 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 247-253 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T46 309-316 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T47 357-364 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T48 421-423 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T49 576-583 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T50 1005-1012 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T51 1232-1234 Chemical denotes AI http://purl.obolibrary.org/obo/CHEBI_73805|http://purl.obolibrary.org/obo/CHEBI_74007|http://purl.obolibrary.org/obo/CHEBI_74088
T54 1330-1339 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T17 20-35 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T46 0-35 Sentence denotes 3 Role of ACE-2 in viral infection
T47 36-170 Sentence denotes The S Protein of SRAS Cov-2 (S Protein) presents a sequence, named Receptor Binding Domain (RBD), which has a high affinity for ACE-2.
T48 171-349 Sentence denotes SARS-CoV-2 is first primed by another membrane protein, TMPRSS2 (a membrane serine protease encoded by the TMPRSS2 gene), which cleaves S Protein and favors its binding to ACE-2.
T49 350-552 Sentence denotes This S Protein is then separated in 2 subunits, S1 bound to ACE-2, and S2, which helps the viral envelope to merge with the infected cell membrane, permitting the viral RNA entrance and replication [9].
T50 553-656 Sentence denotes The binding of viral S Protein to ACE-2 is a critical phenomenon for infection and disease progression.
T51 657-849 Sentence denotes Interestingly, ACE-2, which is a transmembrane cell surface expressed enzyme, can form a dimer with a high affinity for S1 trimers, which increases binding of viruses and their cell entry [9].
T52 850-911 Sentence denotes In addition, ACE-2 is present in a soluble form in the blood.
T53 912-1070 Sentence denotes In infected patients, it could circulate bound to SARS-CoV-2 or to the S1 subunit of viral S Protein, and virus has been detected in blood from some patients.
T54 1071-1388 Sentence denotes As ACE-2 plays a major role in patients with hypertension, CVD, obesity, or type 2 diabetes, by opposing the harmful effects of the RAAS, mainly through the ACE-AI [[1], [2], [3], [4], [5], [6], [7]] axis and Mas Receptor, the ACE/ACE-2 ratio could be a good indicator of disease progression [[10], [11], [12], [13]].
T55 1389-1488 Sentence denotes Lastly, there are polymorphisms of ACE and ACE-2 which increase the risk to develop these diseases.
T56 1489-1756 Sentence denotes From these considerations, the role of ACE-2 (and impairment of its function when complexed with S1) can be important for Covid-19 clinical complications, especially those associated with comorbidities, and not only because it is the entrance receptor for SARS-CoV-2.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 1116-1128 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 1135-1142 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T19 1147-1162 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978

2_test

Id Subject Object Predicate Lexical cue
32387238-32125455-142271861 549-550 32125455 denotes 9
32387238-32125455-142271862 846-847 32125455 denotes 9
32387238-21148624-142271863 1365-1367 21148624 denotes 10
32387238-27081112-142271864 1377-1379 27081112 denotes 12