> top > docs > PMC:7252009 > annotations

PMC:7252009 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 0-10 Species denotes SARS CoV-2 Tax:2697049
3 12-20 Disease denotes COVID-19 MESH:C000657245
12 91-138 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
13 140-150 Species denotes SARS CoV-2 Tax:2697049
14 651-659 Species denotes patients Tax:9606
15 176-200 Disease denotes Coronavirus Disease 2019 MESH:C000657245
16 202-210 Disease denotes COVID-19 MESH:C000657245
17 352-361 Disease denotes pneumonia MESH:D011014
18 395-414 Disease denotes respiratory failure MESH:D012131
19 536-545 Disease denotes mortality MESH:D003643
22 876-884 Disease denotes COVID-19 MESH:C000657245
23 1212-1221 Disease denotes infection MESH:D007239
37 1424-1432 Species denotes Patients Tax:9606
38 1811-1819 Species denotes patients Tax:9606
39 1700-1712 Disease denotes Hypertension MESH:D006973
40 1714-1737 Disease denotes cardiovascular diseases MESH:D002318
41 1739-1759 Disease denotes hypercholesterolemia MESH:D006937
42 1765-1773 Disease denotes diabetes MESH:D003920
43 1824-1828 Disease denotes died MESH:D003643
44 1834-1842 Disease denotes COVID-19 MESH:C000657245
45 1863-1872 Disease denotes mortality MESH:D003643
46 1907-1915 Disease denotes COVID-19 MESH:C000657245
47 1964-1972 Disease denotes COVID-19 MESH:C000657245
48 2279-2288 Disease denotes mortality MESH:D003643
49 2416-2424 Disease denotes COVID-19 MESH:C000657245
52 3202-3210 Species denotes patients Tax:9606
53 2777-2805 Disease denotes musculoskeletal dysfunctions MESH:D009140
63 3235-3243 Species denotes patients Tax:9606
64 3413-3420 Species denotes patient Tax:9606
65 3470-3478 Species denotes patients Tax:9606
66 3529-3537 Species denotes patients Tax:9606
67 3964-3972 Species denotes patients Tax:9606
68 3249-3257 Disease denotes COVID-19 MESH:C000657245
69 3709-3724 Disease denotes muscle weakness MESH:D018908
70 3831-3840 Disease denotes mortality MESH:D003643
71 4068-4075 Disease denotes dyspnea MESH:D004417
87 5028-5036 Species denotes patients Tax:9606
88 5278-5286 Species denotes patients Tax:9606
89 4376-4384 Disease denotes COVID-19 MESH:C000657245
90 4781-4790 Disease denotes pneumonia MESH:D011014
91 4823-4858 Disease denotes Acute Respiratory Distress Syndrome MESH:D012128
92 4860-4864 Disease denotes ARDS MESH:D012128
93 4889-4898 Disease denotes hypoxemia MESH:D000860
94 4947-4955 Disease denotes COVID-19 MESH:C000657245
95 5052-5061 Disease denotes hypoxemia MESH:D000860
96 5126-5135 Disease denotes hypoxemia MESH:D000860
97 5162-5208 Disease denotes loss of the hypoxic pulmonary vasoconstriction MESH:D011665
98 5295-5304 Disease denotes hypoxemia MESH:D000860
99 5379-5383 Disease denotes ARDS MESH:D012128
100 5410-5418 Disease denotes COVID-19 MESH:C000657245
101 5423-5427 Disease denotes ARDS MESH:D012128
105 6128-6133 Species denotes human Tax:9606
106 5561-5569 Disease denotes COVID-19 MESH:C000657245
107 5915-5923 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1299-1303 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T2 3709-3715 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T3 4918-4922 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T4 5067-5085 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T5 5246-5251 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1299-1303 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T2 4918-4922 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 5067-5085 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T4 5246-5251 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-4 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T2 12-20 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 91-138 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 91-124 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 140-144 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T6 176-200 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T7 202-210 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 352-361 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T9 395-414 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T10 876-884 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1212-1221 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1700-1737 Disease denotes Hypertension, cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0001302
T13 1700-1712 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T14 1714-1737 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T15 1765-1773 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T16 1907-1915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1964-1972 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 2416-2424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 3249-3257 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 4376-4384 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 4781-4790 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T22 4823-4858 Disease denotes Acute Respiratory Distress Syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T23 4829-4858 Disease denotes Respiratory Distress Syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T24 4860-4864 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T25 4947-4955 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 5379-5383 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T27 5410-5418 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 5423-5427 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T29 5561-5569 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 5915-5923 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 362-365 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 422-425 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 660-663 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 704-705 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 865-869 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3, 4
T6 1397-1398 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 1597-1598 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1934-1936 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T9 2271-2272 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 2300-2301 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 3386-3392 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T12 3709-3715 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T13 3709-3715 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T14 3709-3715 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T15 3709-3715 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T16 3841-3843 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T17 4022-4030 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 4406-4407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 4918-4922 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T20 4918-4922 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T21 4981-4986 http://purl.obolibrary.org/obo/UBERON_0001456 denotes faced
T22 5067-5085 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T23 5246-5251 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T24 5246-5251 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T25 5349-5350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 5578-5579 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 5676-5677 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 5962-5963 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 6109-6110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 6128-6133 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 5269-5274 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3393-3402 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2 3448-3456 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T3 4058-4066 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T4 5192-5208 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T5 5222-5232 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes SARS CoV-2 (COVID-19): lessons to be learned by Brazilian Physical Therapists
T2 79-869 Sentence denotes The current severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) pandemic, also known as Coronavirus Disease 2019 (COVID-19), puts us at the forefront of scenarios with serious consequences for health systems in Brazil and in the world.1 Current viral interstitial pneumonia has resulted in severe hypoxemic respiratory failure, which has resulted in overcrowding in intensive care units (ICUs), shortage of equipment and personnel, and significant mortality, especially in populations at risk who have chronic health conditions.2 In most countries, the volume of patients has exceeded critical care capacities, with a shortage of personal protection equipment, multi-professional teams, and mechanical ventilators dominating the discussions in local hospitals and in the media.3, 4
T3 870-1077 Sentence denotes While COVID-19 brought several challenges to the overall health care system, it also specifically highlighted the need for physical therapists to be properly trained and prepared to respond to such pandemic.
T4 1078-1354 Sentence denotes First, it demonstrated the importance for every professional being updated, trained, and qualified in all technical skills related to infection control strategies such as wearing adequate professional clothing, effective hand washing, and use of personal protective equipment.
T5 1355-1423 Sentence denotes Second, the importance of primary care in a good health care system.
T6 1424-1520 Sentence denotes Patients with at least one comorbidity have higher odds of being hospitalized and being in ICUs.
T7 1521-1699 Sentence denotes Also, individuals with chronic health conditions are more likely to develop a more severe form of the disease requiring ICU admission, mechanical ventilation, and more resources.
T8 1700-2425 Sentence denotes Hypertension, cardiovascular diseases, hypercholesterolemia, and diabetes are the most common comorbidities in patients who died from COVID-19.5 Consequently, the mortality rate (6.4%) of confirmed cases of COVID-19 in Brazil, within 52 days from the beginning of COVID-19 in every country, is around twice that of other countries, like Germany and Canada (3.0% and 4.1%, respectively), where the primary health care system is more effective in providing primary care.6, 7, 8 Thus, countries that have greater control over chronic health conditions may consequently have a lower mortality rate, with a population in better health being an important benefit in pandemic situations like the one we are witnessing with COVID-19.
T9 2426-2547 Sentence denotes Third, the importance of the Cardiorespiratory and Intensivists (CRI) Physical Therapists in the Brazilian health system.
T10 2548-2714 Sentence denotes CRI Physical Therapy is an established profession worldwide; however, the number of professionals in Brazil is much higher, and dozens of thousands work in hospitals.
T11 2715-2988 Sentence denotes Interestingly, the ventilatory support and the improvement in musculoskeletal dysfunctions in ICUs are assisted by two professionals (Physical Therapists and Respiratory Therapists) in most countries; however, the CRI Physical Therapists are responsible for both in Brazil.
T12 2989-3211 Sentence denotes The cumulative function reinforces the importance of the CRI Physical Therapists in the ICUs, as part of the multiprofessional team, minimizing the consequences of hospitalization and facilitating the recovery of patients.
T13 3212-3949 Sentence denotes Ventilatory support in patients with COVID-19 includes several approaches: assistance in orotracheal intubation, support and management in mechanical ventilation, removal of airway secretion, changing patient's decubitus to improve gas exchange, and weaning patients from mechanical ventilation.9 Additionally, these patients can present with consequences due to intensive care syndrome, including prolonged intubation, continuous sedation, and use of neuromuscular blocking agents that result in muscle weakness.10 All these consequences from prolonged stay in the ICU are associated with an increase in morbidity and mortality.11 Therefore, it is essential to start early rehabilitation in the ICU to promote rapid functional recovery.
T14 3950-4141 Sentence denotes Some of these patients will present low exercise capacity, low physical activity level, increased sedentary behavior, dyspnea on exertion, and poorer quality of life after hospital discharge.
T15 4142-4253 Sentence denotes CRI Physical Therapists will also be requested to help with the post hospital discharge rehabilitation program.
T16 4254-4371 Sentence denotes Fourth and finally, this pandemic reinforces the importance for physical therapists to remain scientifically updated.
T17 4372-4701 Sentence denotes The COVID-19 pandemic resulted in a significant increase in the number of studies reporting the impact of the disease9; despite that, the pulmonary repercussion of the disease remains poorly known.12 The difficulty in understanding how to offer optimal ventilatory support was the primary barrier for the CRI Physical Therapists.
T18 4702-4934 Sentence denotes The previous professional experience was to administer ventilatory support for pneumonia based on the pathophysiology of Acute Respiratory Distress Syndrome (ARDS), where the severity of hypoxemia is associated with lung compliance.
T19 4935-5022 Sentence denotes However, in COVID-19, CRI Physical Therapists faced, at least, two distinct phenotypes.
T20 5023-5257 Sentence denotes Some patients present severe hypoxemia with respiratory system compliance remaining near normal, where hypoxemia seems to occur due to the loss of the hypoxic pulmonary vasoconstriction and impaired regulation of pulmonary blood flow.
T21 5258-5545 Sentence denotes In another group of patients, severe hypoxemia is associated with lower compliance values, a condition similar to severe ARDS.12 The difference between COVID-19 and ARDS required CRI Physical Therapists to be updated almost daily to understand how to give the proper ventilatory support.
T22 5546-5694 Sentence denotes In conclusion, COVID-19 imposed a huge impact on the health care system in all countries, and everyone had to respond promptly in a very short time.
T23 5695-5924 Sentence denotes Brazilian hospitals entire buildings and wards have been converted in semi-intensive and ICUs, and multidisciplinary teams, including CRI Physical Therapists, Physicians, and Nurses, have to receive special training for COVID-19.
T24 5925-6091 Sentence denotes The Brazilian health system presents a special environment because it can count on the presence of CRI Physical Therapists as part of the ICUs multidisciplinary team.
T25 6092-6307 Sentence denotes However, this is a unique moment in human history, and the countries that have adequately invested in research, the entire health care system, and hospital infrastructure are those that will suffer less in this war.
T26 6309-6316 Sentence denotes Funding
T27 6317-6354 Sentence denotes Conselho Nacional de Pesquisa (CNPq).
T28 6356-6377 Sentence denotes Conflicts of interest
T29 6378-6423 Sentence denotes The authors declare no conflicts of interest.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 352-361 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 395-414 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T3 1700-1712 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 1714-1737 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T5 1739-1759 Phenotype denotes hypercholesterolemia http://purl.obolibrary.org/obo/HP_0003124
T6 3709-3724 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T7 4068-4075 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T8 4781-4790 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T9 4829-4849 Phenotype denotes Respiratory Distress http://purl.obolibrary.org/obo/HP_0002098
T10 4889-4898 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T11 5052-5061 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T12 5126-5135 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T13 5295-5304 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418