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PMC:7247521 / 9811-10597 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
153 591-595 Gene denotes OCT2 Gene:6582
154 660-664 Gene denotes hERG Gene:2078
155 678-682 Gene denotes hERG Gene:2078
156 702-705 Species denotes rat Tax:10116
157 611-619 Disease denotes toxicity MESH:D064420
158 626-634 Disease denotes toxicity MESH:D064420
159 712-720 Disease denotes toxicity MESH:D064420
160 729-743 Disease denotes hepatotoxicity MESH:D056486
161 745-763 Disease denotes skin sensitisation MESH:D012871
162 776-784 Disease denotes toxicity MESH:D064420
163 400-406 CellLine denotes Caco-2 CVCL:0025

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T99 46-55 CHEBI:36357;CHEBI:36357 denotes compounds
T100 298-313 CHEBI:52217;CHEBI:52217 denotes pharmacokinetic
T101 400-406 CL_1 denotes Caco-2
T102 492-511 UBERON:0000120 denotes blood-brain barrier
T103 516-538 UBERON:0001017 denotes central nervous system
T104 554-563 GO:0007588 denotes excretion
T105 585-590 UBERON:0002113 denotes renal
T106 591-595 PR:000013036 denotes OCT2
T107 621-625 CHEBI:34018;CHEBI:34018 denotes AMES
T108 660-664 PR:P11308 denotes hERG
T109 667-676 CHEBI:35222;CHEBI:35222 denotes inhibitor
T110 678-682 PR:P11308 denotes hERG
T111 686-695 CHEBI:35222;CHEBI:35222 denotes inhibitor
T112 697-701 UBERON:0000165 denotes oral
T113 702-705 NCBITaxon:10114 denotes rat

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T13 407-411 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 434-438 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T15 492-497 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T16 498-503 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T17 516-538 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T18 745-749 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T7 434-438 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T8 492-511 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T9 492-497 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 498-503 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T11 516-538 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T12 524-538 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T13 745-749 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T66 39-45 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T67 132-138 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T68 363-365 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T69 400-411 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2 cell
T70 434-438 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T71 434-438 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T72 434-438 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T73 434-438 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T74 434-438 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T75 492-497 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T76 492-497 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T77 498-503 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T78 498-503 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T79 516-538 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T80 516-538 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T81 516-538 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T82 745-749 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T83 745-749 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T84 745-749 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T85 745-749 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T86 745-749 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T44 193-195 Chemical denotes MW http://purl.obolibrary.org/obo/CHEBI_74709
T45 667-676 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T46 683-685 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T47 686-695 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 554-563 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T63 0-55 Sentence denotes 2.5 ADMET evaluation of the predicted active compounds
T64 56-289 Sentence denotes Based on the SwissADME database [21], the physicochemical properties of the active components was predicted, including molecular weight (MW), rotatable bonds count, H-bond acceptors and donors count, TPSA and leadlikeness violations.
T65 290-786 Sentence denotes Second, pharmacokinetic properties was predicted through pkCSM database [22], which contained the absorption (Caco-2 cell permeability, HIA and skin permeability), distribution (VDss, unbound fraction, blood-brain barrier and central nervous system permeability), excretion (total clearance and renal OCT2 substrate) and toxicity (AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity).

2_test

Id Subject Object Predicate Lexical cue
32554251-28256516-6393500 89-91 28256516 denotes 21
32554251-25860834-6393501 363-365 25860834 denotes 22