PMC:7247521 / 918-1404 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"28","span":{"begin":60,"end":64},"obj":"Gene"},{"id":"29","span":{"begin":230,"end":236},"obj":"Gene"},{"id":"30","span":{"begin":247,"end":251},"obj":"Gene"},{"id":"31","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"37","span":{"begin":38,"end":45},"obj":"Chemical"},{"id":"40","span":{"begin":124,"end":136},"obj":"Disease"},{"id":"41","span":{"begin":146,"end":167},"obj":"Disease"},{"id":"42","span":{"begin":169,"end":175},"obj":"Disease"},{"id":"43","span":{"begin":177,"end":214},"obj":"Disease"},{"id":"44","span":{"begin":324,"end":333},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:5465"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:406959"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Gene:1022"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Gene:59272"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D013256"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:D003141"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D007249"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D001249"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D029424"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D011014"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T21","span":{"begin":38,"end":45},"obj":"CHEBI:35341;CHEBI:35341;GO:0006694"},{"id":"T22","span":{"begin":46,"end":58},"obj":"GO:0006694"},{"id":"T23","span":{"begin":197,"end":206},"obj":"UBERON:0002048"},{"id":"T24","span":{"begin":223,"end":228},"obj":"SO:0000276"},{"id":"T25","span":{"begin":247,"end":251},"obj":"PR:000005265"},{"id":"T26","span":{"begin":338,"end":342},"obj":"G_3;PG_10;PR:000003622"},{"id":"T27","span":{"begin":346,"end":356},"obj":"GO:0010467"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":357,"end":365},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T6","span":{"begin":146,"end":167},"obj":"Disease"},{"id":"T7","span":{"begin":169,"end":175},"obj":"Disease"},{"id":"T8","span":{"begin":177,"end":214},"obj":"Disease"},{"id":"T9","span":{"begin":324,"end":333},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0004979"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T7","span":{"begin":65,"end":74},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T8","span":{"begin":98,"end":107},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T9","span":{"begin":465,"end":471},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":38,"end":45},"obj":"Chemical"},{"id":"T4","span":{"begin":124,"end":127},"obj":"Chemical"},{"id":"T5","span":{"begin":257,"end":259},"obj":"Chemical"},{"id":"T6","span":{"begin":357,"end":365},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_73659"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":169,"end":175},"obj":"Phenotype"},{"id":"T2","span":{"begin":177,"end":214},"obj":"Phenotype"},{"id":"T3","span":{"begin":324,"end":333},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":38,"end":58},"obj":"http://purl.obolibrary.org/obo/GO_0006694"},{"id":"T6","span":{"begin":46,"end":58},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T7","span":{"begin":60,"end":82},"obj":"http://purl.obolibrary.org/obo/GO_0035357"},{"id":"T8","span":{"begin":65,"end":82},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T9","span":{"begin":65,"end":74},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T10","span":{"begin":84,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0033211"},{"id":"T11","span":{"begin":84,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0033210"},{"id":"T12","span":{"begin":84,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0033209"},{"id":"T13","span":{"begin":98,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T14","span":{"begin":98,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T15","span":{"begin":257,"end":259},"obj":"http://purl.obolibrary.org/obo/GO_0000981"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}

{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":267,"end":366},"obj":"Sentence"},{"id":"T14","span":{"begin":367,"end":484},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"static process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. I"}