PMC:7247521 / 7792-8510 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"126","span":{"begin":128,"end":131},"obj":"Disease"},{"id":"127","span":{"begin":304,"end":320},"obj":"Disease"}],"attributes":[{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:D003141"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T87","span":{"begin":242,"end":246},"obj":"SO:0000704"},{"id":"T88","span":{"begin":356,"end":364},"obj":"SO:0000646"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":242,"end":246},"obj":"Body_part"},{"id":"T10","span":{"begin":565,"end":568},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma67847"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T57","span":{"begin":242,"end":246},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T58","span":{"begin":531,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T59","span":{"begin":554,"end":559},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T60","span":{"begin":677,"end":684},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T28","span":{"begin":309,"end":312},"obj":"Chemical"},{"id":"T29","span":{"begin":393,"end":395},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_73659"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T24","span":{"begin":369,"end":391},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T25","span":{"begin":393,"end":395},"obj":"http://purl.obolibrary.org/obo/GO_0000981"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"LitCovid-sentences","denotations":[{"id":"T50","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T51","span":{"begin":64,"end":341},"obj":"Sentence"},{"id":"T52","span":{"begin":342,"end":640},"obj":"Sentence"},{"id":"T53","span":{"begin":641,"end":718},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}

{"project":"2_test","denotations":[{"id":"32554251-15980575-6393497","span":{"begin":531,"end":533},"obj":"15980575"}],"text":"2.2 Functional and pathway enrichment analyses of QFPD targets\nTo better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses. Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package. P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment."}