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PMC:7247521 / 41458-43580 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
734 261-275 Gene denotes oxidoreductase Gene:8630
735 854-858 Gene denotes PPAR Gene:5465
736 1041-1045 Gene denotes PPAR Gene:5465
737 1963-1968 Gene denotes Cdc20 Gene:991
738 1970-1974 Gene denotes Ido1 Gene:3620
739 1976-1980 Gene denotes Ifng Gene:3458
740 1982-1986 Gene denotes Il10 Gene:3586
741 1988-1991 Gene denotes Il6 Gene:3569
742 1993-1999 Gene denotes Ptger4 Gene:5734
743 2001-2005 Gene denotes Spi1 Gene:6688
744 2007-2010 Gene denotes Tnf Gene:7124
745 1070-1074 Species denotes H1N1 Tax:114727
746 286-291 Chemical denotes lipid MESH:D008055
747 311-316 Chemical denotes lipid MESH:D008055
748 530-535 Chemical denotes lipid MESH:D008055
749 722-727 Chemical denotes lipid MESH:D008055
750 1307-1314 Chemical denotes calcium MESH:D002118
751 80-85 Disease denotes COVID MESH:C000657245
752 204-207 Disease denotes XCH
753 1075-1084 Disease denotes infection MESH:D007239
754 1850-1853 Disease denotes XCH
755 1882-1890 Disease denotes COVID-19 MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T611 286-291 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T612 292-309 GO:0006629 denotes metabolic process
T613 311-316 CHEBI:18059;CHEBI:18059 denotes lipid
T614 332-340 CHEBI:36357;CHEBI:36357 denotes molecule
T615 341-358 GO:0044281 denotes metabolic process
T616 364-383 GO:0042592 denotes homeostatic process
T617 421-426 NCBITaxon:10239 denotes viral
T618 444-453 GO:0008152 denotes metabolic
T619 530-535 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T620 536-545 GO:0006629 denotes metabolic
T621 586-591 GO:0006260;NCBITaxon:10239 denotes virus
T622 592-603 GO:0006260 denotes replication
T623 722-727 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T624 728-738 GO:0006629 denotes metabolism
T625 757-773 UBERON:0000949 denotes endocrine system
T626 1099-1110 GO:0042592 denotes homeostasis
T627 1114-1124 GO:0008152 denotes metabolism
T628 1240-1253 UBERON:0002405 denotes immune system
T629 1263-1284 GO:0005783 denotes endoplasmic reticulum
T630 1286-1305 GO:0007267 denotes cell-cell signaling
T631 1343-1356 UBERON:0004237;GO:0014829 denotes smooth muscle
T632 1357-1368 GO:0014829 denotes contraction
T633 1370-1391 CHEBI:67079;CHEBI:67079 denotes inflammatory mediator
T634 1392-1402 GO:0065007 denotes regulation
T635 1420-1434 UBERON:0001133;GO:0060048 denotes cardiac muscle
T636 1435-1446 GO:0060048 denotes contraction
T637 1882-1890 SP_7 denotes COVID-19
T638 1932-1941 GO:0010467 denotes expressed
T639 1942-1946 CHEBI:23888;CHEBI:23888 denotes drug
T640 1963-1968 PR:000005188 denotes Cdc20
T641 1970-1974 PR:000009030 denotes Ido1
T642 1976-1980 PR:000000017 denotes Ifng
T643 1982-1986 PR:000001471 denotes Il10
T644 1988-1991 PR:000001393 denotes Il6
T645 1993-1999 PR:000001548 denotes Ptger4
T646 2001-2005 PR:000001944 denotes Spi1
T647 2038-2047 NCBITaxon:2 denotes bacterial
T648 2052-2057 NCBITaxon:10239 denotes viral
T649 2079-2092 UBERON:0002405 denotes immune system

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T159 286-291 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T160 311-316 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T161 530-535 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T162 722-727 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T163 757-773 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T164 1240-1253 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T165 1263-1284 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T166 1286-1290 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 1291-1295 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T168 1350-1356 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T169 1428-1434 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T170 2069-2077 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T171 2079-2092 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T48 757-773 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T49 1240-1253 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T50 2079-2092 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T89 1075-1084 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90 1882-1890 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T347 276-284 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T348 427-435 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T349 497-498 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 515-518 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T351 586-591 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T352 757-773 http://purl.obolibrary.org/obo/UBERON_0000949 denotes endocrine system
T353 757-773 http://www.ebi.ac.uk/efo/EFO_0002969 denotes endocrine system
T354 859-868 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T355 895-904 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T356 914-915 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T357 929-932 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T358 1046-1055 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T359 1240-1253 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T360 1286-1290 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T361 1291-1295 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T362 1296-1305 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T363 1315-1324 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T364 1350-1356 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T365 1350-1356 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T366 1350-1356 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T367 1350-1356 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T368 1420-1434 http://purl.obolibrary.org/obo/UBERON_0001133 denotes cardiac muscle
T369 1560-1561 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 2079-2092 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T371 2094-2103 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T338 286-291 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T339 311-316 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T340 332-340 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T341 530-535 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T342 657-666 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T343 722-727 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T344 757-766 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T345 1307-1314 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T347 1593-1596 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T348 1637-1640 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T349 1942-1946 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T105 276-309 http://purl.obolibrary.org/obo/GO_0045834 denotes activity, lipid metabolic process
T106 286-309 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic process
T107 292-309 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T108 326-358 http://purl.obolibrary.org/obo/GO_0044281 denotes small molecule metabolic process
T109 341-358 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T110 364-383 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostatic process
T111 530-545 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic
T112 722-738 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolism
T113 728-738 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T114 854-876 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T115 859-876 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T116 859-868 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T117 881-912 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T118 881-912 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T119 881-912 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T120 895-912 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T121 895-904 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T122 1041-1063 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T123 1046-1063 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T124 1046-1055 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T125 1099-1110 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T126 1114-1124 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T127 1240-1261 http://purl.obolibrary.org/obo/GO_0002376 denotes immune system process
T128 1247-1261 http://purl.obolibrary.org/obo/GO_0003008 denotes system process
T129 1286-1305 http://purl.obolibrary.org/obo/GO_0007267 denotes cell-cell signaling
T130 1296-1305 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T131 1307-1324 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T132 1315-1324 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T133 1334-1368 http://purl.obolibrary.org/obo/GO_0014829 denotes vascular smooth muscle contraction
T134 1343-1368 http://purl.obolibrary.org/obo/GO_0006939 denotes smooth muscle contraction
T135 1350-1368 http://purl.obolibrary.org/obo/GO_0006936 denotes muscle contraction
T136 1392-1402 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T137 1420-1446 http://purl.obolibrary.org/obo/GO_0060048 denotes cardiac muscle contraction
T138 1428-1446 http://purl.obolibrary.org/obo/GO_0006936 denotes muscle contraction
T139 2058-2077 http://purl.obolibrary.org/obo/GO_0034097 denotes responses, cytokine
T140 2094-2116 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T141 2094-2103 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 2104-2116 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T318 0-118 Sentence denotes To our knowledge, this is the first study to explore the mechanisms of QFPD for COVID based on intra-functional units.
T319 119-463 Sentence denotes In this study, GO enrichment analysis showed that the common GO terms of MSXG, SGMH, XCH, WLS and Others targets were significant enriched in oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, and homeostatic process etc., suggesting QFPD may exert anti-viral activity through metabolic function.
T320 464-680 Sentence denotes In agreement with these results, a recent research has found that lipid metabolic reprograming plays an important role in virus replication, which may be an appealing and applicable target for antiviral therapy [32].
T321 681-913 Sentence denotes KEGG analysis showed that in addition to lipid metabolism-related pathways, endocrine system pathways were also significantly enriched in more than four formulae, including PPAR signaling pathway and adipocytokine signaling pathway.
T322 914-1146 Sentence denotes A recent study has showed that the host can exert anti-inflammatory functions to inhibit excessive inflammatory damage through PPAR signaling pathway after H1N1 infection, thus keeping homeostasis of metabolism and development [33].
T323 1147-1452 Sentence denotes In addition, other common terms were significant enriched in more than two formulae, such as immune system process, endoplasmic reticulum, cell-cell signaling, calcium signaling pathway, vascular smooth muscle contraction, inflammatory mediator regulation of TRP channels, cardiac muscle contraction, etc.
T324 1453-1655 Sentence denotes Therefore, the multi-pathway and multi-target results of our intra functional unit of QFPD not only showed a new useful method for studying TCM, but may demonstrate the rationality of TCM compatibility.
T325 1656-1719 Sentence denotes Moreover, TCMATCOV platform was used to validate these results.
T326 1720-2122 Sentence denotes Interestingly, all the five FUs of QFPD showed higher disturbance score than negative control (BXTM), indicating that MSXG, SGMH, XCH, WLS and Others may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf) which were related to the bacterial and viral responses, cytokine, immune system, signaling transduction, etc.

2_test

Id Subject Object Predicate Lexical cue
32554251-30631056-6393507 676-678 30631056 denotes 32
32554251-21819625-6393508 1142-1144 21819625 denotes 33