> top > docs > PMC:7247521 > spans > 37275-40378 > annotations

PMC:7247521 / 37275-40378 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
622 53-61 Disease denotes COVID-19 MESH:C000657245
623 70-91 Disease denotes robustness of disease MESH:D003141
626 700-708 Disease denotes COVID-19 MESH:C000657245
627 950-953 Disease denotes XCH
633 1378-1412 Gene denotes MXO1 SO1 SX1 WO1 XO1 Main Protease
634 1520-1524 Gene denotes RdRp Gene:43740578
635 1575-1579 Gene denotes RdRp Gene:43740578
636 1635-1643 Gene denotes Helicase Gene:164045
637 1698-1706 Gene denotes Helicase Gene:164045
639 1331-1340 Species denotes 2019-nCov Tax:2697049
641 2158-2161 Disease denotes XCH
645 209-217 Disease denotes COVID-19 MESH:C000657245
646 294-297 Disease denotes XCH
647 328-336 Disease denotes COVID-19 MESH:C000657245
649 2704-2712 Disease denotes COVID-19 MESH:C000657245
665 2405-2410 Gene denotes Cdc20 Gene:991
666 2412-2416 Gene denotes Ido1 Gene:3620
667 2418-2422 Gene denotes Ifng Gene:3458
668 2424-2428 Gene denotes Il10 Gene:3586
669 2430-2433 Gene denotes Il6 Gene:3569
670 2435-2441 Gene denotes Ptger4 Gene:5734
671 2443-2447 Gene denotes Spi1 Gene:6688
672 2449-2452 Gene denotes Tnf Gene:7124
673 2597-2606 Species denotes influenza Tax:11320
674 2224-2232 Disease denotes COVID-19 MESH:C000657245
675 2346-2349 Disease denotes XCH
676 2489-2497 Disease denotes COVID-19 MESH:C000657245
677 2522-2547 Disease denotes Graft-versus-host disease MESH:D006086
678 2589-2595 Disease denotes asthma MESH:D001249
679 2610-2636 Disease denotes inflammatory bowel disease MESH:D015212

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T567 19-23 CHEBI:23888;CHEBI:23888 denotes drug
T568 53-61 SP_7 denotes COVID-19
T569 209-217 SP_7 denotes COVID-19
T570 328-336 SP_7 denotes COVID-19
T578 700-708 SP_7 denotes COVID-19
T579 744-748 CHEBI:23888;CHEBI:23888 denotes drug
T580 871-875 CHEBI:23888;CHEBI:23888 denotes drug
T581 1331-1340 SP_7 denotes 2019-nCov
T582 2224-2232 SP_7 denotes COVID-19
T583 2384-2388 CHEBI:23888;CHEBI:23888 denotes drug
T584 2405-2410 PR:000005188 denotes Cdc20
T585 2412-2416 PR:000009030 denotes Ido1
T586 2418-2422 PR:000000017 denotes Ifng
T587 2424-2428 PR:000001471 denotes Il10
T588 2435-2441 PR:000001548 denotes Ptger4
T589 2443-2447 PR:000001944 denotes Spi1
T590 2449-2452 PR:000000134 denotes Tnf
T591 2462-2466 CHEBI:23888;CHEBI:23888 denotes drug
T592 2489-2497 SP_7 denotes COVID-19
T593 2610-2628 UBERON:0000160 denotes inflammatory bowel
T594 2638-2656 GO:0007259 denotes JAK-STAT signaling
T596 2704-2712 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T147 1341-1349 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T148 1530-1533 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T149 1588-1591 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T150 1767-1771 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T151 2011-2018 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T152 2071-2078 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T153 2549-2557 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T154 2558-2566 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T155 2623-2628 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 53-61 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 209-217 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 328-336 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 700-708 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T72 2224-2232 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T73 2489-2497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T74 2522-2547 Disease denotes Graft-versus-host disease http://purl.obolibrary.org/obo/MONDO_0013730
T75 2589-2595 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T76 2597-2606 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T77 2610-2636 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T78 2704-2712 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T325 267-269 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T326 631-633 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T327 778-779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 818-822 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T329 1360-1363 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T330 1360-1363 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T331 2234-2235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 2607-2608 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T333 2647-2656 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T334 2722-2723 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T335 2778-2779 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T321 19-23 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T322 744-748 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T323 871-875 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T324 1341-1349 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T325 1644-1647 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T328 2011-2018 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T329 2071-2078 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T330 2079-2082 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T331 2384-2388 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T332 2462-2466 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T333 2857-2864 Chemical denotes diamond http://purl.obolibrary.org/obo/CHEBI_33417

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T20 2589-2595 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T21 2610-2636 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T103 2079-2090 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T104 2647-2656 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T275 0-99 Sentence denotes 3.8 Validation of drug positioning for QFPD against COVID-19 via the robustness of disease network
T276 100-234 Sentence denotes Firstly, the robustness of whole networks against formula attack was assessed to evaluate QFPD attack on the COVID-19 disease network.
T277 235-513 Sentence denotes Interestingly, Table 4 and Fig. 11 showed that MSXG, SGMH, XCH, WLS and Others attack on the COVID-19 network were characterized by greater disturbance score than negative control (BXTM), and increasing dependence on hub nodes, indicating greater fragility under formula attack.
T278 514-625 Sentence denotes In addition, SGMH, MSXG, and Others exerted higher disturbance score than the positive control (YDBF) Table 5 .
T279 626-717 Sentence denotes Fig. 11 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.
T280 718-823 Sentence denotes Blue normal distribution: drug attack on random networks as a null distribution for the permutation test.
T281 824-904 Sentence denotes Red vertical line: the disturbance rate of the drug to the real disease network.
T282 905-982 Sentence denotes Fist row: MXSG, second row: SGMH, third row: XCH, fourth row: WLS, fifth row:
T283 983-990 Sentence denotes Others.
T284 991-1269 Sentence denotes Fist column: average connectivity, second row: average length of shortest path, third row: connection centrality, fourth row: closeness centrality. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T285 1270-1350 Sentence denotes Table 5 Docking score between common ingredients of QFPD and 2019-nCov proteins.
T286 1351-1398 Sentence denotes Molecule MS1 MX16 MX17 MX8 MXO1 SO1 SX1 WO1 XO1
T287 1399-1455 Sentence denotes Main Protease −7.6 −7 −7.8 −7.8 −7.8 −7.2 −7.1 −7.4 −7.4
T288 1456-1519 Sentence denotes Papain-like protease −8 −8.2 −8.1 −8.1 −8.2 −8.2 −9.2 −8.7 −8.3
T289 1520-1574 Sentence denotes RdRp with RNA −8.6 −8 −7.9 −7.9 −8 −8.4 −8.2 −8.8 −9.5
T290 1575-1634 Sentence denotes RdRp without RNA −7.1 −6.8 −6.8 −6.8 −7 −7.1 −6.9 −7.5 −7.1
T291 1635-1697 Sentence denotes Helicase ADP site −6.2 −6.5 −6.3 −6.1 −6.2 −6.4 −6.8 −6.2 −6.8
T292 1698-1760 Sentence denotes Helicase NCB site −7.4 −7.1 −7.2 −7.2 −7.5 −7.5 −7.4 −7.6 −7.5
T293 1761-1815 Sentence denotes Nsp14(ExoN) −7.2 −6.6 −6.6 −6.7 −6.9 −7 −6.9 −7.1 −7.1
T294 1816-1876 Sentence denotes Nsp14(N7-MTase) −8.6 −8.3 −8.4 −8.3 −8.6 −8.3 −9.4 −8.7 −8.7
T295 1877-1945 Sentence denotes Nsp15(endoribonuclease) −6.2 −6.8 −6.4 −6.4 −6.3 −6.5 −6.8 −6.4 −6.6
T296 1946-2008 Sentence denotes Nsp16(2′-O-MTase) −8.1 −7.4 −7.6 −7.8 −7.8 −8.3 −7.7 −8.4 −8.2
T297 2009-2068 Sentence denotes N protein NCB site −8.1 −7.9 −8 −8 −7.6 −7.8 −7.5 −7.7 −7.9
T298 2069-2136 Sentence denotes E protein(ion channel) −6.4 −6.9 −7.2 −7.2 −6.9 −6.9 −7.9 −6.8 −6.8
T299 2137-2165 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T300 2166-2173 Sentence denotes Others.
T301 2174-2308 Sentence denotes Next, to illustrate the mechanism of QFPD against COVID-19, a formula-attacked target-KEGG pathway network was constructed (Fig. 12 ).
T302 2309-2662 Sentence denotes This network showed that MSXG, SGMH, XCH, WLS and Others interacted with 8 drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf), and 24 drug-attacked nodes in the COVID-19 network were related to Graft-versus-host disease, cytokine-cytokine receptor interaction, asthma, influenza A, inflammatory bowel disease, JAK-STAT signaling, etc.
T303 2663-2721 Sentence denotes Fig. 12 Disturbance analysis of QFPD for COVID-19 network.
T304 2722-2724 Sentence denotes A:
T305 2725-2777 Sentence denotes Venn diagram of the five formulae’ attacked targets.
T306 2778-2780 Sentence denotes B:
T307 2781-2909 Sentence denotes Formula-attacked target-KEGG pathway network; green square: formula, yellow diamond: attacked target, red circle: KEGG pathways.
T308 2910-3103 Sentence denotes The bigger the size of the nodes is, the higher the degree is. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T8 1391-1394 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690