PMC:7247521 / 35360-37273 JSONTXT

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Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

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2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

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Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T34","span":{"begin":44,"end":50},"obj":"Body_part"},{"id":"T35","span":{"begin":245,"end":250},"obj":"Body_part"},{"id":"T36","span":{"begin":252,"end":258},"obj":"Body_part"},{"id":"T37","span":{"begin":270,"end":277},"obj":"Body_part"},{"id":"T38","span":{"begin":299,"end":305},"obj":"Body_part"},{"id":"T39","span":{"begin":306,"end":312},"obj":"Body_part"},{"id":"T40","span":{"begin":350,"end":354},"obj":"Body_part"},{"id":"T41","span":{"begin":403,"end":409},"obj":"Body_part"},{"id":"T42","span":{"begin":421,"end":428},"obj":"Body_part"},{"id":"T43","span":{"begin":447,"end":452},"obj":"Body_part"},{"id":"T44","span":{"begin":461,"end":470},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0003688"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0003688"},{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0000947"},{"id":"A44","pred":"uberon_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/UBERON_0000026"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T63","span":{"begin":554,"end":563},"obj":"Disease"},{"id":"T64","span":{"begin":661,"end":670},"obj":"Disease"},{"id":"T65","span":{"begin":943,"end":951},"obj":"Disease"},{"id":"T66","span":{"begin":978,"end":987},"obj":"Disease"},{"id":"T67","span":{"begin":1335,"end":1344},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T293","span":{"begin":44,"end":50},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T294","span":{"begin":180,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T295","span":{"begin":245,"end":250},"obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"T296","span":{"begin":252,"end":258},"obj":"http://www.ebi.ac.uk/efo/EFO_0000984"},{"id":"T297","span":{"begin":270,"end":277},"obj":"http://purl.obolibrary.org/obo/UBERON_0003688"},{"id":"T298","span":{"begin":299,"end":305},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T299","span":{"begin":299,"end":305},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T300","span":{"begin":299,"end":305},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T301","span":{"begin":306,"end":312},"obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"T302","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T303","span":{"begin":350,"end":354},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T304","span":{"begin":403,"end":409},"obj":"http://www.ebi.ac.uk/efo/EFO_0000984"},{"id":"T305","span":{"begin":421,"end":428},"obj":"http://purl.obolibrary.org/obo/UBERON_0003688"},{"id":"T306","span":{"begin":447,"end":452},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T307","span":{"begin":461,"end":470},"obj":"http://purl.obolibrary.org/obo/UBERON_0000026"},{"id":"T308","span":{"begin":461,"end":470},"obj":"http://www.ebi.ac.uk/efo/EFO_0000799"},{"id":"T309","span":{"begin":487,"end":498},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T310","span":{"begin":608,"end":613},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T311","span":{"begin":641,"end":646},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T312","span":{"begin":749,"end":754},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T313","span":{"begin":766,"end":773},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T314","span":{"begin":774,"end":784},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T315","span":{"begin":785,"end":790},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T316","span":{"begin":1090,"end":1095},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T317","span":{"begin":1097,"end":1098},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T318","span":{"begin":1276,"end":1277},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T319","span":{"begin":1365,"end":1370},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T320","span":{"begin":1408,"end":1413},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T321","span":{"begin":1455,"end":1460},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T322","span":{"begin":1464,"end":1471},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"T323","span":{"begin":1472,"end":1482},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T324","span":{"begin":1483,"end":1488},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T314","span":{"begin":682,"end":690},"obj":"Chemical"},{"id":"T315","span":{"begin":717,"end":725},"obj":"Chemical"},{"id":"T316","span":{"begin":1199,"end":1203},"obj":"Chemical"},{"id":"T317","span":{"begin":1293,"end":1301},"obj":"Chemical"},{"id":"T318","span":{"begin":1575,"end":1583},"obj":"Chemical"},{"id":"T319","span":{"begin":1593,"end":1598},"obj":"Chemical"},{"id":"T320","span":{"begin":1754,"end":1762},"obj":"Chemical"}],"attributes":[{"id":"A314","pred":"chebi_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A315","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A316","pred":"chebi_id","subj":"T316","obj":"http://purl.obolibrary.org/obo/CHEBI_22695"},{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A320","pred":"chebi_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T16","span":{"begin":554,"end":563},"obj":"Phenotype"},{"id":"T17","span":{"begin":661,"end":670},"obj":"Phenotype"},{"id":"T18","span":{"begin":978,"end":987},"obj":"Phenotype"},{"id":"T19","span":{"begin":1335,"end":1344},"obj":"Phenotype"}],"attributes":[{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T260","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T261","span":{"begin":172,"end":355},"obj":"Sentence"},{"id":"T262","span":{"begin":356,"end":499},"obj":"Sentence"},{"id":"T263","span":{"begin":500,"end":791},"obj":"Sentence"},{"id":"T264","span":{"begin":792,"end":1022},"obj":"Sentence"},{"id":"T265","span":{"begin":1023,"end":1096},"obj":"Sentence"},{"id":"T266","span":{"begin":1097,"end":1099},"obj":"Sentence"},{"id":"T267","span":{"begin":1100,"end":1158},"obj":"Sentence"},{"id":"T268","span":{"begin":1159,"end":1216},"obj":"Sentence"},{"id":"T269","span":{"begin":1217,"end":1275},"obj":"Sentence"},{"id":"T270","span":{"begin":1276,"end":1278},"obj":"Sentence"},{"id":"T271","span":{"begin":1279,"end":1504},"obj":"Sentence"},{"id":"T272","span":{"begin":1505,"end":1603},"obj":"Sentence"},{"id":"T273","span":{"begin":1604,"end":1693},"obj":"Sentence"},{"id":"T274","span":{"begin":1694,"end":1913},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues. Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung. And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts. Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells. Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.\nFig. 10 ACE2 and CD147 expression across tissues and co-expression genes. A: Radar plot of ACE2 and CD147 expression across 53 tissues. The expression values were converted to base-2 logarithm. Red triangle and square mean the top 5 expression tissues. B: UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic). The horizontal bar graph at the bottom left shows the total number of proteins for each group set. Circles and vertical lines in the x-axis mark the corresponding data sets being compared. The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)"}