PMC:7247521 / 32968-35288
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
512 | 2173-2177 | Gene | denotes | RdRp | Gene:43740578 |
513 | 2210-2214 | Gene | denotes | RdRp | Gene:43740578 |
514 | 1945-1953 | Disease | denotes | COVID-19 | MESH:C000657245 |
515 | 2258-2261 | Disease | denotes | XCH | |
516 | 2276-2279 | Disease | denotes | XCH | |
517 | 2305-2308 | Disease | denotes | XCH | |
537 | 1385-1389 | Gene | denotes | RdRp | Gene:43740578 |
538 | 1665-1669 | Gene | denotes | RdRp | Gene:43740578 |
539 | 640-643 | Chemical | denotes | PRO | MESH:D011392 |
540 | 649-652 | Chemical | denotes | VAL | MESH:D014633 |
541 | 658-661 | Chemical | denotes | LYS | MESH:D008239 |
542 | 670-673 | Chemical | denotes | SER | MESH:D012694 |
543 | 846-849 | Chemical | denotes | PHE | MESH:D010649 |
544 | 1015-1018 | Chemical | denotes | LYS | MESH:D008239 |
545 | 1024-1027 | Chemical | denotes | LYS | MESH:D008239 |
546 | 1033-1036 | Chemical | denotes | VAL | MESH:D014633 |
547 | 1045-1048 | Chemical | denotes | PRO | MESH:D011392 |
548 | 1720-1728 | Chemical | denotes | hydrogen | MESH:D006859 |
549 | 1790-1793 | Chemical | denotes | CYS | MESH:D003545 |
550 | 1799-1802 | Chemical | denotes | GLY | |
551 | 1808-1811 | Chemical | denotes | LYS | MESH:D008239 |
552 | 1820-1823 | Chemical | denotes | ASP | MESH:D001224 |
553 | 502-505 | Disease | denotes | XCH | |
554 | 731-734 | Disease | denotes | XCH | |
555 | 1613-1616 | Disease | denotes | XCH |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T412 | 18-26 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T413 | 86-95 | PG_4 | denotes | N protein |
T414 | 324-329 | PR:000000125 | denotes | nsp14 |
T415 | 472-480 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T416 | 538-543 | PR:000000125 | denotes | nsp15 |
T417 | 684-687 | PR:P19339 | denotes | SX1 |
T418 | 701-709 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T419 | 765-770 | PR:000000125 | denotes | nsp14 |
T420 | 869-872 | PR:P19339 | denotes | SX1 |
T421 | 913-918 | PR:000000125 | denotes | nsp15 |
T422 | 1071-1079 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T423 | 1139-1144 | PR:000000125 | denotes | nsp16 |
T424 | 1230-1235 | CHEBI:17478;CHEBI:17478 | denotes | alkyl |
T425 | 1243-1248 | CHEBI:22563;CHEBI:22563 | denotes | anion |
T426 | 1378-1383 | PR:000000125 | denotes | nsp12 |
T427 | 1484-1490 | CHEBI:36916;CHEBI:36916 | denotes | cation |
T428 | 1498-1503 | CHEBI:22563;CHEBI:22563 | denotes | anion |
T429 | 1592-1600 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T430 | 1658-1663 | PR:000000125 | denotes | nsp12 |
T431 | 1909-1918 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
T432 | 1945-1953 | SP_7 | denotes | COVID-19 |
T433 | 1975-1984 | PG_4 | denotes | N protein |
T434 | 1998-2001 | PR:Q8K4K7 | denotes | MS1 |
T435 | 2006-2011 | PR:000000125 | denotes | nsp14 |
T436 | 2032-2037 | PR:000000125 | denotes | nsp15 |
T437 | 2061-2064 | PR:P19339 | denotes | SX1 |
T438 | 2069-2074 | PR:000000125 | denotes | nsp14 |
T439 | 2090-2093 | PR:P19339 | denotes | SX1 |
T440 | 2098-2103 | PR:000000125 | denotes | nsp15 |
T441 | 2135-2140 | PR:000000125 | denotes | nsp16 |
T442 | 2166-2171 | PR:000000125 | denotes | nsp12 |
T443 | 2203-2208 | PR:000000125 | denotes | nsp12 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T108 | 88-95 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T109 | 331-335 | Body_part | denotes | ExoN | http://purl.org/sig/ont/fma/fma84120 |
T110 | 1398-1401 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T111 | 1675-1678 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T112 | 1954-1962 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T113 | 1977-1984 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T114 | 2013-2017 | Body_part | denotes | ExoN | http://purl.org/sig/ont/fma/fma84120 |
T115 | 2186-2189 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T116 | 2220-2223 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T62 | 1945-1953 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T262 | 0-3 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | MS1 |
T263 | 0-3 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | MS1 |
T264 | 12-13 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T265 | 16-17 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T266 | 280-283 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | MS1 |
T267 | 280-283 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | MS1 |
T268 | 441-444 | http://purl.obolibrary.org/obo/CLO_0037067 | denotes | VAL |
T269 | 470-471 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T270 | 649-652 | http://purl.obolibrary.org/obo/CLO_0037067 | denotes | VAL |
T271 | 674-677 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
T272 | 674-677 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
T273 | 674-677 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
T274 | 674-677 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
T275 | 674-677 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
T276 | 674-677 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
T277 | 674-677 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
T278 | 699-700 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T279 | 1033-1036 | http://purl.obolibrary.org/obo/CLO_0037067 | denotes | VAL |
T280 | 1069-1070 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T281 | 1535-1538 | http://purl.obolibrary.org/obo/CLO_0001417 | denotes | 556 |
T282 | 1590-1591 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T283 | 1636-1639 | http://purl.obolibrary.org/obo/CLO_0050884 | denotes | ten |
T284 | 1794-1797 | http://purl.obolibrary.org/obo/CLO_0001001 | denotes | 813 |
T285 | 1964-1965 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T286 | 1967-1970 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | MS1 |
T287 | 1967-1970 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | MS1 |
T288 | 1995-1996 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T289 | 1998-2001 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | MS1 |
T290 | 1998-2001 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | MS1 |
T291 | 2226-2228 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T261 | 88-95 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T262 | 136-138 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T263 | 139-144 | Chemical | denotes | Donor | http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891 |
T265 | 145-153 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T266 | 160-162 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T267 | 170-172 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T268 | 173-175 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T269 | 188-190 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T270 | 241-244 | Chemical | denotes | ALA | http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432 |
T272 | 371-373 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T273 | 374-376 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T274 | 420-423 | Chemical | denotes | PHE | http://purl.obolibrary.org/obo/CHEBI_28044 |
T275 | 604-606 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T276 | 658-661 | Chemical | denotes | LYS | http://purl.obolibrary.org/obo/CHEBI_25094 |
T277 | 792-794 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T278 | 795-797 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T279 | 810-812 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T280 | 846-849 | Chemical | denotes | PHE | http://purl.obolibrary.org/obo/CHEBI_28044 |
T281 | 979-981 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T282 | 1015-1018 | Chemical | denotes | LYS | http://purl.obolibrary.org/obo/CHEBI_25094 |
T283 | 1024-1027 | Chemical | denotes | LYS | http://purl.obolibrary.org/obo/CHEBI_25094 |
T284 | 1064-1066 | Chemical | denotes | 9F | http://purl.obolibrary.org/obo/CHEBI_24061 |
T285 | 1189-1195 | Chemical | denotes | Carbon | http://purl.obolibrary.org/obo/CHEBI_27594 |
T286 | 1196-1204 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T287 | 1211-1213 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T288 | 1214-1216 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T289 | 1227-1229 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T290 | 1240-1242 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T291 | 1243-1248 | Chemical | denotes | anion | http://purl.obolibrary.org/obo/CHEBI_22563 |
T292 | 1276-1279 | Chemical | denotes | PHE | http://purl.obolibrary.org/obo/CHEBI_28044 |
T293 | 1434-1440 | Chemical | denotes | Carbon | http://purl.obolibrary.org/obo/CHEBI_27594 |
T294 | 1441-1449 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T295 | 1468-1473 | Chemical | denotes | Donor | http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891 |
T297 | 1474-1479 | Chemical | denotes | Donor | http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891 |
T299 | 1481-1483 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T300 | 1484-1490 | Chemical | denotes | cation | http://purl.obolibrary.org/obo/CHEBI_36916 |
T301 | 1495-1497 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T302 | 1498-1503 | Chemical | denotes | anion | http://purl.obolibrary.org/obo/CHEBI_22563 |
T303 | 1711-1713 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T304 | 1714-1719 | Chemical | denotes | Donor | http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891 |
T306 | 1720-1728 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T307 | 1735-1737 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T308 | 1738-1740 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T309 | 1754-1756 | Chemical | denotes | Pi | http://purl.obolibrary.org/obo/CHEBI_35780 |
T310 | 1808-1811 | Chemical | denotes | LYS | http://purl.obolibrary.org/obo/CHEBI_25094 |
T311 | 1954-1962 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T312 | 1977-1984 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T313 | 2226-2228 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T251 | 0-453 | Sentence | denotes | MS1 (Fig. 9 A), a compound in formulae MXSG and SGMH, showed eleven interactions with N protein NCB site including H-bond interactions, Pi-Donor hydrogen bond, Pi-sigma, Pi-Pi stacked and Pi-alkyl, which were connected with SER 51, THR 109, ALA 50 and PRO 42, etc.; additionally, MS1 (Fig. 9B) showed five interactions with nsp14 [ExoN] including H-bond interactions and Pi-Pi stacked, which were connected with GLU 92, PHE 190, ASP 273 and VAL 91, etc. |
T252 | 454-683 | Sentence | denotes | MX16 (Fig. 9C), a compound in formulae MXSG and XCH, showed seven interactions with nsp15 [endoribonuclease] including H-bond interactions, Alkyl and Pi-alkyl, which were connected with PRO 343, VAL 275, LYS 344 and SER 293, etc. |
T253 | 684-1053 | Sentence | denotes | SX1 (Fig. 9D), a compound in formulae SGMH and XCH, showed two interactions with nsp14 [N7-MTase] including Pi-Pi stacked and Pi-alkyl, which were connected with PHE 426; additionally, SX1 (Fig. 9E) showed five interactions with nsp15 [endoribonuclease] including H-bond interactions, Alkyl and Pi-alkyl, which were connected with LYS 344, LYS 289, VAL 291 and PRO 343. |
T254 | 1054-1574 | Sentence | denotes | WO1 (Fig. 9F), a compound in formulae WLS and Others, showed seven interactions with nsp16 [2′-O-MTase] including H-bond interactions, Carbon hydrogen bond, Pi-Pi T-shaped, Pi-alkyl and Pi-anion, which were connected with PHE 149, CYS 115, ASP 99 and SER 74, etc.; additionally, WO1 (Fig. 9G) showed seven interactions with nsp12 [RdRp without RNA] including H-bond interactions, Carbon hydrogen bond, Unfavorable Donor-Donor, Pi-cation and Pi-anion, which were connected with THR 556, ARG 553, ASP 623 and SER 682, etc. |
T255 | 1575-1833 | Sentence | denotes | XO1 (Fig. 9H), a compound in formulae XCH and Others, showed ten interactions with nsp12 [RdRp with RNA] including H-bond interactions, Pi-Donor hydrogen bond, Pi-Pi T-shaped and Pi-alkyl, which were connected with CYS 813, GLY 590, LYS 593 and ASP 865, etc. |
T256 | 1834-1963 | Sentence | denotes | Fig. 9 Schematic (3D and 2D) representation that molecular model of common compounds of the five formulae with COVID-19 proteins. |
T257 | 1964-2225 | Sentence | denotes | A: MS1 and N protein NCB site, B: MS1 and nsp14 [ExoN], C: MX16 and nsp15 [endoribonuclease], D: SX1 and nsp14 [N7-MTase], E: SX1 and nsp15 [endoribonuclease], F: WO1 and nsp16 [2′-O-MTase], G: WO1 and nsp12 [RdRp without RNA], H: XO1 and nsp12 [RdRp with RNA]. |
T258 | 2226-2320 | Sentence | denotes | MS: MXSG and SGMH, MX: MXSG and XCH, SX: SGMH and XCH, WO: WLS and Others, XO: XCH and Others. |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T4 | 1054-1057 | GlycoEpitope | denotes | WO1 | http://www.glycoepitope.jp/epitopes/AN0690 |
T5 | 1333-1336 | GlycoEpitope | denotes | WO1 | http://www.glycoepitope.jp/epitopes/AN0690 |
T6 | 2127-2130 | GlycoEpitope | denotes | WO1 | http://www.glycoepitope.jp/epitopes/AN0690 |
T7 | 2158-2161 | GlycoEpitope | denotes | WO1 | http://www.glycoepitope.jp/epitopes/AN0690 |