PMC:7247521 / 29823-30843 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"418","span":{"begin":267,"end":271},"obj":"Gene"},{"id":"419","span":{"begin":336,"end":340},"obj":"Gene"},{"id":"420","span":{"begin":408,"end":416},"obj":"Gene"},{"id":"421","span":{"begin":477,"end":485},"obj":"Gene"},{"id":"423","span":{"begin":63,"end":72},"obj":"Species"},{"id":"425","span":{"begin":1005,"end":1008},"obj":"Disease"}],"attributes":[{"id":"A418","pred":"tao:has_database_id","subj":"418","obj":"Gene:43740578"},{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"Gene:43740578"},{"id":"A420","pred":"tao:has_database_id","subj":"420","obj":"Gene:164045"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"Gene:164045"},{"id":"A423","pred":"tao:has_database_id","subj":"423","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T397","span":{"begin":63,"end":72},"obj":"SP_7"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T101","span":{"begin":73,"end":81},"obj":"Body_part"},{"id":"T102","span":{"begin":277,"end":280},"obj":"Body_part"},{"id":"T103","span":{"begin":349,"end":352},"obj":"Body_part"},{"id":"T104","span":{"begin":556,"end":560},"obj":"Body_part"},{"id":"T105","span":{"begin":840,"end":847},"obj":"Body_part"},{"id":"T106","span":{"begin":910,"end":917},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A104","pred":"fma_id","subj":"T104","obj":"http://purl.org/sig/ont/fma/fma84120"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T251","span":{"begin":98,"end":100},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T252","span":{"begin":101,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T204","span":{"begin":73,"end":81},"obj":"Chemical"},{"id":"T205","span":{"begin":92,"end":94},"obj":"Chemical"},{"id":"T207","span":{"begin":101,"end":103},"obj":"Chemical"},{"id":"T208","span":{"begin":123,"end":125},"obj":"Chemical"},{"id":"T209","span":{"begin":417,"end":420},"obj":"Chemical"},{"id":"T212","span":{"begin":840,"end":847},"obj":"Chemical"},{"id":"T213","span":{"begin":910,"end":917},"obj":"Chemical"},{"id":"T214","span":{"begin":918,"end":921},"obj":"Chemical"}],"attributes":[{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_51083"},{"id":"A206","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_53453"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A210","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A211","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A212","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A213","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T101","span":{"begin":918,"end":929},"obj":"http://purl.obolibrary.org/obo/GO_0022831"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}

{"project":"LitCovid-sentences","denotations":[{"id":"T220","span":{"begin":0,"end":82},"obj":"Sentence"},{"id":"T221","span":{"begin":83,"end":125},"obj":"Sentence"},{"id":"T222","span":{"begin":126,"end":194},"obj":"Sentence"},{"id":"T223","span":{"begin":195,"end":266},"obj":"Sentence"},{"id":"T224","span":{"begin":267,"end":335},"obj":"Sentence"},{"id":"T225","span":{"begin":336,"end":407},"obj":"Sentence"},{"id":"T226","span":{"begin":408,"end":476},"obj":"Sentence"},{"id":"T227","span":{"begin":477,"end":549},"obj":"Sentence"},{"id":"T228","span":{"begin":550,"end":616},"obj":"Sentence"},{"id":"T229","span":{"begin":617,"end":685},"obj":"Sentence"},{"id":"T230","span":{"begin":686,"end":764},"obj":"Sentence"},{"id":"T231","span":{"begin":765,"end":837},"obj":"Sentence"},{"id":"T232","span":{"begin":838,"end":907},"obj":"Sentence"},{"id":"T233","span":{"begin":908,"end":983},"obj":"Sentence"},{"id":"T234","span":{"begin":984,"end":1012},"obj":"Sentence"},{"id":"T235","span":{"begin":1013,"end":1020},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.\nMolecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2\nMain Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4\nPapain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2\nRdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6\nRdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1\nHelicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5\nHelicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4\nNsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9\nNsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5\nNsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4\nNsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4\nN protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6\nE protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8\nM: MXSG, S: SGMH, X: XCH, O: Others."}