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PMC:7247521 / 27354-28994 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
391 1625-1628 Disease denotes XCH
403 663-667 Gene denotes OCT2 Gene:6582
404 790-794 Gene denotes hERG Gene:2078
405 808-812 Gene denotes hERG Gene:2078
406 832-835 Species denotes rat Tax:10116
407 723-731 Disease denotes toxicity MESH:D064420
408 756-764 Disease denotes toxicity MESH:D064420
409 842-850 Disease denotes toxicity MESH:D064420
410 859-873 Disease denotes hepatotoxicity MESH:D056486
411 875-893 Disease denotes skin sensitisation MESH:D012871
412 906-914 Disease denotes toxicity MESH:D064420
413 127-133 CellLine denotes Caco-2 CVCL:0025

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T342 44-53 CHEBI:36357;CHEBI:36357 denotes compounds
T343 87-91 UBERON:0000165 denotes oral
T344 127-133 CL_1 denotes Caco-2
T345 184-188 CHEBI:23888;CHEBI:23888 denotes drug
T346 234-243 CHEBI:36357;CHEBI:36357 denotes compounds
T347 259-265 UBERON:0000479 denotes tissue
T348 279-285 UBERON:0000479 denotes tissue
T349 300-306 UBERON:0001969 denotes plasma
T350 388-403 CHEBI:52217;CHEBI:52217 denotes pharmacological
T351 475-494 UBERON:0000120 denotes blood-brain barrier
T352 496-499 UBERON:0000120 denotes BBB
T353 505-527 UBERON:0001017 denotes central nervous system
T354 529-532 UBERON:0001017 denotes CNS
T355 551-560 CHEBI:36357;CHEBI:36357 denotes compounds
T356 578-583 UBERON:0002113 denotes renal
T357 627-632 UBERON:0002113 denotes renal
T358 633-647 CHEBI:25697;CHEBI:25697;PR:000014988 denotes organic cation
T359 648-661 PR:000014988 denotes transporter 2
T360 663-667 PR:000013036 denotes OCT2
T361 682-691 CHEBI:36357;CHEBI:36357 denotes compounds
T362 751-755 CHEBI:34018;CHEBI:34018 denotes AMES
T363 790-794 PR:P11308 denotes hERG
T364 797-806 CHEBI:35222;CHEBI:35222 denotes inhibitor
T365 808-812 PR:P11308 denotes hERG
T366 816-825 CHEBI:35222;CHEBI:35222 denotes inhibitor
T367 827-831 UBERON:0000165 denotes oral
T368 832-835 NCBITaxon:10114 denotes rat
T372 954-963 CHEBI:36357;CHEBI:36357 denotes compounds

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T85 134-138 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 161-165 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T87 259-265 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T88 279-285 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T89 300-306 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T90 475-480 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T91 481-486 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T92 505-527 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T93 529-532 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T94 875-879 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 161-165 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T25 259-265 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 279-285 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T27 475-494 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T28 475-480 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T29 481-486 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T30 505-527 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T31 513-527 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T32 529-532 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T33 875-879 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T215 75-76 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 127-138 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2 cell
T217 161-165 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T218 161-165 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T219 161-165 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T220 161-165 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T221 161-165 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T222 300-306 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T223 475-480 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T224 475-480 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T225 481-486 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T226 481-486 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T227 505-527 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T228 505-527 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T229 505-527 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T230 529-532 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T231 529-532 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T232 529-532 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T233 571-572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 633-640 http://purl.obolibrary.org/obo/OBI_0100026 denotes organic
T235 633-640 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organic
T236 875-879 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T237 875-879 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T238 875-879 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T239 875-879 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T240 875-879 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T241 947-953 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T242 1079-1081 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T243 1260-1262 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T244 1370-1373 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T245 1370-1373 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T246 1402-1404 http://purl.obolibrary.org/obo/CLO_0009126 denotes SR

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T168 184-188 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T169 633-647 Chemical denotes organic cation http://purl.obolibrary.org/obo/CHEBI_25697
T170 641-647 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T171 797-806 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T172 813-815 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T173 816-825 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T174 1052-1054 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T176 1079-1081 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T177 1115-1125 Chemical denotes Medicarpin http://purl.obolibrary.org/obo/CHEBI_6714
T178 1137-1147 Chemical denotes Cianidanol http://purl.obolibrary.org/obo/CHEBI_15600
T179 1207-1209 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T180 1263-1272 Chemical denotes letrozole http://purl.obolibrary.org/obo/CHEBI_6413
T181 1349-1359 Chemical denotes naringenin http://purl.obolibrary.org/obo/CHEBI_50202
T182 1374-1387 Chemical denotes Leucocyanidol http://purl.obolibrary.org/obo/CHEBI_11412|http://purl.obolibrary.org/obo/CHEBI_15758
T184 1472-1475 Chemical denotes Tyr http://purl.obolibrary.org/obo/CHEBI_17895|http://purl.obolibrary.org/obo/CHEBI_18186|http://purl.obolibrary.org/obo/CHEBI_46858
T187 1478-1481 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T189 1498-1512 Chemical denotes Liquiritigenin http://purl.obolibrary.org/obo/CHEBI_28777
T190 1531-1540 Chemical denotes taxifolin http://purl.obolibrary.org/obo/CHEBI_38747
T191 1593-1602 Chemical denotes flavanone http://purl.obolibrary.org/obo/CHEBI_5070

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T99 633-659 http://purl.obolibrary.org/obo/GO_0015695 denotes organic cation transporter

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T196 0-179 Sentence denotes Regarding the absorption parameters, all 20 compounds (Table 2 ) presented a promising oral availability including the optimal Caco-2 cell permeability, HIA and skin permeability.
T197 180-411 Sentence denotes The drug distribution results showed that most of the compounds distributed in tissue (VDss> 0.45: tissue, VDss <−0.15: plasma) with good unbound fraction scores, thus becoming available to interact with the pharmacological target.
T198 412-534 Sentence denotes Only compound W5 and W11 were entirely unable to penetrate the blood-brain barrier (BBB) and central nervous system (CNS).
T199 535-669 Sentence denotes In addition, 15 compounds presented a good renal elimination and were not substrates of the renal organic cation transporter 2 (OCT2).
T200 670-925 Sentence denotes Finally, 14 compounds did not present any particular toxicity problems including AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity (Fig. 7B).
T201 926-974 Sentence denotes Table 2 20 potential active compounds from QFPD.
T202 975-1040 Sentence denotes Pubchem Molecular Name Structure Pubchem Molecular Name Structure
T203 1041-1101 Sentence denotes CID6918970 M3 ZINC5356864 CID10019512 S5 3-O-Methylviolanone
T204 1102-1147 Sentence denotes CID336327 M5 Medicarpin CID9064 W5 Cianidanol
T205 1148-1194 Sentence denotes CID14057197 O1 – CID182232 W11 (+)-Epicatechin
T206 1195-1251 Sentence denotes CID42607889 O2 Alysifolinone CID25721350 X1 ZINC13130930
T207 1252-1309 Sentence denotes CID3902 S1 letrozole CID14135323 X2 (2S)-dihydrobaicalein
T208 1310-1359 Sentence denotes CID821279 X4 ZINC338038 CID439246 MXO1 naringenin
T209 1360-1419 Sentence denotes CID440833 MS1 Leucocyanidol CID676152 SO1 SR-01,000,767,148
T210 1420-1482 Sentence denotes CID177149 MX16 (+)-Vestitol CID11438306 SX1 cyclo(L-Tyr-l-Phe)
T211 1483-1540 Sentence denotes CID114829 MX17 Liquiritigenin CID712316 WO1 (-)-taxifolin
T212 1541-1603 Sentence denotes CID928837 MX8 ZINC519174 CID373261 XO1 Eriodyctiol (flavanone)
T213 1604-1632 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T214 1633-1640 Sentence denotes Others.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T2 1523-1526 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690