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PMC:7247521 / 26040-27030 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
361 619-623 Gene denotes OCT2 Gene:6582
362 425-430 Species denotes Human Tax:9606
363 510-515 Species denotes Human Tax:9606
364 712-717 Species denotes Human Tax:9606
365 768-771 Species denotes Rat Tax:10116
366 370-375 Chemical denotes Caco2
367 598-600 Chemical denotes TC MESH:D013667
368 682-686 Chemical denotes MTDD
369 256-264 Disease denotes toxicity MESH:D064420
370 672-680 Disease denotes toxicity MESH:D064420
371 778-786 Disease denotes Toxicity MESH:D064420
372 799-813 Disease denotes Hepatotoxicity MESH:D056486
373 819-837 Disease denotes Skin Sensitisation MESH:D012871
374 850-858 Disease denotes toxicity MESH:D064420
375 377-383 CellLine denotes Caco-2 CVCL:0025

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T290 305-314 CHEBI:36357;CHEBI:36357 denotes compounds
T291 370-375 CL_1 denotes Caco2
T292 377-383 CL_1 denotes Caco-2
T293 402-412 UBERON:0000160 denotes Intestinal
T294 425-430 SP_6;NCBITaxon:9606 denotes Human
T295 510-515 SP_6;NCBITaxon:9606 denotes Human
T296 523-534 UBERON:0000120 denotes Blood Brain
T297 557-560 UBERON:0001017 denotes CNS
T298 562-584 UBERON:0001017 denotes Central Nervous System
T299 619-623 PR:000013036 denotes OCT2
T300 625-630 UBERON:0002113 denotes Renal
T301 631-645 CHEBI:25697;CHEBI:25697;PR:000014988 denotes Organic Cation
T302 646-659 PR:000014988 denotes Transporter 2
T303 712-717 SP_6;NCBITaxon:9606 denotes Human
T304 720-724 PR:P11308 denotes hERG
T305 731-735 PR:P11308 denotes hERG
T306 763-767 UBERON:0000165 denotes Oral
T307 768-771 NCBITaxon:10114 denotes Rat
T308 839-841 UBERON:0001448 denotes MT

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T74 402-412 Body_part denotes Intestinal http://purl.org/sig/ont/fma/fma7199
T75 433-437 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T76 439-443 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T77 523-528 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T78 529-534 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T79 557-560 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T80 562-584 Body_part denotes Central Nervous System http://purl.org/sig/ont/fma/fma55675
T81 570-584 Body_part denotes Nervous System http://purl.org/sig/ont/fma/fma7157
T82 819-823 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 433-437 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T19 439-443 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T20 523-542 Body_part denotes Blood Brain Barrier http://purl.obolibrary.org/obo/UBERON_0000120
T21 557-560 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T22 562-584 Body_part denotes Central Nervous System http://purl.obolibrary.org/obo/UBERON_0001017
T23 819-823 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T167 66-67 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T168 87-88 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T169 370-375 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco2
T170 370-375 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco2
T171 370-375 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco2
T172 370-375 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco2
T173 377-383 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T174 377-383 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T175 377-383 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T176 377-383 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T177 402-412 http://purl.obolibrary.org/obo/UBERON_0000160 denotes Intestinal
T178 402-412 http://www.ebi.ac.uk/efo/EFO_0000834 denotes Intestinal
T179 425-430 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T180 433-437 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T181 433-437 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T182 433-437 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T183 433-437 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T184 433-437 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T185 439-443 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T186 439-443 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T187 439-443 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T188 439-443 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T189 439-443 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T190 510-515 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T191 523-528 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T192 523-528 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T193 529-534 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T194 529-534 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T195 557-560 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T196 557-560 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T197 557-560 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T198 562-584 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central Nervous System
T199 562-584 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central Nervous System
T200 562-584 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central Nervous System
T201 631-638 http://purl.obolibrary.org/obo/OBI_0100026 denotes Organic
T202 631-638 http://purl.obolibrary.org/obo/UBERON_0000468 denotes Organic
T203 712-717 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T204 795-797 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T205 819-823 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T206 819-823 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T207 819-823 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T208 819-823 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T209 819-823 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T152 639-645 Chemical denotes Cation http://purl.obolibrary.org/obo/CHEBI_36916
T153 727-729 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T154 742-744 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T155 815-817 Chemical denotes SS http://purl.obolibrary.org/obo/CHEBI_73653
T156 839-841 Chemical denotes MT http://purl.obolibrary.org/obo/CHEBI_73614

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T96 402-423 http://purl.obolibrary.org/obo/GO_0050892 denotes Intestinal Absorption
T97 631-657 http://purl.obolibrary.org/obo/GO_0015695 denotes Organic Cation Transporter

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T176 66-68 Sentence denotes A:
T177 69-369 Sentence denotes Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad.
T178 370-376 Sentence denotes Caco2:
T179 377-401 Sentence denotes Caco-2 Permeability,HIA:
T180 402-438 Sentence denotes Intestinal Absorption (Human), Skin:
T181 439-491 Sentence denotes Skin Permeability, VDss: volume of distribution, FU:
T182 492-522 Sentence denotes Fraction Unbound (Human), BBB:
T183 523-561 Sentence denotes Blood Brain Barrier permeability, CNS:
T184 562-601 Sentence denotes Central Nervous System permeability,TC:
T185 602-624 Sentence denotes Total Clearance, OCT2:
T186 625-687 Sentence denotes Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD:
T187 688-762 Sentence denotes Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50:
T188 763-798 Sentence denotes Oral Rat Acute Toxicity (LD50), HT:
T189 799-818 Sentence denotes Hepatotoxicity, SS:
T190 819-842 Sentence denotes Skin Sensitisation, MT:
T191 843-990 Sentence denotes Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)