PMC:7247521 / 25715-26068 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T286","span":{"begin":13,"end":22},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T287","span":{"begin":165,"end":169},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T288","span":{"begin":216,"end":225},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T289","span":{"begin":289,"end":305},"obj":"UBERON:0005409"}],"text":"21 (31.34 %) compounds passed the stringent lead-like criteria (250 g/mol ≤ MW ≤ 350 g/mol, XLOGP ≤ 3.5 and rotatable bonds ≤ 7), which are excellent candidates for drug discovery (Fig. 7 A). And these lead-likeness compounds were further predicted by pkCSM, with the exception of S3 (low gastrointestinal absorption)\nFig. 7 Chemical properties statisti"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T166","span":{"begin":188,"end":189},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"21 (31.34 %) compounds passed the stringent lead-like criteria (250 g/mol ≤ MW ≤ 350 g/mol, XLOGP ≤ 3.5 and rotatable bonds ≤ 7), which are excellent candidates for drug discovery (Fig. 7 A). And these lead-likeness compounds were further predicted by pkCSM, with the exception of S3 (low gastrointestinal absorption)\nFig. 7 Chemical properties statisti"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T149","span":{"begin":76,"end":78},"obj":"Chemical"},{"id":"T150","span":{"begin":165,"end":169},"obj":"Chemical"},{"id":"T151","span":{"begin":281,"end":283},"obj":"Chemical"}],"attributes":[{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_74709"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"21 (31.34 %) compounds passed the stringent lead-like criteria (250 g/mol ≤ MW ≤ 350 g/mol, XLOGP ≤ 3.5 and rotatable bonds ≤ 7), which are excellent candidates for drug discovery (Fig. 7 A). And these lead-likeness compounds were further predicted by pkCSM, with the exception of S3 (low gastrointestinal absorption)\nFig. 7 Chemical properties statisti"}

{"project":"LitCovid-sentences","denotations":[{"id":"T174","span":{"begin":192,"end":317},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"21 (31.34 %) compounds passed the stringent lead-like criteria (250 g/mol ≤ MW ≤ 350 g/mol, XLOGP ≤ 3.5 and rotatable bonds ≤ 7), which are excellent candidates for drug discovery (Fig. 7 A). And these lead-likeness compounds were further predicted by pkCSM, with the exception of S3 (low gastrointestinal absorption)\nFig. 7 Chemical properties statisti"}