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PMC:7247521 / 2386-6979 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
55 16-38 Species denotes 2019-novel coronavirus Tax:2697049
56 40-49 Species denotes 2019-nCov Tax:2697049
57 168-176 Species denotes patients Tax:9606
58 351-357 Species denotes people Tax:9606
59 395-401 Species denotes people Tax:9606
60 202-227 Disease denotes corona virus disease 2019 MESH:C000657245
61 229-237 Disease denotes COVID-19 MESH:C000657245
83 1469-1477 Species denotes Ma Huang Tax:3387
84 1523-1527 Species denotes Ling Tax:163112
85 602-628 Disease denotes viral infectious pneumonia
86 680-684 Disease denotes SARS MESH:D045169
87 963-1038 Disease denotes Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae
88 1323-1331 Disease denotes COVID-19 MESH:C000657245
89 1510-1513 Disease denotes XCH
90 1603-1618 Disease denotes Febrile Disease MESH:D000071072
91 1765-1769 Disease denotes cold MESH:D000067390
92 1771-1776 Disease denotes fever MESH:D005334
93 1792-1808 Disease denotes virus infections MESH:D001102
94 2092-2098 Disease denotes asthma MESH:D001249
95 2100-2112 Disease denotes inflammation MESH:D007249
96 2114-2125 Disease denotes tonsillitis MESH:D014069
97 2130-2141 Disease denotes sore throat MESH:D010608
98 2147-2150 Disease denotes XCH
99 2357-2396 Disease denotes Rhizoma Alismatis, Polyporus Umbellatus
100 2476-2494 Disease denotes nephritic syndrome MESH:D061325
101 2616-2619 Disease denotes XCH
102 3010-3018 Disease denotes COVID-19 MESH:C000657245
103 3042-3045 Disease denotes XCH
107 3188-3196 Disease denotes COVID-19 MESH:C000657245
108 3939-3947 Disease denotes COVID-19 MESH:C000657245
109 4023-4031 Disease denotes COVID-19 MESH:C000657245
113 4086-4089 Disease denotes XCH
114 4148-4174 Disease denotes viral infectious pneumonia
115 4361-4369 Disease denotes COVID-19 MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T46 27-38 NCBITaxon:11118 denotes coronavirus
T47 40-49 SP_7 denotes 2019-nCov
T48 202-214 NCBITaxon:11118 denotes corona virus
T49 229-237 SP_7 denotes COVID-19
T50 248-253 NCBITaxon:10239 denotes virus
T51 351-357 NCBITaxon:9606 denotes people
T52 395-401 NCBITaxon:9606 denotes people
T53 513-518 CHEBI:23888;CHEBI:23888 denotes drugs
T54 545-550 NCBITaxon:10239 denotes virus
T55 602-607 NCBITaxon:10239 denotes viral
T56 680-684 SP_10 denotes SARS
T57 992-1002 NCBITaxon:158314 denotes Umbellatus
T58 1025-1038 NCBITaxon:9539 denotes Macrocephalae
T59 1040-1045 NCBITaxon:6040 denotes Poria
T60 1323-1331 SP_7 denotes COVID-19
T61 1792-1797 NCBITaxon:10239 denotes virus
T62 1826-1831 NCBITaxon:10239 denotes viral
T63 1832-1839 GO:0009986 denotes surface
T64 1865-1870 NCBITaxon:10239;GO:0035376 denotes viral
T65 1871-1876 GO:0035376 denotes entry
T66 2135-2141 UBERON:0000341 denotes throat
T67 2194-2206 NCBITaxon:4932 denotes Scutellariae
T68 2300-2316 CHEBI:67079;CHEBI:67079 denotes anticarcinogenic
T69 2376-2396 NCBITaxon:158314 denotes Polyporus Umbellatus
T70 2508-2514 UBERON:0002113 denotes kidney
T71 2515-2524 GO:0007588 denotes excretion
T72 3010-3018 SP_7 denotes COVID-19
T73 3188-3196 SP_7 denotes COVID-19
T74 3212-3227 CHEBI:52217;CHEBI:52217 denotes pharmacological
T75 3306-3318 CHEBI:52217;CHEBI:52217 denotes pharmacology
T76 3380-3385 CHEBI:23888;CHEBI:23888 denotes drugs
T77 3523-3535 CHEBI:52217;CHEBI:52217 denotes pharmacology
T78 3939-3947 SP_7 denotes COVID-19
T79 4023-4031 SP_7 denotes COVID-19
T80 4148-4153 NCBITaxon:10239 denotes viral
T81 4224-4233 CHEBI:36357;CHEBI:36357 denotes compounds
T82 4361-4369 SP_7 denotes COVID-19
T83 4409-4421 CHEBI:52217;CHEBI:52217 denotes pharmacology

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 902-907 Body_part denotes Semen http://purl.org/sig/ont/fma/fma62966
T6 1677-1682 Body_part denotes Semen http://purl.org/sig/ont/fma/fma62966
T7 2135-2141 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T8 2508-2514 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 902-907 Body_part denotes Semen http://purl.obolibrary.org/obo/UBERON_0001968
T3 1677-1682 Body_part denotes Semen http://purl.obolibrary.org/obo/UBERON_0001968
T4 1832-1849 Body_part denotes surface structure http://purl.obolibrary.org/obo/UBERON_0003102
T5 2135-2141 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T6 2508-2514 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T13 202-227 Disease denotes corona virus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T14 229-237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 608-618 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T16 619-628 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T17 680-684 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 1323-1331 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1758-1769 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T20 1782-1791 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T21 1792-1808 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T22 2073-2076 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T23 2092-2098 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T24 2100-2112 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T25 2114-2125 Disease denotes tonsillitis http://purl.obolibrary.org/obo/MONDO_0001039
T26 2130-2141 Disease denotes sore throat http://purl.obolibrary.org/obo/MONDO_0002258
T27 3010-3018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 3188-3196 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 3939-3947 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 4023-4031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 4154-4164 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T32 4165-4174 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T33 4361-4369 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T19 209-214 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T20 248-253 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T21 254-257 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 258-259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 365-368 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 369-370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 484-485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 545-550 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T27 581-584 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28 585-586 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 633-636 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T30 643-644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 790-797 http://purl.obolibrary.org/obo/UBERON_0000982 denotes jointly
T32 790-797 http://purl.obolibrary.org/obo/UBERON_0004905 denotes jointly
T33 805-806 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 1386-1387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 1719-1722 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T36 1792-1797 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T37 2027-2028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 2114-2125 http://purl.obolibrary.org/obo/UBERON_0002372 denotes tonsillitis
T39 2442-2443 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 2508-2514 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T41 2508-2514 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T42 2508-2514 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T43 2691-2698 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T44 2750-2751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 3077-3078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3320-3321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 3423-3424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 3893-3895 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T49 4291-4292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 4373-4374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 4486-4487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 4570-4571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T14 202-208 Chemical denotes corona http://purl.obolibrary.org/obo/CHEBI_37409
T15 513-518 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 572-580 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T17 1413-1416 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T18 2274-2283 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T19 2779-2787 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T20 2875-2883 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T21 3380-3385 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T22 3481-3484 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T23 3569-3572 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T24 3673-3676 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 619-628 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 1771-1776 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T6 2092-2098 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T7 2114-2125 Phenotype denotes tonsillitis http://purl.obolibrary.org/obo/HP_0011110
T8 2130-2141 Phenotype denotes sore throat http://purl.obolibrary.org/obo/HP_0033050
T9 4165-4174 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T20 2100-2112 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T21 2515-2524 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T22 2538-2567 http://purl.obolibrary.org/obo/GO_0050728 denotes inhibit inflammatory response
T23 2546-2567 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T20 0-15 Sentence denotes 1 Introduction
T21 16-129 Sentence denotes 2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world.
T22 130-243 Sentence denotes By April 3, 2020, more than 1 million patients have been diagnosed with corona virus disease 2019 (COVID-19) [1].
T23 244-459 Sentence denotes The virus has a long incubation period, is highly contagious, and is generally susceptible to all types of people, which has a huge negative impact on people's health, economic development, and social stability [2].
T24 460-551 Sentence denotes However, there is still a lack of effective clinical drugs or vaccine to control the virus.
T25 552-685 Sentence denotes Traditional Chinese medicine has a good effect on viral infectious pneumonia and has shown a certain effect in the treatment of SARS.
T26 686-1377 Sentence denotes On February 7, 2020, the China Health Commission and the Administration of Traditional Chinese Medicine jointly issued a notice recommending formula Qingfei Paidu decoction (QFPD, Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum, Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Herba Pogostemonis) for the treatment of COVID-19 according to clinical treatment and efficacy.
T27 1378-1634 Sentence denotes QFPD is a compound prescription in TCM including Ma Xing Shi Gan decoction (MSXG), She Gan Ma Huang decoction (SGMH), Xiao Chai Hu (XCH), and Wu Ling San (WLS), which was first discovered in the classic Treatise on Exogenous Febrile Disease (Shanghan Lun).
T28 1635-1881 Sentence denotes MXSG (Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum) has been used for the treatment of the common cold, fever, and influenza virus infections via damaging the viral surface structure and inhibiting viral entry [3].
T29 1882-2146 Sentence denotes SGMH (Herba Ephedrae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari) is a classical prescription for the treatment of flu-like symptoms, asthma, inflammation, tonsillitis and sore throat [4].
T30 2147-2332 Sentence denotes XCH (Radix Glycyrrhizae, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens) possesses antiviral [5] and various anticarcinogenic properties [6].
T31 2333-2572 Sentence denotes WLS (Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria), a famous Chinese prescription for nephritic syndrome, can improve kidney excretion function and inhibit inflammatory response [7].
T32 2573-2668 Sentence denotes These researches indicate that MXSG, SGMH, XCH and WLS may be functional units of formula QFPD.
T33 2669-2788 Sentence denotes Previous studies have focused on the mechanism of compound prescription based on a single traditional Chinese medicine.
T34 2789-2884 Sentence denotes However, it may not reflect functional compatibility mechanism of traditional Chinese medicine.
T35 2885-3062 Sentence denotes Therefore, it is worthy of comparing the similarities and differences of different QFPD functional units in the treatment of COVID-19, including MXSG, SGMH, XCH, WLS and Others.
T36 3063-3297 Sentence denotes QFPD contains a total of 21 traditional Chinese medicines, and it is difficult to elucidate the complex mechanism of QFPD on COVID-19 by traditional pharmacological methods due to the multi-components and multi-targets of the formula.
T37 3298-3455 Sentence denotes Network pharmacology, a new method in recent years, can integrate interactions of drugs, targets, pathways and diseases into a biological network system [8].
T38 3456-3727 Sentence denotes Therefore, more and more TCM researchers have begun to use network pharmacology to explore the material basis of TCM, and to reveal the overall comprehensive effects of multi-path, multi-component and multi-target of TCM prescription and its treatment of diseases [9,10].
T39 3728-3897 Sentence denotes More importantly, previous study reported that disease conditions can be more fragile than health systems against various perturbations for the un-optimized system [11].
T40 3898-4053 Sentence denotes So the formula may be more effective for COVID-19 disease via the stronger effects on the reduction of the robustness of the COVID-19 disease network [12].
T41 4054-4274 Sentence denotes In our study, since MSXG, SGMH, XCH and WLS have been independently used for the treatment of viral infectious pneumonia, this study firstly screened out major effective compounds from five functional units respectively.
T42 4275-4593 Sentence denotes Then we offered a new understanding of the functional units mechanism of QFPD against COVID-19 by a novel functional units of network pharmacology (FUNP) approach and formula perturbation analysis, and provided a combination strategy to explore mechanisms of inter-ingredients interactions from a holistic perspective.

2_test

Id Subject Object Predicate Lexical cue
32554251-32007143-6393485 456-457 32007143 denotes 2
32554251-22710290-6393486 1878-1879 22710290 denotes 3
32554251-16644487-6393487 2285-2286 16644487 denotes 5
32554251-25914040-6393488 2569-2570 25914040 denotes 7
32554251-17921993-6393489 3452-3453 17921993 denotes 8
32554251-17318209-6393490 3893-3895 17318209 denotes 11
32554251-30809144-6393491 4049-4051 30809144 denotes 12