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PMC:7247521 / 2386-48395 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
55 16-38 Species denotes 2019-novel coronavirus Tax:2697049
56 40-49 Species denotes 2019-nCov Tax:2697049
57 168-176 Species denotes patients Tax:9606
58 351-357 Species denotes people Tax:9606
59 395-401 Species denotes people Tax:9606
60 202-227 Disease denotes corona virus disease 2019 MESH:C000657245
61 229-237 Disease denotes COVID-19 MESH:C000657245
83 1469-1477 Species denotes Ma Huang Tax:3387
84 1523-1527 Species denotes Ling Tax:163112
85 602-628 Disease denotes viral infectious pneumonia
86 680-684 Disease denotes SARS MESH:D045169
87 963-1038 Disease denotes Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae
88 1323-1331 Disease denotes COVID-19 MESH:C000657245
89 1510-1513 Disease denotes XCH
90 1603-1618 Disease denotes Febrile Disease MESH:D000071072
91 1765-1769 Disease denotes cold MESH:D000067390
92 1771-1776 Disease denotes fever MESH:D005334
93 1792-1808 Disease denotes virus infections MESH:D001102
94 2092-2098 Disease denotes asthma MESH:D001249
95 2100-2112 Disease denotes inflammation MESH:D007249
96 2114-2125 Disease denotes tonsillitis MESH:D014069
97 2130-2141 Disease denotes sore throat MESH:D010608
98 2147-2150 Disease denotes XCH
99 2357-2396 Disease denotes Rhizoma Alismatis, Polyporus Umbellatus
100 2476-2494 Disease denotes nephritic syndrome MESH:D061325
101 2616-2619 Disease denotes XCH
102 3010-3018 Disease denotes COVID-19 MESH:C000657245
103 3042-3045 Disease denotes XCH
107 3188-3196 Disease denotes COVID-19 MESH:C000657245
108 3939-3947 Disease denotes COVID-19 MESH:C000657245
109 4023-4031 Disease denotes COVID-19 MESH:C000657245
113 4086-4089 Disease denotes XCH
114 4148-4174 Disease denotes viral infectious pneumonia
115 4361-4369 Disease denotes COVID-19 MESH:C000657245
120 4693-4696 Disease denotes XCH
121 4820-4822 Disease denotes OB MESH:D009765
122 4868-4872 Disease denotes CIDs
123 5126-5130 Disease denotes CIDs
126 5534-5537 Disease denotes XCH
127 5710-5726 Disease denotes OMIM/TTD disease MESH:D003141
132 6660-6699 Gene denotes Kyoto Encyclopedia of Genes and Genomes
133 6470-6482 Species denotes Homo sapiens Tax:9606
134 6289-6292 Disease denotes XCH
135 6813-6816 Disease denotes XCH
139 7038-7041 Disease denotes XCH
140 7265-7268 Disease denotes XCH
141 7359-7362 Disease denotes XCH
153 8016-8020 Gene denotes OCT2 Gene:6582
154 8085-8089 Gene denotes hERG Gene:2078
155 8103-8107 Gene denotes hERG Gene:2078
156 8127-8130 Species denotes rat Tax:10116
157 8036-8044 Disease denotes toxicity MESH:D064420
158 8051-8059 Disease denotes toxicity MESH:D064420
159 8137-8145 Disease denotes toxicity MESH:D064420
160 8154-8168 Disease denotes hepatotoxicity MESH:D056486
161 8170-8188 Disease denotes skin sensitisation MESH:D012871
162 8201-8209 Disease denotes toxicity MESH:D064420
163 7825-7831 CellLine denotes Caco-2 CVCL:0025
176 8543-8547 Gene denotes Mpro Gene:8673700
177 8563-8567 Gene denotes RdRp Gene:43740578
178 8586-8590 Gene denotes RdRp Gene:43740578
179 8612-8620 Gene denotes Helicase Gene:164045
180 8639-8647 Gene denotes Helicase Gene:164045
181 8549-8554 Gene denotes PLpro Gene:43740578
182 8324-8328 Species denotes ncov Tax:2697049
183 8517-8526 Species denotes 2019-nCov Tax:2697049
184 8273-8281 Disease denotes COVID-19 MESH:C000657245
185 8291-8299 Disease denotes COVID-19 MESH:C000657245
186 8402-8410 Disease denotes COVID-19 MESH:C000657245
187 9098-9106 Disease denotes COVID-19 MESH:C000657245
190 9130-9134 Gene denotes ACE2 Gene:59272
191 9139-9144 Gene denotes CD147 Gene:682
198 9244-9248 Gene denotes ACE2 Gene:59272
199 9253-9258 Gene denotes CD147 Gene:682
200 9386-9390 Gene denotes ACE2 Gene:59272
201 9395-9400 Gene denotes CD147 Gene:682
202 9618-9622 Gene denotes ACE2 Gene:59272
203 9510-9519 Disease denotes pneumonia MESH:D011014
206 9907-9915 Disease denotes COVID-19 MESH:C000657245
207 9924-9945 Disease denotes robustness of disease MESH:D003141
216 9976-9984 Disease denotes COVID-19 MESH:C000657245
217 10523-10531 Disease denotes COVID-19 MESH:C000657245
218 10595-10603 Disease denotes COVID-19 MESH:C000657245
219 10647-10651 Disease denotes SARS MESH:D045169
220 10786-10794 Disease denotes COVID-19 MESH:C000657245
221 10962-10965 Disease denotes XCH
222 11138-11146 Disease denotes COVID-19 MESH:C000657245
223 11342-11362 Disease denotes Banxia tianma baizhu
227 13388-13479 Disease denotes CID1174,CID3026,CID5789,CID6782,CID6998,CID8437,CID8679,CID13625,CID117158,CID159225,CID185
228 13776-13862 Disease denotes CID5488781,CID5491637,CID64959,CID64982,CID676152,CID71307581,CID72307,CID13688752 XCH
229 14933-15003 Disease denotes CID64959,CID64971,CID64982,CID73205,CID821279,CID928837,CID9927807 WLS
235 11588-11590 Disease denotes OB MESH:D009765
236 11859-11862 Disease denotes XCH
237 12074-12077 Disease denotes XCH
238 12126-12129 Disease denotes XCH
239 12294-12297 Disease denotes XCH
260 15851-15865 Gene denotes oxidoreductase Gene:8630
261 16304-16308 Gene denotes PPAR Gene:5465
262 15876-15881 Chemical denotes lipid MESH:D008055
263 15901-15906 Chemical denotes lipid MESH:D008055
264 16178-16185 Chemical denotes dteroid
265 16274-16281 Chemical denotes steroid MESH:D013256
266 16328-16336 Chemical denotes arginine MESH:D001120
267 16341-16348 Chemical denotes proline MESH:D011392
268 16779-16791 Chemical denotes beta-Alanine MESH:D015091
269 16518-16522 Disease denotes acne MESH:D000152
270 16530-16540 Disease denotes 'S disease MESH:D000755
271 16542-16569 Disease denotes benign prostate hyperplasia MESH:D011470
272 16571-16595 Disease denotes intrahepatic cholestasis MESH:D002780
273 16600-16612 Disease denotes brain injury MESH:D001930
274 16689-16692 Disease denotes XCH
275 16859-16879 Disease denotes parasitic infections MESH:D010272
276 16928-16940 Disease denotes hypertension MESH:D006973
277 16951-16954 Disease denotes XCH
278 17008-17031 Disease denotes ovarian steroidogenesis MESH:D010049
279 17044-17065 Disease denotes inflammatory diseases MESH:D007249
284 17334-17341 Gene denotes MIR-183 Gene:406959
285 17346-17354 Gene denotes MIR-130A Gene:406919
286 17535-17539 Gene denotes CDK7 Gene:1022
287 17592-17595 Disease denotes XCH
289 19425-19428 Disease denotes XCH
295 18846-18852 Gene denotes COX7A1 Gene:1346
296 18922-18929 Gene denotes ALDH1A1 Gene:216
297 18997-19001 Gene denotes CNR2 Gene:1269
298 19119-19126 Chemical denotes calcium MESH:D002118
299 19182-19185 Chemical denotes TRP MESH:D014364
302 19683-19689 Gene denotes COX7A1 Gene:1346
303 19768-19788 Disease denotes huntington's disease MESH:D006816
305 20102-20106 Gene denotes CNR2 Gene:1269
310 20548-20553 Gene denotes ACSS1 Gene:84532
311 20620-20624 Gene denotes CNR2 Gene:1269
312 20691-20696 Gene denotes PRKCG Gene:5582
313 20773-20780 Gene denotes insulin Gene:3630
323 21108-21114 Gene denotes COX7A1 Gene:1346
324 21184-21188 Gene denotes RRM1 Gene:6240
325 21256-21260 Gene denotes CNR2 Gene:1269
326 21330-21335 Gene denotes ACSS1 Gene:84532
327 21402-21407 Gene denotes FFAR1 Gene:2864
328 21483-21490 Chemical denotes calcium MESH:D002118
329 21510-21514 Chemical denotes cGMP MESH:D006152
330 20903-20906 Disease denotes XCH
331 21454-21457 Disease denotes XCH
335 22582-22586 Gene denotes KEGG
336 22707-22711 Disease denotes OMIN
337 22756-22759 Disease denotes XCH
342 21728-21731 Disease denotes XCH
343 21921-21924 Disease denotes XCH
344 22175-22178 Disease denotes XCH
345 22366-22374 Disease denotes COVID-19 MESH:C000657245
361 24273-24277 Gene denotes OCT2 Gene:6582
362 24079-24084 Species denotes Human Tax:9606
363 24164-24169 Species denotes Human Tax:9606
364 24366-24371 Species denotes Human Tax:9606
365 24422-24425 Species denotes Rat Tax:10116
366 24024-24029 Chemical denotes Caco2
367 24252-24254 Chemical denotes TC MESH:D013667
368 24336-24340 Chemical denotes MTDD
369 23910-23918 Disease denotes toxicity MESH:D064420
370 24326-24334 Disease denotes toxicity MESH:D064420
371 24432-24440 Disease denotes Toxicity MESH:D064420
372 24453-24467 Disease denotes Hepatotoxicity MESH:D056486
373 24473-24491 Disease denotes Skin Sensitisation MESH:D012871
374 24504-24512 Disease denotes toxicity MESH:D064420
375 24031-24037 CellLine denotes Caco-2 CVCL:0025
383 24825-24833 Gene denotes Helicase Gene:164045
384 24892-24897 Gene denotes PLpro Gene:43740578
385 24909-24913 Gene denotes Mpro Gene:8673700
386 24925-24929 Gene denotes Mpro Gene:8673700
387 24862-24870 Gene denotes Helicase Gene:164045
388 24754-24762 Disease denotes COVID-19 MESH:C000657245
389 24952-24955 Disease denotes XCH
391 26593-26596 Disease denotes XCH
403 25631-25635 Gene denotes OCT2 Gene:6582
404 25758-25762 Gene denotes hERG Gene:2078
405 25776-25780 Gene denotes hERG Gene:2078
406 25800-25803 Species denotes rat Tax:10116
407 25691-25699 Disease denotes toxicity MESH:D064420
408 25724-25732 Disease denotes toxicity MESH:D064420
409 25810-25818 Disease denotes toxicity MESH:D064420
410 25827-25841 Disease denotes hepatotoxicity MESH:D056486
411 25843-25861 Disease denotes skin sensitisation MESH:D012871
412 25874-25882 Disease denotes toxicity MESH:D064420
413 25095-25101 CellLine denotes Caco-2 CVCL:0025
418 27704-27708 Gene denotes RdRp Gene:43740578
419 27773-27777 Gene denotes RdRp Gene:43740578
420 27845-27853 Gene denotes Helicase Gene:164045
421 27914-27922 Gene denotes Helicase Gene:164045
423 27500-27509 Species denotes 2019-nCov Tax:2697049
425 28442-28445 Disease denotes XCH
429 28774-28780 Gene denotes ClC −6 Gene:1185
430 28564-28576 Disease denotes SGMH XCH WLS
431 28685-28688 Disease denotes APL MESH:D015473
433 28532-28540 Disease denotes COVID-19 MESH:C000657245
436 29208-29212 Chemical denotes BXTM
437 29070-29073 Disease denotes APL MESH:D015473
446 26841-26856 Gene denotes SX1, O1, X2, X1
447 26919-26923 Gene denotes Mpro Gene:8673700
448 26939-26943 Gene denotes RdRp Gene:43740578
449 26962-26966 Gene denotes RdRp Gene:43740578
450 26988-26996 Gene denotes Helicase Gene:164045
451 27015-27023 Gene denotes Helicase Gene:164045
452 26925-26930 Gene denotes PLpro Gene:43740578
453 26652-26660 Disease denotes COVID-19 MESH:C000657245
480 29524-29532 Gene denotes Helicase Gene:164045
481 30193-30197 Gene denotes Mpro Gene:8673700
482 30421-30425 Gene denotes Mpro Gene:8673700
483 29976-29981 Gene denotes PLpro Gene:43740578
484 29752-29760 Gene denotes Helicase Gene:164045
485 29419-29422 Chemical denotes TYR MESH:D014443
486 29427-29430 Chemical denotes ALA MESH:D000409
487 29435-29438 Chemical denotes ILE MESH:D007532
488 29446-29449 Chemical denotes PRO MESH:D011392
489 29624-29627 Chemical denotes ASN MESH:D001216
490 29633-29636 Chemical denotes ARG MESH:D001120
491 29642-29645 Chemical denotes LEU MESH:D007930
492 29653-29656 Chemical denotes PRO MESH:D011392
493 30238-30246 Chemical denotes hydrogen MESH:D006859
494 30301-30304 Chemical denotes GLU MESH:D018698
495 30310-30313 Chemical denotes LEU MESH:D007930
496 30322-30325 Chemical denotes CYS MESH:D003545
497 30336-30338 Chemical denotes O2 MESH:D010100
498 30457-30463 Chemical denotes Carbon MESH:D002244
499 30464-30472 Chemical denotes hydrogen MESH:D006859
500 30482-30487 Chemical denotes anion MESH:D000838
501 30492-30498 Chemical denotes sulfur MESH:D013455
502 30548-30551 Chemical denotes GLY
503 30556-30559 Chemical denotes LEU MESH:D007930
504 30568-30571 Chemical denotes CYS MESH:D003545
505 30157-30160 Disease denotes XCH
512 32755-32759 Gene denotes RdRp Gene:43740578
513 32792-32796 Gene denotes RdRp Gene:43740578
514 32527-32535 Disease denotes COVID-19 MESH:C000657245
515 32840-32843 Disease denotes XCH
516 32858-32861 Disease denotes XCH
517 32887-32890 Disease denotes XCH
537 31967-31971 Gene denotes RdRp Gene:43740578
538 32247-32251 Gene denotes RdRp Gene:43740578
539 31222-31225 Chemical denotes PRO MESH:D011392
540 31231-31234 Chemical denotes VAL MESH:D014633
541 31240-31243 Chemical denotes LYS MESH:D008239
542 31252-31255 Chemical denotes SER MESH:D012694
543 31428-31431 Chemical denotes PHE MESH:D010649
544 31597-31600 Chemical denotes LYS MESH:D008239
545 31606-31609 Chemical denotes LYS MESH:D008239
546 31615-31618 Chemical denotes VAL MESH:D014633
547 31627-31630 Chemical denotes PRO MESH:D011392
548 32302-32310 Chemical denotes hydrogen MESH:D006859
549 32372-32375 Chemical denotes CYS MESH:D003545
550 32381-32384 Chemical denotes GLY
551 32390-32393 Chemical denotes LYS MESH:D008239
552 32402-32405 Chemical denotes ASP MESH:D001224
553 31084-31087 Disease denotes XCH
554 31313-31316 Disease denotes XCH
555 32195-32198 Disease denotes XCH
558 32909-32913 Gene denotes ACE2 Gene:59272
559 32918-32923 Gene denotes CD147 Gene:682
570 34005-34009 Gene denotes ACE2 Gene:59272
571 34014-34019 Gene denotes CD147 Gene:682
572 34088-34092 Gene denotes ACE2 Gene:59272
573 34097-34102 Gene denotes CD147 Gene:682
574 34320-34324 Gene denotes ACE2 Gene:59272
575 34362-34367 Gene denotes CD147 Gene:682
576 34410-34414 Gene denotes ACE2 Gene:59272
577 34309-34318 Disease denotes pneumonia MESH:D011014
578 34438-34445 Disease denotes colonic MESH:D003110
579 34469-34476 Disease denotes colonic MESH:D003110
600 33033-33037 Gene denotes ACE2 Gene:59272
601 33042-33047 Gene denotes CD147 Gene:682
602 33112-33116 Gene denotes ACE2 Gene:59272
603 33121-33126 Gene denotes CD147 Gene:682
604 33200-33204 Gene denotes ACE2 Gene:59272
605 33366-33371 Gene denotes CD147 Gene:682
606 33591-33595 Gene denotes ACE2 Gene:59272
607 33624-33629 Gene denotes CD147 Gene:682
608 33732-33736 Gene denotes ACE2 Gene:59272
609 33963-33967 Gene denotes ACE2 Gene:59272
610 33972-33977 Gene denotes CD147 Gene:682
611 32980-32989 Species denotes 2019-nCov Tax:2697049
612 33541-33550 Species denotes 2019-nCov Tax:2697049
613 33941-33950 Species denotes 2019-nCov Tax:2697049
614 33428-33444 Disease denotes atrial appendage MESH:D018280
615 33528-33537 Disease denotes pneumonia MESH:D011014
616 33635-33644 Disease denotes pneumonia MESH:D011014
617 33740-33747 Disease denotes colonic MESH:D003110
618 33917-33925 Disease denotes COVID-19 MESH:C000657245
619 33952-33961 Disease denotes pneumonia MESH:D011014
622 34942-34950 Disease denotes COVID-19 MESH:C000657245
623 34959-34980 Disease denotes robustness of disease MESH:D003141
626 35589-35597 Disease denotes COVID-19 MESH:C000657245
627 35839-35842 Disease denotes XCH
633 36267-36301 Gene denotes MXO1 SO1 SX1 WO1 XO1 Main Protease
634 36409-36413 Gene denotes RdRp Gene:43740578
635 36464-36468 Gene denotes RdRp Gene:43740578
636 36524-36532 Gene denotes Helicase Gene:164045
637 36587-36595 Gene denotes Helicase Gene:164045
639 36220-36229 Species denotes 2019-nCov Tax:2697049
641 37047-37050 Disease denotes XCH
645 35098-35106 Disease denotes COVID-19 MESH:C000657245
646 35183-35186 Disease denotes XCH
647 35217-35225 Disease denotes COVID-19 MESH:C000657245
649 37593-37601 Disease denotes COVID-19 MESH:C000657245
665 37294-37299 Gene denotes Cdc20 Gene:991
666 37301-37305 Gene denotes Ido1 Gene:3620
667 37307-37311 Gene denotes Ifng Gene:3458
668 37313-37317 Gene denotes Il10 Gene:3586
669 37319-37322 Gene denotes Il6 Gene:3569
670 37324-37330 Gene denotes Ptger4 Gene:5734
671 37332-37336 Gene denotes Spi1 Gene:6688
672 37338-37341 Gene denotes Tnf Gene:7124
673 37486-37495 Species denotes influenza Tax:11320
674 37113-37121 Disease denotes COVID-19 MESH:C000657245
675 37235-37238 Disease denotes XCH
676 37378-37386 Disease denotes COVID-19 MESH:C000657245
677 37411-37436 Disease denotes Graft-versus-host disease MESH:D006086
678 37478-37484 Disease denotes asthma MESH:D001249
679 37499-37525 Disease denotes inflammatory bowel disease MESH:D015212
696 38246-38254 Species denotes patients Tax:9606
697 38817-38825 Species denotes patients Tax:9606
698 38838-38855 Species denotes novel coronavirus Tax:2697049
699 38014-38047 Disease denotes coronavirus (2019-nCov) infection MESH:C000657245
700 38106-38115 Disease denotes infection MESH:D007239
701 38128-38163 Disease denotes acute respiratory distress syndrome MESH:D012128
702 38165-38169 Disease denotes ARDS MESH:D012128
703 38175-38185 Disease denotes septicemia MESH:D018805
704 38210-38215 Disease denotes death MESH:D003643
705 38265-38299 Disease denotes multi-organ damage and dysfunction MESH:D009102
706 38379-38387 Disease denotes COVID-19 MESH:C000657245
707 38627-38635 Disease denotes COVID-19 MESH:C000657245
708 38694-38699 Disease denotes fever MESH:D005334
709 38807-38816 Disease denotes pneumonia MESH:D011014
710 38826-38834 Disease denotes infected MESH:D007239
711 38933-38941 Disease denotes COVID-19 MESH:C000657245
734 39333-39347 Gene denotes oxidoreductase Gene:8630
735 39926-39930 Gene denotes PPAR Gene:5465
736 40113-40117 Gene denotes PPAR Gene:5465
737 41035-41040 Gene denotes Cdc20 Gene:991
738 41042-41046 Gene denotes Ido1 Gene:3620
739 41048-41052 Gene denotes Ifng Gene:3458
740 41054-41058 Gene denotes Il10 Gene:3586
741 41060-41063 Gene denotes Il6 Gene:3569
742 41065-41071 Gene denotes Ptger4 Gene:5734
743 41073-41077 Gene denotes Spi1 Gene:6688
744 41079-41082 Gene denotes Tnf Gene:7124
745 40142-40146 Species denotes H1N1 Tax:114727
746 39358-39363 Chemical denotes lipid MESH:D008055
747 39383-39388 Chemical denotes lipid MESH:D008055
748 39602-39607 Chemical denotes lipid MESH:D008055
749 39794-39799 Chemical denotes lipid MESH:D008055
750 40379-40386 Chemical denotes calcium MESH:D002118
751 39152-39157 Disease denotes COVID MESH:C000657245
752 39276-39279 Disease denotes XCH
753 40147-40156 Disease denotes infection MESH:D007239
754 40922-40925 Disease denotes XCH
755 40954-40962 Disease denotes COVID-19 MESH:C000657245
771 41418-41422 Gene denotes ACE2 Gene:59272
772 41497-41501 Gene denotes ACE2 Gene:59272
773 41702-41706 Gene denotes ACE2 Gene:59272
774 41243-41252 Species denotes 2019-nCov Tax:2697049
775 41677-41686 Species denotes 2019-nCov Tax:2697049
776 41279-41290 Disease denotes dysfunction MESH:D009461
777 41688-41697 Disease denotes pneumonia MESH:D011014
778 41786-41794 Disease denotes COVID-19 MESH:C000657245
779 41927-41935 Disease denotes COVID-19 MESH:C000657245
780 41969-41990 Disease denotes inflammatory diseases MESH:D007249
781 41992-41998 Disease denotes asthma MESH:D001249
782 42000-42026 Disease denotes inflammatory bowel disease MESH:D015212
783 42028-42065 Disease denotes chronic obstructive pulmonary disease MESH:D029424
784 42067-42091 Disease denotes intrahepatic cholestasis MESH:D002780
785 42101-42108 Disease denotes ileitis MESH:D007079
791 42757-42766 Gene denotes X2 and O2
792 42906-42915 Species denotes 2019-nCov Tax:2697049
793 42132-42150 Chemical denotes ADMETox prediction
794 42526-42534 Disease denotes toxicity MESH:D064420
795 42982-42990 Disease denotes COVID-19 MESH:C000657245
818 43386-43392 Gene denotes MIR183 Gene:406959
819 43397-43410 Gene denotes MIR130A/B/301 Gene:406919
820 43544-43548 Gene denotes CDKs Gene:1022
821 43788-43792 Gene denotes CDK7 Gene:1022
822 43911-43915 Gene denotes CDK7 Gene:1022
823 43295-43301 Gene denotes MIR183 Gene:406959
824 43321-43325 Species denotes H1N1 Tax:114727
825 43326-43334 Species denotes patients Tax:9606
826 43627-43632 Species denotes human Tax:9606
827 43658-43679 Species denotes human cytomegalovirus Tax:10359
828 43726-43731 Species denotes HSV-2 Tax:10310
829 44115-44119 Species denotes H1N1 Tax:114727
830 43681-43685 Species denotes HCMV Tax:10359
831 44034-44045 Chemical denotes cholesterol MESH:D002784
832 43187-43202 Disease denotes virus infection MESH:D001102
833 43499-43507 Disease denotes COVID-19 MESH:C000657245
834 43633-43656 Disease denotes HIV-1, papillomaviruses MESH:D015658
835 43890-43898 Disease denotes COVID-19 MESH:C000657245
836 44065-44077 Disease denotes inflammation MESH:D007249
837 44130-44145 Disease denotes virus infection MESH:D001102
838 44214-44217 Disease denotes XCH
839 44330-44345 Disease denotes virus infection MESH:D001102
849 44397-44405 Disease denotes COVID-19 MESH:C000657245
850 44616-44620 Disease denotes SARS MESH:D045169
851 44666-44674 Disease denotes COVID-19 MESH:C000657245
852 44696-44704 Disease denotes COVID-19 MESH:C000657245
853 44745-44753 Disease denotes COVID-19 MESH:C000657245
854 44971-44979 Disease denotes COVID-19 MESH:C000657245
855 45076-45084 Disease denotes COVID-19 MESH:C000657245
856 45343-45351 Disease denotes COVID-19 MESH:C000657245
857 45450-45458 Disease denotes COVID-19 MESH:C000657245
860 45701-45705 Species denotes Ling Tax:163112
861 45817-45821 Species denotes Ling Tax:163112

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T46 27-38 NCBITaxon:11118 denotes coronavirus
T47 40-49 SP_7 denotes 2019-nCov
T48 202-214 NCBITaxon:11118 denotes corona virus
T49 229-237 SP_7 denotes COVID-19
T50 248-253 NCBITaxon:10239 denotes virus
T51 351-357 NCBITaxon:9606 denotes people
T52 395-401 NCBITaxon:9606 denotes people
T53 513-518 CHEBI:23888;CHEBI:23888 denotes drugs
T54 545-550 NCBITaxon:10239 denotes virus
T55 602-607 NCBITaxon:10239 denotes viral
T56 680-684 SP_10 denotes SARS
T57 992-1002 NCBITaxon:158314 denotes Umbellatus
T58 1025-1038 NCBITaxon:9539 denotes Macrocephalae
T59 1040-1045 NCBITaxon:6040 denotes Poria
T60 1323-1331 SP_7 denotes COVID-19
T61 1792-1797 NCBITaxon:10239 denotes virus
T62 1826-1831 NCBITaxon:10239 denotes viral
T63 1832-1839 GO:0009986 denotes surface
T64 1865-1870 NCBITaxon:10239;GO:0035376 denotes viral
T65 1871-1876 GO:0035376 denotes entry
T66 2135-2141 UBERON:0000341 denotes throat
T67 2194-2206 NCBITaxon:4932 denotes Scutellariae
T68 2300-2316 CHEBI:67079;CHEBI:67079 denotes anticarcinogenic
T69 2376-2396 NCBITaxon:158314 denotes Polyporus Umbellatus
T70 2508-2514 UBERON:0002113 denotes kidney
T71 2515-2524 GO:0007588 denotes excretion
T72 3010-3018 SP_7 denotes COVID-19
T73 3188-3196 SP_7 denotes COVID-19
T74 3212-3227 CHEBI:52217;CHEBI:52217 denotes pharmacological
T75 3306-3318 CHEBI:52217;CHEBI:52217 denotes pharmacology
T76 3380-3385 CHEBI:23888;CHEBI:23888 denotes drugs
T77 3523-3535 CHEBI:52217;CHEBI:52217 denotes pharmacology
T78 3939-3947 SP_7 denotes COVID-19
T79 4023-4031 SP_7 denotes COVID-19
T80 4148-4153 NCBITaxon:10239 denotes viral
T81 4224-4233 CHEBI:36357;CHEBI:36357 denotes compounds
T82 4361-4369 SP_7 denotes COVID-19
T83 4409-4421 CHEBI:52217;CHEBI:52217 denotes pharmacology
T84 4764-4768 CHEBI:23888;CHEBI:23888 denotes drug
T85 4880-4889 CHEBI:36357;CHEBI:36357 denotes compounds
T86 5074-5079 SO:0001867 denotes genes
T87 5648-5652 SO:0000704 denotes Gene
T88 5762-5770 SO:0000646 denotes microRNA
T89 6169-6176 SO:0000417 denotes modules
T90 6209-6224 CHEBI:52217;CHEBI:52217 denotes pharmacological
T91 6450-6457 NCBITaxon:species denotes species
T92 6470-6482 SP_6;NCBITaxon:9606 denotes Homo sapiens
T93 6551-6558 SO:0000417 denotes modules
T94 6682-6687 SO:0000704 denotes Genes
T95 6692-6699 SO:0001026 denotes Genomes
T96 6790-6797 SO:0000417 denotes modules
T97 7239-7248 CHEBI:36357;CHEBI:36357 denotes compounds
T98 7334-7343 CHEBI:36357;CHEBI:36357 denotes compounds
T99 7471-7480 CHEBI:36357;CHEBI:36357 denotes compounds
T100 7723-7738 CHEBI:52217;CHEBI:52217 denotes pharmacokinetic
T101 7825-7831 CL_1 denotes Caco-2
T102 7917-7936 UBERON:0000120 denotes blood-brain barrier
T103 7941-7963 UBERON:0001017 denotes central nervous system
T104 7979-7988 GO:0007588 denotes excretion
T105 8010-8015 UBERON:0002113 denotes renal
T106 8016-8020 PR:000013036 denotes OCT2
T107 8046-8050 CHEBI:34018;CHEBI:34018 denotes AMES
T108 8085-8089 PR:P11308 denotes hERG
T109 8092-8101 CHEBI:35222;CHEBI:35222 denotes inhibitor
T110 8103-8107 PR:P11308 denotes hERG
T111 8111-8120 CHEBI:35222;CHEBI:35222 denotes inhibitor
T112 8122-8126 UBERON:0000165 denotes oral
T113 8127-8130 NCBITaxon:10114 denotes rat
T114 8250-8254 CHEBI:23888;CHEBI:23888 denotes drug
T115 8273-8281 SP_7 denotes COVID-19
T116 8291-8299 SP_7 denotes COVID-19
T117 8402-8410 SP_7 denotes COVID-19
T118 8517-8526 SP_7 denotes 2019-nCov
T119 8556-8561 PR:000000125 denotes nsp12
T120 8579-8584 PR:000000125 denotes nsp12
T121 8605-8610 PR:000000125 denotes nsp13
T122 8621-8629 SO:0000346 denotes ADP site
T123 8632-8637 PR:000000125 denotes nsp13
T124 8659-8664 PR:000000125 denotes nsp14
T125 8673-8678 PR:000000125 denotes nsp14
T126 8691-8696 PR:000000125 denotes nsp15
T127 8717-8722 PR:000000125 denotes nsp16
T128 8737-8746 PG_4 denotes N protein
T129 8760-8769 PG_2 denotes E protein
T130 8771-8774 CHEBI:24870;CHEBI:24870 denotes ion
T131 8901-8905 SO:0000346 denotes site
T132 9080-9089 CHEBI:36357;CHEBI:36357 denotes compounds
T133 9098-9106 SP_7 denotes COVID-19
T134 9130-9134 G_3;PG_10;PR:000003622 denotes ACE2
T135 9139-9144 PR:000001324 denotes CD147
T136 9145-9155 GO:0010467 denotes expression
T137 9163-9170 UBERON:0000479 denotes tissues
T138 9178-9188 GO:0010467 denotes expression
T139 9189-9194 SO:0000704 denotes genes
T140 9213-9223 GO:0010467 denotes expression
T141 9244-9248 G_3;PG_10;PR:000003622 denotes ACE2
T142 9253-9258 PR:000001324 denotes CD147
T143 9266-9273 UBERON:0000479 denotes tissues
T144 9301-9308 UBERON:0000479 denotes tissues
T145 9366-9376 GO:0010467 denotes expression
T146 9377-9382 SO:0000704 denotes genes
T147 9386-9390 G_3;PG_10;PR:000003622 denotes ACE2
T148 9395-9400 PR:000001324 denotes CD147
T149 9531-9536 SO:0000704 denotes genes
T150 9598-9608 GO:0010467 denotes expression
T151 9609-9614 SO:0000704 denotes genes
T152 9618-9622 G_3;PG_10;PR:000003622 denotes ACE2
T153 9626-9633 UBERON:0001155;CL:0011108 denotes colonic
T154 9634-9644 CL:0011108;UBERON:0000483 denotes epithelial
T155 9645-9650 CL:0011108 denotes cells
T156 9676-9680 GO:0018995 denotes host
T157 9873-9877 CHEBI:23888;CHEBI:23888 denotes drug
T158 9907-9915 SP_7 denotes COVID-19
T159 9976-9984 SP_7 denotes COVID-19
T160 10158-10163 CHEBI:23888;CHEBI:23888 denotes drugs
T161 10235-10240 CHEBI:23888;CHEBI:23888 denotes drugs
T162 10325-10330 CHEBI:23888;CHEBI:23888 denotes drugs
T163 10423-10427 CHEBI:23888;CHEBI:23888 denotes drug
T164 10495-10500 CHEBI:23888;CHEBI:23888 denotes drugs
T165 10523-10531 SP_7 denotes COVID-19
T166 10595-10603 SP_7 denotes COVID-19
T167 10628-10637 GO:0010467 denotes expressed
T168 10638-10643 SO:0000704 denotes genes
T169 10647-10651 SP_10 denotes SARS
T170 10786-10794 SP_7 denotes COVID-19
T171 11059-11063 CHEBI:23888;CHEBI:23888 denotes drug
T172 11138-11146 SP_7 denotes COVID-19
T173 11287-11292 CHEBI:23888;CHEBI:23888 denotes drugs
T174 15635-15644 CHEBI:36357;CHEBI:36357 denotes compounds
T175 15661-15670 CHEBI:36357;CHEBI:36357 denotes compounds
T178 15876-15881 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T179 15882-15899 GO:0006629 denotes metabolic process
T180 15901-15906 CHEBI:18059;CHEBI:18059 denotes lipid
T181 15922-15930 CHEBI:36357;CHEBI:36357 denotes molecule
T182 15931-15948 GO:0044281 denotes metabolic process
T183 15950-15969 GO:0042592 denotes homeostatic process
T184 16002-16020 GO:0008283 denotes cell proliferation
T185 16178-16185 CHEBI:26537;CHEBI:26537 denotes dteroid
T186 16186-16198 GO:0006695 denotes biosynthesis
T187 16274-16281 GO:0006695;CHEBI:26764;CHEBI:26764 denotes steroid
T188 16282-16289 CHEBI:26764;CHEBI:26764;GO:0042446 denotes hormone
T189 16290-16302 GO:0042446 denotes biosynthesis
T190 16328-16336 GO:0006520 denotes arginine
T191 16341-16359 GO:0006560 denotes proline metabolism
T192 16549-16557 UBERON:0002367 denotes prostate
T193 16571-16583 UBERON:0002107 denotes intrahepatic
T194 16600-16605 UBERON:0000955 denotes brain
T195 16747-16766 UBERON:0001016 denotes neurological system
T196 16779-16791 GO:0006635 denotes beta-Alanine
T197 16792-16802 GO:0019482 denotes metabolism
T198 16833-16841 GO:0016020 denotes membrane
T199 16887-16890 UBERON:0000970 denotes eye
T200 16917-16923 GO:0007623 denotes rhythm
T201 16956-16963 GO:0005634 denotes nucleic
T202 17008-17015 UBERON:0000992 denotes ovarian
T203 17016-17031 GO:0006694 denotes steroidogenesis
T204 17310-17316 SO:0000276 denotes miRNAs
T205 17476-17482 SO:0000276 denotes miRNAs
T206 17535-17539 PR:000005265 denotes CDK7
T207 17794-17799 SO:0000276 denotes miRNA
T208 17951-17956 SO:0000646 denotes miRNA
T209 17996-18001 SO:0000276 denotes miRNA
T210 18100-18105 SO:0000276 denotes miRNA
T211 18146-18151 SO:0000276 denotes miRNA
T217 18215-18222 SO:0000417 denotes modules
T218 18353-18359 GO:0007601 denotes visual
T219 18432-18437 SO:0001867 denotes genes
T220 18634-18640 SO:0000417 denotes module
T221 18719-18726 SO:0000417 denotes modules
T222 18837-18841 SO:0000704 denotes gene
T223 18846-18852 PR:000005786 denotes COX7A1
T224 18913-18917 SO:0000704 denotes gene
T225 18922-18929 PR:000003920 denotes ALDH1A1
T226 18988-18992 SO:0000704 denotes gene
T227 18997-19001 PR:000001126 denotes CNR2
T228 19053-19060 SO:0000417 denotes modules
T229 19119-19144 GO:0019722 denotes calcium signaling pathway
T230 19146-19167 CHEBI:67079;CHEBI:67079 denotes inflammatory mediator
T231 19168-19178 GO:0065007 denotes regulation
T232 19182-19185 PR:000016138 denotes TRP
T233 19233-19240 SO:0000417 denotes modules
T234 19376-19383 SO:0000417 denotes modules
T237 19464-19469 SO:0001867 denotes genes
T238 19674-19678 SO:0000704 denotes gene
T239 19683-19689 PR:000005786 denotes COX7A1
T240 19743-19750 SO:0000417 denotes modules
T241 19790-19800 GO:0006096 denotes glycolysis
T242 19803-19818 GO:0006094 denotes gluconeogenesis
T243 19820-19843 GO:0007219 denotes Notch signaling pathway
T244 19885-19890 SO:0001867 denotes genes
T245 20093-20097 SO:0000704 denotes gene
T246 20102-20106 PR:000001126 denotes CNR2
T247 20157-20164 SO:0000417 denotes modules
T248 20182-20189 UBERON:0002046;GO:0048538;CHEBI:60311;CHEBI:60311 denotes thyroid
T249 20190-20197 CHEBI:60311;CHEBI:60311;GO:0007179 denotes hormone
T250 20198-20207 GO:0007179 denotes signaling
T251 20333-20338 SO:0001867 denotes genes
T252 20539-20543 SO:0000704 denotes gene
T253 20548-20553 PR:000003671 denotes ACSS1
T254 20611-20615 SO:0000704 denotes gene
T255 20620-20624 PR:000001126 denotes CNR2
T256 20682-20686 SO:0000704 denotes gene
T257 20748-20755 SO:0000417 denotes modules
T258 20773-20780 PR:000009054 denotes insulin
T259 20807-20816 GO:0019221 denotes signaling
T260 20826-20830 CL:0000899 denotes Th17
T261 20831-20835 CL:0000899;GO:0030154 denotes cell
T262 20836-20851 GO:0030154 denotes differentiation
T263 20894-20899 SO:0001867 denotes genes
T264 21099-21103 SO:0000704 denotes gene
T265 21108-21114 PR:000005786 denotes COX7A1
T266 21175-21179 SO:0000704 denotes gene
T267 21184-21188 PR:000014305 denotes RRM1
T268 21247-21251 SO:0000704 denotes gene
T269 21256-21260 PR:000001126 denotes CNR2
T270 21321-21325 SO:0000704 denotes gene
T271 21330-21335 PR:000003671 denotes ACSS1
T272 21393-21397 SO:0000704 denotes gene
T273 21402-21407 PR:000001582 denotes FFAR1
T274 21458-21465 SO:0000417 denotes modules
T275 21483-21508 GO:0019722 denotes calcium signaling pathway
T276 21895-21904 CHEBI:36357;CHEBI:36357 denotes compounds
T277 22339-22344 CHEBI:23888;CHEBI:23888 denotes drugs
T278 22366-22374 SP_7 denotes COVID-19
T279 22524-22533 CHEBI:36357;CHEBI:36357 denotes compounds
T280 22702-22705 NCBITaxon:9606 denotes Man
T283 22940-22949 CHEBI:36357;CHEBI:36357 denotes compounds
T284 22998-23002 CHEBI:23888;CHEBI:23888 denotes drug
T285 23057-23066 CHEBI:36357;CHEBI:36357 denotes compounds
T286 23342-23351 CHEBI:36357;CHEBI:36357 denotes compounds
T287 23494-23498 CHEBI:23888;CHEBI:23888 denotes drug
T288 23545-23554 CHEBI:36357;CHEBI:36357 denotes compounds
T289 23618-23634 UBERON:0005409 denotes gastrointestinal
T290 23959-23968 CHEBI:36357;CHEBI:36357 denotes compounds
T291 24024-24029 CL_1 denotes Caco2
T292 24031-24037 CL_1 denotes Caco-2
T293 24056-24066 UBERON:0000160 denotes Intestinal
T294 24079-24084 SP_6;NCBITaxon:9606 denotes Human
T295 24164-24169 SP_6;NCBITaxon:9606 denotes Human
T296 24177-24188 UBERON:0000120 denotes Blood Brain
T297 24211-24214 UBERON:0001017 denotes CNS
T298 24216-24238 UBERON:0001017 denotes Central Nervous System
T299 24273-24277 PR:000013036 denotes OCT2
T300 24279-24284 UBERON:0002113 denotes Renal
T301 24285-24299 CHEBI:25697;CHEBI:25697;PR:000014988 denotes Organic Cation
T302 24300-24313 PR:000014988 denotes Transporter 2
T303 24366-24371 SP_6;NCBITaxon:9606 denotes Human
T304 24374-24378 PR:P11308 denotes hERG
T305 24385-24389 PR:P11308 denotes hERG
T306 24417-24421 UBERON:0000165 denotes Oral
T307 24422-24425 NCBITaxon:10114 denotes Rat
T308 24493-24495 UBERON:0001448 denotes MT
T309 24722-24731 CHEBI:36357;CHEBI:36357 denotes compounds
T310 24754-24762 SP_7 denotes COVID-19
T311 24783-24792 PG_2 denotes E protein
T312 24794-24797 CHEBI:24870;CHEBI:24870 denotes ion
T313 24818-24823 PR:000000125 denotes nsp13
T314 24855-24860 PR:000000125 denotes nsp13
T315 24918-24920 CHEBI:15379;CHEBI:15379 denotes O2
T342 25012-25021 CHEBI:36357;CHEBI:36357 denotes compounds
T343 25055-25059 UBERON:0000165 denotes oral
T344 25095-25101 CL_1 denotes Caco-2
T345 25152-25156 CHEBI:23888;CHEBI:23888 denotes drug
T346 25202-25211 CHEBI:36357;CHEBI:36357 denotes compounds
T347 25227-25233 UBERON:0000479 denotes tissue
T348 25247-25253 UBERON:0000479 denotes tissue
T349 25268-25274 UBERON:0001969 denotes plasma
T350 25356-25371 CHEBI:52217;CHEBI:52217 denotes pharmacological
T351 25443-25462 UBERON:0000120 denotes blood-brain barrier
T352 25464-25467 UBERON:0000120 denotes BBB
T353 25473-25495 UBERON:0001017 denotes central nervous system
T354 25497-25500 UBERON:0001017 denotes CNS
T355 25519-25528 CHEBI:36357;CHEBI:36357 denotes compounds
T356 25546-25551 UBERON:0002113 denotes renal
T357 25595-25600 UBERON:0002113 denotes renal
T358 25601-25615 CHEBI:25697;CHEBI:25697;PR:000014988 denotes organic cation
T359 25616-25629 PR:000014988 denotes transporter 2
T360 25631-25635 PR:000013036 denotes OCT2
T361 25650-25659 CHEBI:36357;CHEBI:36357 denotes compounds
T362 25719-25723 CHEBI:34018;CHEBI:34018 denotes AMES
T363 25758-25762 PR:P11308 denotes hERG
T364 25765-25774 CHEBI:35222;CHEBI:35222 denotes inhibitor
T365 25776-25780 PR:P11308 denotes hERG
T366 25784-25793 CHEBI:35222;CHEBI:35222 denotes inhibitor
T367 25795-25799 UBERON:0000165 denotes oral
T368 25800-25803 NCBITaxon:10114 denotes rat
T372 25922-25931 CHEBI:36357;CHEBI:36357 denotes compounds
T373 26652-26660 SP_7 denotes COVID-19
T374 26763-26772 CHEBI:36357;CHEBI:36357 denotes compounds
T375 26932-26937 PR:000000125 denotes nsp12
T376 26955-26960 PR:000000125 denotes nsp12
T377 26981-26986 PR:000000125 denotes nsp13
T378 26997-27005 SO:0000346 denotes ADP site
T379 27008-27013 PR:000000125 denotes nsp13
T380 27035-27040 PR:000000125 denotes nsp14
T381 27049-27054 PR:000000125 denotes nsp14
T382 27067-27072 PR:000000125 denotes nsp15
T383 27093-27098 PR:000000125 denotes nsp16
T384 27113-27122 PG_4 denotes N protein
T385 27133-27142 PG_2 denotes E protein
T386 27144-27147 CHEBI:24870;CHEBI:24870 denotes ion
T387 27319-27328 CHEBI:36357;CHEBI:36357 denotes compounds
T388 27371-27380 CHEBI:36357;CHEBI:36357 denotes compounds
T389 27426-27435 CHEBI:36357;CHEBI:36357 denotes compounds
T397 27500-27509 SP_7 denotes 2019-nCov
T398 28532-28540 SP_7 denotes COVID-19
T399 29000-29004 CHEBI:23888;CHEBI:23888 denotes drug
T400 29176-29180 CHEBI:23888;CHEBI:23888 denotes drug
T401 29271-29279 CHEBI:36357;CHEBI:36357 denotes compound
T402 29329-29338 PG_2 denotes E protein
T403 29340-29343 CHEBI:24870;CHEBI:24870 denotes ion
T404 29687-29695 CHEBI:36357;CHEBI:36357 denotes compound
T405 29745-29750 PR:000000125 denotes nsp13
T406 29817-29822 CHEBI:32988;CHEBI:32988 denotes Amide
T407 29995-30000 CHEBI:22563;CHEBI:22563 denotes anion
T408 30136-30144 CHEBI:36357;CHEBI:36357 denotes compound
T409 30336-30338 CHEBI:15379;CHEBI:15379 denotes O2
T410 30361-30369 CHEBI:36357;CHEBI:36357 denotes compound
T411 30482-30487 CHEBI:22563;CHEBI:22563 denotes anion
T412 30600-30608 CHEBI:36357;CHEBI:36357 denotes compound
T413 30668-30677 PG_4 denotes N protein
T414 30906-30911 PR:000000125 denotes nsp14
T415 31054-31062 CHEBI:36357;CHEBI:36357 denotes compound
T416 31120-31125 PR:000000125 denotes nsp15
T417 31266-31269 PR:P19339 denotes SX1
T418 31283-31291 CHEBI:36357;CHEBI:36357 denotes compound
T419 31347-31352 PR:000000125 denotes nsp14
T420 31451-31454 PR:P19339 denotes SX1
T421 31495-31500 PR:000000125 denotes nsp15
T422 31653-31661 CHEBI:36357;CHEBI:36357 denotes compound
T423 31721-31726 PR:000000125 denotes nsp16
T424 31812-31817 CHEBI:17478;CHEBI:17478 denotes alkyl
T425 31825-31830 CHEBI:22563;CHEBI:22563 denotes anion
T426 31960-31965 PR:000000125 denotes nsp12
T427 32066-32072 CHEBI:36916;CHEBI:36916 denotes cation
T428 32080-32085 CHEBI:22563;CHEBI:22563 denotes anion
T429 32174-32182 CHEBI:36357;CHEBI:36357 denotes compound
T430 32240-32245 PR:000000125 denotes nsp12
T431 32491-32500 CHEBI:36357;CHEBI:36357 denotes compounds
T432 32527-32535 SP_7 denotes COVID-19
T433 32557-32566 PG_4 denotes N protein
T434 32580-32583 PR:Q8K4K7 denotes MS1
T435 32588-32593 PR:000000125 denotes nsp14
T436 32614-32619 PR:000000125 denotes nsp15
T437 32643-32646 PR:P19339 denotes SX1
T438 32651-32656 PR:000000125 denotes nsp14
T439 32672-32675 PR:P19339 denotes SX1
T440 32680-32685 PR:000000125 denotes nsp15
T441 32717-32722 PR:000000125 denotes nsp16
T442 32748-32753 PR:000000125 denotes nsp12
T443 32785-32790 PR:000000125 denotes nsp12
T457 32909-32913 G_3;PG_10;PR:000003622 denotes ACE2
T458 32918-32923 PR:000001324 denotes CD147
T459 32924-32934 GO:0010467 denotes expression
T460 32942-32949 UBERON:0000479 denotes tissues
T461 32957-32967 GO:0010467 denotes expression
T462 32968-32973 SO:0000704 denotes genes
T463 32980-32989 SP_7 denotes 2019-nCov
T464 33006-33013 UBERON:0000479 denotes tissues
T465 33018-33024 UBERON:0000062 denotes organs
T466 33033-33037 G_3;PG_10;PR:000003622 denotes ACE2
T467 33042-33047 PR:000001324 denotes CD147
T468 33081-33091 GO:0010467 denotes expression
T469 33112-33116 G_3;PG_10;PR:000003622 denotes ACE2
T470 33121-33126 PR:000001324 denotes CD147
T471 33137-33144 UBERON:0000479 denotes tissues
T472 33178-33188 GO:0010467 denotes expression
T473 33189-33196 UBERON:0000479 denotes tissues
T474 33200-33204 G_3;PG_10;PR:000003622 denotes ACE2
T475 33219-33224 UBERON:0002116 denotes ileum
T476 33226-33232 UBERON:0000473 denotes testis
T477 33234-33242 UBERON:0004877 denotes visceral
T478 33244-33251 UBERON:0003688 denotes omentum
T479 33254-33268 UBERON:0002084 denotes left ventricle
T480 33273-33286 UBERON:0001225 denotes kidney cortex
T481 33324-33328 UBERON:0002048 denotes lung
T482 33344-33354 GO:0010467 denotes expression
T483 33355-33362 UBERON:0000479 denotes tissues
T484 33366-33371 PR:000001324 denotes CD147
T485 33377-33383 UBERON:0000473 denotes testis
T486 33385-33393 UBERON:0004877 denotes visceral
T487 33395-33402 UBERON:0003688 denotes omentum
T488 33405-33419 UBERON:0002084 denotes left ventricle
T489 33421-33426 UBERON:0000947 denotes aorta
T490 33428-33444 UBERON:0006618 denotes atrial appendage
T491 33461-33472 CL:0000057 denotes fibroblasts
T492 33541-33550 SP_7 denotes 2019-nCov
T493 33571-33581 GO:0010467 denotes expression
T494 33582-33587 SO:0000704 denotes genes
T495 33591-33595 G_3;PG_10;PR:000003622 denotes ACE2
T496 33604-33614 GO:0010467 denotes expression
T497 33615-33620 SO:0000704 denotes genes
T498 33624-33629 PR:000001324 denotes CD147
T499 33712-33722 GO:0010467 denotes expression
T500 33723-33728 SO:0000704 denotes genes
T501 33732-33736 G_3;PG_10;PR:000003622 denotes ACE2
T502 33740-33747 UBERON:0001155;CL:0011108 denotes colonic
T503 33748-33758 CL:0011108;UBERON:0002424 denotes epithelial
T504 33759-33764 CL:0011108 denotes cells
T505 33917-33925 SP_7 denotes COVID-19
T506 33941-33950 SP_7 denotes 2019-nCov
T507 33963-33967 G_3;PG_10;PR:000003622 denotes ACE2
T508 33972-33977 PR:000001324 denotes CD147
T538 34005-34009 G_3;PG_10;PR:000003622 denotes ACE2
T539 34014-34019 PR:000001324 denotes CD147
T540 34020-34030 GO:0010467 denotes expression
T541 34038-34045 UBERON:0000479 denotes tissues
T542 34053-34063 GO:0010467 denotes expression
T543 34064-34069 SO:0000704 denotes genes
T544 34088-34092 G_3;PG_10;PR:000003622 denotes ACE2
T545 34097-34102 PR:000001324 denotes CD147
T546 34103-34113 GO:0010467 denotes expression
T547 34124-34131 UBERON:0000479 denotes tissues
T548 34137-34147 GO:0010467 denotes expression
T549 34230-34240 GO:0010467 denotes expression
T550 34241-34248 UBERON:0000479 denotes tissues
T551 34320-34324 G_3;PG_10;PR:000003622 denotes ACE2
T552 34328-34338 GO:0010467 denotes expression
T553 34339-34344 SO:0000704 denotes genes
T554 34346-34350 G_3;PG_10;PR:000003622 denotes ACE2
T555 34362-34367 PR:000001324 denotes CD147
T556 34371-34381 GO:0010467 denotes expression
T557 34382-34387 SO:0000704 denotes genes
T558 34389-34394 PR:000001324 denotes CD147
T559 34410-34414 G_3;PG_10;PR:000003622 denotes ACE2
T560 34418-34428 GO:0010467 denotes expression
T561 34429-34434 SO:0000704 denotes genes
T562 34438-34445 UBERON:0001155;CL:0011108 denotes colonic
T563 34446-34456 CL:0011108;UBERON:0000483 denotes epithelial
T564 34457-34462 CL:0011108 denotes cells
T565 34464-34468 G_3;PG_10;PR:000003622 denotes ACE2
T566 34469-34476 UBERON:0001155 denotes colonic
T567 34908-34912 CHEBI:23888;CHEBI:23888 denotes drug
T568 34942-34950 SP_7 denotes COVID-19
T569 35098-35106 SP_7 denotes COVID-19
T570 35217-35225 SP_7 denotes COVID-19
T578 35589-35597 SP_7 denotes COVID-19
T579 35633-35637 CHEBI:23888;CHEBI:23888 denotes drug
T580 35760-35764 CHEBI:23888;CHEBI:23888 denotes drug
T581 36220-36229 SP_7 denotes 2019-nCov
T582 37113-37121 SP_7 denotes COVID-19
T583 37273-37277 CHEBI:23888;CHEBI:23888 denotes drug
T584 37294-37299 PR:000005188 denotes Cdc20
T585 37301-37305 PR:000009030 denotes Ido1
T586 37307-37311 PR:000000017 denotes Ifng
T587 37313-37317 PR:000001471 denotes Il10
T588 37324-37330 PR:000001548 denotes Ptger4
T589 37332-37336 PR:000001944 denotes Spi1
T590 37338-37341 PR:000000134 denotes Tnf
T591 37351-37355 CHEBI:23888;CHEBI:23888 denotes drug
T592 37378-37386 SP_7 denotes COVID-19
T593 37499-37517 UBERON:0000160 denotes inflammatory bowel
T594 37527-37545 GO:0007259 denotes JAK-STAT signaling
T596 37593-37601 SP_7 denotes COVID-19
T597 38014-38025 NCBITaxon:11118 denotes coronavirus
T598 38027-38036 SP_7 denotes 2019-nCov
T599 38068-38072 UBERON:0002048 denotes lung
T600 38077-38090 UBERON:0002405 denotes immune system
T601 38134-38145 UBERON:0001004 denotes respiratory
T602 38210-38215 GO:0016265 denotes death
T603 38271-38276 UBERON:0000062 denotes organ
T604 38337-38342 CHEBI:23888;CHEBI:23888 denotes drugs
T605 38379-38387 SP_7 denotes COVID-19
T606 38438-38442 CHEBI:23888;CHEBI:23888 denotes drug
T607 38627-38635 SP_7 denotes COVID-19
T608 38844-38855 NCBITaxon:11118 denotes coronavirus
T609 38933-38941 SP_7 denotes COVID-19
T610 38953-38965 CHEBI:52217;CHEBI:52217 denotes pharmacology
T611 39358-39363 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T612 39364-39381 GO:0006629 denotes metabolic process
T613 39383-39388 CHEBI:18059;CHEBI:18059 denotes lipid
T614 39404-39412 CHEBI:36357;CHEBI:36357 denotes molecule
T615 39413-39430 GO:0044281 denotes metabolic process
T616 39436-39455 GO:0042592 denotes homeostatic process
T617 39493-39498 NCBITaxon:10239 denotes viral
T618 39516-39525 GO:0008152 denotes metabolic
T619 39602-39607 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T620 39608-39617 GO:0006629 denotes metabolic
T621 39658-39663 GO:0006260;NCBITaxon:10239 denotes virus
T622 39664-39675 GO:0006260 denotes replication
T623 39794-39799 CHEBI:18059;CHEBI:18059;GO:0006629 denotes lipid
T624 39800-39810 GO:0006629 denotes metabolism
T625 39829-39845 UBERON:0000949 denotes endocrine system
T626 40171-40182 GO:0042592 denotes homeostasis
T627 40186-40196 GO:0008152 denotes metabolism
T628 40312-40325 UBERON:0002405 denotes immune system
T629 40335-40356 GO:0005783 denotes endoplasmic reticulum
T630 40358-40377 GO:0007267 denotes cell-cell signaling
T631 40415-40428 UBERON:0004237;GO:0014829 denotes smooth muscle
T632 40429-40440 GO:0014829 denotes contraction
T633 40442-40463 CHEBI:67079;CHEBI:67079 denotes inflammatory mediator
T634 40464-40474 GO:0065007 denotes regulation
T635 40492-40506 UBERON:0001133;GO:0060048 denotes cardiac muscle
T636 40507-40518 GO:0060048 denotes contraction
T637 40954-40962 SP_7 denotes COVID-19
T638 41004-41013 GO:0010467 denotes expressed
T639 41014-41018 CHEBI:23888;CHEBI:23888 denotes drug
T640 41035-41040 PR:000005188 denotes Cdc20
T641 41042-41046 PR:000009030 denotes Ido1
T642 41048-41052 PR:000000017 denotes Ifng
T643 41054-41058 PR:000001471 denotes Il10
T644 41060-41063 PR:000001393 denotes Il6
T645 41065-41071 PR:000001548 denotes Ptger4
T646 41073-41077 PR:000001944 denotes Spi1
T647 41110-41119 NCBITaxon:2 denotes bacterial
T648 41124-41129 NCBITaxon:10239 denotes viral
T649 41151-41164 UBERON:0002405 denotes immune system
T650 41243-41252 SP_7 denotes 2019-nCov
T651 41272-41278 UBERON:0000062 denotes organs
T652 41302-41307 UBERON:0002107 denotes liver
T653 41314-41322 UBERON:0001264 denotes pancreas
T654 41329-41335 UBERON:0002113 denotes kidney
T655 41342-41348 UBERON:0000341 denotes throat
T656 41353-41359 UBERON:0001052 denotes rectum
T657 41418-41422 G_3;PG_10;PR:000003622 denotes ACE2
T658 41436-41443 UBERON:0000479 denotes tissues
T659 41497-41501 G_3;PG_10;PR:000003622 denotes ACE2
T660 41513-41522 GO:0010467 denotes expressed
T661 41535-41540 UBERON:0002116 denotes ileum
T662 41542-41548 UBERON:0000473 denotes testis
T663 41550-41557 UBERON:0001013 denotes adipose
T664 41558-41566 UBERON:0004877 denotes visceral
T665 41567-41574 UBERON:0003688 denotes omentum
T666 41576-41596 UBERON:0002084 denotes heart left ventricle
T667 41598-41611 UBERON:0001225 denotes kidney cortex
T668 41616-41623 UBERON:0002046 denotes thyroid
T669 41677-41686 SP_7 denotes 2019-nCov
T670 41702-41706 G_3;PG_10;PR:000003622 denotes ACE2
T671 41715-41720 SO:0000704 denotes genes
T672 41786-41794 SP_7 denotes COVID-19
T673 41927-41935 SP_7 denotes COVID-19
T674 42000-42018 UBERON:0000160 denotes inflammatory bowel
T675 42048-42057 UBERON:0002048 denotes pulmonary
T676 42067-42079 UBERON:0000160 denotes intrahepatic
T677 42191-42195 CHEBI:23888;CHEBI:23888 denotes drug
T678 42235-42239 CHEBI:23888;CHEBI:23888;GO:0017144 denotes drug
T679 42240-42251 GO:0032502 denotes development
T680 42313-42322 CHEBI:36357;CHEBI:36357 denotes compounds
T681 42434-42440 CHEBI:30563;CHEBI:30563 denotes silico
T682 42441-42445 CHEBI:23888;CHEBI:23888 denotes drug
T683 42477-42493 UBERON:0005409 denotes gastrointestinal
T684 42858-42867 CHEBI:36357;CHEBI:36357 denotes compounds
T685 42906-42915 SP_7 denotes 2019-nCov
T686 42982-42990 SP_7 denotes COVID-19
T687 43120-43124 GO:0018995 denotes host
T688 43134-43143 SO:0000276 denotes microRNAs
T689 43145-43151 SO:0000276 denotes miRNAs
T690 43173-43183 GO:0065007 denotes regulation
T691 43187-43192 NCBITaxon:10239 denotes virus
T692 43269-43275 PR:000010182 denotes MIR301
T693 43295-43301 PR:000010182 denotes MIR183
T694 43474-43483 SO:0000646 denotes microRNAs
T695 43499-43507 SP_7 denotes COVID-19
T696 43585-43596 GO:0006260 denotes replication
T697 43608-43615 NCBITaxon:10239 denotes viruses
T698 43627-43632 SP_6;NCBITaxon:9606 denotes human
T699 43636-43637 NCBITaxon:10376 denotes -
T700 43640-43656 NCBITaxon:9258 denotes papillomaviruses
T701 43658-43663 SP_6;NCBITaxon:9606 denotes human
T702 43664-43679 NCBITaxon:10358 denotes cytomegalovirus
T703 43681-43685 NCBITaxon:10358 denotes HCMV
T704 43688-43694 NCBITaxon:9606 denotes herpes
T705 43695-43708 NCBITaxon:10376 denotes simplex virus
T706 43710-43713 NCBITaxon:10298 denotes HSV
T707 43726-43729 NCBITaxon:10298 denotes HSV
T708 43788-43792 PR:000005265 denotes CDK7
T709 43866-43874 GO:0065007 denotes regulate
T710 43875-43886 GO:0006260 denotes replication
T711 43890-43898 SP_7 denotes COVID-19
T712 43899-43906 NCBITaxon:10239 denotes viruses
T713 43911-43915 PR:000005265 denotes CDK7
T714 43925-43935 GO:0007049 denotes cell cycle
T715 44025-44033 GO:0065007 denotes regulate
T716 44034-44045 CHEBI:16113;CHEBI:16113;GO:0042632 denotes cholesterol
T717 44046-44057 GO:0042632 denotes homeostasis
T718 44098-44107 GO:0065007 denotes regulated
T719 44120-44129 NCBITaxon:7719 denotes influenza
T720 44130-44135 NCBITaxon:10239 denotes virus
T721 44260-44268 GO:0065007 denotes regulate
T722 44269-44278 GO:0008152 denotes metabolic
T723 44321-44329 SP_7 denotes COVID-19
T724 44330-44335 NCBITaxon:10239 denotes virus
T725 44397-44405 SP_7 denotes COVID-19
T726 44616-44620 SP_10 denotes SARS
T727 44666-44674 SP_7 denotes COVID-19
T728 44696-44704 SP_7 denotes COVID-19
T729 44745-44753 SP_7 denotes COVID-19
T730 44899-44911 CHEBI:52217;CHEBI:52217 denotes pharmacology
T731 44971-44979 SP_7 denotes COVID-19
T732 45076-45084 SP_7 denotes COVID-19
T733 45282-45288 SO:0000276 denotes miRNAs
T734 45343-45351 SP_7 denotes COVID-19
T735 45450-45458 SP_7 denotes COVID-19
T14 42906-42915 SP_7 denotes 2019-nCov

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 902-907 Body_part denotes Semen http://purl.org/sig/ont/fma/fma62966
T6 1677-1682 Body_part denotes Semen http://purl.org/sig/ont/fma/fma62966
T7 2135-2141 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T8 2508-2514 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T9 5648-5652 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T10 5971-5974 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T11 6369-6377 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T12 6692-6699 Body_part denotes Genomes http://purl.org/sig/ont/fma/fma84116
T13 7832-7836 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 7859-7863 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T15 7917-7922 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T16 7923-7928 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T17 7941-7963 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T18 8170-8174 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T19 8505-8513 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T20 8573-8576 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T21 8599-8602 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T22 8666-8670 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T23 8739-8746 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 8762-8769 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 8808-8815 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T26 8865-8868 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T27 8885-8888 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 8931-8935 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T29 9114-9122 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T30 9163-9170 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T31 9266-9273 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T32 9301-9308 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T33 9634-9650 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T34 9645-9650 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 9681-9689 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T36 9826-9834 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T37 10582-10591 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T38 12355-12363 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T39 15876-15881 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T40 15901-15906 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T41 16002-16006 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 16274-16289 Body_part denotes steroid hormone http://purl.org/sig/ont/fma/fma83353
T43 16328-16336 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T44 16341-16348 Body_part denotes proline http://purl.org/sig/ont/fma/fma82761
T45 16549-16557 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T46 16600-16605 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T47 16784-16791 Body_part denotes Alanine http://purl.org/sig/ont/fma/fma82749
T48 16833-16854 Body_part denotes membrane organization http://purl.org/sig/ont/fma/fma7145
T49 16887-16890 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448
T50 18582-18589 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 18837-18841 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T52 18913-18917 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T53 18988-18992 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T54 19674-19678 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T55 19820-19825 Body_part denotes Notch http://purl.org/sig/ont/fma/fma75036
T56 20093-20097 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T57 20182-20189 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T58 20190-20197 Body_part denotes hormone http://purl.org/sig/ont/fma/fma12278
T59 20539-20543 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T60 20611-20615 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T61 20682-20686 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T62 20773-20780 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T63 20831-20835 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 21099-21103 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T65 21175-21179 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T66 21247-21251 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T67 21321-21325 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T68 21393-21397 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T69 22011-22019 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T70 22082-22090 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T71 22150-22158 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T72 22219-22227 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T73 22292-22300 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T74 24056-24066 Body_part denotes Intestinal http://purl.org/sig/ont/fma/fma7199
T75 24087-24091 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T76 24093-24097 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T77 24177-24182 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T78 24183-24188 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T79 24211-24214 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T80 24216-24238 Body_part denotes Central Nervous System http://purl.org/sig/ont/fma/fma55675
T81 24224-24238 Body_part denotes Nervous System http://purl.org/sig/ont/fma/fma7157
T82 24473-24477 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T83 24763-24771 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T84 24785-24792 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 25102-25106 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 25129-25133 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T87 25227-25233 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T88 25247-25253 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T89 25268-25274 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T90 25443-25448 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T91 25449-25454 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T92 25473-25495 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T93 25497-25500 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T94 25843-25847 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T95 26909-26917 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T96 26949-26952 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T97 26975-26978 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T98 27042-27046 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T99 27115-27122 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 27135-27142 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T101 27510-27518 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 27714-27717 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T103 27786-27789 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 27993-27997 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T105 28277-28284 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T106 28347-28354 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T107 29331-29338 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T108 30670-30677 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T109 30913-30917 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T110 31980-31983 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T111 32257-32260 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T112 32536-32544 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T113 32559-32566 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T114 32595-32599 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T115 32768-32771 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T116 32802-32805 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T117 32942-32949 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T118 33006-33013 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T119 33137-33144 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T120 33189-33196 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T121 33210-33224 Body_part denotes terminal ileum http://purl.org/sig/ont/fma/fma14966
T122 33226-33232 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T123 33244-33251 Body_part denotes omentum http://purl.org/sig/ont/fma/fma14650
T124 33254-33268 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T125 33273-33279 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T126 33280-33286 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T127 33324-33328 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T128 33355-33362 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T129 33377-33383 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T130 33395-33402 Body_part denotes omentum http://purl.org/sig/ont/fma/fma14650
T131 33405-33419 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T132 33421-33426 Body_part denotes aorta http://purl.org/sig/ont/fma/fma3734
T133 33461-33472 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T134 33656-33664 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T135 33691-33699 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T136 33748-33764 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T137 33759-33764 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 34038-34045 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T139 34124-34131 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T140 34241-34248 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T141 34267-34275 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T142 34446-34462 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T143 34457-34462 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T144 34549-34557 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T145 34614-34618 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T146 34728-34736 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T147 36230-36238 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T148 36419-36422 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T149 36477-36480 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T150 36656-36660 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T151 36900-36907 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T152 36960-36967 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T153 37438-37446 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T154 37447-37455 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T155 37512-37517 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T156 38068-38072 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 38077-38090 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T158 38271-38276 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T159 39358-39363 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T160 39383-39388 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T161 39602-39607 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T162 39794-39799 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T163 39829-39845 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T164 40312-40325 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T165 40335-40356 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T166 40358-40362 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 40363-40367 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T168 40422-40428 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T169 40500-40506 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T170 41141-41149 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T171 41151-41164 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T172 41302-41307 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T173 41314-41322 Body_part denotes pancreas http://purl.org/sig/ont/fma/fma7198
T174 41329-41335 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T175 41342-41348 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T176 41353-41359 Body_part denotes rectum http://purl.org/sig/ont/fma/fma14544
T177 41436-41443 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T178 41526-41540 Body_part denotes terminal ileum http://purl.org/sig/ont/fma/fma14966
T179 41542-41548 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T180 41567-41574 Body_part denotes omentum http://purl.org/sig/ont/fma/fma14650
T181 41576-41581 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T182 41582-41596 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T183 41598-41604 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T184 41605-41611 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T185 41616-41623 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T186 42013-42018 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T187 42944-42952 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T188 43633-43636 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T189 43925-43929 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T190 43940-43943 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T191 44713-44722 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 902-907 Body_part denotes Semen http://purl.obolibrary.org/obo/UBERON_0001968
T3 1677-1682 Body_part denotes Semen http://purl.obolibrary.org/obo/UBERON_0001968
T4 1832-1849 Body_part denotes surface structure http://purl.obolibrary.org/obo/UBERON_0003102
T5 2135-2141 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T6 2508-2514 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T7 7859-7863 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T8 7917-7936 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T9 7917-7922 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 7923-7928 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T11 7941-7963 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T12 7949-7963 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T13 8170-8174 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T14 16600-16605 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T15 16833-16854 Body_part denotes membrane organization http://purl.obolibrary.org/obo/UBERON_0000094
T16 16887-16890 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T17 20182-20189 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046
T18 24087-24091 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T19 24093-24097 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T20 24177-24196 Body_part denotes Blood Brain Barrier http://purl.obolibrary.org/obo/UBERON_0000120
T21 24211-24214 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T22 24216-24238 Body_part denotes Central Nervous System http://purl.obolibrary.org/obo/UBERON_0001017
T23 24473-24477 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T24 25129-25133 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T25 25227-25233 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 25247-25253 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T27 25443-25462 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T28 25443-25448 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T29 25449-25454 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T30 25473-25495 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T31 25481-25495 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T32 25497-25500 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T33 25843-25847 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T34 33018-33024 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T35 33219-33224 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T36 33226-33232 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T37 33244-33251 Body_part denotes omentum http://purl.obolibrary.org/obo/UBERON_0003688
T38 33273-33279 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T39 33280-33286 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T40 33324-33328 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T41 33377-33383 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T42 33395-33402 Body_part denotes omentum http://purl.obolibrary.org/obo/UBERON_0003688
T43 33421-33426 Body_part denotes aorta http://purl.obolibrary.org/obo/UBERON_0000947
T44 33435-33444 Body_part denotes appendage http://purl.obolibrary.org/obo/UBERON_0000026
T45 38068-38072 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T46 38077-38090 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T47 38271-38276 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T48 39829-39845 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T49 40312-40325 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T50 41151-41164 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T51 41272-41278 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T52 41302-41307 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T53 41314-41322 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264
T54 41329-41335 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T55 41342-41348 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T56 41353-41359 Body_part denotes rectum http://purl.obolibrary.org/obo/UBERON_0001052
T57 41535-41540 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T58 41542-41548 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T59 41567-41574 Body_part denotes omentum http://purl.obolibrary.org/obo/UBERON_0003688
T60 41576-41596 Body_part denotes heart left ventricle http://purl.obolibrary.org/obo/UBERON_0002084
T61 41576-41581 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T62 41598-41604 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T63 41605-41611 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T64 41616-41623 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T13 202-227 Disease denotes corona virus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T14 229-237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 608-618 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T16 619-628 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T17 680-684 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 1323-1331 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1758-1769 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T20 1782-1791 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T21 1792-1808 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T22 2073-2076 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T23 2092-2098 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T24 2100-2112 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T25 2114-2125 Disease denotes tonsillitis http://purl.obolibrary.org/obo/MONDO_0001039
T26 2130-2141 Disease denotes sore throat http://purl.obolibrary.org/obo/MONDO_0002258
T27 3010-3018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 3188-3196 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 3939-3947 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 4023-4031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 4154-4164 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T32 4165-4174 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T33 4361-4369 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 8273-8281 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 8291-8299 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 8402-8410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 9098-9106 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 9510-9519 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T39 9907-9915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 9976-9984 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 10523-10531 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 10595-10603 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T43 10647-10651 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T44 10786-10794 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T45 11138-11146 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T46 16518-16522 Disease denotes acne http://purl.obolibrary.org/obo/MONDO_0011438
T47 16524-16540 Disease denotes Behcet'S disease http://purl.obolibrary.org/obo/MONDO_0007191
T48 16542-16569 Disease denotes benign prostate hyperplasia http://purl.obolibrary.org/obo/MONDO_0010811
T49 16558-16569 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T50 16571-16595 Disease denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/MONDO_0019072
T51 16584-16595 Disease denotes cholestasis http://purl.obolibrary.org/obo/MONDO_0001751
T52 16600-16612 Disease denotes brain injury http://purl.obolibrary.org/obo/MONDO_0043510
T53 16606-16612 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T54 16859-16879 Disease denotes parasitic infections http://purl.obolibrary.org/obo/MONDO_0005135
T55 16928-16940 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T56 17044-17065 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T57 19768-19788 Disease denotes huntington's disease http://purl.obolibrary.org/obo/MONDO_0007739
T58 22366-22374 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 24754-24762 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T60 26652-26660 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 28532-28540 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 32527-32535 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 33528-33537 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T64 33635-33644 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T65 33917-33925 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T66 33952-33961 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T67 34309-34318 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T68 34942-34950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 35098-35106 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 35217-35225 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 35589-35597 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T72 37113-37121 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T73 37378-37386 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T74 37411-37436 Disease denotes Graft-versus-host disease http://purl.obolibrary.org/obo/MONDO_0013730
T75 37478-37484 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T76 37486-37495 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T77 37499-37525 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T78 37593-37601 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T79 38026-38047 Disease denotes (2019-nCov) infection http://purl.obolibrary.org/obo/MONDO_0100096
T80 38038-38047 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81 38106-38115 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82 38128-38163 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T83 38134-38163 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T84 38165-38169 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T85 38379-38387 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 38627-38635 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 38807-38816 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T88 38933-38941 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 40147-40156 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90 40954-40962 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 41314-41322 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T92 41688-41697 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T93 41786-41794 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 41927-41935 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 41969-41990 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T96 41992-41998 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T97 42000-42026 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T98 42028-42065 Disease denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005002
T99 42048-42065 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T100 42067-42091 Disease denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/MONDO_0019072
T101 42080-42091 Disease denotes cholestasis http://purl.obolibrary.org/obo/MONDO_0001751
T102 42101-42108 Disease denotes ileitis http://purl.obolibrary.org/obo/MONDO_0000709
T103 42982-42990 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 43187-43202 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T105 43193-43202 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 43499-43507 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T107 43688-43702 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T108 43890-43898 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T109 44065-44077 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T110 44115-44129 Disease denotes H1N1 influenza http://purl.obolibrary.org/obo/MONDO_0005460
T111 44120-44129 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T112 44130-44145 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T113 44136-44145 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T114 44321-44329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 44330-44345 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T116 44336-44345 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T117 44397-44405 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 44616-44620 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 44666-44674 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 44696-44704 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 44745-44753 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 44971-44979 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T123 45076-45084 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 45343-45351 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 45450-45458 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T19 209-214 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T20 248-253 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T21 254-257 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 258-259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 365-368 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 369-370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 484-485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 545-550 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T27 581-584 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28 585-586 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 633-636 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T30 643-644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 790-797 http://purl.obolibrary.org/obo/UBERON_0000982 denotes jointly
T32 790-797 http://purl.obolibrary.org/obo/UBERON_0004905 denotes jointly
T33 805-806 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 1386-1387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 1719-1722 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T36 1792-1797 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T37 2027-2028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 2114-2125 http://purl.obolibrary.org/obo/UBERON_0002372 denotes tonsillitis
T39 2442-2443 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 2508-2514 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T41 2508-2514 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T42 2508-2514 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T43 2691-2698 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T44 2750-2751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 3077-3078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3320-3321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 3423-3424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 3893-3895 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T49 4291-4292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 4373-4374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 4486-4487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 4570-4571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 4825-4833 http://purl.obolibrary.org/obo/CLO_0001279 denotes 30 % [15
T54 5074-5079 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T55 5087-5093 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T56 5311-5314 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T57 5648-5652 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T58 5937-5939 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T59 5960-5965 http://purl.obolibrary.org/obo/CLO_0050421 denotes chord
T60 6083-6090 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T61 6470-6482 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Homo sapiens
T62 6512-6513 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 6682-6687 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Genes
T64 6701-6710 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T65 6925-6931 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T66 7464-7470 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T67 7557-7563 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T68 7788-7790 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T69 7825-7836 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2 cell
T70 7859-7863 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T71 7859-7863 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T72 7859-7863 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T73 7859-7863 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T74 7859-7863 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T75 7917-7922 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T76 7917-7922 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T77 7923-7928 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T78 7923-7928 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T79 7941-7963 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T80 7941-7963 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T81 7941-7963 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T82 8170-8174 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T83 8170-8174 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T84 8170-8174 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T85 8170-8174 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T86 8170-8174 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T87 9189-9194 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T88 9275-9276 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 9377-9382 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T90 9531-9536 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T91 9609-9614 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T92 9626-9633 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T93 9634-9644 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T94 9645-9650 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T95 10605-10607 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T96 10638-10643 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T97 11513-11519 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T98 11713-11714 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 11824-11826 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T100 12138-12139 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T101 12152-12153 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 13377-13379 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T103 15628-15634 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T104 15658-15659 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T105 15672-15673 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T106 15774-15776 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T107 15866-15874 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T108 15971-15977 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T109 15989-16006 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity and cell
T110 16214-16223 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T111 16309-16318 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T112 16389-16390 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 16600-16605 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T114 16600-16605 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T115 16833-16841 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T116 16842-16854 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T117 16887-16890 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T118 16998-17006 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T119 17081-17084 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T120 17272-17273 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T121 17281-17282 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T122 17355-17356 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T123 17491-17492 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T124 17778-17780 http://purl.obolibrary.org/obo/CLO_0001387 denotes 4C
T125 17869-17874 http://purl.obolibrary.org/obo/CLO_0050421 denotes Chord
T126 18085-18091 http://purl.obolibrary.org/obo/CLO_0050421 denotes Chords
T127 18143-18144 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T128 18153-18154 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T129 18432-18437 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T130 18680-18681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 18745-18746 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T132 18837-18841 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T133 18913-18917 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T134 18966-18968 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T135 18988-18992 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T136 19127-19136 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T137 19385-19386 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T138 19394-19395 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T139 19464-19469 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T140 19674-19678 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T141 19826-19835 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T142 19885-19890 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T143 20093-20097 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T144 20198-20207 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T145 20231-20240 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T146 20333-20338 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T147 20539-20543 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T148 20611-20615 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T149 20682-20686 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T150 20773-20780 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T151 20807-20816 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T152 20831-20835 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T153 20894-20899 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T154 21099-21103 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T155 21175-21179 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T156 21247-21251 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T157 21299-21301 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T158 21321-21325 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T159 21393-21397 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T160 21491-21500 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T161 21519-21528 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T162 22129-22131 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T163 22376-22377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 22727-22728 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T165 22736-22737 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T166 23517-23518 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T167 23720-23721 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T168 23741-23742 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T169 24024-24029 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco2
T170 24024-24029 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco2
T171 24024-24029 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco2
T172 24024-24029 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco2
T173 24031-24037 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T174 24031-24037 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T175 24031-24037 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T176 24031-24037 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T177 24056-24066 http://purl.obolibrary.org/obo/UBERON_0000160 denotes Intestinal
T178 24056-24066 http://www.ebi.ac.uk/efo/EFO_0000834 denotes Intestinal
T179 24079-24084 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T180 24087-24091 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T181 24087-24091 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T182 24087-24091 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T183 24087-24091 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T184 24087-24091 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T185 24093-24097 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T186 24093-24097 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T187 24093-24097 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T188 24093-24097 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T189 24093-24097 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T190 24164-24169 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T191 24177-24182 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T192 24177-24182 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T193 24183-24188 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T194 24183-24188 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T195 24211-24214 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T196 24211-24214 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T197 24211-24214 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T198 24216-24238 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central Nervous System
T199 24216-24238 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central Nervous System
T200 24216-24238 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central Nervous System
T201 24285-24292 http://purl.obolibrary.org/obo/OBI_0100026 denotes Organic
T202 24285-24292 http://purl.obolibrary.org/obo/UBERON_0000468 denotes Organic
T203 24366-24371 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T204 24449-24451 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T205 24473-24477 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T206 24473-24477 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T207 24473-24477 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T208 24473-24477 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T209 24473-24477 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T210 24773-24774 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T211 24808-24809 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T212 24848-24850 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T213 24882-24887 http://purl.obolibrary.org/obo/CLO_0002821 denotes D: S1
T214 24882-24887 http://purl.obolibrary.org/obo/CLO_0002822 denotes D: S1
T215 25043-25044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 25095-25106 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2 cell
T217 25129-25133 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T218 25129-25133 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T219 25129-25133 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T220 25129-25133 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T221 25129-25133 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T222 25268-25274 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T223 25443-25448 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T224 25443-25448 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T225 25449-25454 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T226 25449-25454 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T227 25473-25495 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T228 25473-25495 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T229 25473-25495 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T230 25497-25500 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T231 25497-25500 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T232 25497-25500 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T233 25539-25540 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 25601-25608 http://purl.obolibrary.org/obo/OBI_0100026 denotes organic
T235 25601-25608 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organic
T236 25843-25847 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T237 25843-25847 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T238 25843-25847 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T239 25843-25847 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T240 25843-25847 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T241 25915-25921 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T242 26047-26049 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T243 26228-26230 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T244 26338-26341 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T245 26338-26341 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T246 26370-26372 http://purl.obolibrary.org/obo/CLO_0009126 denotes SR
T247 26774-26776 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T248 26837-26839 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T249 26862-26865 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T250 26862-26865 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T251 27535-27537 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T252 27538-27540 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T253 28774-28777 http://purl.obolibrary.org/obo/CLO_0002494 denotes ClC
T254 28898-28901 http://purl.obolibrary.org/obo/CLO_0002494 denotes ClC
T255 29260-29261 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T256 29662-29664 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T257 29676-29677 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 29933-29935 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T259 30125-30126 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T260 30350-30351 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T261 30552-30554 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T262 30582-30585 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T263 30582-30585 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T264 30594-30595 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T265 30598-30599 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T266 30862-30865 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T267 30862-30865 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T268 31023-31026 http://purl.obolibrary.org/obo/CLO_0037067 denotes VAL
T269 31052-31053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 31231-31234 http://purl.obolibrary.org/obo/CLO_0037067 denotes VAL
T271 31256-31259 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T272 31256-31259 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T273 31256-31259 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T274 31256-31259 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T275 31256-31259 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T276 31256-31259 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T277 31256-31259 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T278 31281-31282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 31615-31618 http://purl.obolibrary.org/obo/CLO_0037067 denotes VAL
T280 31651-31652 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 32117-32120 http://purl.obolibrary.org/obo/CLO_0001417 denotes 556
T282 32172-32173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 32218-32221 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T284 32376-32379 http://purl.obolibrary.org/obo/CLO_0001001 denotes 813
T285 32546-32547 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T286 32549-32552 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T287 32549-32552 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T288 32577-32578 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T289 32580-32583 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T290 32580-32583 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T291 32808-32810 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T292 32968-32973 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T293 33018-33024 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T294 33154-33155 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T295 33219-33224 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T296 33226-33232 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T297 33244-33251 http://purl.obolibrary.org/obo/UBERON_0003688 denotes omentum
T298 33273-33279 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T299 33273-33279 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T300 33273-33279 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T301 33280-33286 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T302 33324-33328 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T303 33324-33328 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T304 33377-33383 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T305 33395-33402 http://purl.obolibrary.org/obo/UBERON_0003688 denotes omentum
T306 33421-33426 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aorta
T307 33435-33444 http://purl.obolibrary.org/obo/UBERON_0000026 denotes appendage
T308 33435-33444 http://www.ebi.ac.uk/efo/EFO_0000799 denotes appendage
T309 33461-33472 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T310 33582-33587 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T311 33615-33620 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T312 33723-33728 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T313 33740-33747 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T314 33748-33758 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T315 33759-33764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T316 34064-34069 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T317 34071-34072 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T318 34250-34251 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T319 34339-34344 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T320 34382-34387 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T321 34429-34434 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T322 34438-34445 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T323 34446-34456 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T324 34457-34462 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T325 35156-35158 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T326 35520-35522 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T327 35667-35668 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 35707-35711 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T329 36249-36252 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T330 36249-36252 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T331 37123-37124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 37496-37497 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T333 37536-37545 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T334 37611-37612 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T335 37667-37668 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T336 38068-38072 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T337 38068-38072 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T338 38077-38090 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T339 38234-38235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T340 38271-38276 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T341 38420-38421 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T342 38455-38456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T343 38568-38571 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T344 38572-38573 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T345 38980-38981 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T346 39048-39049 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T347 39348-39356 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T348 39499-39507 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T349 39569-39570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 39587-39590 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T351 39658-39663 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T352 39829-39845 http://purl.obolibrary.org/obo/UBERON_0000949 denotes endocrine system
T353 39829-39845 http://www.ebi.ac.uk/efo/EFO_0002969 denotes endocrine system
T354 39931-39940 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T355 39967-39976 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T356 39986-39987 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T357 40001-40004 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T358 40118-40127 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T359 40312-40325 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T360 40358-40362 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T361 40363-40367 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T362 40368-40377 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T363 40387-40396 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T364 40422-40428 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T365 40422-40428 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T366 40422-40428 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T367 40422-40428 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T368 40492-40506 http://purl.obolibrary.org/obo/UBERON_0001133 denotes cardiac muscle
T369 40632-40633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 41151-41164 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T371 41166-41175 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T372 41206-41207 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T373 41272-41278 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T374 41302-41307 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T375 41302-41307 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T376 41309-41311 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T377 41314-41322 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
T378 41324-41326 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T379 41329-41335 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T380 41329-41335 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T381 41329-41335 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T382 41337-41339 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T383 41353-41359 http://purl.obolibrary.org/obo/UBERON_0001052 denotes rectum
T384 41353-41359 http://purl.obolibrary.org/obo/UBERON_0006866 denotes rectum
T385 41395-41396 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 41535-41540 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T387 41542-41548 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T388 41550-41557 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose
T389 41567-41574 http://purl.obolibrary.org/obo/UBERON_0003688 denotes omentum
T390 41576-41581 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T391 41576-41581 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T392 41576-41581 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T393 41576-41581 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T394 41598-41604 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T395 41598-41604 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T396 41598-41604 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T397 41605-41611 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T398 41640-41643 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T399 41715-41720 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T400 41810-41811 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T401 42189-42190 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 42455-42459 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T403 42753-42755 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T404 42794-42797 http://purl.obolibrary.org/obo/CLO_0007875 denotes MS1
T405 42794-42797 http://purl.obolibrary.org/obo/CLO_0052410 denotes MS1
T406 43074-43075 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T407 43097-43100 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 43187-43192 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T409 43204-43206 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T410 43209-43210 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T411 43405-43406 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T412 43508-43516 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T413 43561-43562 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T414 43608-43615 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T415 43627-43632 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T416 43658-43663 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T417 43703-43708 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T418 43899-43906 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T419 43925-43929 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T420 43983-43984 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T421 44130-44135 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T422 44147-44149 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T423 44330-44335 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T424 45088-45089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T425 45537-45541 http://purl.obolibrary.org/obo/CLO_0001979 denotes bing
T426 45656-45660 http://purl.obolibrary.org/obo/CLO_0001979 denotes Bing
T427 45732-45736 http://purl.obolibrary.org/obo/CLO_0001979 denotes Bing

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T14 202-208 Chemical denotes corona http://purl.obolibrary.org/obo/CHEBI_37409
T15 513-518 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 572-580 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T17 1413-1416 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T18 2274-2283 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T19 2779-2787 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T20 2875-2883 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T21 3380-3385 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T22 3481-3484 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T23 3569-3572 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T24 3673-3676 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T25 4764-4768 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T26 4779-4781 Chemical denotes DL http://purl.obolibrary.org/obo/CHEBI_68596
T27 4953-4956 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T28 5715-5718 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T29 5799-5801 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T30 6147-6150 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T32 6242-6245 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T34 6317-6320 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T36 6369-6377 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T37 6427-6430 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T39 6562-6565 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T41 6841-6844 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T43 6951-6954 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T44 7618-7620 Chemical denotes MW http://purl.obolibrary.org/obo/CHEBI_74709
T45 8092-8101 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T46 8108-8110 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T47 8111-8120 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T48 8250-8254 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T49 8505-8513 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T50 8621-8624 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T53 8739-8746 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T54 8762-8769 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T55 8771-8774 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T56 8808-8815 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T57 8897-8900 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T60 9114-9122 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T61 9681-9689 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T62 9826-9834 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T63 9873-9877 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T64 10158-10163 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T65 10235-10240 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T66 10325-10330 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T67 10423-10427 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T68 10495-10500 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T69 11059-11063 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T70 11287-11292 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T71 11574-11576 Chemical denotes DL http://purl.obolibrary.org/obo/CHEBI_68596
T72 11780-11783 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T73 12213-12216 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T74 12355-12363 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T75 15876-15881 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T76 15901-15906 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T77 15922-15930 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T78 16245-16251 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T79 16274-16289 Chemical denotes steroid hormone http://purl.obolibrary.org/obo/CHEBI_26764
T80 16274-16281 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T81 16282-16289 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T82 16328-16336 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T85 16341-16348 Chemical denotes proline http://purl.obolibrary.org/obo/CHEBI_17203|http://purl.obolibrary.org/obo/CHEBI_26271
T87 16364-16367 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T88 16406-16409 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T89 16723-16726 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T90 16779-16791 Chemical denotes beta-Alanine http://purl.obolibrary.org/obo/CHEBI_16958
T91 16779-16783 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T92 16784-16791 Chemical denotes Alanine http://purl.obolibrary.org/obo/CHEBI_16449
T93 16956-16968 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T94 16964-16968 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T95 17228-17231 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T96 17284-17287 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T97 17462-17467 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T98 17632-17634 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T99 17684-17686 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T100 17754-17759 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T101 17812-17814 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T102 17969-17971 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T103 18009-18011 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T104 18113-18115 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T105 18167-18169 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T106 18193-18196 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T108 18300-18303 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T110 18463-18466 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T112 18582-18589 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 18613-18616 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T115 19090-19096 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T116 19119-19126 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T118 19324-19327 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T120 19497-19500 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T122 19610-19612 Chemical denotes 5B http://purl.obolibrary.org/obo/CHEBI_27560
T123 19915-19918 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T125 20182-20197 Chemical denotes thyroid hormone http://purl.obolibrary.org/obo/CHEBI_60311
T126 20190-20197 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T127 20262-20268 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T128 20364-20367 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T130 20773-20780 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T131 20924-20927 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T133 21483-21490 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T135 21510-21514 Chemical denotes cGMP http://purl.obolibrary.org/obo/CHEBI_16356
T136 21550-21556 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T137 21636-21639 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T138 22011-22019 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T139 22082-22090 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T140 22150-22158 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T141 22219-22227 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T142 22292-22300 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T143 22339-22344 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T144 22513-22515 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T145 22637-22640 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T146 22702-22705 Chemical denotes Man http://purl.obolibrary.org/obo/CHEBI_37684
T147 22998-23002 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T148 23154-23156 Chemical denotes MW http://purl.obolibrary.org/obo/CHEBI_74709
T149 23405-23407 Chemical denotes MW http://purl.obolibrary.org/obo/CHEBI_74709
T150 23494-23498 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T151 23610-23612 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T152 24293-24299 Chemical denotes Cation http://purl.obolibrary.org/obo/CHEBI_36916
T153 24381-24383 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T154 24396-24398 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T155 24469-24471 Chemical denotes SS http://purl.obolibrary.org/obo/CHEBI_73653
T156 24493-24495 Chemical denotes MT http://purl.obolibrary.org/obo/CHEBI_73614
T157 24763-24771 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T158 24776-24778 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T160 24785-24792 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 24794-24797 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T162 24811-24813 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T164 24871-24874 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T167 24918-24920 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T168 25152-25156 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T169 25601-25615 Chemical denotes organic cation http://purl.obolibrary.org/obo/CHEBI_25697
T170 25609-25615 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T171 25765-25774 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T172 25781-25783 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T173 25784-25793 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T174 26020-26022 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T176 26047-26049 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T177 26083-26093 Chemical denotes Medicarpin http://purl.obolibrary.org/obo/CHEBI_6714
T178 26105-26115 Chemical denotes Cianidanol http://purl.obolibrary.org/obo/CHEBI_15600
T179 26175-26177 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T180 26231-26240 Chemical denotes letrozole http://purl.obolibrary.org/obo/CHEBI_6413
T181 26317-26327 Chemical denotes naringenin http://purl.obolibrary.org/obo/CHEBI_50202
T182 26342-26355 Chemical denotes Leucocyanidol http://purl.obolibrary.org/obo/CHEBI_11412|http://purl.obolibrary.org/obo/CHEBI_15758
T184 26440-26443 Chemical denotes Tyr http://purl.obolibrary.org/obo/CHEBI_17895|http://purl.obolibrary.org/obo/CHEBI_18186|http://purl.obolibrary.org/obo/CHEBI_46858
T187 26446-26449 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T189 26466-26480 Chemical denotes Liquiritigenin http://purl.obolibrary.org/obo/CHEBI_28777
T190 26499-26508 Chemical denotes taxifolin http://purl.obolibrary.org/obo/CHEBI_38747
T191 26561-26570 Chemical denotes flavanone http://purl.obolibrary.org/obo/CHEBI_5070
T192 26637-26648 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T193 26833-26835 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T195 26837-26839 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T196 26858-26860 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T197 26909-26917 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T198 26997-27000 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T201 27115-27122 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T202 27135-27142 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T203 27144-27147 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T204 27510-27518 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T205 27529-27531 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T207 27538-27540 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T208 27560-27562 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T209 27854-27857 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T212 28277-28284 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T213 28347-28354 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T214 28355-28358 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T215 29000-29004 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T216 29176-29180 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T217 29246-29248 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T219 29331-29338 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 29340-29343 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T221 29363-29365 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T222 29373-29375 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T223 29427-29430 Chemical denotes ALA http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432
T225 29474-29476 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T227 29565-29570 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T229 29571-29576 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T231 29578-29580 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T232 29624-29627 Chemical denotes ASN http://purl.obolibrary.org/obo/CHEBI_22653
T233 29761-29764 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T236 29817-29822 Chemical denotes Amide http://purl.obolibrary.org/obo/CHEBI_32988
T237 29823-29825 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T238 29838-29840 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T239 29874-29877 Chemical denotes ALA http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432
T241 29992-29994 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T242 29995-30000 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T243 30002-30004 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T244 30005-30007 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T245 30017-30019 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T246 30020-30022 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T247 30036-30038 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T248 30229-30231 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T249 30232-30237 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T251 30238-30246 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T252 30256-30258 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T253 30336-30338 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T254 30457-30463 Chemical denotes Carbon http://purl.obolibrary.org/obo/CHEBI_27594
T255 30464-30472 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T256 30479-30481 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T257 30482-30487 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T258 30489-30491 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T259 30492-30498 Chemical denotes sulfur http://purl.obolibrary.org/obo/CHEBI_26833
T260 30503-30505 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T261 30670-30677 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T262 30718-30720 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T263 30721-30726 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T265 30727-30735 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T266 30742-30744 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T267 30752-30754 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T268 30755-30757 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T269 30770-30772 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T270 30823-30826 Chemical denotes ALA http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432
T272 30953-30955 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T273 30956-30958 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T274 31002-31005 Chemical denotes PHE http://purl.obolibrary.org/obo/CHEBI_28044
T275 31186-31188 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T276 31240-31243 Chemical denotes LYS http://purl.obolibrary.org/obo/CHEBI_25094
T277 31374-31376 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T278 31377-31379 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T279 31392-31394 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T280 31428-31431 Chemical denotes PHE http://purl.obolibrary.org/obo/CHEBI_28044
T281 31561-31563 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T282 31597-31600 Chemical denotes LYS http://purl.obolibrary.org/obo/CHEBI_25094
T283 31606-31609 Chemical denotes LYS http://purl.obolibrary.org/obo/CHEBI_25094
T284 31646-31648 Chemical denotes 9F http://purl.obolibrary.org/obo/CHEBI_24061
T285 31771-31777 Chemical denotes Carbon http://purl.obolibrary.org/obo/CHEBI_27594
T286 31778-31786 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T287 31793-31795 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T288 31796-31798 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T289 31809-31811 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T290 31822-31824 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T291 31825-31830 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T292 31858-31861 Chemical denotes PHE http://purl.obolibrary.org/obo/CHEBI_28044
T293 32016-32022 Chemical denotes Carbon http://purl.obolibrary.org/obo/CHEBI_27594
T294 32023-32031 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T295 32050-32055 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T297 32056-32061 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T299 32063-32065 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T300 32066-32072 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T301 32077-32079 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T302 32080-32085 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T303 32293-32295 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T304 32296-32301 Chemical denotes Donor http://purl.obolibrary.org/obo/CHEBI_17499|http://purl.obolibrary.org/obo/CHEBI_17891
T306 32302-32310 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T307 32317-32319 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T308 32320-32322 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T309 32336-32338 Chemical denotes Pi http://purl.obolibrary.org/obo/CHEBI_35780
T310 32390-32393 Chemical denotes LYS http://purl.obolibrary.org/obo/CHEBI_25094
T311 32536-32544 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T312 32559-32566 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T313 32808-32810 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T314 33656-33664 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T315 33691-33699 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T316 34173-34177 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T317 34267-34275 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T318 34549-34557 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T319 34567-34572 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T320 34728-34736 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T321 34908-34912 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T322 35633-35637 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T323 35760-35764 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T324 36230-36238 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T325 36533-36536 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T328 36900-36907 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T329 36960-36967 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T330 36968-36971 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T331 37273-37277 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T332 37351-37355 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T333 37746-37753 Chemical denotes diamond http://purl.obolibrary.org/obo/CHEBI_33417
T334 38337-38342 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T335 38438-38442 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T336 38554-38562 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T337 38564-38567 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T338 39358-39363 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T339 39383-39388 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T340 39404-39412 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T341 39602-39607 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T342 39729-39738 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T343 39794-39799 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T344 39829-39838 Chemical denotes endocrine http://purl.obolibrary.org/obo/CHEBI_24621
T345 40379-40386 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T347 40665-40668 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T348 40709-40712 Chemical denotes TCM http://purl.obolibrary.org/obo/CHEBI_145500
T349 41014-41018 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T350 41842-41845 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T351 42191-42195 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T352 42235-42239 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T353 42370-42372 Chemical denotes MW http://purl.obolibrary.org/obo/CHEBI_74709
T354 42441-42445 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T355 42749-42751 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T357 42764-42766 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T358 42944-42952 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T359 43955-43957 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T360 44034-44045 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 619-628 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 1771-1776 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T6 2092-2098 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T7 2114-2125 Phenotype denotes tonsillitis http://purl.obolibrary.org/obo/HP_0011110
T8 2130-2141 Phenotype denotes sore throat http://purl.obolibrary.org/obo/HP_0033050
T9 4165-4174 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T10 9510-9519 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T11 16518-16522 Phenotype denotes acne http://purl.obolibrary.org/obo/HP_0001061
T12 16542-16569 Phenotype denotes benign prostate hyperplasia http://purl.obolibrary.org/obo/HP_0008711
T13 16571-16595 Phenotype denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/HP_0001406
T14 16928-16940 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T15 20773-20791 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855
T16 33528-33537 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T17 33635-33644 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 33952-33961 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 34309-34318 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T20 37478-37484 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T21 37499-37525 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T22 38099-38115 Phenotype denotes Severe infection http://purl.obolibrary.org/obo/HP_0032169
T23 38134-38154 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T24 38694-38699 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T25 38807-38816 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T26 41688-41697 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T27 41992-41998 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T28 42000-42026 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T29 42028-42065 Phenotype denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/HP_0006510
T30 42067-42091 Phenotype denotes intrahepatic cholestasis http://purl.obolibrary.org/obo/HP_0001406
T31 42101-42108 Phenotype denotes ileitis http://purl.obolibrary.org/obo/HP_0032564

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T20 2100-2112 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T21 2515-2524 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T22 2538-2567 http://purl.obolibrary.org/obo/GO_0050728 denotes inhibit inflammatory response
T23 2546-2567 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T24 5775-5797 http://purl.obolibrary.org/obo/GO_0000981 denotes transcriptional factor
T25 5799-5801 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T26 6701-6718 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T27 6701-6710 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T28 7979-7988 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T29 8771-8782 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T30 15866-15899 http://purl.obolibrary.org/obo/GO_0045834 denotes activity, lipid metabolic process
T31 15876-15899 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic process
T32 15882-15899 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T33 15916-15948 http://purl.obolibrary.org/obo/GO_0044281 denotes small molecule metabolic process
T34 15931-15948 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T35 15950-15969 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostatic process
T36 15989-16020 http://purl.obolibrary.org/obo/GO_0008284 denotes activity and cell proliferation
T37 16002-16020 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T38 16186-16198 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T39 16200-16231 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T40 16200-16231 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T41 16200-16231 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T42 16214-16231 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T43 16214-16223 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 16282-16302 http://purl.obolibrary.org/obo/GO_0042446 denotes hormone biosynthesis
T45 16290-16302 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T46 16304-16326 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T47 16309-16326 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T48 16309-16318 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 16341-16359 http://purl.obolibrary.org/obo/GO_0006560 denotes proline metabolism
T50 16349-16359 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T51 16364-16380 http://purl.obolibrary.org/obo/GO_0140359 denotes ABC transporters
T52 16747-16774 http://purl.obolibrary.org/obo/GO_0050877 denotes neurological system process
T53 16760-16774 http://purl.obolibrary.org/obo/GO_0003008 denotes system process
T54 16779-16802 http://purl.obolibrary.org/obo/GO_0019482 denotes beta-Alanine metabolism
T55 16792-16802 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T56 16833-16854 http://purl.obolibrary.org/obo/GO_0061024 denotes membrane organization
T57 16907-16923 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T58 16917-16923 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T59 16956-17006 http://purl.obolibrary.org/obo/GO_0003700 denotes nucleic acid binding transcription factor activity
T60 16977-16997 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T61 16977-16990 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T62 17016-17031 http://purl.obolibrary.org/obo/GO_0006694 denotes steroidogenesis
T63 17085-17094 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T64 17632-17634 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T65 17684-17686 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T66 17812-17814 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T67 17969-17971 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T68 18009-18011 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T69 18113-18115 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T70 18167-18169 http://purl.obolibrary.org/obo/GO_0000981 denotes TF
T71 19119-19136 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T72 19127-19136 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73 19168-19178 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T74 19790-19800 http://purl.obolibrary.org/obo/GO_0006096 denotes glycolysis
T75 19803-19818 http://purl.obolibrary.org/obo/GO_0006094 denotes gluconeogenesis
T76 19820-19843 http://purl.obolibrary.org/obo/GO_0007219 denotes Notch signaling pathway
T77 19826-19843 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T78 19826-19835 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T79 20198-20215 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T80 20198-20207 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T81 20217-20248 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T82 20217-20248 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T83 20217-20248 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T84 20231-20248 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T85 20231-20240 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T86 20793-20824 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T87 20793-20824 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T88 20793-20824 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T89 20807-20824 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T90 20807-20816 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T91 20831-20851 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T92 21483-21500 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T93 21491-21500 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T94 21519-21536 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T95 21519-21528 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T96 24056-24077 http://purl.obolibrary.org/obo/GO_0050892 denotes Intestinal Absorption
T97 24285-24311 http://purl.obolibrary.org/obo/GO_0015695 denotes Organic Cation Transporter
T98 24794-24805 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T99 25601-25627 http://purl.obolibrary.org/obo/GO_0015695 denotes organic cation transporter
T100 27144-27155 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T101 28355-28366 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T102 29340-29351 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T103 36968-36979 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T104 37536-37545 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T105 39348-39381 http://purl.obolibrary.org/obo/GO_0045834 denotes activity, lipid metabolic process
T106 39358-39381 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic process
T107 39364-39381 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T108 39398-39430 http://purl.obolibrary.org/obo/GO_0044281 denotes small molecule metabolic process
T109 39413-39430 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic process
T110 39436-39455 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostatic process
T111 39602-39617 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolic
T112 39794-39810 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolism
T113 39800-39810 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T114 39926-39948 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T115 39931-39948 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T116 39931-39940 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T117 39953-39984 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T118 39953-39984 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T119 39953-39984 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T120 39967-39984 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T121 39967-39976 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T122 40113-40135 http://purl.obolibrary.org/obo/GO_0035357 denotes PPAR signaling pathway
T123 40118-40135 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T124 40118-40127 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T125 40171-40182 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T126 40186-40196 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T127 40312-40333 http://purl.obolibrary.org/obo/GO_0002376 denotes immune system process
T128 40319-40333 http://purl.obolibrary.org/obo/GO_0003008 denotes system process
T129 40358-40377 http://purl.obolibrary.org/obo/GO_0007267 denotes cell-cell signaling
T130 40368-40377 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T131 40379-40396 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T132 40387-40396 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T133 40406-40440 http://purl.obolibrary.org/obo/GO_0014829 denotes vascular smooth muscle contraction
T134 40415-40440 http://purl.obolibrary.org/obo/GO_0006939 denotes smooth muscle contraction
T135 40422-40440 http://purl.obolibrary.org/obo/GO_0006936 denotes muscle contraction
T136 40464-40474 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T137 40492-40518 http://purl.obolibrary.org/obo/GO_0060048 denotes cardiac muscle contraction
T138 40500-40518 http://purl.obolibrary.org/obo/GO_0006936 denotes muscle contraction
T139 41130-41149 http://purl.obolibrary.org/obo/GO_0034097 denotes responses, cytokine
T140 41166-41188 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T141 41166-41175 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 41176-41188 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T143 43173-43183 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T144 43925-43935 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T145 43958-43971 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T146 44034-44057 http://purl.obolibrary.org/obo/GO_0042632 denotes cholesterol homeostasis
T147 44046-44057 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T148 44065-44077 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T20 0-15 Sentence denotes 1 Introduction
T21 16-129 Sentence denotes 2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world.
T22 130-243 Sentence denotes By April 3, 2020, more than 1 million patients have been diagnosed with corona virus disease 2019 (COVID-19) [1].
T23 244-459 Sentence denotes The virus has a long incubation period, is highly contagious, and is generally susceptible to all types of people, which has a huge negative impact on people's health, economic development, and social stability [2].
T24 460-551 Sentence denotes However, there is still a lack of effective clinical drugs or vaccine to control the virus.
T25 552-685 Sentence denotes Traditional Chinese medicine has a good effect on viral infectious pneumonia and has shown a certain effect in the treatment of SARS.
T26 686-1377 Sentence denotes On February 7, 2020, the China Health Commission and the Administration of Traditional Chinese Medicine jointly issued a notice recommending formula Qingfei Paidu decoction (QFPD, Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum, Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Herba Pogostemonis) for the treatment of COVID-19 according to clinical treatment and efficacy.
T27 1378-1634 Sentence denotes QFPD is a compound prescription in TCM including Ma Xing Shi Gan decoction (MSXG), She Gan Ma Huang decoction (SGMH), Xiao Chai Hu (XCH), and Wu Ling San (WLS), which was first discovered in the classic Treatise on Exogenous Febrile Disease (Shanghan Lun).
T28 1635-1881 Sentence denotes MXSG (Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum) has been used for the treatment of the common cold, fever, and influenza virus infections via damaging the viral surface structure and inhibiting viral entry [3].
T29 1882-2146 Sentence denotes SGMH (Herba Ephedrae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari) is a classical prescription for the treatment of flu-like symptoms, asthma, inflammation, tonsillitis and sore throat [4].
T30 2147-2332 Sentence denotes XCH (Radix Glycyrrhizae, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens) possesses antiviral [5] and various anticarcinogenic properties [6].
T31 2333-2572 Sentence denotes WLS (Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria), a famous Chinese prescription for nephritic syndrome, can improve kidney excretion function and inhibit inflammatory response [7].
T32 2573-2668 Sentence denotes These researches indicate that MXSG, SGMH, XCH and WLS may be functional units of formula QFPD.
T33 2669-2788 Sentence denotes Previous studies have focused on the mechanism of compound prescription based on a single traditional Chinese medicine.
T34 2789-2884 Sentence denotes However, it may not reflect functional compatibility mechanism of traditional Chinese medicine.
T35 2885-3062 Sentence denotes Therefore, it is worthy of comparing the similarities and differences of different QFPD functional units in the treatment of COVID-19, including MXSG, SGMH, XCH, WLS and Others.
T36 3063-3297 Sentence denotes QFPD contains a total of 21 traditional Chinese medicines, and it is difficult to elucidate the complex mechanism of QFPD on COVID-19 by traditional pharmacological methods due to the multi-components and multi-targets of the formula.
T37 3298-3455 Sentence denotes Network pharmacology, a new method in recent years, can integrate interactions of drugs, targets, pathways and diseases into a biological network system [8].
T38 3456-3727 Sentence denotes Therefore, more and more TCM researchers have begun to use network pharmacology to explore the material basis of TCM, and to reveal the overall comprehensive effects of multi-path, multi-component and multi-target of TCM prescription and its treatment of diseases [9,10].
T39 3728-3897 Sentence denotes More importantly, previous study reported that disease conditions can be more fragile than health systems against various perturbations for the un-optimized system [11].
T40 3898-4053 Sentence denotes So the formula may be more effective for COVID-19 disease via the stronger effects on the reduction of the robustness of the COVID-19 disease network [12].
T41 4054-4274 Sentence denotes In our study, since MSXG, SGMH, XCH and WLS have been independently used for the treatment of viral infectious pneumonia, this study firstly screened out major effective compounds from five functional units respectively.
T42 4275-4593 Sentence denotes Then we offered a new understanding of the functional units mechanism of QFPD against COVID-19 by a novel functional units of network pharmacology (FUNP) approach and formula perturbation analysis, and provided a combination strategy to explore mechanisms of inter-ingredients interactions from a holistic perspective.
T43 4595-4619 Sentence denotes 2 Materials and methods
T44 4621-4642 Sentence denotes 2.1 Data preparation
T45 4643-4835 Sentence denotes Compounds of the main herb in formula MSXG, SGMH, XCH, WLS and Others were searched in TCMSP [13], and screened based on drug-likeness (DL) ≥0.18 [14] and oral bioavailability (OB) ≥30 % [15].
T46 4836-4936 Sentence denotes Then, the corresponding Pubchem CIDs of the compounds were retrieved from the Pubchem database [16].
T47 4937-5132 Sentence denotes Finally, BATMAN-TCM [17], an bioinformatics analysis tool for studying TCM’s molecular mechanisms, was used to identify potential target genes of the active components (uploaded by Pubchem CIDs).
T48 5133-5213 Sentence denotes To make the results more credible, we set the cutoff score ≥ 30 as the standard.
T49 5214-5404 Sentence denotes Finally, to discovery the co-differentially presented targets in the five formulae, we conducted pan-formula analysis using Venn diagrams (http://bioinformatics.psb.ugent.be/webtools/Venn/).
T50 5406-5469 Sentence denotes 2.2 Functional and pathway enrichment analyses of QFPD targets
T51 5470-5747 Sentence denotes To better understand the functional involvements of MSXG, SGMH, XCH, WLS and Others targets, bioinformatics analyses of multiple formulae targets were first performed, including Gene Ontology (GO) function term, KEGG biological pathway and OMIM/TTD disease enrichment analyses.
T52 5748-6046 Sentence denotes Then, kinase, microRNA and transcriptional factor (TF) enrichment analyses of the five formulae targets were conducted using the tool WebGestalt (http://bioinfo.vanderbilt.edu/webgestalt) [18] and the bubble and chord plot map were drawn with the R language ggplot2 and GOplot installation package.
T53 6047-6124 Sentence denotes P-values were adjusted for multiple testing by Benjamini-Hochberg adjustment.
T54 6126-6185 Sentence denotes 2.3 Construction of PPI network and MCODE modules analysis
T55 6186-6329 Sentence denotes To further explore the pharmacological mechanisms, five PPI networks were built including: MSXG, SGMH, XCH, WLS and Others targets PPI network.
T56 6330-6484 Sentence denotes Specifically, the five kinds of target proteins were respectively uploaded to Metascape to build PPI networks, with the species limited to “Homo sapiens”.
T57 6485-6644 Sentence denotes Next, MCODE analysis [19], a method for finding densely connected modules in PPI networks, was carried out by Cytoscape 3.2.1 (http://www.cytoscape.org/) [20].
T58 6645-6868 Sentence denotes Finally, KEGG (Kyoto Encyclopedia of Genes and Genomes) signaling pathway enrichment analysis was further conducted on the identified functional modules of MSXG, SGMH, XCH, WLS and Others targets PPI networks, respectively.
T59 6870-6895 Sentence denotes 2.4 Network construction
T60 6896-7059 Sentence denotes Based on the five formulae’s active components, BATMAN-TCM was used to set up five networks of components-target-pathway-disease (MSXG, SGMH, XCH, WLS and Others).
T61 7060-7300 Sentence denotes To emphasize the important elements of the five networks, we only exhibited the hub targets according to the default criteria (targets with no fewer than 6, 5, 8, 7 and 4 linking compounds for MSXG, SGMH, XCH, WLS and Others, respectively).
T62 7301-7423 Sentence denotes Finally, these important linking compounds of MSXG, SGMH, XCH, WLS and Others networks were obtained for further analysis.
T63 7425-7480 Sentence denotes 2.5 ADMET evaluation of the predicted active compounds
T64 7481-7714 Sentence denotes Based on the SwissADME database [21], the physicochemical properties of the active components was predicted, including molecular weight (MW), rotatable bonds count, H-bond acceptors and donors count, TPSA and leadlikeness violations.
T65 7715-8211 Sentence denotes Second, pharmacokinetic properties was predicted through pkCSM database [22], which contained the absorption (Caco-2 cell permeability, HIA and skin permeability), distribution (VDss, unbound fraction, blood-brain barrier and central nervous system permeability), excretion (total clearance and renal OCT2 substrate) and toxicity (AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity).
T66 8213-8235 Sentence denotes 2.6 Molecular docking
T67 8236-8452 Sentence denotes To facilitate drug discovery against COVID-19, we used COVID-19 Docking Server (https://ncov.schanglab.org.cn/index.php) [23] to predict the binding modes between 12 COVID-19 targets and the 20 lead-likeness of QFPD.
T68 8453-8997 Sentence denotes Specifically, the 10 nonstructural and 2 structural proteins of 2019-nCov were collected (Mpro, PLpro, nsp12 [RdRp with RNA], nsp12 [RdRp without RNA], nsp13 [Helicase ADP site], nsp13 [Helicase NCB site], nsp14 [ExoN], nsp14 [N7-MTase], nsp15 [endoribonuclease], nsp16 [2′-O-MTase], N protein NCB site and E protein [ion channel]); and the corresponding Protein Data Bank (PDB)codes were 6LU7, 4OW0, 3H5Y (with RNA), 3H5Y (without RNA), 6JYT (ADP site), 6JYT (NCB site), 5C8S (ExoN),5C8S (N7-MTase), 2RHB, 2XYR, 4KYJ, and 5 × 29, respectively.
T69 8998-9123 Sentence denotes Finally, Discovery Studio software elucidated the 14 best docking results between compounds and the COVID-19 target proteins.
T70 9125-9194 Sentence denotes 2.7 ACE2 and CD147 expression across tissues and co-expression genes
T71 9195-9346 Sentence denotes To understand the expression and distribution of ACE2 and CD147 across tissues, a radar plot including 53 tissues was performed through COXPRESdb [24].
T72 9347-9441 Sentence denotes And the top 200 co-expression genes of ACE2 and CD147 (P < 1E-16) were obtained, respectively.
T73 9442-9581 Sentence denotes Then, text mining method from the literature was used to screen for pneumonia-associated genes through COREMINE (http://www.coremine.com/).
T74 9582-9725 Sentence denotes In addition, co-expression genes of ACE2 in colonic epithelial cells [25] and HCoV-associated host proteins with references [26] were obtained.
T75 9726-9852 Sentence denotes Finally, we performed UpsetView analysis (http://www.ehbio.com/ImageGP/) between these five sets of proteins and QFPD targets.
T76 9854-9953 Sentence denotes 2.8 Validation of drug positioning for QFPD against COVID-19 via the robustness of disease network
T77 9954-10195 Sentence denotes Since QFPD effects on COVID-19 via multi-component and multi-target, we evaluate the potential efficacy of QFPD through TCMATCOV platform, which uses the quantitative evaluation algorithm of multi-target drugs to disturb the disease network.
T78 10196-10300 Sentence denotes Specifically, the disturbing effect of drugs on diseases is simulated by deleting disease network nodes.
T79 10301-10513 Sentence denotes The disturbance rate of drugs is calculated by comparing the changes of network topology characteristics before and after drug intervention, which is used to evaluate the intervention effect of drugs on diseases.
T80 10514-10683 Sentence denotes Firstly, COVID-19 disease network was constructed based on specific cytokines of COVID-19 [27] and differentially expressed genes of SARS (GSE36969, GSE51387, GSE68820).
T81 10684-10926 Sentence denotes Then, this platform uses four kinds of network topology characteristics to evaluate the robustness of COVID-19 network, including network average connectivity, network average shortest path, connectivity centrality and compactness centrality.
T82 10927-11077 Sentence denotes And the five formulae (MSXG, SGMH, XCH, WLS and Others) disturbance scores are calculated according to the changes before and after drug intervention.
T83 11078-11333 Sentence denotes Finally, the disturbance effect of the five formulae on the COVID-19 network was compared with null models with the total score of the disturbance, and the higher the value is, the higher the damage degree of drugs to the stability of the network is [12].
T84 11334-11481 Sentence denotes We take Banxia tianma baizhu decoction (BXTM) as negative control; and another efficient formula Yi du bi fei decoction (YDBF) as positive control.
T85 11483-11492 Sentence denotes 3 Result
T86 11494-11560 Sentence denotes 3.1 Prediction of active components and potential targets of QFPD
T87 11561-11698 Sentence denotes Firstly, the DL ≥ 0.18 and OB ≥ 30 %.s were set as the standard to screen the chemical components obtained through online database TCMSP.
T88 11699-11918 Sentence denotes Specifically, a total of 175 effective components of QFPD were screened from the TCM database, including 82 species of MSXG, 35 species of SGMH, 105 species of XCH, 21 species of WLS and 32 species of Others (Table 1 ).
T89 11919-12141 Sentence denotes Among these effective components, 89 (50.86 %) components exited in more than two formulae; CID5280343 and CID5280794 were owned by MXSG, Others, SGMH and XCH; CID12303645 was owned by MXSG, Others, WLS and XCH (Fig. 1 A).
T90 12142-12342 Sentence denotes Secondly, a total of 300 targets of QFPD were screened from the BATMAN-TCM database, including 192 targets of MSXG, 201 targets of SGMH, 221 targets of XCH, 96 targets of WLS and 99 targets of Others.
T91 12343-12415 Sentence denotes Among these proteins, 21 (7%) targets exited in five formulae (Fig. 1B).
T92 12416-12453 Sentence denotes Table 1 Effective components of QFPD.
T93 12454-12475 Sentence denotes Formula N PubChem_Cid
T94 12476-13371 Sentence denotes MSXG 82 CID10090416,CID10542808,CID10881804,CID11267805,CID114829,CID11558452,CID11602329,CID11975273,CID120074,CID12303645,CID124049,CID124052,CID13965473,CID14604077,CID14604078,CID14604081,CID15228663,CID15380912,CID162412,CID177149,CID193679,CID197678,CID23724664,CID25015742,CID268208,CID336327,CID354368,CID3764,CID439246,CID440833,CID442411,CID44257530,CID480774,CID480780,CID480787,CID480859,CID480873,CID49856081,CID503731,CID503737,CID5280343,CID5280378,CID5280448,CID5280544,CID5280794,CID5280863,CID5281619,CID5281654,CID5281789,CID5282768,CID5282805,CID5312521,CID5316900,CID5317300,CID5317478,CID5317479,CID5317480,CID5317652,CID5317768,CID5317777,CID5318437,CID5318585,CID5318679,CID5318869,CID5318998,CID5318999,CID5319013,CID5320083,CID5460988,CID5481234,CID5481948,CID5481949,CID5997,CID636883,CID637112,CID64971,CID6918970,CID73205,CID928837,CID9927807,CID15840593,CID15228662
T95 13372-13858 Sentence denotes SGMH 35 CID1135,CID1174,CID3026,CID5789,CID6782,CID6998,CID8437,CID8679,CID13625,CID117158,CID159225,CID185,CID10019512,CID11438306,CID11869417,CID11870462,CID12315507,CID162350,CID16726037,CID222284,CID389888,CID3902,CID440833,CID5280343,CID5280445,CID5280544,CID5280794,CID5280863,CID5281331,CID5281605,CID5281616,CID5281628,CID5281654,CID5281779,CID5282768,CID5315890,CID5316876,CID5320945,CID5484202,CID5488781,CID5491637,CID64959,CID64982,CID676152,CID71307581,CID72307,CID13688752
T96 13859-14999 Sentence denotes XCH 105 CID10090416,CID10542808,CID10881804,CID11267805,CID11438306,CID114829,CID11558452,CID11602329,CID117443,CID12303645,CID124049,CID124052,CID124211,CID13965473,CID14135323,CID14604077,CID14604078,CID14604081,CID15228662,CID15228663,CID15380912,CID156992,CID158311,CID15840593,CID159029,CID161271,CID162412,CID177149,CID185034,CID193679,CID197678,CID222284,CID23724664,CID25015742,CID25721350,CID268208,CID336327,CID354368,CID373261,CID3764,CID389001,CID389888,CID439246,CID442411,CID44257530,CID44258628,CID480774,CID480780,CID480787,CID480859,CID480873,CID49856081,CID503731,CID503737,CID5280343,CID5280378,CID5280442,CID5280448,CID5280794,CID5280863,CID5281605,CID5281619,CID5281654,CID5281674,CID5281703,CID5281789,CID5282768,CID5312521,CID5316900,CID5317300,CID5317478,CID5317479,CID5317480,CID5317652,CID5317768,CID5317777,CID5318437,CID5318585,CID5318679,CID5318869,CID5318998,CID5318999,CID5319013,CID5319042,CID5319252,CID5320083,CID5320315,CID5320399,CID5321865,CID5322059,CID5322078,CID5460988,CID5481234,CID5481948,CID5481949,CID5484202,CID636883,CID637112,CID64959,CID64971,CID64982,CID73205,CID821279,CID928837,CID9927807
T97 15000-15240 Sentence denotes WLS 21 CID10181133,CID10743008,CID12303645,CID14036811,CID15225964,CID15226717,CID15976101,CID182232,CID222284,CID44575602,CID5283628,CID5471851,CID5471852,CID56668247,CID6436630,CID712316,CID73402,CID9064,CID9805290,CID14448075,CID14236575
T98 15241-15585 Sentence denotes Others 32 CID10212,CID11824478,CID122159,CID12303645,CID14057197,CID145659,CID17897,CID33934,CID373261,CID40429858,CID42607889,CID439246,CID442834,CID443024,CID5280343,CID5280445,CID5280794,CID5281326,CID5281617,CID5281781,CID5319406,CID5320621,CID5495928,CID5997,CID631170,CID632135,CID676152,CID712316,CID72344,CID79730,CID1149877,CID45359875
T99 15586-15657 Sentence denotes Fig. 1 Venn diagram of the five formulae’ active compounds and targets.
T100 15658-15683 Sentence denotes A: compounds, B: targets.
T101 15685-15748 Sentence denotes 3.2 Functional and pathway enrichment analyses of QFPD targets
T102 15749-16021 Sentence denotes As shown in Fig. 2 , the 11 enriched GO terms of the targets in all five formulae were found, such as oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, homeostatic process, signal transducer activity and cell proliferation.
T103 16022-16392 Sentence denotes Furthermore, the results of pathway enrichment analysis showed that the 7 KEGG pathways were significantly related to more than 4 formula groups, including dteroid biosynthesis, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, steroid hormone biosynthesis, PPAR signaling pathway, arginine and proline metabolism and ABC transporters (Fig. 3 A).
T104 16393-16623 Sentence denotes In addition, TTD analysis showed that the 8 diseases were significantly association with more than 3 formula groups, such as acne, Behcet'S disease, benign prostate hyperplasia, intrahepatic cholestasis and brain injury (Fig. 3B).
T105 16624-16733 Sentence denotes However, the five formulae contained their specific (MSXG, SGMH, XCH, WLS and Others) GO, KEGG and TTD terms.
T106 16734-17127 Sentence denotes For example, neurological system process and beta-Alanine metabolism terms were specific for MXSG; membrane organization and parasitic infections of the eye terms for SGMH; circadian rhythm and hypertension terms for XCH; nucleic acid binding transcription factor activity, ovarian steroidogenesis and chronic inflammatory diseases terms for WLS; fat digestion and absorption terms for Others.
T107 17128-17196 Sentence denotes Fig. 2 Bubble plot of the GO analysis of the five formulae’ targets.
T108 17197-17271 Sentence denotes Fig. 3 Bubble plot of the KEGG/TTD analysis of the five formulae’ targets.
T109 17272-17288 Sentence denotes A: KEGG, B: TTD.
T110 17289-17494 Sentence denotes In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A).
T111 17495-17622 Sentence denotes In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B).
T112 17623-17782 Sentence denotes Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).
T113 17783-17868 Sentence denotes Fig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt.
T114 17869-17978 Sentence denotes Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms.
T115 17979-18084 Sentence denotes Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right).
T116 18085-18142 Sentence denotes Chords connect miRNA/kinase/TF term with formulae groups.
T117 18143-18170 Sentence denotes A: miRNA, B: kinase, C: TF.
T118 18172-18231 Sentence denotes 3.3 Construction of PPI network and MCODE modules analysis
T119 18232-18397 Sentence denotes To further explore the functional relationship among five formulae, PPI networks were constructed through Metascape, and visual composition carried out by Cytoscape.
T120 18398-18603 Sentence denotes Firstly, the potential 192 target genes of MXSG were analyzed by PPI network, and the results showed that there were 144 nodes and 510 edges, which represented the interaction between protein and function.
T121 18604-18748 Sentence denotes The MXSG PPI network function module was confirmed by the MCODE plug-in and a list of the corresponding meaningful modules presented (Fig. 5 A).
T122 18749-18777 Sentence denotes 3 modules scores were > 2.5.
T123 18778-18794 Sentence denotes Module 1 (score:
T124 18795-18870 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T125 18871-18947 Sentence denotes 4.429) consisted of 14 nodes and the seed gene was ALDH1A1; module 3 (score:
T126 18948-19002 Sentence denotes 5.0) consisted of 11 nodes and the seed gene was CNR2.
T127 19003-19202 Sentence denotes KEGG pathway enrichment analysis showed that MXSG modules were enriched in neuroactive ligand-receptor interaction, calcium signaling pathway, inflammatory mediator regulation of TRP channels, et.al.
T128 19203-19241 Sentence denotes Fig. 5 KEGG analysis of MCODE modules.
T129 19242-19384 Sentence denotes MCODE analysis was performed after the construction of the five formulae’ targets PPI; then, KEGG analysis was conducted on the MCODE modules.
T130 19385-19396 Sentence denotes A: MXSG, B:
T131 19397-19429 Sentence denotes Others, C: WLS, D: SGMH, E: XCH.
T132 19430-19572 Sentence denotes Secondly, the potential 99 target genes of Others were analyzed by PPI network, and the results showed that there were 77 nodes and 194 edges.
T133 19573-19614 Sentence denotes Only 1 module score were > 2.5 (Fig. 5B).
T134 19615-19631 Sentence denotes Module 1 (score:
T135 19632-19690 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1.
T136 19691-19851 Sentence denotes KEGG pathway enrichment analysis showed that Others modules were enriched in huntington's disease, glycolysis / gluconeogenesis, Notch signaling pathway, et.al.
T137 19852-19990 Sentence denotes Thirdly, the potential 96 target genes of WLS were analyzed by PPI network, and the results showed that there were 60 nodes and 143 edges.
T138 19991-20033 Sentence denotes Only 1 modules score were > 2.5 (Fig. 5C).
T139 20034-20050 Sentence denotes Module 1 (score:
T140 20051-20107 Sentence denotes 2.706) consisted of 17 nodes and the seed gene was CNR2.
T141 20108-20297 Sentence denotes KEGG pathway enrichment analysis showed that WLS modules were enriched in thyroid hormone signaling pathway, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, et.al.
T142 20298-20440 Sentence denotes Fourthly, the potential 201 target genes of SGMH were analyzed by PPI network, and the results showed that there were 153 nodes and 505 edges.
T143 20441-20479 Sentence denotes 3 modules scores were > 2.5 (Fig. 5D).
T144 20480-20496 Sentence denotes Module 1 (score:
T145 20497-20571 Sentence denotes 3.529) consisted of 17 nodes and the seed gene was ACSS1; Module 2 (score:
T146 20572-20642 Sentence denotes 4.5) consisted of 7 nodes and the seed gene was CNR2; module 3 (score:
T147 20643-20697 Sentence denotes 3.5) consisted of 8 nodes and the seed gene was PRKCG.
T148 20698-20859 Sentence denotes KEGG pathway enrichment analysis showed that SGMH modules were enriched in insulin resistance, adipocytokine signaling pathway, Th17 cell differentiation, et.al.
T149 20860-21000 Sentence denotes At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges.
T150 21001-21039 Sentence denotes 5 modules scores were > 2.5 (Fig. 5E).
T151 21040-21056 Sentence denotes Module 1 (score:
T152 21057-21132 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T153 21133-21206 Sentence denotes 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score:
T154 21207-21278 Sentence denotes 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score:
T155 21279-21353 Sentence denotes 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score:
T156 21354-21408 Sentence denotes 3.0) consisted of 7 nodes and the seed gene was FFAR1.
T157 21409-21585 Sentence denotes KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al.
T158 21587-21612 Sentence denotes 3.4 Network construction
T159 21613-21748 Sentence denotes After using the BATMAN-TCM, we constructed five ingredients-target-pathway-disease networks, including MSXG, SGMH, XCH, WLS and Others.
T160 21749-21965 Sentence denotes In order to emphasize the important network elements, we showed the networks that exhibit those targets with larger than 6, 5, 8, 7 and 4 linking compounds for MSXG, SGMH, XCH, WLS and Others, respectively (Fig. 6 ).
T161 21966-22316 Sentence denotes MSXG network contained 31 key components, 50 proteins and 17 pathways; SGMH network contained 15 key components, 20 proteins and 8 pathways; WLS network contained 18 key components, 9 proteins and 4 pathways; XCH network contained 32 key components, 15 proteins and 12 pathways; Others network contained 10 key components, 13 proteins and 3 pathways.
T162 22317-22434 Sentence denotes To find the potential drugs of formulae QFPD for COVID-19, a total of 67 hub components were used for ADMET analysis.
T163 22435-22487 Sentence denotes Fig. 6 The component-target-pathway-disease network.
T164 22488-22504 Sentence denotes Purple polygons:
T165 22505-22607 Sentence denotes PubChem ID of QFPD compounds; blue pentagrams: QFPD targets; yellow circles: KEGG pathway; red square:
T166 22608-22669 Sentence denotes Therapeutic Target Database (TTD) disease term, green square:
T167 22670-22726 Sentence denotes Online Mendelian Inheritance in Man (OMIN) disease term.
T168 22727-22763 Sentence denotes A: MXSG, B: SGMH, C: WLS, D: XCH, E:
T169 22764-22902 Sentence denotes Others. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T170 22904-22949 Sentence denotes 3.5 ADMET evaluation of the 67 key compounds
T171 22950-23105 Sentence denotes Since in silico ADMET prediction can help early drug design and evaluation, ADMET properties of the 67 key compounds were predicted by SwissADME and pkCSM.
T172 23106-23300 Sentence denotes Chemical properties including molecular weight (MW), rotatable bonds count, H-bond acceptors and donors count, TPSA and leadlikeness violations were calculated by SwissADME and shown as Fig. 8A.
T173 23301-23520 Sentence denotes It is worth mentioning that 21 (31.34 %) compounds passed the stringent lead-like criteria (250 g/mol ≤ MW ≤ 350 g/mol, XLOGP ≤ 3.5 and rotatable bonds ≤ 7), which are excellent candidates for drug discovery (Fig. 7 A).
T174 23521-23646 Sentence denotes And these lead-likeness compounds were further predicted by pkCSM, with the exception of S3 (low gastrointestinal absorption)
T175 23647-23719 Sentence denotes Fig. 7 Chemical properties statistics of hub components in the formulae.
T176 23720-23722 Sentence denotes A:
T177 23723-24023 Sentence denotes Molecular weight, B: rotatable bond count, C: H-bond acceptors count, D: H-bond donors count, E: topological polar surface area (TPSA), F: leadlikeness violations, G: pharmacokinetic and toxicity evaluated parameters of 20 leadlikeness compounds by pkCSM; green = good, yellow = tolerable, red = bad.
T178 24024-24030 Sentence denotes Caco2:
T179 24031-24055 Sentence denotes Caco-2 Permeability,HIA:
T180 24056-24092 Sentence denotes Intestinal Absorption (Human), Skin:
T181 24093-24145 Sentence denotes Skin Permeability, VDss: volume of distribution, FU:
T182 24146-24176 Sentence denotes Fraction Unbound (Human), BBB:
T183 24177-24215 Sentence denotes Blood Brain Barrier permeability, CNS:
T184 24216-24255 Sentence denotes Central Nervous System permeability,TC:
T185 24256-24278 Sentence denotes Total Clearance, OCT2:
T186 24279-24341 Sentence denotes Renal Organic Cation Transporter 2, AMES: AMES toxicity, MTDD:
T187 24342-24416 Sentence denotes Maximum Tolerated Dose (Human), hERG I/II: hERG I and II Inhibitors, LD50:
T188 24417-24452 Sentence denotes Oral Rat Acute Toxicity (LD50), HT:
T189 24453-24472 Sentence denotes Hepatotoxicity, SS:
T190 24473-24496 Sentence denotes Skin Sensitisation, MT:
T191 24497-24644 Sentence denotes Minnow toxicity. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T192 24645-24772 Sentence denotes Fig. 8 Schematic (3D and 2D) representation that molecular model of specific compounds of each formulae with COVID-19 proteins.
T193 24773-24930 Sentence denotes A: M3 and E protein [ion channel], B: M3 and nsp13 [Helicase NCB site], C: S1 and nsp13 [Helicase ADP site], D: S1 and PLpro, E: X2 and Mpro, F: O2 and Mpro.
T194 24931-24959 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T195 24960-24967 Sentence denotes Others.
T196 24968-25147 Sentence denotes Regarding the absorption parameters, all 20 compounds (Table 2 ) presented a promising oral availability including the optimal Caco-2 cell permeability, HIA and skin permeability.
T197 25148-25379 Sentence denotes The drug distribution results showed that most of the compounds distributed in tissue (VDss> 0.45: tissue, VDss <−0.15: plasma) with good unbound fraction scores, thus becoming available to interact with the pharmacological target.
T198 25380-25502 Sentence denotes Only compound W5 and W11 were entirely unable to penetrate the blood-brain barrier (BBB) and central nervous system (CNS).
T199 25503-25637 Sentence denotes In addition, 15 compounds presented a good renal elimination and were not substrates of the renal organic cation transporter 2 (OCT2).
T200 25638-25893 Sentence denotes Finally, 14 compounds did not present any particular toxicity problems including AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity (Fig. 7B).
T201 25894-25942 Sentence denotes Table 2 20 potential active compounds from QFPD.
T202 25943-26008 Sentence denotes Pubchem Molecular Name Structure Pubchem Molecular Name Structure
T203 26009-26069 Sentence denotes CID6918970 M3 ZINC5356864 CID10019512 S5 3-O-Methylviolanone
T204 26070-26115 Sentence denotes CID336327 M5 Medicarpin CID9064 W5 Cianidanol
T205 26116-26162 Sentence denotes CID14057197 O1 – CID182232 W11 (+)-Epicatechin
T206 26163-26219 Sentence denotes CID42607889 O2 Alysifolinone CID25721350 X1 ZINC13130930
T207 26220-26277 Sentence denotes CID3902 S1 letrozole CID14135323 X2 (2S)-dihydrobaicalein
T208 26278-26327 Sentence denotes CID821279 X4 ZINC338038 CID439246 MXO1 naringenin
T209 26328-26387 Sentence denotes CID440833 MS1 Leucocyanidol CID676152 SO1 SR-01,000,767,148
T210 26388-26450 Sentence denotes CID177149 MX16 (+)-Vestitol CID11438306 SX1 cyclo(L-Tyr-l-Phe)
T211 26451-26508 Sentence denotes CID114829 MX17 Liquiritigenin CID712316 WO1 (-)-taxifolin
T212 26509-26571 Sentence denotes CID928837 MX8 ZINC519174 CID373261 XO1 Eriodyctiol (flavanone)
T213 26572-26600 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T214 26601-26608 Sentence denotes Others.
T215 26610-26632 Sentence denotes 3.6 Molecular docking
T216 26633-27158 Sentence denotes The application of COVID-19 docking server and Discovery Studio software elucidated the interactions between the 20 lead-likeness compounds (S1, W5, MX17, MX16, W11, M5, XO1, MXO1, SO1, WO1, X4, MX8, M3, S5, SX1, O1, X2, X1, O2, MS1) and the 10 nonstructural and 2 structural proteins (Mpro, PLpro, nsp12 [RdRp with RNA], nsp12 [RdRp without RNA], nsp13 [Helicase ADP site], nsp13 [Helicase NCB site], nsp14 [ExoN], nsp14 [N7-MTase], nsp15 [endoribonuclease], nsp16 [2′-O-MTase], N protein NCB site, E protein [ion channel]).
T217 27159-27213 Sentence denotes The docking scores were depicted in Table 3, Table 4 .
T218 27214-27358 Sentence denotes The smaller of docking score, the lower of energy would be required, which means the binding between the compounds and the targets are stronger.
T219 27359-27436 Sentence denotes There are 9 compounds presenting better bonding ability than other compounds.
T220 27437-27519 Sentence denotes Table 3 Docking score between specific ingredients of QFPD and 2019-nCov proteins.
T221 27520-27562 Sentence denotes Molecule M3 M5 S1 S5 W11 W5 X1 X2 X4 O1 O2
T222 27563-27631 Sentence denotes Main Protease −7.7 −7.3 −6.8 −6.9 −7.2 −7.5 −7.1 −7.9 −7.3 −7.1 −7.4
T223 27632-27703 Sentence denotes Papain-like protease −8.7 −8.5 −9.9 −7.7 −8 −8 −8.4 −8.7 −8.2 −8.6 −8.2
T224 27704-27772 Sentence denotes RdRp with RNA −8.4 −8.5 −8.5 −8.3 −9.1 −9.1 −8.4 −8.2 −8.2 −8.3 −8.6
T225 27773-27844 Sentence denotes RdRp without RNA −6.8 −6.8 −6.9 −6.8 −6.7 −6.9 −7.1 −7.2 −6.5 −7.3 −7.1
T226 27845-27913 Sentence denotes Helicase ADP site −6.3 −6.3 −7.3 −6.5 −6 −6 −6.3 −6.5 −6.2 −6.1 −6.5
T227 27914-27986 Sentence denotes Helicase NCB site −7.9 −6.9 −7.2 −7.1 −7.2 −7.2 −7.4 −7.5 −7.3 −7.4 −7.4
T228 27987-28053 Sentence denotes Nsp14(ExoN) −6.8 −6.6 −6.3 −6.4 −6.9 −6.8 −6.7 −6.9 −6.4 −6.6 −6.9
T229 28054-28122 Sentence denotes Nsp14(N7-MTase) −8.8 −8.1 −8.5 −7.5 −8.4 −8.4 −8.3 −8.5 −8 −8.3 −8.5
T230 28123-28201 Sentence denotes Nsp15(endoribonuclease) −6.6 −6.3 −6.3 −5.9 −6.2 −6.2 −6.2 −6.3 −6.2 −6.4 −6.4
T231 28202-28274 Sentence denotes Nsp16(2′-O-MTase) −7.5 −7.4 −7.5 −7.2 −8.2 −8.2 −7.7 −7.9 −7.7 −7.9 −8.4
T232 28275-28344 Sentence denotes N protein NCB site −7.6 −7.5 −7.8 −7.6 −7.6 −7.6 −8 −8 −7.5 −7.6 −7.6
T233 28345-28420 Sentence denotes E protein(ion channel) −8.1 −7 −7.8 −6.7 −6.4 −6.4 −7.2 −7.3 −7.2 −7.1 −6.8
T234 28421-28449 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T235 28450-28457 Sentence denotes Others.
T236 28458-28549 Sentence denotes Table 4 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.
T237 28550-28593 Sentence denotes Topology MXSG SGMH XCH WLS Others BXTM YDBF
T238 28594-28639 Sentence denotes DTS 25.66 26.71 21.02 17.64 23.16 14.52 22.71
T239 28640-28684 Sentence denotes AC −4.63 −5.21 −3.02 −3.49 −5.38 −2.32 −3.78
T240 28685-28727 Sentence denotes APL 13.35 13.40 9.96 6.49 10.66 4.59 11.17
T241 28728-28773 Sentence denotes CoC −1.44 −1.64 −1.59 −1.30 −1.23 −1.15 −1.25
T242 28774-28819 Sentence denotes ClC −6.24 −6.46 −6.45 −6.36 −5.88 −6.46 −6.52
T243 28820-29005 Sentence denotes Average connectivity (AC), Connection centrality (CoC), Closeness centrality (ClC): the larger the quotient is, the more stable the network and, the less the influence made by the drug.
T244 29006-29181 Sentence denotes Disturbance total score (DTS), Average length of shortest path (APL), : the larger the quotient is, the less stable the network and, the larger the influence made by the drug.
T245 29182-29213 Sentence denotes Negative control formula: BXTM.
T246 29214-29245 Sentence denotes Positive control formula: YDBF.
T247 29246-29661 Sentence denotes M3 (Fig. 8A), a specific compound in formulae MXSG, showed eight interactions with E protein [ion channel] including Pi-sigma, Pi-alkyl and Alkyl, which were connected with TYR 57, ALA 32, ILE 46 and PRO 54, etc.; additionally, M3 (Fig. 8B) showed five interactions with nsp13 [Helicase NCB site] including Unfavorable Donor-Donor, Pi-alkyl and Alkyl, which were connected with ASN 559, ARG 409, LEU 42 and PRO 406.
T248 29662-30110 Sentence denotes S1 (Fig. 8C), a specific compound in formulae SGMH, showed seven interactions with nsp13 [Helicase ADP site] including H-bond interactions, van der waals, Amide-Pi stacked and Pi-alkyl, which were connected with ALA 313, ASP 374, GLN 537 and SER 289, etc.; additionally, S1 (Fig. 8D) showed five interactions with PLpro including Pi-anion, Pi-Pi stacked, Pi-Pi T-shaped and Pi-alkyl, which were connected with TYR 264, ASP 164, TYR 268 and PRO 248.
T249 30111-30335 Sentence denotes X2 (Fig. 8E), a specific compound in formulae XCH, showed seven interactions with Mpro including H-bond interactions, Pi-Donor hydrogen bond and Pi-alkyl, which were connected with MET 165, GLU 166, LEU 141 and CYS 145, etc.
T250 30336-30581 Sentence denotes O2 (Fig. 8F), a specific compound in formulae Others, showed seven interactions with Mpro including H-bond interactions, Carbon hydrogen bond, Pi-anion, Pi-sulfur and Pi-alkyl, which were connected with MET 131, GLY 71, LEU 100 and CYS 115, etc.
T251 30582-31035 Sentence denotes MS1 (Fig. 9 A), a compound in formulae MXSG and SGMH, showed eleven interactions with N protein NCB site including H-bond interactions, Pi-Donor hydrogen bond, Pi-sigma, Pi-Pi stacked and Pi-alkyl, which were connected with SER 51, THR 109, ALA 50 and PRO 42, etc.; additionally, MS1 (Fig. 9B) showed five interactions with nsp14 [ExoN] including H-bond interactions and Pi-Pi stacked, which were connected with GLU 92, PHE 190, ASP 273 and VAL 91, etc.
T252 31036-31265 Sentence denotes MX16 (Fig. 9C), a compound in formulae MXSG and XCH, showed seven interactions with nsp15 [endoribonuclease] including H-bond interactions, Alkyl and Pi-alkyl, which were connected with PRO 343, VAL 275, LYS 344 and SER 293, etc.
T253 31266-31635 Sentence denotes SX1 (Fig. 9D), a compound in formulae SGMH and XCH, showed two interactions with nsp14 [N7-MTase] including Pi-Pi stacked and Pi-alkyl, which were connected with PHE 426; additionally, SX1 (Fig. 9E) showed five interactions with nsp15 [endoribonuclease] including H-bond interactions, Alkyl and Pi-alkyl, which were connected with LYS 344, LYS 289, VAL 291 and PRO 343.
T254 31636-32156 Sentence denotes WO1 (Fig. 9F), a compound in formulae WLS and Others, showed seven interactions with nsp16 [2′-O-MTase] including H-bond interactions, Carbon hydrogen bond, Pi-Pi T-shaped, Pi-alkyl and Pi-anion, which were connected with PHE 149, CYS 115, ASP 99 and SER 74, etc.; additionally, WO1 (Fig. 9G) showed seven interactions with nsp12 [RdRp without RNA] including H-bond interactions, Carbon hydrogen bond, Unfavorable Donor-Donor, Pi-cation and Pi-anion, which were connected with THR 556, ARG 553, ASP 623 and SER 682, etc.
T255 32157-32415 Sentence denotes XO1 (Fig. 9H), a compound in formulae XCH and Others, showed ten interactions with nsp12 [RdRp with RNA] including H-bond interactions, Pi-Donor hydrogen bond, Pi-Pi T-shaped and Pi-alkyl, which were connected with CYS 813, GLY 590, LYS 593 and ASP 865, etc.
T256 32416-32545 Sentence denotes Fig. 9 Schematic (3D and 2D) representation that molecular model of common compounds of the five formulae with COVID-19 proteins.
T257 32546-32807 Sentence denotes A: MS1 and N protein NCB site, B: MS1 and nsp14 [ExoN], C: MX16 and nsp15 [endoribonuclease], D: SX1 and nsp14 [N7-MTase], E: SX1 and nsp15 [endoribonuclease], F: WO1 and nsp16 [2′-O-MTase], G: WO1 and nsp12 [RdRp without RNA], H: XO1 and nsp12 [RdRp with RNA].
T258 32808-32902 Sentence denotes MS: MXSG and SGMH, MX: MXSG and XCH, SX: SGMH and XCH, WO: WLS and Others, XO: XCH and Others.
T259 32904-32973 Sentence denotes 3.7 ACE2 and CD147 expression across tissues and co-expression genes
T260 32974-33145 Sentence denotes Since 2019-nCov may enter other tissues and organs through ACE2 and CD147 binding, we firstly explored the expression and distribution of ACE2 and CD147 across 53 tissues.
T261 33146-33329 Sentence denotes Fig. 10 A showed that the 5 top expression tissues of ACE2 were terminal ileum, testis, visceral (omentum), left ventricle and kidney cortex, which are 3 fold change higher than lung.
T262 33330-33473 Sentence denotes And the 5 top expression tissues of CD147 were testis, visceral (omentum), left ventricle, aorta, atrial appendage and transformed fibroblasts.
T263 33474-33765 Sentence denotes Then, to further understand whether QFPD only targets pneumonia or 2019-nCov, we obtained 200 co-expression genes of ACE2, 200 co-expression genes of CD147, 470 pneumonia-associated proteins, 119 HCoV-associated host proteins, and 476 co-expression genes of ACE2 in colonic epithelial cells.
T264 33766-33996 Sentence denotes Fig. 10B displayed that QFPD had some common targets with these five sets, while specific 254 targets for QFPD, indicating other mechanisms of QFPD on COVID-19 in addition to 2019-nCov, pneumonia, ACE2 and CD147 related functions.
T265 33997-34070 Sentence denotes Fig. 10 ACE2 and CD147 expression across tissues and co-expression genes.
T266 34071-34073 Sentence denotes A:
T267 34074-34132 Sentence denotes Radar plot of ACE2 and CD147 expression across 53 tissues.
T268 34133-34190 Sentence denotes The expression values were converted to base-2 logarithm.
T269 34191-34249 Sentence denotes Red triangle and square mean the top 5 expression tissues.
T270 34250-34252 Sentence denotes B:
T271 34253-34478 Sentence denotes UpSet plot of proteins among QFPD, HCoV (Host_protein), pneumonia, ACE2 co-expression genes (ACE2_database), CD147 co-expression genes (CD147_database), and ACE2 co-expression genes in colonic epithelial cells (ACE2_colonic).
T272 34479-34577 Sentence denotes The horizontal bar graph at the bottom left shows the total number of proteins for each group set.
T273 34578-34667 Sentence denotes Circles and vertical lines in the x-axis mark the corresponding data sets being compared.
T274 34668-34887 Sentence denotes The vertical bar graph at the top quantitates the number of proteins in the comparisons. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T275 34889-34988 Sentence denotes 3.8 Validation of drug positioning for QFPD against COVID-19 via the robustness of disease network
T276 34989-35123 Sentence denotes Firstly, the robustness of whole networks against formula attack was assessed to evaluate QFPD attack on the COVID-19 disease network.
T277 35124-35402 Sentence denotes Interestingly, Table 4 and Fig. 11 showed that MSXG, SGMH, XCH, WLS and Others attack on the COVID-19 network were characterized by greater disturbance score than negative control (BXTM), and increasing dependence on hub nodes, indicating greater fragility under formula attack.
T278 35403-35514 Sentence denotes In addition, SGMH, MSXG, and Others exerted higher disturbance score than the positive control (YDBF) Table 5 .
T279 35515-35606 Sentence denotes Fig. 11 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.
T280 35607-35712 Sentence denotes Blue normal distribution: drug attack on random networks as a null distribution for the permutation test.
T281 35713-35793 Sentence denotes Red vertical line: the disturbance rate of the drug to the real disease network.
T282 35794-35871 Sentence denotes Fist row: MXSG, second row: SGMH, third row: XCH, fourth row: WLS, fifth row:
T283 35872-35879 Sentence denotes Others.
T284 35880-36158 Sentence denotes Fist column: average connectivity, second row: average length of shortest path, third row: connection centrality, fourth row: closeness centrality. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T285 36159-36239 Sentence denotes Table 5 Docking score between common ingredients of QFPD and 2019-nCov proteins.
T286 36240-36287 Sentence denotes Molecule MS1 MX16 MX17 MX8 MXO1 SO1 SX1 WO1 XO1
T287 36288-36344 Sentence denotes Main Protease −7.6 −7 −7.8 −7.8 −7.8 −7.2 −7.1 −7.4 −7.4
T288 36345-36408 Sentence denotes Papain-like protease −8 −8.2 −8.1 −8.1 −8.2 −8.2 −9.2 −8.7 −8.3
T289 36409-36463 Sentence denotes RdRp with RNA −8.6 −8 −7.9 −7.9 −8 −8.4 −8.2 −8.8 −9.5
T290 36464-36523 Sentence denotes RdRp without RNA −7.1 −6.8 −6.8 −6.8 −7 −7.1 −6.9 −7.5 −7.1
T291 36524-36586 Sentence denotes Helicase ADP site −6.2 −6.5 −6.3 −6.1 −6.2 −6.4 −6.8 −6.2 −6.8
T292 36587-36649 Sentence denotes Helicase NCB site −7.4 −7.1 −7.2 −7.2 −7.5 −7.5 −7.4 −7.6 −7.5
T293 36650-36704 Sentence denotes Nsp14(ExoN) −7.2 −6.6 −6.6 −6.7 −6.9 −7 −6.9 −7.1 −7.1
T294 36705-36765 Sentence denotes Nsp14(N7-MTase) −8.6 −8.3 −8.4 −8.3 −8.6 −8.3 −9.4 −8.7 −8.7
T295 36766-36834 Sentence denotes Nsp15(endoribonuclease) −6.2 −6.8 −6.4 −6.4 −6.3 −6.5 −6.8 −6.4 −6.6
T296 36835-36897 Sentence denotes Nsp16(2′-O-MTase) −8.1 −7.4 −7.6 −7.8 −7.8 −8.3 −7.7 −8.4 −8.2
T297 36898-36957 Sentence denotes N protein NCB site −8.1 −7.9 −8 −8 −7.6 −7.8 −7.5 −7.7 −7.9
T298 36958-37025 Sentence denotes E protein(ion channel) −6.4 −6.9 −7.2 −7.2 −6.9 −6.9 −7.9 −6.8 −6.8
T299 37026-37054 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T300 37055-37062 Sentence denotes Others.
T301 37063-37197 Sentence denotes Next, to illustrate the mechanism of QFPD against COVID-19, a formula-attacked target-KEGG pathway network was constructed (Fig. 12 ).
T302 37198-37551 Sentence denotes This network showed that MSXG, SGMH, XCH, WLS and Others interacted with 8 drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf), and 24 drug-attacked nodes in the COVID-19 network were related to Graft-versus-host disease, cytokine-cytokine receptor interaction, asthma, influenza A, inflammatory bowel disease, JAK-STAT signaling, etc.
T303 37552-37610 Sentence denotes Fig. 12 Disturbance analysis of QFPD for COVID-19 network.
T304 37611-37613 Sentence denotes A:
T305 37614-37666 Sentence denotes Venn diagram of the five formulae’ attacked targets.
T306 37667-37669 Sentence denotes B:
T307 37670-37798 Sentence denotes Formula-attacked target-KEGG pathway network; green square: formula, yellow diamond: attacked target, red circle: KEGG pathways.
T308 37799-37992 Sentence denotes The bigger the size of the nodes is, the higher the degree is. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T309 37994-38007 Sentence denotes 4 Discussion
T310 38008-38098 Sentence denotes Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage.
T311 38099-38220 Sentence denotes Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2].
T312 38221-38305 Sentence denotes In addition, a number of patients presented multi-organ damage and dysfunction [28].
T313 38306-38388 Sentence denotes However, there are no specific drugs or vaccine for the treatment of the COVID-19.
T314 38389-38511 Sentence denotes This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29].
T315 38512-38733 Sentence denotes Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30].
T316 38734-38879 Sentence denotes It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31].
T317 38880-39071 Sentence denotes Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective.
T318 39072-39190 Sentence denotes To our knowledge, this is the first study to explore the mechanisms of QFPD for COVID based on intra-functional units.
T319 39191-39535 Sentence denotes In this study, GO enrichment analysis showed that the common GO terms of MSXG, SGMH, XCH, WLS and Others targets were significant enriched in oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, and homeostatic process etc., suggesting QFPD may exert anti-viral activity through metabolic function.
T320 39536-39752 Sentence denotes In agreement with these results, a recent research has found that lipid metabolic reprograming plays an important role in virus replication, which may be an appealing and applicable target for antiviral therapy [32].
T321 39753-39985 Sentence denotes KEGG analysis showed that in addition to lipid metabolism-related pathways, endocrine system pathways were also significantly enriched in more than four formulae, including PPAR signaling pathway and adipocytokine signaling pathway.
T322 39986-40218 Sentence denotes A recent study has showed that the host can exert anti-inflammatory functions to inhibit excessive inflammatory damage through PPAR signaling pathway after H1N1 infection, thus keeping homeostasis of metabolism and development [33].
T323 40219-40524 Sentence denotes In addition, other common terms were significant enriched in more than two formulae, such as immune system process, endoplasmic reticulum, cell-cell signaling, calcium signaling pathway, vascular smooth muscle contraction, inflammatory mediator regulation of TRP channels, cardiac muscle contraction, etc.
T324 40525-40727 Sentence denotes Therefore, the multi-pathway and multi-target results of our intra functional unit of QFPD not only showed a new useful method for studying TCM, but may demonstrate the rationality of TCM compatibility.
T325 40728-40791 Sentence denotes Moreover, TCMATCOV platform was used to validate these results.
T326 40792-41194 Sentence denotes Interestingly, all the five FUs of QFPD showed higher disturbance score than negative control (BXTM), indicating that MSXG, SGMH, XCH, WLS and Others may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf) which were related to the bacterial and viral responses, cytokine, immune system, signaling transduction, etc.
T327 41195-41449 Sentence denotes Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38].
T328 41450-41721 Sentence denotes In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes.
T329 41722-41831 Sentence denotes These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment.
T330 41832-42114 Sentence denotes Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc.
T331 42115-42265 Sentence denotes It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39].
T332 42266-42505 Sentence denotes In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 & XLOGP ≤ 3.5 & Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption.
T333 42506-42683 Sentence denotes Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD.
T334 42684-43018 Sentence denotes Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy.
T335 43019-43093 Sentence denotes However, these newly monomer components should provide a further research.
T336 43094-43208 Sentence denotes It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41].
T337 43209-43340 Sentence denotes A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42].
T338 43341-43530 Sentence denotes Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD.
T339 43531-43740 Sentence denotes In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44].
T340 43741-43972 Sentence denotes In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription.
T341 43973-44151 Sentence denotes Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45].
T342 44152-44346 Sentence denotes Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection.
T343 44347-44406 Sentence denotes In summary, QFPD is effective in the treatment of COVID-19.
T344 44407-44584 Sentence denotes However, some shortcomings in our study include lack of an in-depth study of predictive monomers and key targets and pathways, thus need further validation in vivo and in vitro.
T345 44585-44851 Sentence denotes And the TCMATCOV platform uses SARS disease network, which is different from the COVID-19 disease network, and COVID-19-related cytokines are related to severe COVID-19 disease, so the results of platform analysis more reflect the potential efficacy of severe stage.
T346 44852-45007 Sentence denotes Nevertheless, this study confirms that network pharmacology can help explore the mechanism of QFPD on the treatment of COVID-19 with time- and cost-saving.
T347 45008-45200 Sentence denotes Moreover, based on our new FUNP analysis, we reveal that QFPD treat COVID-19 by a holistic treatment and multi-component synergy, and are further demonstrated by formula perturbation analysis.
T348 45201-45352 Sentence denotes In addition, this study provides possible candidate monomers of QFPD and related miRNAs, kinases and TFs with potential therapeutic effect on COVID-19.
T349 45353-45470 Sentence denotes This will hopefully provide evidence and new insights for further researches on the treatment of COVID-19 using QFPD.
T350 45472-45492 Sentence denotes Author contributions
T351 45493-45929 Sentence denotes Conceiving the research, Jian Chen and Yong-bing Cao; Data curation, Jian Chen, Wen-jie Sun, and Zhi-qiang Liang; Funding acquisition, Jian Chen, Zhi-qiang Liang, Bing-yong Cao and Ye-min Cao; Investigation, Ling-San Hu, Jian-ru Wang, and Bing-yong Cao; Methodology, Yong-kui Wang, Jiang-wei Yang and Ye-min Cao; Resources, Ling-San Hu and Yong-kui Wang; Visualization, Jian-ru Wang, Jiang-wei Yang; Writing – original draft, Jian Chen.
T352 45931-45964 Sentence denotes Declaration of Competing Interest
T353 45965-46009 Sentence denotes The authors declare no conflict of interest.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T2 26491-26494 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T3 26819-26822 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T4 31636-31639 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T5 31915-31918 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T6 32709-32712 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T7 32740-32743 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T8 36280-36283 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690
T9 42810-42813 GlycoEpitope denotes WO1 http://www.glycoepitope.jp/epitopes/AN0690

2_test

Id Subject Object Predicate Lexical cue
32554251-32007143-6393485 456-457 32007143 denotes 2
32554251-22710290-6393486 1878-1879 22710290 denotes 3
32554251-16644487-6393487 2285-2286 16644487 denotes 5
32554251-25914040-6393488 2569-2570 25914040 denotes 7
32554251-17921993-6393489 3452-3453 17921993 denotes 8
32554251-17318209-6393490 3893-3895 17318209 denotes 11
32554251-30809144-6393491 4049-4051 30809144 denotes 12
32554251-24735618-6393492 4737-4739 24735618 denotes 13
32554251-17033281-6393493 4790-4792 17033281 denotes 14
32554251-22837674-6393494 4831-4833 22837674 denotes 15
32554251-26400175-6393495 4932-4934 26400175 denotes 16
32554251-26879404-6393496 4958-4960 26879404 denotes 17
32554251-15980575-6393497 5937-5939 15980575 denotes 18
32554251-12525261-6393498 6507-6509 12525261 denotes 19
32554251-14597658-6393499 6640-6642 14597658 denotes 20
32554251-28256516-6393500 7514-7516 28256516 denotes 21
32554251-25860834-6393501 7788-7790 25860834 denotes 22
32554251-30462320-6393502 9342-9344 30462320 denotes 24
32554251-31986264-6393503 10605-10607 31986264 denotes 27
32554251-30809144-6393504 11329-11331 30809144 denotes 12
32554251-32007143-6393505 38217-38218 32007143 denotes 2
32554251-31978945-6393506 38301-38303 31978945 denotes 28
32554251-30631056-6393507 39748-39750 30631056 denotes 32
32554251-21819625-6393508 40214-40216 21819625 denotes 33
32554251-31745103-6393509 42261-42263 31745103 denotes 39
32554251-23962477-6393510 43204-43206 23962477 denotes 41
32554251-12097601-6393511 43733-43735 12097601 denotes 43
32554251-23153050-6393512 44147-44149 23153050 denotes 45