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PMC:7247521 / 20558-23971 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
289 1253-1256 Disease denotes XCH
295 674-680 Gene denotes COX7A1 Gene:1346
296 750-757 Gene denotes ALDH1A1 Gene:216
297 825-829 Gene denotes CNR2 Gene:1269
298 947-954 Chemical denotes calcium MESH:D002118
299 1010-1013 Chemical denotes TRP MESH:D014364
302 1511-1517 Gene denotes COX7A1 Gene:1346
303 1596-1616 Disease denotes huntington's disease MESH:D006816
305 1930-1934 Gene denotes CNR2 Gene:1269
310 2376-2381 Gene denotes ACSS1 Gene:84532
311 2448-2452 Gene denotes CNR2 Gene:1269
312 2519-2524 Gene denotes PRKCG Gene:5582
313 2601-2608 Gene denotes insulin Gene:3630
323 2936-2942 Gene denotes COX7A1 Gene:1346
324 3012-3016 Gene denotes RRM1 Gene:6240
325 3084-3088 Gene denotes CNR2 Gene:1269
326 3158-3163 Gene denotes ACSS1 Gene:84532
327 3230-3235 Gene denotes FFAR1 Gene:2864
328 3311-3318 Chemical denotes calcium MESH:D002118
329 3338-3342 Chemical denotes cGMP MESH:D006152
330 2731-2734 Disease denotes XCH
331 3282-3285 Disease denotes XCH

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T217 43-50 SO:0000417 denotes modules
T218 181-187 GO:0007601 denotes visual
T219 260-265 SO:0001867 denotes genes
T220 462-468 SO:0000417 denotes module
T221 547-554 SO:0000417 denotes modules
T222 665-669 SO:0000704 denotes gene
T223 674-680 PR:000005786 denotes COX7A1
T224 741-745 SO:0000704 denotes gene
T225 750-757 PR:000003920 denotes ALDH1A1
T226 816-820 SO:0000704 denotes gene
T227 825-829 PR:000001126 denotes CNR2
T228 881-888 SO:0000417 denotes modules
T229 947-972 GO:0019722 denotes calcium signaling pathway
T230 974-995 CHEBI:67079;CHEBI:67079 denotes inflammatory mediator
T231 996-1006 GO:0065007 denotes regulation
T232 1010-1013 PR:000016138 denotes TRP
T233 1061-1068 SO:0000417 denotes modules
T234 1204-1211 SO:0000417 denotes modules
T237 1292-1297 SO:0001867 denotes genes
T238 1502-1506 SO:0000704 denotes gene
T239 1511-1517 PR:000005786 denotes COX7A1
T240 1571-1578 SO:0000417 denotes modules
T241 1618-1628 GO:0006096 denotes glycolysis
T242 1631-1646 GO:0006094 denotes gluconeogenesis
T243 1648-1671 GO:0007219 denotes Notch signaling pathway
T244 1713-1718 SO:0001867 denotes genes
T245 1921-1925 SO:0000704 denotes gene
T246 1930-1934 PR:000001126 denotes CNR2
T247 1985-1992 SO:0000417 denotes modules
T248 2010-2017 UBERON:0002046;GO:0048538;CHEBI:60311;CHEBI:60311 denotes thyroid
T249 2018-2025 CHEBI:60311;CHEBI:60311;GO:0007179 denotes hormone
T250 2026-2035 GO:0007179 denotes signaling
T251 2161-2166 SO:0001867 denotes genes
T252 2367-2371 SO:0000704 denotes gene
T253 2376-2381 PR:000003671 denotes ACSS1
T254 2439-2443 SO:0000704 denotes gene
T255 2448-2452 PR:000001126 denotes CNR2
T256 2510-2514 SO:0000704 denotes gene
T257 2576-2583 SO:0000417 denotes modules
T258 2601-2608 PR:000009054 denotes insulin
T259 2635-2644 GO:0019221 denotes signaling
T260 2654-2658 CL:0000899 denotes Th17
T261 2659-2663 CL:0000899;GO:0030154 denotes cell
T262 2664-2679 GO:0030154 denotes differentiation
T263 2722-2727 SO:0001867 denotes genes
T264 2927-2931 SO:0000704 denotes gene
T265 2936-2942 PR:000005786 denotes COX7A1
T266 3003-3007 SO:0000704 denotes gene
T267 3012-3016 PR:000014305 denotes RRM1
T268 3075-3079 SO:0000704 denotes gene
T269 3084-3088 PR:000001126 denotes CNR2
T270 3149-3153 SO:0000704 denotes gene
T271 3158-3163 PR:000003671 denotes ACSS1
T272 3221-3225 SO:0000704 denotes gene
T273 3230-3235 PR:000001582 denotes FFAR1
T274 3286-3293 SO:0000417 denotes modules
T275 3311-3336 GO:0019722 denotes calcium signaling pathway

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T50 410-417 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 665-669 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T52 741-745 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T53 816-820 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T54 1502-1506 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T55 1648-1653 Body_part denotes Notch http://purl.org/sig/ont/fma/fma75036
T56 1921-1925 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T57 2010-2017 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T58 2018-2025 Body_part denotes hormone http://purl.org/sig/ont/fma/fma12278
T59 2367-2371 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T60 2439-2443 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T61 2510-2514 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T62 2601-2608 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T63 2659-2663 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 2927-2931 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T65 3003-3007 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T66 3075-3079 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T67 3149-3153 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T68 3221-3225 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 2010-2017 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T57 1596-1616 Disease denotes huntington's disease http://purl.obolibrary.org/obo/MONDO_0007739

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T129 260-265 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T130 508-509 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 573-574 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T132 665-669 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T133 741-745 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T134 794-796 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T135 816-820 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T136 955-964 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T137 1213-1214 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T138 1222-1223 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T139 1292-1297 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T140 1502-1506 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T141 1654-1663 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T142 1713-1718 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T143 1921-1925 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T144 2026-2035 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T145 2059-2068 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T146 2161-2166 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T147 2367-2371 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T148 2439-2443 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T149 2510-2514 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T150 2601-2608 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T151 2635-2644 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T152 2659-2663 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T153 2722-2727 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T154 2927-2931 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T155 3003-3007 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T156 3075-3079 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T157 3127-3129 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T158 3149-3153 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T159 3221-3225 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T160 3319-3328 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T161 3347-3356 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T106 21-24 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T108 128-131 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T110 291-294 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T112 410-417 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 441-444 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T115 918-924 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T116 947-954 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T118 1152-1155 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T120 1325-1328 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T122 1438-1440 Chemical denotes 5B http://purl.obolibrary.org/obo/CHEBI_27560
T123 1743-1746 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T125 2010-2025 Chemical denotes thyroid hormone http://purl.obolibrary.org/obo/CHEBI_60311
T126 2018-2025 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T127 2090-2096 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T128 2192-2195 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T130 2601-2608 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T131 2752-2755 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T133 3311-3318 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T135 3338-3342 Chemical denotes cGMP http://purl.obolibrary.org/obo/CHEBI_16356
T136 3378-3384 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 2601-2619 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T71 947-964 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T72 955-964 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73 996-1006 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T74 1618-1628 http://purl.obolibrary.org/obo/GO_0006096 denotes glycolysis
T75 1631-1646 http://purl.obolibrary.org/obo/GO_0006094 denotes gluconeogenesis
T76 1648-1671 http://purl.obolibrary.org/obo/GO_0007219 denotes Notch signaling pathway
T77 1654-1671 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T78 1654-1663 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T79 2026-2043 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T80 2026-2035 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T81 2045-2076 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T82 2045-2076 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T83 2045-2076 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T84 2059-2076 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T85 2059-2068 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T86 2621-2652 http://purl.obolibrary.org/obo/GO_0033211 denotes adipocytokine signaling pathway
T87 2621-2652 http://purl.obolibrary.org/obo/GO_0033210 denotes adipocytokine signaling pathway
T88 2621-2652 http://purl.obolibrary.org/obo/GO_0033209 denotes adipocytokine signaling pathway
T89 2635-2652 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T90 2635-2644 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T91 2659-2679 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T92 3311-3328 http://purl.obolibrary.org/obo/GO_0019722 denotes calcium signaling
T93 3319-3328 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T94 3347-3364 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T95 3347-3356 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T118 0-59 Sentence denotes 3.3 Construction of PPI network and MCODE modules analysis
T119 60-225 Sentence denotes To further explore the functional relationship among five formulae, PPI networks were constructed through Metascape, and visual composition carried out by Cytoscape.
T120 226-431 Sentence denotes Firstly, the potential 192 target genes of MXSG were analyzed by PPI network, and the results showed that there were 144 nodes and 510 edges, which represented the interaction between protein and function.
T121 432-576 Sentence denotes The MXSG PPI network function module was confirmed by the MCODE plug-in and a list of the corresponding meaningful modules presented (Fig. 5 A).
T122 577-605 Sentence denotes 3 modules scores were > 2.5.
T123 606-622 Sentence denotes Module 1 (score:
T124 623-698 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T125 699-775 Sentence denotes 4.429) consisted of 14 nodes and the seed gene was ALDH1A1; module 3 (score:
T126 776-830 Sentence denotes 5.0) consisted of 11 nodes and the seed gene was CNR2.
T127 831-1030 Sentence denotes KEGG pathway enrichment analysis showed that MXSG modules were enriched in neuroactive ligand-receptor interaction, calcium signaling pathway, inflammatory mediator regulation of TRP channels, et.al.
T128 1031-1069 Sentence denotes Fig. 5 KEGG analysis of MCODE modules.
T129 1070-1212 Sentence denotes MCODE analysis was performed after the construction of the five formulae’ targets PPI; then, KEGG analysis was conducted on the MCODE modules.
T130 1213-1224 Sentence denotes A: MXSG, B:
T131 1225-1257 Sentence denotes Others, C: WLS, D: SGMH, E: XCH.
T132 1258-1400 Sentence denotes Secondly, the potential 99 target genes of Others were analyzed by PPI network, and the results showed that there were 77 nodes and 194 edges.
T133 1401-1442 Sentence denotes Only 1 module score were > 2.5 (Fig. 5B).
T134 1443-1459 Sentence denotes Module 1 (score:
T135 1460-1518 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1.
T136 1519-1679 Sentence denotes KEGG pathway enrichment analysis showed that Others modules were enriched in huntington's disease, glycolysis / gluconeogenesis, Notch signaling pathway, et.al.
T137 1680-1818 Sentence denotes Thirdly, the potential 96 target genes of WLS were analyzed by PPI network, and the results showed that there were 60 nodes and 143 edges.
T138 1819-1861 Sentence denotes Only 1 modules score were > 2.5 (Fig. 5C).
T139 1862-1878 Sentence denotes Module 1 (score:
T140 1879-1935 Sentence denotes 2.706) consisted of 17 nodes and the seed gene was CNR2.
T141 1936-2125 Sentence denotes KEGG pathway enrichment analysis showed that WLS modules were enriched in thyroid hormone signaling pathway, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, et.al.
T142 2126-2268 Sentence denotes Fourthly, the potential 201 target genes of SGMH were analyzed by PPI network, and the results showed that there were 153 nodes and 505 edges.
T143 2269-2307 Sentence denotes 3 modules scores were > 2.5 (Fig. 5D).
T144 2308-2324 Sentence denotes Module 1 (score:
T145 2325-2399 Sentence denotes 3.529) consisted of 17 nodes and the seed gene was ACSS1; Module 2 (score:
T146 2400-2470 Sentence denotes 4.5) consisted of 7 nodes and the seed gene was CNR2; module 3 (score:
T147 2471-2525 Sentence denotes 3.5) consisted of 8 nodes and the seed gene was PRKCG.
T148 2526-2687 Sentence denotes KEGG pathway enrichment analysis showed that SGMH modules were enriched in insulin resistance, adipocytokine signaling pathway, Th17 cell differentiation, et.al.
T149 2688-2828 Sentence denotes At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges.
T150 2829-2867 Sentence denotes 5 modules scores were > 2.5 (Fig. 5E).
T151 2868-2884 Sentence denotes Module 1 (score:
T152 2885-2960 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T153 2961-3034 Sentence denotes 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score:
T154 3035-3106 Sentence denotes 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score:
T155 3107-3181 Sentence denotes 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score:
T156 3182-3236 Sentence denotes 3.0) consisted of 7 nodes and the seed gene was FFAR1.
T157 3237-3413 Sentence denotes KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al.