PMC:7247521 / 19675-20556 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"284","span":{"begin":45,"end":52},"obj":"Gene"},{"id":"285","span":{"begin":57,"end":65},"obj":"Gene"},{"id":"286","span":{"begin":246,"end":250},"obj":"Gene"},{"id":"287","span":{"begin":303,"end":306},"obj":"Disease"}],"attributes":[{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"Gene:406959"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:406919"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Gene:1022"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T204","span":{"begin":21,"end":27},"obj":"SO:0000276"},{"id":"T205","span":{"begin":187,"end":193},"obj":"SO:0000276"},{"id":"T206","span":{"begin":246,"end":250},"obj":"PR:000005265"},{"id":"T207","span":{"begin":505,"end":510},"obj":"SO:0000276"},{"id":"T208","span":{"begin":662,"end":667},"obj":"SO:0000646"},{"id":"T209","span":{"begin":707,"end":712},"obj":"SO:0000276"},{"id":"T210","span":{"begin":811,"end":816},"obj":"SO:0000276"},{"id":"T211","span":{"begin":857,"end":862},"obj":"SO:0000276"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T122","span":{"begin":66,"end":67},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T123","span":{"begin":202,"end":203},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T124","span":{"begin":489,"end":491},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T125","span":{"begin":580,"end":585},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T126","span":{"begin":796,"end":802},"obj":"http://purl.obolibrary.org/obo/CLO_0050421"},{"id":"T127","span":{"begin":854,"end":855},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T128","span":{"begin":864,"end":865},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T97","span":{"begin":173,"end":178},"obj":"Chemical"},{"id":"T98","span":{"begin":343,"end":345},"obj":"Chemical"},{"id":"T99","span":{"begin":395,"end":397},"obj":"Chemical"},{"id":"T100","span":{"begin":465,"end":470},"obj":"Chemical"},{"id":"T101","span":{"begin":523,"end":525},"obj":"Chemical"},{"id":"T102","span":{"begin":680,"end":682},"obj":"Chemical"},{"id":"T103","span":{"begin":720,"end":722},"obj":"Chemical"},{"id":"T104","span":{"begin":824,"end":826},"obj":"Chemical"},{"id":"T105","span":{"begin":878,"end":880},"obj":"Chemical"}],"attributes":[{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_74862"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T64","span":{"begin":343,"end":345},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T65","span":{"begin":395,"end":397},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T66","span":{"begin":523,"end":525},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T67","span":{"begin":680,"end":682},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T68","span":{"begin":720,"end":722},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T69","span":{"begin":824,"end":826},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T70","span":{"begin":878,"end":880},"obj":"http://purl.obolibrary.org/obo/GO_0000981"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}

{"project":"LitCovid-sentences","denotations":[{"id":"T110","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T111","span":{"begin":206,"end":333},"obj":"Sentence"},{"id":"T112","span":{"begin":334,"end":493},"obj":"Sentence"},{"id":"T113","span":{"begin":494,"end":579},"obj":"Sentence"},{"id":"T114","span":{"begin":580,"end":689},"obj":"Sentence"},{"id":"T115","span":{"begin":690,"end":795},"obj":"Sentence"},{"id":"T116","span":{"begin":796,"end":853},"obj":"Sentence"},{"id":"T117","span":{"begin":854,"end":881},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A). In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B). Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).\nFig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt. Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms. Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right). Chords connect miRNA/kinase/TF term with formulae groups. A: miRNA, B: kinase, C: TF."}