PMC:7247521 / 1443-2583 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"32","span":{"begin":217,"end":226},"obj":"Gene"},{"id":"34","span":{"begin":334,"end":343},"obj":"Species"},{"id":"45","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"46","span":{"begin":477,"end":485},"obj":"Disease"},{"id":"47","span":{"begin":739,"end":747},"obj":"Disease"},{"id":"55","span":{"begin":959,"end":981},"obj":"Species"},{"id":"56","span":{"begin":983,"end":992},"obj":"Species"},{"id":"57","span":{"begin":1111,"end":1119},"obj":"Species"}],"attributes":[{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:2697049"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:C000657245"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:C000657245"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:C000657245"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:2697049"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:2697049"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T28","span":{"begin":6,"end":15},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T29","span":{"begin":70,"end":74},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T30","span":{"begin":99,"end":115},"obj":"UBERON:0001555"},{"id":"T31","span":{"begin":224,"end":226},"obj":"CHEBI:15379;CHEBI:15379"},{"id":"T32","span":{"begin":334,"end":343},"obj":"SP_7"},{"id":"T33","span":{"begin":391,"end":395},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T34","span":{"begin":412,"end":420},"obj":"SP_7"},{"id":"T35","span":{"begin":477,"end":485},"obj":"SP_7"},{"id":"T36","span":{"begin":527,"end":536},"obj":"GO:0010467"},{"id":"T37","span":{"begin":537,"end":541},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T38","span":{"begin":583,"end":592},"obj":"NCBITaxon:2"},{"id":"T39","span":{"begin":597,"end":602},"obj":"NCBITaxon:10239"},{"id":"T40","span":{"begin":614,"end":627},"obj":"UBERON:0002405"},{"id":"T41","span":{"begin":739,"end":747},"obj":"SP_7"},{"id":"T42","span":{"begin":751,"end":761},"obj":"GO:0065007"},{"id":"T43","span":{"begin":862,"end":872},"obj":"GO:0065007"},{"id":"T44","span":{"begin":881,"end":886},"obj":"NCBITaxon:10239"},{"id":"T45","span":{"begin":919,"end":928},"obj":"GO:0008152"},{"id":"T46","span":{"begin":970,"end":981},"obj":"NCBITaxon:11118"},{"id":"T47","span":{"begin":983,"end":992},"obj":"SP_7"},{"id":"T11","span":{"begin":881,"end":886},"obj":"NCBITaxon:10239"},{"id":"T12","span":{"begin":892,"end":905},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T13","span":{"begin":919,"end":928},"obj":"GO:0008152"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T3","span":{"begin":372,"end":380},"obj":"Body_part"},{"id":"T4","span":{"begin":614,"end":627},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":614,"end":627},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T10","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"T11","span":{"begin":477,"end":485},"obj":"Disease"},{"id":"T12","span":{"begin":739,"end":747},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T10","span":{"begin":84,"end":88},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T11","span":{"begin":213,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T12","span":{"begin":254,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0007875"},{"id":"T13","span":{"begin":254,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0052410"},{"id":"T14","span":{"begin":614,"end":627},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T15","span":{"begin":629,"end":638},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T16","span":{"begin":716,"end":717},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17","span":{"begin":762,"end":763},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T18","span":{"begin":906,"end":914},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":70,"end":74},"obj":"Chemical"},{"id":"T8","span":{"begin":209,"end":211},"obj":"Chemical"},{"id":"T10","span":{"begin":224,"end":226},"obj":"Chemical"},{"id":"T11","span":{"begin":372,"end":380},"obj":"Chemical"},{"id":"T12","span":{"begin":391,"end":395},"obj":"Chemical"},{"id":"T13","span":{"begin":537,"end":541},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_51083"},{"id":"A9","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_53453"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T16","span":{"begin":629,"end":651},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T17","span":{"begin":629,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T18","span":{"begin":639,"end":651},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T19","span":{"begin":862,"end":872},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-sentences","denotations":[{"id":"T16","span":{"begin":175,"end":381},"obj":"Sentence"},{"id":"T17","span":{"begin":382,"end":657},"obj":"Sentence"},{"id":"T18","span":{"begin":658,"end":815},"obj":"Sentence"},{"id":"T19","span":{"begin":816,"end":941},"obj":"Sentence"},{"id":"T20","span":{"begin":943,"end":958},"obj":"Sentence"},{"id":"T21","span":{"begin":959,"end":1072},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":270,"end":273},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/AN0690"}],"text":"at 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 \u003e 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.\n\n1 Introduction\n2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world. By April 3, 2020, more than 1 million patients have been diagnosed "}