PMC:7247521 / 10101-10597
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 153 | 301-305 | Gene | denotes | OCT2 | Gene:6582 |
| 154 | 370-374 | Gene | denotes | hERG | Gene:2078 |
| 155 | 388-392 | Gene | denotes | hERG | Gene:2078 |
| 156 | 412-415 | Species | denotes | rat | Tax:10116 |
| 157 | 321-329 | Disease | denotes | toxicity | MESH:D064420 |
| 158 | 336-344 | Disease | denotes | toxicity | MESH:D064420 |
| 159 | 422-430 | Disease | denotes | toxicity | MESH:D064420 |
| 160 | 439-453 | Disease | denotes | hepatotoxicity | MESH:D056486 |
| 161 | 455-473 | Disease | denotes | skin sensitisation | MESH:D012871 |
| 162 | 486-494 | Disease | denotes | toxicity | MESH:D064420 |
| 163 | 110-116 | CellLine | denotes | Caco-2 | CVCL:0025 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T100 | 8-23 | CHEBI:52217;CHEBI:52217 | denotes | pharmacokinetic |
| T101 | 110-116 | CL_1 | denotes | Caco-2 |
| T102 | 202-221 | UBERON:0000120 | denotes | blood-brain barrier |
| T103 | 226-248 | UBERON:0001017 | denotes | central nervous system |
| T104 | 264-273 | GO:0007588 | denotes | excretion |
| T105 | 295-300 | UBERON:0002113 | denotes | renal |
| T106 | 301-305 | PR:000013036 | denotes | OCT2 |
| T107 | 331-335 | CHEBI:34018;CHEBI:34018 | denotes | AMES |
| T108 | 370-374 | PR:P11308 | denotes | hERG |
| T109 | 377-386 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T110 | 388-392 | PR:P11308 | denotes | hERG |
| T111 | 396-405 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T112 | 407-411 | UBERON:0000165 | denotes | oral |
| T113 | 412-415 | NCBITaxon:10114 | denotes | rat |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T13 | 117-121 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T14 | 144-148 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T15 | 202-207 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T16 | 208-213 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T17 | 226-248 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T18 | 455-459 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 144-148 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T8 | 202-221 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T9 | 202-207 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T10 | 208-213 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T11 | 226-248 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T12 | 234-248 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T13 | 455-459 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T68 | 73-75 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T69 | 110-121 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 cell |
| T70 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T71 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T72 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T73 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T74 | 144-148 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T75 | 202-207 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T76 | 202-207 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T77 | 208-213 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T78 | 208-213 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T79 | 226-248 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T80 | 226-248 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T81 | 226-248 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
| T82 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T83 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T84 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T85 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T86 | 455-459 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T45 | 377-386 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T46 | 393-395 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T47 | 396-405 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T28 | 264-273 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 0-496 | Sentence | denotes | Second, pharmacokinetic properties was predicted through pkCSM database [22], which contained the absorption (Caco-2 cell permeability, HIA and skin permeability), distribution (VDss, unbound fraction, blood-brain barrier and central nervous system permeability), excretion (total clearance and renal OCT2 substrate) and toxicity (AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32554251-25860834-6393501 | 73-75 | 25860834 | denotes | 22 |