PMC:7247521 / 10101-10597
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
153 | 301-305 | Gene | denotes | OCT2 | Gene:6582 |
154 | 370-374 | Gene | denotes | hERG | Gene:2078 |
155 | 388-392 | Gene | denotes | hERG | Gene:2078 |
156 | 412-415 | Species | denotes | rat | Tax:10116 |
157 | 321-329 | Disease | denotes | toxicity | MESH:D064420 |
158 | 336-344 | Disease | denotes | toxicity | MESH:D064420 |
159 | 422-430 | Disease | denotes | toxicity | MESH:D064420 |
160 | 439-453 | Disease | denotes | hepatotoxicity | MESH:D056486 |
161 | 455-473 | Disease | denotes | skin sensitisation | MESH:D012871 |
162 | 486-494 | Disease | denotes | toxicity | MESH:D064420 |
163 | 110-116 | CellLine | denotes | Caco-2 | CVCL:0025 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T100 | 8-23 | CHEBI:52217;CHEBI:52217 | denotes | pharmacokinetic |
T101 | 110-116 | CL_1 | denotes | Caco-2 |
T102 | 202-221 | UBERON:0000120 | denotes | blood-brain barrier |
T103 | 226-248 | UBERON:0001017 | denotes | central nervous system |
T104 | 264-273 | GO:0007588 | denotes | excretion |
T105 | 295-300 | UBERON:0002113 | denotes | renal |
T106 | 301-305 | PR:000013036 | denotes | OCT2 |
T107 | 331-335 | CHEBI:34018;CHEBI:34018 | denotes | AMES |
T108 | 370-374 | PR:P11308 | denotes | hERG |
T109 | 377-386 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
T110 | 388-392 | PR:P11308 | denotes | hERG |
T111 | 396-405 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
T112 | 407-411 | UBERON:0000165 | denotes | oral |
T113 | 412-415 | NCBITaxon:10114 | denotes | rat |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T13 | 117-121 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T14 | 144-148 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
T15 | 202-207 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T16 | 208-213 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T17 | 226-248 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
T18 | 455-459 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T7 | 144-148 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
T8 | 202-221 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
T9 | 202-207 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T10 | 208-213 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T11 | 226-248 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
T12 | 234-248 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
T13 | 455-459 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T68 | 73-75 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T69 | 110-121 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 cell |
T70 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
T71 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
T72 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
T73 | 144-148 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
T74 | 144-148 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
T75 | 202-207 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T76 | 202-207 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T77 | 208-213 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T78 | 208-213 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T79 | 226-248 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
T80 | 226-248 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
T81 | 226-248 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
T82 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
T83 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
T84 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
T85 | 455-459 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
T86 | 455-459 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T45 | 377-386 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T46 | 393-395 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T47 | 396-405 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T28 | 264-273 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T65 | 0-496 | Sentence | denotes | Second, pharmacokinetic properties was predicted through pkCSM database [22], which contained the absorption (Caco-2 cell permeability, HIA and skin permeability), distribution (VDss, unbound fraction, blood-brain barrier and central nervous system permeability), excretion (total clearance and renal OCT2 substrate) and toxicity (AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity). |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32554251-25860834-6393501 | 73-75 | 25860834 | denotes | 22 |