PMC:7243778 / 8305-8894 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"195","span":{"begin":17,"end":30},"obj":"Species"}],"attributes":[{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Tax:11118"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T35","span":{"begin":6,"end":13},"obj":"Body_part"},{"id":"T36","span":{"begin":38,"end":49},"obj":"Body_part"},{"id":"T37","span":{"begin":85,"end":106},"obj":"Body_part"},{"id":"T38","span":{"begin":365,"end":370},"obj":"Body_part"},{"id":"T39","span":{"begin":374,"end":381},"obj":"Body_part"},{"id":"T40","span":{"begin":514,"end":521},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67858"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T86","span":{"begin":54,"end":55},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T87","span":{"begin":140,"end":141},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T88","span":{"begin":169,"end":171},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T89","span":{"begin":185,"end":186},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T90","span":{"begin":341,"end":350},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T91","span":{"begin":365,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T92","span":{"begin":382,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T93","span":{"begin":386,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T94","span":{"begin":412,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T95","span":{"begin":522,"end":525},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T96","span":{"begin":526,"end":527},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T28","span":{"begin":6,"end":13},"obj":"Chemical"},{"id":"T29","span":{"begin":38,"end":49},"obj":"Chemical"},{"id":"T30","span":{"begin":38,"end":43},"obj":"Chemical"},{"id":"T31","span":{"begin":44,"end":49},"obj":"Chemical"},{"id":"T32","span":{"begin":99,"end":106},"obj":"Chemical"},{"id":"T33","span":{"begin":374,"end":381},"obj":"Chemical"},{"id":"T34","span":{"begin":514,"end":521},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T16","span":{"begin":554,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0009606"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T66","span":{"begin":0,"end":173},"obj":"Sentence"},{"id":"T67","span":{"begin":174,"end":371},"obj":"Sentence"},{"id":"T68","span":{"begin":372,"end":511},"obj":"Sentence"},{"id":"T69","span":{"begin":512,"end":589},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}

{"project":"2_test","denotations":[{"id":"32450171-19321428-66454448","span":{"begin":169,"end":171},"obj":"19321428"},{"id":"32450171-2170676-66454449","span":{"begin":507,"end":509},"obj":"2170676"}],"text":"The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18]. It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells. S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19]. S protein has a decisive role in cellular tropism and for pathogenicity [20]."}