PMC:7243778 / 33919-34512
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 885 | 406-410 | Gene | denotes | ACE2 | Gene:59272 |
| 886 | 146-156 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 887 | 173-181 | Species | denotes | SARS-CoV | Tax:694009 |
| 888 | 250-258 | Species | denotes | SARS-CoV | Tax:694009 |
| 889 | 340-350 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 890 | 391-401 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 891 | 501-506 | Species | denotes | human | Tax:9606 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T175 | 146-154 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T176 | 173-181 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T177 | 250-258 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 340-348 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 391-399 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T398 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T399 | 16-25 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humanized |
| T400 | 214-221 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T401 | 292-300 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T402 | 501-506 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T403 | 512-514 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T404 | 560-568 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T262 | 0-127 | Sentence | denotes | A panel of five humanized single domain antibodies (sdAbs) or nanobodies, 1E2, 2F2, 3F11, 4D8 and 5F8, was recently discovered. |
| T263 | 128-259 | Sentence | denotes | These sdAbs bound SARS-CoV-2 tightly but not SARS-CoV, except for 5F8 could bind both viruses but with weaker affinity to SARS-CoV. |
| T264 | 260-351 | Sentence | denotes | They also showed neutralization activity against both pseudotyped and authentic SARS-CoV-2. |
| T265 | 352-467 | Sentence | denotes | 1E2, 3F11 and 4D8 completely prevented SARS-CoV-2 RBD-ACE2 binding but this effect of 2F2 and 5F8 was only partial. |
| T266 | 468-593 | Sentence | denotes | Interestingly, the fusion of the human IgG1 Fc to these sdAbs improved their neutralization activity by 10- to 80-fold [112]. |