PMC:7243778 / 33246-33918 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"876","span":{"begin":282,"end":283},"obj":"Gene"},{"id":"877","span":{"begin":661,"end":671},"obj":"Species"}],"attributes":[{"id":"A876","pred":"tao:has_database_id","subj":"876","obj":"Gene:43740568"},{"id":"A877","pred":"tao:has_database_id","subj":"877","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T164","span":{"begin":30,"end":34},"obj":"Body_part"},{"id":"T165","span":{"begin":156,"end":167},"obj":"Body_part"},{"id":"T166","span":{"begin":175,"end":179},"obj":"Body_part"},{"id":"T167","span":{"begin":284,"end":291},"obj":"Body_part"},{"id":"T168","span":{"begin":299,"end":303},"obj":"Body_part"},{"id":"T169","span":{"begin":335,"end":338},"obj":"Body_part"},{"id":"T170","span":{"begin":516,"end":520},"obj":"Body_part"}],"attributes":[{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T174","span":{"begin":661,"end":669},"obj":"Disease"}],"attributes":[{"id":"A174","pred":"mondo_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T390","span":{"begin":28,"end":34},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T391","span":{"begin":173,"end":179},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T392","span":{"begin":297,"end":303},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T393","span":{"begin":319,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T394","span":{"begin":418,"end":426},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T395","span":{"begin":438,"end":446},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T396","span":{"begin":507,"end":508},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T397","span":{"begin":514,"end":520},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T188","span":{"begin":156,"end":167},"obj":"Chemical"},{"id":"T189","span":{"begin":156,"end":161},"obj":"Chemical"},{"id":"T190","span":{"begin":162,"end":167},"obj":"Chemical"},{"id":"T191","span":{"begin":284,"end":291},"obj":"Chemical"},{"id":"T192","span":{"begin":418,"end":426},"obj":"Chemical"},{"id":"T193","span":{"begin":438,"end":446},"obj":"Chemical"}],"attributes":[{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A189","pred":"chebi_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A190","pred":"chebi_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A191","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T256","span":{"begin":0,"end":135},"obj":"Sentence"},{"id":"T257","span":{"begin":136,"end":168},"obj":"Sentence"},{"id":"T258","span":{"begin":169,"end":292},"obj":"Sentence"},{"id":"T259","span":{"begin":293,"end":389},"obj":"Sentence"},{"id":"T260","span":{"begin":390,"end":551},"obj":"Sentence"},{"id":"T261","span":{"begin":552,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis. 17 of them have \u003e14 amino acids. The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein. 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found. Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111]. These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2."}