PMC:7243778 / 2146-2914 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"44","span":{"begin":658,"end":661},"obj":"Gene"},{"id":"45","span":{"begin":734,"end":737},"obj":"Gene"},{"id":"46","span":{"begin":44,"end":49},"obj":"Species"},{"id":"47","span":{"begin":555,"end":564},"obj":"Chemical"}],"attributes":[{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Gene:3492"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Gene:3535"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"Tax:9606"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D004220"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":44,"end":54},"obj":"Body_part"},{"id":"T10","span":{"begin":71,"end":84},"obj":"Body_part"},{"id":"T11","span":{"begin":274,"end":276},"obj":"Body_part"},{"id":"T12","span":{"begin":317,"end":319},"obj":"Body_part"},{"id":"T13","span":{"begin":407,"end":412},"obj":"Body_part"},{"id":"T14","span":{"begin":427,"end":429},"obj":"Body_part"},{"id":"T15","span":{"begin":467,"end":477},"obj":"Body_part"},{"id":"T16","span":{"begin":618,"end":622},"obj":"Body_part"},{"id":"T17","span":{"begin":636,"end":650},"obj":"Body_part"},{"id":"T18","span":{"begin":669,"end":673},"obj":"Body_part"},{"id":"T19","span":{"begin":712,"end":726},"obj":"Body_part"},{"id":"T20","span":{"begin":745,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma305853"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":71,"end":84},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T15","span":{"begin":35,"end":42},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T16","span":{"begin":44,"end":49},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T17","span":{"begin":55,"end":58},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T18","span":{"begin":71,"end":84},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T19","span":{"begin":128,"end":133},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T20","span":{"begin":180,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T21","span":{"begin":199,"end":208},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T22","span":{"begin":245,"end":246},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T23","span":{"begin":377,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0001686"},{"id":"T24","span":{"begin":405,"end":412},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T25","span":{"begin":616,"end":622},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T26","span":{"begin":669,"end":673},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T27","span":{"begin":745,"end":749},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":264,"end":272},"obj":"Chemical"},{"id":"T2","span":{"begin":274,"end":276},"obj":"Chemical"},{"id":"T5","span":{"begin":317,"end":319},"obj":"Chemical"},{"id":"T8","span":{"begin":427,"end":429},"obj":"Chemical"},{"id":"T11","span":{"begin":555,"end":564},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_30512"},{"id":"A3","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_9141"},{"id":"A4","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_30512"},{"id":"A6","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_9141"},{"id":"A7","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_30512"},{"id":"A9","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_9141"},{"id":"A10","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":199,"end":208},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T5","span":{"begin":616,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0030183"},{"id":"T6","span":{"begin":618,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0048468"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T22","span":{"begin":0,"end":113},"obj":"Sentence"},{"id":"T23","span":{"begin":114,"end":282},"obj":"Sentence"},{"id":"T24","span":{"begin":283,"end":381},"obj":"Sentence"},{"id":"T25","span":{"begin":382,"end":466},"obj":"Sentence"},{"id":"T26","span":{"begin":467,"end":596},"obj":"Sentence"},{"id":"T27","span":{"begin":597,"end":768},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}

{"project":"2_test","denotations":[{"id":"32450171-27784796-66454436","span":{"begin":279,"end":280},"obj":"27784796"},{"id":"32450171-12185262-66454437","span":{"begin":463,"end":464},"obj":"12185262"},{"id":"32450171-24441474-66454438","span":{"begin":765,"end":766},"obj":"24441474"}],"text":"In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion. Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2]. More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags. During an Ab response, B-cells which express Ag receptors are clonally expanded [3]. Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ). In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4]."}