PMC:7243778 / 18980-19709 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"469","span":{"begin":204,"end":226},"obj":"Gene"},{"id":"470","span":{"begin":228,"end":232},"obj":"Gene"},{"id":"471","span":{"begin":282,"end":286},"obj":"Gene"},{"id":"472","span":{"begin":315,"end":316},"obj":"Gene"},{"id":"473","span":{"begin":14,"end":22},"obj":"Species"},{"id":"474","span":{"begin":86,"end":102},"obj":"Species"},{"id":"475","span":{"begin":109,"end":117},"obj":"Species"},{"id":"476","span":{"begin":290,"end":298},"obj":"Species"},{"id":"477","span":{"begin":303,"end":313},"obj":"Species"},{"id":"478","span":{"begin":410,"end":418},"obj":"Species"},{"id":"479","span":{"begin":451,"end":460},"obj":"Species"}],"attributes":[{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"Gene:1803"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"Gene:1803"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"Gene:59272"},{"id":"A472","pred":"tao:has_database_id","subj":"472","obj":"Gene:43740568"},{"id":"A473","pred":"tao:has_database_id","subj":"473","obj":"Tax:1335626"},{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"Tax:694002"},{"id":"A475","pred":"tao:has_database_id","subj":"475","obj":"Tax:1335626"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"Tax:694009"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"Tax:2697049"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"Tax:1335626"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T81","span":{"begin":82,"end":85},"obj":"Body_part"},{"id":"T82","span":{"begin":133,"end":140},"obj":"Body_part"},{"id":"T83","span":{"begin":153,"end":157},"obj":"Body_part"},{"id":"T84","span":{"begin":241,"end":257},"obj":"Body_part"},{"id":"T85","span":{"begin":252,"end":257},"obj":"Body_part"},{"id":"T86","span":{"begin":317,"end":324},"obj":"Body_part"},{"id":"T87","span":{"begin":377,"end":384},"obj":"Body_part"},{"id":"T88","span":{"begin":421,"end":428},"obj":"Body_part"},{"id":"T89","span":{"begin":659,"end":666},"obj":"Body_part"}],"attributes":[{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":290,"end":298},"obj":"Disease"},{"id":"T65","span":{"begin":303,"end":311},"obj":"Disease"},{"id":"T66","span":{"begin":451,"end":455},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T250","span":{"begin":26,"end":27},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T251","span":{"begin":153,"end":157},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T252","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T253","span":{"begin":491,"end":493},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T254","span":{"begin":521,"end":529},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T255","span":{"begin":547,"end":549},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T256","span":{"begin":547,"end":549},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T257","span":{"begin":561,"end":562},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T258","span":{"begin":579,"end":586},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T117","span":{"begin":86,"end":90},"obj":"Chemical"},{"id":"T118","span":{"begin":133,"end":140},"obj":"Chemical"},{"id":"T119","span":{"begin":317,"end":324},"obj":"Chemical"},{"id":"T120","span":{"begin":377,"end":384},"obj":"Chemical"},{"id":"T121","span":{"begin":421,"end":428},"obj":"Chemical"},{"id":"T122","span":{"begin":547,"end":549},"obj":"Chemical"},{"id":"T123","span":{"begin":579,"end":586},"obj":"Chemical"},{"id":"T124","span":{"begin":659,"end":666},"obj":"Chemical"}],"attributes":[{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T150","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T151","span":{"begin":109,"end":314},"obj":"Sentence"},{"id":"T152","span":{"begin":315,"end":390},"obj":"Sentence"},{"id":"T153","span":{"begin":391,"end":651},"obj":"Sentence"},{"id":"T154","span":{"begin":652,"end":729},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}

{"project":"2_test","denotations":[{"id":"32450171-23075143-66454489","span":{"begin":104,"end":106},"obj":"23075143"},{"id":"32450171-27083424-66454490","span":{"begin":386,"end":388},"obj":"27083424"},{"id":"32450171-23835475-66454491","span":{"begin":725,"end":727},"obj":"23835475"}],"text":"Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62]."}