PMC:7243778 / 17978-21850 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243778","sourcedb":"PMC","sourceid":"7243778","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243778","text":"5 MERS-CoV: from 2012 to present\nMERS-CoV, a zoonotic virus, belonging to lineage C in the genre betacoronavirus of the family Coronaviridae, caused the Middle East respiratory syndrome, in 2012. As of August 11, 2016, the virus had infected 1791 patients, with a mortality rate of 35.6% [53]. The natural reservoir of MERS-CoV is assumedly bats whereas intermediate host is possibly dromedary camels [[54], [55], [56], [57]]. BtCoV-HKU4 and BtCoV-HKU5 bat viruses have been shown to be the closest phylogenetically even if these viruses are not direct ancestors [15]. The first transmission of a bat virus to camels for an adaptation before its emergence into human was suggested. nAbs anti-MERS-CoV could accordingly be found in camels. Moreover, the viruses circulating in dromedaries and in humans are very close suggesting that the dromedary is a reservoir of the virus [58,59]. The genomic structures of bat, human and camel MERS-CoVs are similar but their genomic sequences are different [16].\nStructurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60]. MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2. S protein is therefore the most exposed and immunogenic viral protein [61]. The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2. This S protein is also the target to develop nAbs, particularly the RBD [62].\nUsing the fragment containing residues 358–588 of S protein, the neutralization against MERS-CoV of induced Abs were observed [63]. Other studies, also approaching RBD, reported the generated Abs with the epitopes aa 377–662 or aa 377–588 of MERS-CoV RBD. The latter elicited the strongest effect which effectively neutralized MERS-CoV infection [64,65]. The epitope aa 736–761 also induced nAbs [66].\nUsing a novel panning strategy, seven anti-S1 scFvs Abs, named 1E9, 1F8, 3A1, 3B12, 3C12, 3B11, and M14D3, which bind one or several of these three different epitopes (aa 21–358, 349–751 and 349–590) were identified. They neutralized MERS-CoV infection at nanomolar of concentration [67].\nOther Abs, such as MERS-4 and its variant MERS-4 V2, were intriguingly discovered to bind RBD and compete with DPP4 but from outside. MERS-4 Fab and MERS-4V2 scFv interact with β5-β6, β6-β7, and β7-β8 loops of RBD resulting in the inhibition of MERS-CoV infection [68,69].\nThree human monoclonal Abs, m336, m337, and m338 bind RBD of MERS-CoV at extremely low concentration, 4.2, 9.3, and 15 nM, respectively. m336, that neutralized 50% of both pseudotyped and live MERS-CoV at 0.005 and 0.07 μg/mL, respectively, suggested the prophylaxis and therapy of MERS-CoV infection [70].\nIn another study, using MERS-RBD to immunize mice, two monoclonal nAbs 4C2 and 2E6 recognizing an epitope that partially overlaps the receptor-binding footprint in MERS-CoV RBD were identified. The 4C2 could further reduce the number of viral particles in MERS-CoV infected mice [71].\nRecently, other nAbs, such as human mAbs or Fabs (MERS-27, MERS-GD27, or MCA1), humanized mAbs (hMS-1, 4C2 h), mouse mAbs (Mersmab1, 4C2, or D12), single-domain antibodies (nanobodies Nbs) HCAb-83 or NbMS10-Fc and transchromosomic cattle antibody SAB-301 recognizing epitopes on the RBD have been demonstrated to neutralize pseudotyped and/or live MERS-CoVs [31]. Only SAB-301 is under phase I clinical trial [72].\nDespite the efforts of scientists to find anti-MERS-CoV antibodies, no vaccine has been found yet and the virus continues to circulate in human beings and other species.","divisions":[{"label":"label","span":{"begin":0,"end":1}},{"label":"title","span":{"begin":3,"end":33}},{"label":"p","span":{"begin":34,"end":1001}},{"label":"p","span":{"begin":1002,"end":1731}},{"label":"p","span":{"begin":1732,"end":2133}},{"label":"p","span":{"begin":2134,"end":2422}},{"label":"p","span":{"begin":2423,"end":2695}},{"label":"p","span":{"begin":2696,"end":3002}},{"label":"p","span":{"begin":3003,"end":3287}},{"label":"p","span":{"begin":3288,"end":3702}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"413","span":{"begin":3,"end":11},"obj":"Species"},{"id":"436","span":{"begin":34,"end":42},"obj":"Species"},{"id":"437","span":{"begin":98,"end":113},"obj":"Species"},{"id":"438","span":{"begin":128,"end":141},"obj":"Species"},{"id":"439","span":{"begin":248,"end":256},"obj":"Species"},{"id":"440","span":{"begin":320,"end":328},"obj":"Species"},{"id":"441","span":{"begin":385,"end":394},"obj":"Species"},{"id":"442","span":{"begin":395,"end":401},"obj":"Species"},{"id":"443","span":{"begin":611,"end":617},"obj":"Species"},{"id":"444","span":{"begin":662,"end":667},"obj":"Species"},{"id":"445","span":{"begin":732,"end":738},"obj":"Species"},{"id":"446","span":{"begin":777,"end":788},"obj":"Species"},{"id":"447","span":{"begin":796,"end":802},"obj":"Species"},{"id":"448","span":{"begin":838,"end":847},"obj":"Species"},{"id":"449","span":{"begin":916,"end":921},"obj":"Species"},{"id":"450","span":{"begin":926,"end":931},"obj":"Species"},{"id":"451","span":{"begin":932,"end":941},"obj":"Species"},{"id":"452","span":{"begin":434,"end":438},"obj":"Species"},{"id":"453","span":{"begin":449,"end":453},"obj":"Species"},{"id":"454","span":{"begin":693,"end":701},"obj":"Species"},{"id":"455","span":{"begin":46,"end":54},"obj":"Disease"},{"id":"456","span":{"begin":234,"end":242},"obj":"Disease"},{"id":"457","span":{"begin":265,"end":274},"obj":"Disease"},{"id":"469","span":{"begin":1206,"end":1228},"obj":"Gene"},{"id":"470","span":{"begin":1230,"end":1234},"obj":"Gene"},{"id":"471","span":{"begin":1284,"end":1288},"obj":"Gene"},{"id":"472","span":{"begin":1317,"end":1318},"obj":"Gene"},{"id":"473","span":{"begin":1016,"end":1024},"obj":"Species"},{"id":"474","span":{"begin":1088,"end":1104},"obj":"Species"},{"id":"475","span":{"begin":1111,"end":1119},"obj":"Species"},{"id":"476","span":{"begin":1292,"end":1300},"obj":"Species"},{"id":"477","span":{"begin":1305,"end":1315},"obj":"Species"},{"id":"478","span":{"begin":1412,"end":1420},"obj":"Species"},{"id":"479","span":{"begin":1453,"end":1462},"obj":"Species"},{"id":"483","span":{"begin":1820,"end":1828},"obj":"Species"},{"id":"484","span":{"begin":1974,"end":1982},"obj":"Species"},{"id":"485","span":{"begin":2064,"end":2077},"obj":"Disease"},{"id":"487","span":{"begin":2368,"end":2386},"obj":"Disease"},{"id":"492","span":{"begin":2534,"end":2538},"obj":"Gene"},{"id":"493","span":{"begin":2564,"end":2567},"obj":"Gene"},{"id":"494","span":{"begin":2581,"end":2585},"obj":"Gene"},{"id":"495","span":{"begin":2673,"end":2686},"obj":"Disease"},{"id":"500","span":{"begin":2757,"end":2765},"obj":"Species"},{"id":"501","span":{"begin":2889,"end":2897},"obj":"Species"},{"id":"502","span":{"begin":2702,"end":2707},"obj":"Species"},{"id":"503","span":{"begin":2983,"end":2996},"obj":"Disease"},{"id":"508","span":{"begin":3167,"end":3175},"obj":"Species"},{"id":"509","span":{"begin":3277,"end":3281},"obj":"Species"},{"id":"510","span":{"begin":3048,"end":3052},"obj":"Species"},{"id":"511","span":{"begin":3264,"end":3276},"obj":"Disease"},{"id":"516","span":{"begin":3318,"end":3323},"obj":"Species"},{"id":"517","span":{"begin":3399,"end":3404},"obj":"Species"},{"id":"518","span":{"begin":3636,"end":3645},"obj":"Species"},{"id":"519","span":{"begin":3657,"end":3664},"obj":"Chemical"},{"id":"522","span":{"begin":3841,"end":3846},"obj":"Species"},{"id":"523","span":{"begin":3750,"end":3758},"obj":"Species"}],"attributes":[{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"Tax:1335626"},{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Tax:1335626"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Tax:694002"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"Tax:11118"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Tax:9606"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Tax:1335626"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Tax:9838"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Tax:9838"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Tax:9838"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Tax:9606"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"Tax:9838"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"Tax:9838"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"Tax:9606"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"Tax:9838"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"Tax:9606"},{"id":"A450","pred":"tao:has_database_id","subj":"450","obj":"Tax:9838"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"Tax:1335626"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"Tax:694007"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"Tax:290028"},{"id":"A454","pred":"tao:has_database_id","subj":"454","obj":"Tax:1335626"},{"id":"A455","pred":"tao:has_database_id","subj":"455","obj":"MESH:D015047"},{"id":"A456","pred":"tao:has_database_id","subj":"456","obj":"MESH:D007239"},{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"MESH:D003643"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"Gene:1803"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"Gene:1803"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"Gene:59272"},{"id":"A472","pred":"tao:has_database_id","subj":"472","obj":"Gene:43740568"},{"id":"A473","pred":"tao:has_database_id","subj":"473","obj":"Tax:1335626"},{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"Tax:694002"},{"id":"A475","pred":"tao:has_database_id","subj":"475","obj":"Tax:1335626"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"Tax:694009"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"Tax:2697049"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"Tax:1335626"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"Tax:694009"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"Tax:1335626"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"Tax:1335626"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"MESH:D018352"},{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"MESH:D018352"},{"id":"A492","pred":"tao:has_database_id","subj":"492","obj":"Gene:1803"},{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"Gene:2187"},{"id":"A494","pred":"tao:has_database_id","subj":"494","obj":"Gene:652070"},{"id":"A495","pred":"tao:has_database_id","subj":"495","obj":"MESH:D018352"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"Tax:1335626"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"Tax:1335626"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"Tax:9606"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"MESH:D018352"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"Tax:1335626"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"Tax:10090"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"Tax:10090"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"MESH:D018352"},{"id":"A516","pred":"tao:has_database_id","subj":"516","obj":"Tax:9606"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"Tax:10090"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Tax:1335626"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"Tax:9606"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"Tax:1335626"},{"subj":"413","pred":"source","obj":"LitCovid-PubTator"},{"subj":"436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"438","pred":"source","obj":"LitCovid-PubTator"},{"subj":"439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"453","pred":"source","obj":"LitCovid-PubTator"},{"subj":"454","pred":"source","obj":"LitCovid-PubTator"},{"subj":"455","pred":"source","obj":"LitCovid-PubTator"},{"subj":"456","pred":"source","obj":"LitCovid-PubTator"},{"subj":"457","pred":"source","obj":"LitCovid-PubTator"},{"subj":"469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"471","pred":"source","obj":"LitCovid-PubTator"},{"subj":"472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"473","pred":"source","obj":"LitCovid-PubTator"},{"subj":"474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"479","pred":"source","obj":"LitCovid-PubTator"},{"subj":"483","pred":"source","obj":"LitCovid-PubTator"},{"subj":"484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"485","pred":"source","obj":"LitCovid-PubTator"},{"subj":"487","pred":"source","obj":"LitCovid-PubTator"},{"subj":"492","pred":"source","obj":"LitCovid-PubTator"},{"subj":"493","pred":"source","obj":"LitCovid-PubTator"},{"subj":"494","pred":"source","obj":"LitCovid-PubTator"},{"subj":"495","pred":"source","obj":"LitCovid-PubTator"},{"subj":"500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"502","pred":"source","obj":"LitCovid-PubTator"},{"subj":"503","pred":"source","obj":"LitCovid-PubTator"},{"subj":"508","pred":"source","obj":"LitCovid-PubTator"},{"subj":"509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"516","pred":"source","obj":"LitCovid-PubTator"},{"subj":"517","pred":"source","obj":"LitCovid-PubTator"},{"subj":"518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"519","pred":"source","obj":"LitCovid-PubTator"},{"subj":"522","pred":"source","obj":"LitCovid-PubTator"},{"subj":"523","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T81","span":{"begin":1084,"end":1087},"obj":"Body_part"},{"id":"T82","span":{"begin":1135,"end":1142},"obj":"Body_part"},{"id":"T83","span":{"begin":1155,"end":1159},"obj":"Body_part"},{"id":"T84","span":{"begin":1243,"end":1259},"obj":"Body_part"},{"id":"T85","span":{"begin":1254,"end":1259},"obj":"Body_part"},{"id":"T86","span":{"begin":1319,"end":1326},"obj":"Body_part"},{"id":"T87","span":{"begin":1379,"end":1386},"obj":"Body_part"},{"id":"T88","span":{"begin":1423,"end":1430},"obj":"Body_part"},{"id":"T89","span":{"begin":1661,"end":1668},"obj":"Body_part"},{"id":"T90","span":{"begin":1784,"end":1791},"obj":"Body_part"},{"id":"T91","span":{"begin":2472,"end":2474},"obj":"Body_part"},{"id":"T93","span":{"begin":3526,"end":3534},"obj":"Body_part"}],"attributes":[{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma13443"},{"id":"A92","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma68615"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":1292,"end":1300},"obj":"Disease"},{"id":"T65","span":{"begin":1305,"end":1313},"obj":"Disease"},{"id":"T66","span":{"begin":1453,"end":1457},"obj":"Disease"},{"id":"T67","span":{"begin":2068,"end":2077},"obj":"Disease"},{"id":"T68","span":{"begin":2377,"end":2386},"obj":"Disease"},{"id":"T69","span":{"begin":2677,"end":2686},"obj":"Disease"},{"id":"T70","span":{"begin":2987,"end":2996},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T227","span":{"begin":44,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T228","span":{"begin":55,"end":60},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T229","span":{"begin":210,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T230","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T231","span":{"begin":263,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T232","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T233","span":{"begin":395,"end":401},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9837"},{"id":"T234","span":{"begin":454,"end":457},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T235","span":{"begin":458,"end":465},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T236","span":{"begin":531,"end":538},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T237","span":{"begin":596,"end":597},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T238","span":{"begin":598,"end":601},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T239","span":{"begin":602,"end":607},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T240","span":{"begin":611,"end":617},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9837"},{"id":"T241","span":{"begin":662,"end":667},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T242","span":{"begin":732,"end":738},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9837"},{"id":"T243","span":{"begin":754,"end":761},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T244","span":{"begin":796,"end":802},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T245","span":{"begin":851,"end":852},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T246","span":{"begin":870,"end":875},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T247","span":{"begin":911,"end":914},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T248","span":{"begin":916,"end":921},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T249","span":{"begin":926,"end":931},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9837"},{"id":"T250","span":{"begin":1028,"end":1029},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T251","span":{"begin":1155,"end":1159},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T252","span":{"begin":1254,"end":1259},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T253","span":{"begin":1493,"end":1495},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T254","span":{"begin":1523,"end":1531},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T255","span":{"begin":1549,"end":1551},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T256","span":{"begin":1549,"end":1551},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T257","span":{"begin":1563,"end":1564},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T258","span":{"begin":1581,"end":1588},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T259","span":{"begin":1946,"end":1948},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T260","span":{"begin":1960,"end":1962},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T261","span":{"begin":2099,"end":2101},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T262","span":{"begin":2140,"end":2141},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T263","span":{"begin":2177,"end":2179},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T264","span":{"begin":2224,"end":2228},"obj":"http://purl.obolibrary.org/obo/CLO_0001329"},{"id":"T265","span":{"begin":2302,"end":2304},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T266","span":{"begin":2702,"end":2707},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T267","span":{"begin":2769,"end":2778},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T268","span":{"begin":3082,"end":3085},"obj":"http://purl.obolibrary.org/obo/CLO_0001258"},{"id":"T269","span":{"begin":3283,"end":3285},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T270","span":{"begin":3318,"end":3323},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T271","span":{"begin":3343,"end":3345},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T272","span":{"begin":3368,"end":3377},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T273","span":{"begin":3399,"end":3404},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T274","span":{"begin":3495,"end":3497},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T275","span":{"begin":3782,"end":3785},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T276","span":{"begin":3809,"end":3814},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T277","span":{"begin":3841,"end":3853},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T227","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T117","span":{"begin":1088,"end":1092},"obj":"Chemical"},{"id":"T118","span":{"begin":1135,"end":1142},"obj":"Chemical"},{"id":"T119","span":{"begin":1319,"end":1326},"obj":"Chemical"},{"id":"T120","span":{"begin":1379,"end":1386},"obj":"Chemical"},{"id":"T121","span":{"begin":1423,"end":1430},"obj":"Chemical"},{"id":"T122","span":{"begin":1549,"end":1551},"obj":"Chemical"},{"id":"T123","span":{"begin":1581,"end":1588},"obj":"Chemical"},{"id":"T124","span":{"begin":1661,"end":1668},"obj":"Chemical"},{"id":"T125","span":{"begin":1784,"end":1791},"obj":"Chemical"},{"id":"T126","span":{"begin":2091,"end":2098},"obj":"Chemical"},{"id":"T127","span":{"begin":3101,"end":3108},"obj":"Chemical"}],"attributes":[{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T142","span":{"begin":0,"end":33},"obj":"Sentence"},{"id":"T143","span":{"begin":34,"end":196},"obj":"Sentence"},{"id":"T144","span":{"begin":197,"end":294},"obj":"Sentence"},{"id":"T145","span":{"begin":295,"end":427},"obj":"Sentence"},{"id":"T146","span":{"begin":428,"end":569},"obj":"Sentence"},{"id":"T147","span":{"begin":570,"end":739},"obj":"Sentence"},{"id":"T148","span":{"begin":740,"end":884},"obj":"Sentence"},{"id":"T149","span":{"begin":885,"end":1001},"obj":"Sentence"},{"id":"T150","span":{"begin":1002,"end":1110},"obj":"Sentence"},{"id":"T151","span":{"begin":1111,"end":1316},"obj":"Sentence"},{"id":"T152","span":{"begin":1317,"end":1392},"obj":"Sentence"},{"id":"T153","span":{"begin":1393,"end":1653},"obj":"Sentence"},{"id":"T154","span":{"begin":1654,"end":1731},"obj":"Sentence"},{"id":"T155","span":{"begin":1732,"end":1863},"obj":"Sentence"},{"id":"T156","span":{"begin":1864,"end":1987},"obj":"Sentence"},{"id":"T157","span":{"begin":1988,"end":2086},"obj":"Sentence"},{"id":"T158","span":{"begin":2087,"end":2133},"obj":"Sentence"},{"id":"T159","span":{"begin":2134,"end":2350},"obj":"Sentence"},{"id":"T160","span":{"begin":2351,"end":2422},"obj":"Sentence"},{"id":"T161","span":{"begin":2423,"end":2556},"obj":"Sentence"},{"id":"T162","span":{"begin":2557,"end":2695},"obj":"Sentence"},{"id":"T163","span":{"begin":2696,"end":3002},"obj":"Sentence"},{"id":"T164","span":{"begin":3003,"end":3196},"obj":"Sentence"},{"id":"T165","span":{"begin":3197,"end":3287},"obj":"Sentence"},{"id":"T166","span":{"begin":3288,"end":3651},"obj":"Sentence"},{"id":"T167","span":{"begin":3652,"end":3702},"obj":"Sentence"},{"id":"T168","span":{"begin":3703,"end":3872},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T142","pred":"source","obj":"LitCovid-sentences"},{"subj":"T143","pred":"source","obj":"LitCovid-sentences"},{"subj":"T144","pred":"source","obj":"LitCovid-sentences"},{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"},{"subj":"T148","pred":"source","obj":"LitCovid-sentences"},{"subj":"T149","pred":"source","obj":"LitCovid-sentences"},{"subj":"T150","pred":"source","obj":"LitCovid-sentences"},{"subj":"T151","pred":"source","obj":"LitCovid-sentences"},{"subj":"T152","pred":"source","obj":"LitCovid-sentences"},{"subj":"T153","pred":"source","obj":"LitCovid-sentences"},{"subj":"T154","pred":"source","obj":"LitCovid-sentences"},{"subj":"T155","pred":"source","obj":"LitCovid-sentences"},{"subj":"T156","pred":"source","obj":"LitCovid-sentences"},{"subj":"T157","pred":"source","obj":"LitCovid-sentences"},{"subj":"T158","pred":"source","obj":"LitCovid-sentences"},{"subj":"T159","pred":"source","obj":"LitCovid-sentences"},{"subj":"T160","pred":"source","obj":"LitCovid-sentences"},{"subj":"T161","pred":"source","obj":"LitCovid-sentences"},{"subj":"T162","pred":"source","obj":"LitCovid-sentences"},{"subj":"T163","pred":"source","obj":"LitCovid-sentences"},{"subj":"T164","pred":"source","obj":"LitCovid-sentences"},{"subj":"T165","pred":"source","obj":"LitCovid-sentences"},{"subj":"T166","pred":"source","obj":"LitCovid-sentences"},{"subj":"T167","pred":"source","obj":"LitCovid-sentences"},{"subj":"T168","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32450171-27576010-66454480","span":{"begin":290,"end":292},"obj":"27576010"},{"id":"32450171-26414077-66454481","span":{"begin":404,"end":406},"obj":"26414077"},{"id":"32450171-23622767-66454482","span":{"begin":410,"end":412},"obj":"23622767"},{"id":"32450171-24206838-66454483","span":{"begin":416,"end":418},"obj":"24206838"},{"id":"32450171-23831647-66454484","span":{"begin":422,"end":424},"obj":"23831647"},{"id":"32450171-25211075-66454485","span":{"begin":565,"end":567},"obj":"25211075"},{"id":"32450171-23933067-66454486","span":{"begin":877,"end":879},"obj":"23933067"},{"id":"32450171-25810418-66454487","span":{"begin":880,"end":882},"obj":"25810418"},{"id":"32450171-30531947-66454488","span":{"begin":997,"end":999},"obj":"30531947"},{"id":"32450171-23075143-66454489","span":{"begin":1106,"end":1108},"obj":"23075143"},{"id":"32450171-27083424-66454490","span":{"begin":1388,"end":1390},"obj":"27083424"},{"id":"32450171-23835475-66454491","span":{"begin":1727,"end":1729},"obj":"23835475"},{"id":"32450171-23785207-66454492","span":{"begin":1859,"end":1861},"obj":"23785207"},{"id":"32450171-23824801-66454493","span":{"begin":2079,"end":2081},"obj":"23824801"},{"id":"32450171-25387086-66454494","span":{"begin":2129,"end":2131},"obj":"25387086"},{"id":"32450171-29996104-66454495","span":{"begin":2691,"end":2693},"obj":"29996104"},{"id":"32450171-24789777-66454496","span":{"begin":2998,"end":3000},"obj":"24789777"},{"id":"32450171-26391698-66454497","span":{"begin":3283,"end":3285},"obj":"26391698"}],"attributes":[{"subj":"32450171-27576010-66454480","pred":"source","obj":"2_test"},{"subj":"32450171-26414077-66454481","pred":"source","obj":"2_test"},{"subj":"32450171-23622767-66454482","pred":"source","obj":"2_test"},{"subj":"32450171-24206838-66454483","pred":"source","obj":"2_test"},{"subj":"32450171-23831647-66454484","pred":"source","obj":"2_test"},{"subj":"32450171-25211075-66454485","pred":"source","obj":"2_test"},{"subj":"32450171-23933067-66454486","pred":"source","obj":"2_test"},{"subj":"32450171-25810418-66454487","pred":"source","obj":"2_test"},{"subj":"32450171-30531947-66454488","pred":"source","obj":"2_test"},{"subj":"32450171-23075143-66454489","pred":"source","obj":"2_test"},{"subj":"32450171-27083424-66454490","pred":"source","obj":"2_test"},{"subj":"32450171-23835475-66454491","pred":"source","obj":"2_test"},{"subj":"32450171-23785207-66454492","pred":"source","obj":"2_test"},{"subj":"32450171-23824801-66454493","pred":"source","obj":"2_test"},{"subj":"32450171-25387086-66454494","pred":"source","obj":"2_test"},{"subj":"32450171-29996104-66454495","pred":"source","obj":"2_test"},{"subj":"32450171-24789777-66454496","pred":"source","obj":"2_test"},{"subj":"32450171-26391698-66454497","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93bcec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d6ec93"},{"id":"LitCovid-PD-MONDO","color":"#e893ec"},{"id":"LitCovid-PD-CLO","color":"#93ecce"},{"id":"LitCovid-PD-CHEBI","color":"#ecb493"},{"id":"LitCovid-sentences","color":"#9a93ec"},{"id":"2_test","color":"#a5ec93"}]}]}}