PMC:7243778 / 1176-2103 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243778","sourcedb":"PMC","sourceid":"7243778","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243778","text":"1 Introduction\nIn full social distancing crisis, far from lab work, in looking anxiously at the red dots growing every day in the graphic map of coronavirus disease 2019 (COVID-19) pandemic [1], we wonder how were the other major pandemics and how antibodies, natural or artificial, can fight the diseases.\nSeveral pandemics have occurred throughout history, some had more effects on human's life and/or on economics than the others. As scientists, a key step in vaccines research is to learn from the past. By that mean, what we are doing now might be cornerstone preparing us for future pandemics.\nIn this review, we look for the diversity and variability of coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, which cause pandemics from 21th century. The origins, impacts and molecular structure with insights of vulnerable sites of viruses who are targets of antibodies and its humoral responses will be 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