> top > docs > PMC:7243778 > spans > 10445-15904 > annotations

PMC:7243778 / 10445-15904 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
225 518-526 Species denotes SARS-CoV Tax:694009
226 528-536 Species denotes MERS-CoV Tax:1335626
227 545-562 Species denotes novel coronavirus Tax:2697049
228 563-573 Species denotes SARS-CoV-2 Tax:2697049
229 65-81 Disease denotes viral infections MESH:D001102
230 295-303 Disease denotes infected MESH:D007239
231 421-430 Disease denotes infection MESH:D007239
240 1256-1264 Species denotes SARS-CoV Tax:694009
241 1266-1274 Species denotes MERS-CoV Tax:1335626
242 1276-1286 Species denotes SARS-CoV-2 Tax:2697049
243 1605-1613 Species denotes SARS-CoV Tax:694009
244 1618-1628 Species denotes SARS-CoV-2 Tax:2697049
245 1658-1666 Species denotes SARS-CoV Tax:694009
246 1682-1690 Species denotes MERS-CoV Tax:1335626
247 1701-1711 Species denotes SARS-CoV-2 Tax:2697049
252 715-723 Species denotes SARS-CoV Tax:694009
253 823-831 Species denotes SARS-CoV Tax:694009
254 1101-1109 Species denotes SARS-CoV Tax:694009
255 1142-1150 Species denotes SARS-CoV Tax:694009
287 1850-1854 Gene denotes scFv Gene:652070
288 1877-1880 Gene denotes ACE Gene:1636
289 2163-2167 Gene denotes scFv Gene:652070
290 2903-2907 Gene denotes scFv Gene:652070
291 3213-3217 Gene denotes scFv Gene:652070
292 2470-2473 Gene denotes fab Gene:2187
293 1805-1810 Species denotes human Tax:9606
294 2065-2075 Species denotes SARS-CoV-2 Tax:2697049
295 2608-2616 Species denotes SARS-CoV Tax:694009
296 2792-2800 Species denotes SARS-CoV Tax:694009
297 2971-2979 Species denotes SARS-CoV Tax:694009
298 3176-3186 Species denotes SARS-CoV-2 Tax:2697049
299 3261-3269 Species denotes SARS-CoV Tax:694009
300 3352-3360 Species denotes SARS-CoV Tax:694009
301 2455-2460 Species denotes human Tax:9606
302 2872-2877 Species denotes human Tax:9606
303 3124-3132 Species denotes SARS-CoV Tax:694009
304 2740-2744 Gene denotes S3.1 Gene:3354
305 2001-2007 Chemical denotes lysine MESH:D008239
306 2131-2134 Chemical denotes nAb
307 2304-2307 Chemical denotes 80R
308 2600-2604 Chemical denotes D408
309 2627-2631 Chemical denotes m396
310 2918-2924 Chemical denotes CR3014
311 3027-3033 Chemical denotes CR3014
312 3193-3199 Chemical denotes CR3022
313 3342-3348 Chemical denotes CR3014
314 2398-2403 Mutation denotes D480A p.D480A
315 2281-2286 Mutation denotes D480A p.D480A
316 3384-3389 Mutation denotes P426L p.P426L
317 3039-3044 Mutation denotes P426L p.P426L
326 3717-3721 Gene denotes ACE2 Gene:59272
327 3795-3796 Gene denotes N Gene:43740575
328 3961-3962 Gene denotes S Gene:43740568
329 3439-3444 Species denotes mouse Tax:10090
330 3483-3488 Species denotes human Tax:9606
331 4005-4013 Species denotes SARS-CoV Tax:694009
332 3591-3594 CellLine denotes H12 CVCL:G696
333 4171-4174 CellLine denotes H12 CVCL:G696
339 4333-4337 Gene denotes ACE2 Gene:59272
340 4492-4496 Gene denotes ACE2 Gene:59272
341 4455-4456 Gene denotes N Gene:43740575
342 4274-4289 Species denotes transgenic mice Tax:10090
343 4248-4253 Species denotes human Tax:9606
347 4555-4559 Species denotes mice Tax:10090
348 4630-4638 Species denotes SARS-CoV Tax:694009
349 4789-4797 Species denotes SARS-CoV Tax:694009
358 4985-4990 Gene denotes ACE-2 Gene:59272
359 4938-4948 Species denotes SARS-CoV-2 Tax:2697049
360 5057-5067 Species denotes SARS-CoV-2 Tax:2697049
361 5131-5148 Species denotes novel coronavirus Tax:2697049
362 4875-4883 Species denotes SARS-CoV Tax:694009
363 4884-4889 Species denotes mouse Tax:10090
364 5024-5030 Chemical denotes CR3022
365 5082-5088 Chemical denotes CR3022
370 5212-5216 Gene denotes S3.1 Gene:3354
371 5285-5290 Species denotes human Tax:9606
372 5402-5410 Species denotes SARS-CoV Tax:694009
373 5183-5188 Species denotes human Tax:9606

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T46 233-238 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47 304-309 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 743-754 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T49 776-783 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 807-819 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T51 1245-1252 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 1783-1792 Body_part denotes Cytoplasm http://purl.org/sig/ont/fma/fma66835
T53 1856-1864 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T54 2001-2007 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T55 2461-2469 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T56 2834-2838 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T57 2889-2897 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T58 3063-3075 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T59 3165-3172 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 3445-3459 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T61 3489-3503 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T62 3899-3910 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T63 3963-3970 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 4064-4072 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 4362-4369 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 4890-4898 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T67 5293-5298 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 5430-5434 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T27 65-81 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T28 421-430 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 518-526 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 563-571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 715-723 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 823-831 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 1101-1109 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 1142-1150 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 1256-1264 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 1276-1284 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 1605-1613 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 1618-1626 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 1658-1666 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 1701-1709 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 2065-2073 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 2608-2616 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 2792-2800 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 2971-2979 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 3124-3132 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 3176-3184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 3261-3269 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 3352-3360 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 4005-4013 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 4630-4638 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 4789-4797 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 4875-4883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 4938-4946 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 5057-5065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 5402-5410 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T123 10-12 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T124 195-202 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T125 233-238 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 304-309 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T127 355-357 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T128 456-458 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T129 582-584 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T130 930-932 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T131 1024-1026 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T132 1024-1026 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T133 1073-1074 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 1717-1723 http://purl.obolibrary.org/obo/SO_0000418 denotes Signal
T135 1724-1731 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T136 1744-1751 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T137 1779-1781 http://purl.obolibrary.org/obo/PR_000005794 denotes CP
T138 1805-1810 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 1906-1908 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T140 2111-2116 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T141 2118-2120 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T142 2150-2151 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 2379-2380 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 2438-2440 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T145 2445-2448 http://purl.obolibrary.org/obo/CLO_0054064 denotes 491
T146 2455-2460 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T147 2502-2504 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T148 2539-2540 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 2622-2624 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T150 2859-2861 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T151 2872-2877 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T152 2934-2936 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T153 3010-3015 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 3188-3190 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T155 3283-3285 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T156 3303-3304 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T157 3439-3444 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T158 3460-3465 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T159 3480-3488 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes by human
T160 3504-3509 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T161 3538-3540 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T162 3553-3555 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T163 3632-3635 http://purl.obolibrary.org/obo/CLO_0001435 denotes 5E4
T164 3675-3677 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T165 3696-3701 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T166 3769-3771 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T167 3914-3916 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T168 4055-4057 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T169 4061-4063 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T170 4061-4063 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T171 4086-4088 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T172 4248-4253 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T173 4359-4361 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T174 4385-4387 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T175 4437-4439 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T176 4506-4508 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T177 4679-4681 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T178 4742-4744 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T179 4870-4872 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T180 4884-4889 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T181 4909-4910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 5009-5011 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T183 5036-5039 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T184 5112-5120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T185 5150-5152 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T186 5183-5188 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T187 5261-5266 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T188 5285-5290 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T189 5291-5298 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T190 5353-5361 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T191 5455-5457 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T43 224-232 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T44 743-754 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T45 743-748 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T46 749-754 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T47 776-783 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 807-819 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T49 1024-1026 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T50 1245-1252 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 1713-1715 Chemical denotes SP http://purl.obolibrary.org/obo/CHEBI_74820
T52 1724-1731 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T53 1733-1735 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T54 1744-1751 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T55 1753-1755 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T57 1779-1781 Chemical denotes CP http://purl.obolibrary.org/obo/CHEBI_3380|http://purl.obolibrary.org/obo/CHEBI_73461
T59 1898-1905 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T60 2001-2007 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T62 2030-2037 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T63 2205-2212 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T64 2430-2437 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T65 2541-2545 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T67 2926-2933 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T68 3063-3075 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T69 3165-3172 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 3275-3282 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T71 3760-3767 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T72 3899-3910 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T73 3899-3904 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T74 3905-3910 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T75 3963-3970 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 4061-4063 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T77 4064-4072 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T78 4362-4369 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 4377-4384 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T80 4429-4436 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T81 4671-4678 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T82 4734-4741 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T83 4809-4813 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T85 4850-4854 Chemical denotes R162 http://purl.obolibrary.org/obo/CHEBI_85885

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T19 65-81 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T20 317-322 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T21 1082-1097 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 3575-3578 GlycoEpitope denotes 3A7 http://www.glycoepitope.jp/epitopes/AN0057
T2 3602-3605 GlycoEpitope denotes 4E2 http://www.glycoepitope.jp/epitopes/AN0611
T3 3612-3615 GlycoEpitope denotes 5A5 http://www.glycoepitope.jp/epitopes/AN0206

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T80 0-29 Sentence denotes 4.1 Anti-S1 & RBD antibodies
T81 30-160 Sentence denotes Neutralizing Abs can fight against viral infections by blocking binding to cellular receptors or by interfering with viral fusion.
T82 161-350 Sentence denotes Besides, in the case of enveloped viruses, the Abs can recruit effector cells or the complement, thus allowing the destruction of the infected cells or the lysis of the viral particles [6].
T83 351-431 Sentence denotes The S1 domain contains most of the epitopes recognized by nAbs during infection.
T84 432-599 Sentence denotes The RBD located in this S1 domain would be the most important target for nAbs against SARS-CoV, MERS-CoV and the novel coronavirus SARS-CoV-2 [[26], [27], [28], [29]].
T85 600-707 Sentence denotes More specifically, certain secondary structures such as extended loops seem to be particularly immunogenic.
T86 708-784 Sentence denotes RBD of SARS-CoV is composed of 193 amino acids (N318-V510) within S protein.
T87 785-1115 Sentence denotes Five regions on the S glycoprotein of SARS-CoV (residues 274–306, 510–586, 587–628, 784–803 and 870–893), in which three first regions belong to S1 subunit in the CTD2 and CTD3 (C-terminal domain) and two later belong to HR1 domain of the S2 subunit, were predicted to be associated with a robust immune response to SARS-CoV [30].
T88 1116-1235 Sentence denotes Several specific-nAbs for SARS-CoV were discovered; unfortunately none of them are under clinical trial [31] (Fig. 2 ).
T89 1236-1336 Sentence denotes Fig. 2 S protein of SARS-CoV, MERS-CoV, SARS-CoV-2 with its subdomains are the target of antibodies.
T90 1337-1577 Sentence denotes The antibodies cited in this review have different origins or techniques, and some of them have specific targets such as the receptor binding domain (RBD) containing the receptor binding motif (RBM), the heptad repeat regions (HR1 and HR2).
T91 1578-1629 Sentence denotes Some antibodies could bind SARS-CoV and SARS-CoV-2.
T92 1630-1647 Sentence denotes Background color:
T93 1648-1712 Sentence denotes Black for SARS-CoV, dark grey for MERS-CoV, grey for SARS-CoV-2.
T94 1713-1716 Sentence denotes SP:
T95 1717-1736 Sentence denotes Signal peptide, FP:
T96 1737-1756 Sentence denotes Fusion peptide, TM:
T97 1757-1782 Sentence denotes Transmembrane domain, CP:
T98 1783-1800 Sentence denotes Cytoplasm domain.
T99 1801-2018 Sentence denotes The human single-chain variable region fragment (scFv) antibody 80R blocked ACE-RBD interaction (epitope aa 324–503) [32] but some 80R-escape variants were found with the mutations mostly locating at lysine D480 [33].
T100 2019-2122 Sentence denotes The target epitope of 80R is not conserved in SARS-CoV-2 then it does not affect this novel virus [34].
T101 2123-2252 Sentence denotes Another nAb generated from a non-immune scFv library, named 256, could bind to an epitope of RBD but did not inhibit RBD binding.
T102 2253-2324 Sentence denotes 256 is weak but specific to D480A-muted strains of 80R-escape variants.
T103 2325-2863 Sentence denotes Some engineered broad nAbs, fm6 and fm39, also showed a high affinity to D480A-muted strains [33]. m396 (epitope aa 482–491) from human antibody fab library was cross-reactive [35] and used the D95 of m396 to form a salt bridge with R395 or an electrostatic interaction with D408 of SARS-CoV RBD [34]. m396 potently neutralized GD03 strain isolated from the second outbreak which resisted neutralization by 80R and S3.1. m396 also neutralized isolates from the first SARS-CoV outbreak (Urbani, Tor2) and from palm civets (SZ3, SZ16) [36].
T104 2864-3081 Sentence denotes Another human monoclonal antibody from scFv libraries CR3014 (epitope aa 318–510) showed potent effects on SARS-CoV neutralization; however, this virus can escape CR3014 upon P426L mutation in the S glycoprotein [37].
T105 3082-3192 Sentence denotes Same as 80R, m396 and CR3014 RBD-specific SARS-CoV antibodies failed to bind the S protein of SARS-CoV-2 [34].
T106 3193-3410 Sentence denotes CR3022, always from scFv libraries, could bind noncompetitively the SARS-CoV RBD (epitope aa 318–510) and had a synergistic neutralizing effect with CR3014 on SARS-CoV, even with the escaped P426L-muted variants [37].
T107 3411-3552 Sentence denotes By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found.
T108 3553-3731 Sentence denotes 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor.
T109 3732-3870 Sentence denotes The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding.
T110 3871-3976 Sentence denotes Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39].
T111 3977-4141 Sentence denotes Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40].
T112 4142-4228 Sentence denotes The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants.
T113 4229-4309 Sentence denotes Other neutralizing human monoclonal Abs from transgenic mice were also reported.
T114 4310-4396 Sentence denotes Ab 201 interfered with ACE2 binding by targeting S1 protein at the epitope aa 490–510.
T115 4397-4510 Sentence denotes In contrast to 201, Ab 68 bound epitope aa 130–150 at the N-terminal of RBD but did not affect ACE2 binding [41].
T116 4511-4644 Sentence denotes F26 family of monoclonal Abs generated from mice (F26G9, F26G10, F26G18 and F26G19) showed neutralizing effect against SARS-CoV [42].
T117 4645-4725 Sentence denotes F26G18 binding RBD at the epitope aa 460–476 showed the most potent effect [43].
T118 4726-4874 Sentence denotes F26G19 (epitope aa 486–492 on RBD [44]) or 80R could also bind SARS-CoV by forming salt bridge R426 (RBD)-D56 or D480 (RBD)-R162, respectively [34].
T119 4875-5013 Sentence denotes SARS-CoV mouse antibody 240CD had a nanomolar affinity for the SARS-CoV-2 RBD but did not significantly block ACE-2 receptor binding [45].
T120 5014-5154 Sentence denotes As 240CD, CR3022 also has high affinity to SARS-CoV-2 and moreover, CR3022 had cross-neutralizing activity with this novel coronavirus [34].
T121 5155-5313 Sentence denotes The effects of neutralizing human monoclonal antibodies, S3.1, S215.13 [46] and S230.15, from Epstein-Bar virus transformation of human B cells were observed.
T122 5314-5459 Sentence denotes As m396, S230.15 had potent inhibitory activity against isolates from the first, second SARS-CoV outbreaks and from palm civets (SZ3, SZ16) [36].

2_test

Id Subject Object Predicate Lexical cue
32450171-15163706-66454454 576-578 15163706 denotes 26
32450171-27936982-66454455 582-584 27936982 denotes 27
32450171-32183941-66454456 1111-1113 32183941 denotes 30
32450171-15857975-66454457 1919-1921 15857975 denotes 32
32450171-32065055-66454458 2118-2120 32065055 denotes 34
32450171-16597622-66454459 2502-2504 16597622 denotes 35
32450171-32065055-66454460 2622-2624 32065055 denotes 34
32450171-17620608-66454461 2859-2861 17620608 denotes 36
32450171-32065055-66454462 3188-3190 32065055 denotes 34
32450171-19748648-66454463 3570-3572 19748648 denotes 38
32450171-15313178-66454464 3972-3974 15313178 denotes 39
32450171-19748648-66454465 4134-4136 19748648 denotes 38
32450171-17161858-66454466 4137-4139 17161858 denotes 40
32450171-15655773-66454467 4506-4508 15655773 denotes 41
32450171-15234813-66454468 4640-4642 15234813 denotes 42
32450171-20168090-66454469 4721-4723 20168090 denotes 43
32450171-19324051-66454470 4761-4763 19324051 denotes 44
32450171-32065055-66454471 4870-4872 32065055 denotes 34
32450171-32065055-66454472 5150-5152 32065055 denotes 34
32450171-15247913-66454473 5227-5229 15247913 denotes 46
32450171-17620608-66454474 5455-5457 17620608 denotes 36