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PMC:7243778 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
1 0-13 Species denotes Coronaviruses Tax:11118
14 723-732 Gene denotes cytokines
15 91-103 Species denotes Homo sapiens Tax:9606
16 131-136 Species denotes human Tax:9606
17 220-226 Species denotes people Tax:9606
18 385-390 Species denotes human Tax:9606
19 430-435 Species denotes human Tax:9606
20 928-938 Species denotes SARS-CoV-2 Tax:2697049
21 946-959 Species denotes coronaviruses Tax:11118
22 960-968 Species denotes SARS-CoV Tax:694009
23 973-981 Species denotes MERS-CoV Tax:1335626
24 162-186 Disease denotes coronavirus disease 2019 MESH:C000657245
25 188-196 Disease denotes COVID-19 MESH:C000657245
28 1322-1346 Disease denotes coronavirus disease 2019 MESH:C000657245
29 1348-1356 Disease denotes COVID-19 MESH:C000657245
31 1561-1566 Species denotes human Tax:9606
36 1838-1851 Species denotes coronaviruses Tax:11118
37 1863-1871 Species denotes SARS-CoV Tax:694009
38 1873-1881 Species denotes MERS-CoV Tax:1335626
39 1886-1896 Species denotes SARS-CoV-2 Tax:2697049
44 2804-2807 Gene denotes IgH Gene:3492
45 2880-2883 Gene denotes IgL Gene:3535
46 2190-2195 Species denotes human Tax:9606
47 2701-2710 Chemical denotes disulfide MESH:D004220
49 2962-2977 Disease denotes viral infection MESH:D001102
51 4208-4215 Chemical denotes glycans MESH:D011134
68 5778-5782 Gene denotes ACE2 Gene:59272
69 5858-5862 Gene denotes DPP4 Gene:1803
70 5650-5663 Species denotes coronaviruses Tax:11118
71 5731-5739 Species denotes SARS-CoV Tax:694009
72 5744-5754 Species denotes SARS-CoV-2 Tax:2697049
73 5796-5804 Species denotes MERS-CoV Tax:1335626
74 5864-5872 Species denotes SARS-CoV Tax:694009
75 5881-5899 Species denotes masked palm civets Tax:9675
76 6017-6023 Species denotes humans Tax:9606
77 6030-6040 Species denotes SARS-CoV-2 Tax:2697049
78 6100-6107 Species denotes ferrets Tax:9669
79 6160-6164 Species denotes cats Tax:9685
80 6171-6179 Species denotes MERS-CoV Tax:1335626
81 6257-6263 Species denotes camels Tax:9838
82 6290-6295 Species denotes human Tax:9606
83 5972-5981 Species denotes Horseshoe Tax:49442
104 4777-4790 Species denotes Coronaviruses Tax:11118
105 4836-4849 Species denotes Coronaviridae Tax:11118
106 4930-4943 Species denotes coronaviruses Tax:11118
107 4980-4995 Species denotes betacoronavirus Tax:694002
108 5046-5059 Species denotes Coronaviruses Tax:11118
109 5136-5142 Species denotes humans Tax:9606
110 5171-5188 Species denotes betacoronaviruses Tax:694002
111 5289-5306 Species denotes betacoronaviruses Tax:694002
112 5349-5354 Species denotes human Tax:9606
113 5355-5368 Species denotes coronaviruses Tax:11118
114 5403-5411 Species denotes SARS-CoV Tax:694009
115 5413-5458 Species denotes Severe Acute Respiratory Syndrome Coronavirus Tax:694009
116 5490-5498 Species denotes MERS-CoV Tax:1335626
117 5576-5589 Species denotes coronaviruses Tax:11118
118 5621-5629 Species denotes MERS-CoV Tax:1335626
119 5369-5373 Species denotes HKU1 Tax:290028
120 5378-5382 Species denotes OC43 Tax:31631
121 5590-5594 Species denotes HKU4 Tax:694007
122 5599-5603 Species denotes HKU5 Tax:290028
123 5512-5544 Disease denotes Respiratory Coronavirus Syndrome MESH:D018352
150 7162-7166 Gene denotes ACE2 Gene:59272
151 6312-6317 Species denotes human Tax:9606
152 6318-6331 Species denotes coronaviruses Tax:11118
153 6338-6347 Species denotes HCoV-229E Tax:11137
154 6359-6368 Species denotes HCoV-OC43 Tax:31631
155 6459-6476 Species denotes betacoronaviruses Tax:694002
156 6657-6665 Species denotes SARS-CoV Tax:694009
157 6747-6758 Species denotes coronavirus Tax:11118
158 6779-6784 Species denotes human Tax:9606
159 6966-6972 Species denotes people Tax:9606
160 7027-7035 Species denotes patients Tax:9606
161 7060-7071 Species denotes coronavirus Tax:11118
162 7123-7128 Species denotes human Tax:9606
163 7231-7248 Species denotes masked palm civet Tax:9675
164 7250-7264 Species denotes Paguma larvata Tax:9675
165 7349-7355 Species denotes humans Tax:9606
166 7394-7408 Species denotes Horseshoe bats Tax:49442
167 7470-7478 Species denotes SARS-CoV Tax:694009
168 7559-7564 Species denotes human Tax:9606
169 7607-7612 Species denotes human Tax:9606
170 7672-7678 Species denotes humans Tax:9606
171 6332-6336 Species denotes 229E Tax:11137
172 6353-6357 Species denotes OC43 Tax:31631
173 6850-6877 Disease denotes acute respiratory syndromes MESH:D012120
174 6957-6965 Disease denotes infected MESH:D007239
175 6984-6993 Disease denotes mortality MESH:D003643
177 7708-7716 Species denotes SARS-CoV Tax:694009
180 7736-7744 Species denotes SARS-CoV Tax:694009
181 7785-7809 Species denotes SARS-related coronavirus Tax:694009
188 7985-7986 Gene denotes N Gene:43740575
189 8150-8151 Gene denotes M Gene:43740571
190 8176-8177 Gene denotes E Gene:43740570
191 8195-8200 Gene denotes spike Gene:43740568
192 8202-8203 Gene denotes S Gene:43740568
193 7855-7868 Species denotes Coronaviruses Tax:11118
195 8322-8335 Species denotes coronaviruses Tax:11118
198 9495-9499 Gene denotes ACE2 Gene:59272
199 8908-8916 Species denotes SARS-CoV Tax:694009
209 9848-9852 Gene denotes ACE2 Gene:59272
210 9854-9858 Gene denotes DPP4 Gene:1803
211 10274-10278 Gene denotes ACE2 Gene:59272
212 10335-10339 Gene denotes ACE2 Gene:59272
213 9892-9905 Species denotes coronaviruses Tax:11118
214 9943-9956 Species denotes coronaviruses Tax:11118
215 10068-10081 Species denotes Coronaviruses Tax:11118
216 10258-10266 Species denotes SARS-CoV Tax:694009
217 10418-10437 Disease denotes SARS-CoV infections MESH:C000657245
225 10963-10971 Species denotes SARS-CoV Tax:694009
226 10973-10981 Species denotes MERS-CoV Tax:1335626
227 10990-11007 Species denotes novel coronavirus Tax:2697049
228 11008-11018 Species denotes SARS-CoV-2 Tax:2697049
229 10510-10526 Disease denotes viral infections MESH:D001102
230 10740-10748 Disease denotes infected MESH:D007239
231 10866-10875 Disease denotes infection MESH:D007239
240 11701-11709 Species denotes SARS-CoV Tax:694009
241 11711-11719 Species denotes MERS-CoV Tax:1335626
242 11721-11731 Species denotes SARS-CoV-2 Tax:2697049
243 12050-12058 Species denotes SARS-CoV Tax:694009
244 12063-12073 Species denotes SARS-CoV-2 Tax:2697049
245 12103-12111 Species denotes SARS-CoV Tax:694009
246 12127-12135 Species denotes MERS-CoV Tax:1335626
247 12146-12156 Species denotes SARS-CoV-2 Tax:2697049
252 11160-11168 Species denotes SARS-CoV Tax:694009
253 11268-11276 Species denotes SARS-CoV Tax:694009
254 11546-11554 Species denotes SARS-CoV Tax:694009
255 11587-11595 Species denotes SARS-CoV Tax:694009
287 12295-12299 Gene denotes scFv Gene:652070
288 12322-12325 Gene denotes ACE Gene:1636
289 12608-12612 Gene denotes scFv Gene:652070
290 13348-13352 Gene denotes scFv Gene:652070
291 13658-13662 Gene denotes scFv Gene:652070
292 12915-12918 Gene denotes fab Gene:2187
293 12250-12255 Species denotes human Tax:9606
294 12510-12520 Species denotes SARS-CoV-2 Tax:2697049
295 13053-13061 Species denotes SARS-CoV Tax:694009
296 13237-13245 Species denotes SARS-CoV Tax:694009
297 13416-13424 Species denotes SARS-CoV Tax:694009
298 13621-13631 Species denotes SARS-CoV-2 Tax:2697049
299 13706-13714 Species denotes SARS-CoV Tax:694009
300 13797-13805 Species denotes SARS-CoV Tax:694009
301 12900-12905 Species denotes human Tax:9606
302 13317-13322 Species denotes human Tax:9606
303 13569-13577 Species denotes SARS-CoV Tax:694009
304 13185-13189 Gene denotes S3.1 Gene:3354
305 12446-12452 Chemical denotes lysine MESH:D008239
306 12576-12579 Chemical denotes nAb
307 12749-12752 Chemical denotes 80R
308 13045-13049 Chemical denotes D408
309 13072-13076 Chemical denotes m396
310 13363-13369 Chemical denotes CR3014
311 13472-13478 Chemical denotes CR3014
312 13638-13644 Chemical denotes CR3022
313 13787-13793 Chemical denotes CR3014
314 12843-12848 Mutation denotes D480A p.D480A
315 12726-12731 Mutation denotes D480A p.D480A
316 13829-13834 Mutation denotes P426L p.P426L
317 13484-13489 Mutation denotes P426L p.P426L
326 14162-14166 Gene denotes ACE2 Gene:59272
327 14240-14241 Gene denotes N Gene:43740575
328 14406-14407 Gene denotes S Gene:43740568
329 13884-13889 Species denotes mouse Tax:10090
330 13928-13933 Species denotes human Tax:9606
331 14450-14458 Species denotes SARS-CoV Tax:694009
332 14036-14039 CellLine denotes H12 CVCL:G696
333 14616-14619 CellLine denotes H12 CVCL:G696
339 14778-14782 Gene denotes ACE2 Gene:59272
340 14937-14941 Gene denotes ACE2 Gene:59272
341 14900-14901 Gene denotes N Gene:43740575
342 14719-14734 Species denotes transgenic mice Tax:10090
343 14693-14698 Species denotes human Tax:9606
347 15000-15004 Species denotes mice Tax:10090
348 15075-15083 Species denotes SARS-CoV Tax:694009
349 15234-15242 Species denotes SARS-CoV Tax:694009
358 15430-15435 Gene denotes ACE-2 Gene:59272
359 15383-15393 Species denotes SARS-CoV-2 Tax:2697049
360 15502-15512 Species denotes SARS-CoV-2 Tax:2697049
361 15576-15593 Species denotes novel coronavirus Tax:2697049
362 15320-15328 Species denotes SARS-CoV Tax:694009
363 15329-15334 Species denotes mouse Tax:10090
364 15469-15475 Chemical denotes CR3022
365 15527-15533 Chemical denotes CR3022
370 15657-15661 Gene denotes S3.1 Gene:3354
371 15730-15735 Species denotes human Tax:9606
372 15847-15855 Species denotes SARS-CoV Tax:694009
373 15628-15633 Species denotes human Tax:9606
376 16268-16269 Gene denotes S Gene:43740568
377 16475-16483 Species denotes SARS-CoV Tax:694009
384 16745-16748 Gene denotes Trx Gene:7295
385 16948-16951 Gene denotes Trx Gene:7295
386 16929-16937 Species denotes SARS-CoV Tax:694009
387 16938-16946 Species denotes patients Tax:9606
388 16805-16808 Chemical denotes Leu MESH:D007930
389 16816-16843 Mutation denotes Ala 828 and Pro 1061 to Ser p.A,P828,1061S
392 17060-17063 Gene denotes 4F9 Gene:3732
393 17011-17016 Species denotes human Tax:9606
398 17377-17381 Gene denotes scFv Gene:652070
399 17534-17542 Species denotes SARS-CoV Tax:694009
400 17599-17607 Species denotes SARS-CoV Tax:694009
401 17371-17376 Species denotes human Tax:9606
407 17700-17708 Species denotes patients Tax:9606
408 17715-17723 Species denotes SARS-CoV Tax:694009
409 17732-17741 Disease denotes infection MESH:D007239
410 17850-17858 Disease denotes infected MESH:D007239
411 17952-17970 Disease denotes SARS-CoV infection MESH:C000657245
413 17981-17989 Species denotes MERS-CoV Tax:1335626
436 18012-18020 Species denotes MERS-CoV Tax:1335626
437 18076-18091 Species denotes betacoronavirus Tax:694002
438 18106-18119 Species denotes Coronaviridae Tax:11118
439 18226-18234 Species denotes patients Tax:9606
440 18298-18306 Species denotes MERS-CoV Tax:1335626
441 18363-18372 Species denotes dromedary Tax:9838
442 18373-18379 Species denotes camels Tax:9838
443 18589-18595 Species denotes camels Tax:9838
444 18640-18645 Species denotes human Tax:9606
445 18710-18716 Species denotes camels Tax:9838
446 18755-18766 Species denotes dromedaries Tax:9838
447 18774-18780 Species denotes humans Tax:9606
448 18816-18825 Species denotes dromedary Tax:9838
449 18894-18899 Species denotes human Tax:9606
450 18904-18909 Species denotes camel Tax:9838
451 18910-18919 Species denotes MERS-CoVs Tax:1335626
452 18412-18416 Species denotes HKU4 Tax:694007
453 18427-18431 Species denotes HKU5 Tax:290028
454 18671-18679 Species denotes MERS-CoV Tax:1335626
455 18024-18032 Disease denotes zoonotic MESH:D015047
456 18212-18220 Disease denotes infected MESH:D007239
457 18243-18252 Disease denotes mortality MESH:D003643
469 19184-19206 Gene denotes dipeptidyl peptidase 4 Gene:1803
470 19208-19212 Gene denotes DPP4 Gene:1803
471 19262-19266 Gene denotes ACE2 Gene:59272
472 19295-19296 Gene denotes S Gene:43740568
473 18994-19002 Species denotes MERS-CoV Tax:1335626
474 19066-19082 Species denotes beta-coronavirus Tax:694002
475 19089-19097 Species denotes MERS-CoV Tax:1335626
476 19270-19278 Species denotes SARS-CoV Tax:694009
477 19283-19293 Species denotes SARS-CoV-2 Tax:2697049
478 19390-19398 Species denotes MERS-CoV Tax:1335626
479 19431-19440 Species denotes SARS-CoVs Tax:694009
483 19798-19806 Species denotes MERS-CoV Tax:1335626
484 19952-19960 Species denotes MERS-CoV Tax:1335626
485 20042-20055 Disease denotes CoV infection MESH:D018352
487 20346-20364 Disease denotes MERS-CoV infection MESH:D018352
492 20512-20516 Gene denotes DPP4 Gene:1803
493 20542-20545 Gene denotes Fab Gene:2187
494 20559-20563 Gene denotes scFv Gene:652070
495 20651-20664 Disease denotes CoV infection MESH:D018352
500 20735-20743 Species denotes MERS-CoV Tax:1335626
501 20867-20875 Species denotes MERS-CoV Tax:1335626
502 20680-20685 Species denotes human Tax:9606
503 20961-20974 Disease denotes CoV infection MESH:D018352
508 21145-21153 Species denotes MERS-CoV Tax:1335626
509 21255-21259 Species denotes mice Tax:10090
510 21026-21030 Species denotes mice Tax:10090
511 21242-21254 Disease denotes CoV infected MESH:D018352
516 21296-21301 Species denotes human Tax:9606
517 21377-21382 Species denotes mouse Tax:10090
518 21614-21623 Species denotes MERS-CoVs Tax:1335626
519 21635-21642 Chemical denotes SAB-301
522 21819-21824 Species denotes human Tax:9606
523 21728-21736 Species denotes MERS-CoV Tax:1335626
525 21855-21865 Species denotes SARS-CoV-2 Tax:2697049
540 21898-21908 Species denotes SARS-CoV-2 Tax:2697049
541 21909-21920 Species denotes coronavirus Tax:11118
542 22144-22154 Species denotes SARS-CoV-2 Tax:2697049
543 22184-22192 Species denotes SARS-CoV Tax:694009
544 22219-22232 Species denotes coronaviruses Tax:11118
545 22237-22241 Species denotes CoVs Tax:11118
546 22327-22343 Species denotes beta coronavirus Tax:694002
547 22359-22369 Species denotes SARS-CoV-2 Tax:2697049
548 22423-22431 Species denotes SARS-CoV Tax:694009
549 22485-22493 Species denotes patients Tax:9606
550 22511-22528 Species denotes influenza viruses Tax:11308
551 22530-22538 Species denotes SARS-CoV Tax:694009
552 22543-22553 Species denotes SARS-CoV-2 Tax:2697049
553 22438-22446 Disease denotes COVID-19 MESH:C000657245
559 22912-22922 Species denotes SARS-CoV-2 Tax:2697049
560 23050-23058 Species denotes SARS-CoV Tax:694009
561 23102-23107 Species denotes human Tax:9606
562 23111-23116 Species denotes human Tax:9606
563 23133-23143 Species denotes SARS-CoV-2 Tax:2697049
573 23250-23254 Gene denotes ACE2 Gene:59272
574 23606-23610 Gene denotes ACE2 Gene:59272
575 23220-23221 Gene denotes N Gene:43740575
576 23153-23154 Gene denotes S Gene:43740568
577 23166-23176 Species denotes SARS-CoV-2 Tax:2697049
578 23292-23300 Species denotes SARS-CoV Tax:694009
579 23526-23536 Species denotes SARS-CoV-2 Tax:2697049
580 23515-23524 Disease denotes infection MESH:D007239
581 23939-23954 Disease denotes virus infection MESH:D001102
602 23961-23971 Species denotes SARS-CoV-2 Tax:2697049
603 23998-24006 Species denotes patients Tax:9606
604 24180-24188 Species denotes patients Tax:9606
605 24401-24409 Species denotes patients Tax:9606
606 24434-24442 Species denotes patients Tax:9606
607 24449-24456 Species denotes Patient Tax:9606
608 24502-24512 Species denotes SARS-CoV-2 Tax:2697049
609 24544-24551 Species denotes persons Tax:9606
610 24553-24561 Species denotes Patients Tax:9606
611 24824-24832 Species denotes patients Tax:9606
612 24928-24933 Species denotes Ebola Tax:1570291
613 24937-24945 Species denotes SARS-CoV Tax:694009
614 24990-24995 Species denotes human Tax:9606
615 25337-25345 Species denotes patients Tax:9606
616 25351-25361 Species denotes SARS-CoV-2 Tax:2697049
617 25406-25414 Species denotes patients Tax:9606
618 25422-25430 Species denotes patients Tax:9606
619 25508-25516 Species denotes patients Tax:9606
620 24917-24926 Species denotes influenza Tax:11308
621 24803-24811 Disease denotes COVID-19 MESH:C000657245
623 25905-25915 Species denotes SARS-CoV-2 Tax:2697049
639 26702-26703 Gene denotes S Gene:43740568
640 26275-26276 Gene denotes S Gene:43740568
641 25971-25979 Species denotes SARS-CoV Tax:694009
642 25984-25992 Species denotes MERS-CoV Tax:1335626
643 26117-26125 Species denotes SARS-CoV Tax:694009
644 26126-26134 Species denotes patients Tax:9606
645 26170-26180 Species denotes SARS-CoV-2 Tax:2697049
646 26222-26230 Species denotes SARS-CoV Tax:694009
647 26264-26274 Species denotes SARS-CoV-2 Tax:2697049
648 26381-26389 Species denotes SARS-CoV Tax:694009
649 26423-26433 Species denotes SARS-CoV-2 Tax:2697049
650 26599-26609 Species denotes SARS-CoV-2 Tax:2697049
651 26404-26412 Species denotes MERS-CoV Tax:1335626
652 26045-26065 Disease denotes SARS-CoV-2 infection MESH:C000657245
653 26073-26081 Disease denotes COVID-19 MESH:C000657245
662 27253-27258 Gene denotes spike Gene:43740568
663 27493-27498 Gene denotes spike Gene:43740568
664 26810-26818 Species denotes SARS-CoV Tax:694009
665 26823-26833 Species denotes SARS-CoV-2 Tax:2697049
666 27053-27063 Species denotes SARS-CoV-2 Tax:2697049
667 27079-27087 Species denotes SARS-CoV Tax:694009
668 27581-27591 Species denotes SARS-CoV-2 Tax:2697049
669 27635-27643 Species denotes SARS-CoV Tax:694009
684 28031-28035 Gene denotes CDR3 Gene:8163
685 28105-28109 Gene denotes ACE2 Gene:59272
686 27826-27834 Species denotes SARS-CoV Tax:694009
687 27838-27846 Species denotes MERS-CoV Tax:1335626
688 27906-27916 Species denotes SARS-CoV-2 Tax:2697049
689 27942-27950 Species denotes patients Tax:9606
690 28371-28379 Species denotes SARS-CoV Tax:694009
691 28493-28503 Species denotes SARS-Cov-2 Tax:2697049
692 28585-28595 Species denotes SARS-CoV-2 Tax:2697049
693 27744-27754 Species denotes SARS-CoV-2 Tax:2697049
694 28504-28507 Gene denotes ACE Gene:1636
695 28361-28367 Chemical denotes CR3022
696 28557-28563 Chemical denotes CR3022
697 27774-27782 Disease denotes infected MESH:D007239
714 28834-28838 Gene denotes ACE2 Gene:59272
715 29392-29393 Gene denotes S Gene:43740568
716 28631-28641 Species denotes SARS-CoV-2 Tax:2697049
717 28678-28686 Species denotes SARS-CoV Tax:694009
718 28690-28700 Species denotes SARS-CoV-2 Tax:2697049
719 29044-29052 Species denotes SARS-CoV Tax:694009
720 29113-29123 Species denotes SARS-CoV-2 Tax:2697049
721 29205-29213 Species denotes SARS-CoV Tax:694009
722 29260-29270 Species denotes SARS-CoV-2 Tax:2697049
723 29327-29337 Species denotes SARS-CoV-2 Tax:2697049
724 29405-29415 Species denotes SARS-CoV-2 Tax:2697049
725 29545-29553 Species denotes SARS-CoV Tax:694009
726 29660-29668 Species denotes SARS-CoV Tax:694009
727 29673-29683 Species denotes SARS-CoV-2 Tax:2697049
728 28744-28749 Species denotes human Tax:9606
729 29423-29432 Disease denotes infection MESH:D007239
746 30159-30162 Gene denotes CD4 Gene:920
747 30144-30149 Gene denotes spike Gene:43740568
748 30129-30134 Gene denotes spike Gene:43740568
749 29812-29817 Species denotes human Tax:9606
750 29818-29831 Species denotes coronaviruses Tax:11118
751 29873-29883 Species denotes SARS-CoV-2 Tax:2697049
752 29885-29893 Species denotes SARS-CoV Tax:694009
753 29899-29907 Species denotes MERS-CoV Tax:1335626
754 29947-29957 Species denotes SARS-CoV-2 Tax:2697049
755 29970-29987 Species denotes betacoronaviruses Tax:694002
756 29997-30006 Species denotes HCoV-OC43 Tax:31631
757 30011-30020 Species denotes HCoV-HKU1 Tax:290028
758 30058-30068 Species denotes SARS-CoV-2 Tax:2697049
759 30229-30237 Species denotes patients Tax:9606
760 30209-30228 Disease denotes SARS-CoV-2 infected MESH:C000657245
761 30438-30458 Disease denotes SARS-CoV-2 infection MESH:C000657245
763 30477-30487 Species denotes SARS-CoV-2 Tax:2697049
769 30746-30750 Gene denotes ACE2 Gene:59272
770 30835-30839 Gene denotes ACE2 Gene:59272
771 30566-30576 Species denotes SARS-CoV-2 Tax:2697049
772 30735-30745 Species denotes SARS-CoV-2 Tax:2697049
773 30625-30630 Species denotes human Tax:9606
792 30914-30917 Gene denotes S21 Gene:6227
793 30906-30909 Gene denotes S14 Gene:6208
794 30934-30935 Gene denotes S Gene:43740568
795 30923-30933 Species denotes SARS-CoV-2 Tax:2697049
796 30979-30987 Species denotes patients Tax:9606
797 30999-31007 Species denotes SARS-CoV Tax:694009
798 31008-31016 Species denotes patients Tax:9606
799 31201-31211 Species denotes SARS-CoV-2 Tax:2697049
800 31289-31300 Species denotes coronavirus Tax:11118
801 31354-31362 Species denotes SARS-CoV Tax:694009
802 31367-31377 Species denotes SARS-CoV-2 Tax:2697049
803 31378-31386 Species denotes patients Tax:9606
804 31444-31455 Species denotes coronavirus Tax:11118
805 31484-31492 Species denotes SARS-CoV Tax:694009
806 31493-31501 Species denotes patients Tax:9606
807 31519-31527 Species denotes SARS-CoV Tax:694009
808 31541-31551 Species denotes SARS-CoV-2 Tax:2697049
809 30970-30978 Disease denotes COVID-19 MESH:C000657245
820 31913-31918 Gene denotes HLA-A Gene:3105
821 31926-31931 Gene denotes HLA-B Gene:3106
822 31954-31962 Gene denotes HLA-DRB1 Gene:3123
823 31974-31982 Gene denotes HLA-DRB1 Gene:3123
824 31645-31653 Species denotes SARS-CoV Tax:694009
825 31709-31719 Species denotes SARS-CoV-2 Tax:2697049
826 31764-31774 Species denotes SARS-CoV-2 Tax:2697049
827 32127-32137 Species denotes SARS-CoV-2 Tax:2697049
828 32379-32389 Species denotes SARS-CoV-2 Tax:2697049
829 31668-31673 Gene denotes spike Gene:43740568
845 32608-32612 Gene denotes ACE2 Gene:59272
846 32577-32587 Species denotes SARS-CoV-2 Tax:2697049
847 32706-32716 Species denotes SARS-CoV-2 Tax:2697049
848 32748-32758 Species denotes SARS-CoV-2 Tax:2697049
849 32774-32782 Species denotes SARS-CoV Tax:694009
850 32862-32870 Species denotes SARS-CoV Tax:694009
851 32875-32885 Species denotes SARS-CoV-2 Tax:2697049
852 32909-32919 Species denotes SARS-CoV-2 Tax:2697049
853 32532-32535 Chemical denotes nAb
854 32551-32555 Chemical denotes S309
855 32654-32658 Chemical denotes N343
856 32659-32665 Chemical denotes glycan MESH:D011134
857 32733-32744 Chemical denotes N343-glycan
858 32819-32823 Chemical denotes S309
859 32501-32518 Disease denotes SARS-CoV infected MESH:C000657245
867 33047-33050 Gene denotes C18 Gene:27241
868 33042-33045 Gene denotes C17 Gene:54360
869 33099-33109 Species denotes SARS-CoV-2 Tax:2697049
870 33057-33060 Chemical denotes Co2 MESH:D002245
871 33065-33068 Chemical denotes Co4
872 33160-33170 Chemical denotes Methionine MESH:D008715
873 33175-33183 Chemical denotes Tyrosine MESH:D014443
876 33528-33529 Gene denotes S Gene:43740568
877 33907-33917 Species denotes SARS-CoV-2 Tax:2697049
885 34325-34329 Gene denotes ACE2 Gene:59272
886 34065-34075 Species denotes SARS-CoV-2 Tax:2697049
887 34092-34100 Species denotes SARS-CoV Tax:694009
888 34169-34177 Species denotes SARS-CoV Tax:694009
889 34259-34269 Species denotes SARS-CoV-2 Tax:2697049
890 34310-34320 Species denotes SARS-CoV-2 Tax:2697049
891 34420-34425 Species denotes human Tax:9606
898 34584-34594 Species denotes SARS-CoV-2 Tax:2697049
899 34676-34686 Species denotes SARS-CoV-2 Tax:2697049
900 35071-35079 Species denotes patients Tax:9606
901 34902-34910 Disease denotes COVID-19 MESH:C000657245
902 34942-34952 Mutation denotes 23403A > G g.23403A>G
903 34954-34961 Mutation denotes p.D614G p.D614G
916 35314-35318 Gene denotes ACE2 Gene:59272
917 35557-35561 Gene denotes ACE2 Gene:59272
918 35603-35607 Gene denotes ACE2 Gene:59272
919 35647-35651 Gene denotes ACE2 Gene:59272
920 35700-35704 Gene denotes ACE2 Gene:59272
921 35784-35788 Gene denotes ACE2 Gene:59272
922 35098-35108 Species denotes SARS-COV-2 Tax:2697049
923 35489-35499 Species denotes SARS-CoV-2 Tax:2697049
924 35501-35509 Species denotes SARS-CoV Tax:694009
925 35669-35677 Chemical denotes hydrogen MESH:D006859
926 35711-35719 Chemical denotes hydrogen MESH:D006859
927 35274-35279 Mutation denotes R408I p.R408I
931 35889-35894 Species denotes human Tax:9606
932 36138-36143 Species denotes human Tax:9606
933 35907-35915 Disease denotes COVID-19 MESH:C000657245
938 36282-36295 Species denotes coronaviruses Tax:11118
939 36392-36397 Species denotes human Tax:9606
940 36398-36411 Species denotes coronaviruses Tax:11118
941 36501-36514 Species denotes coronaviruses Tax:11118
960 36938-36943 Gene denotes gp120 Gene:3700
961 36962-36963 Gene denotes S Gene:43740568
962 36805-36822 Species denotes influenza viruses Tax:11308
963 36831-36841 Species denotes SARS-CoV-2 Tax:2697049
964 36975-36985 Species denotes SARS-CoV-2 Tax:2697049
965 37323-37331 Species denotes SARS-CoV Tax:694009
966 37336-37344 Species denotes MERS-CoV Tax:1335626
967 37612-37622 Species denotes SARS-CoV-2 Tax:2697049
968 38068-38078 Species denotes SARS-CoV-2 Tax:2697049
969 37914-37923 Species denotes influenza Tax:11308
970 38210-38221 Species denotes coronavirus Tax:11118
971 36824-36827 Disease denotes HIV MESH:D015658
972 36955-36958 Disease denotes HIV MESH:D015658
973 37381-37393 Disease denotes lung disease MESH:D008171
974 37500-37509 Disease denotes infection MESH:D007239
975 37599-37608 Disease denotes infection MESH:D007239
976 37928-37931 Disease denotes HIV MESH:D015658
977 38134-38142 Disease denotes COVID-19 MESH:C000657245
981 38760-38765 Species denotes Ebola Tax:1570291
982 38829-38834 Species denotes Ebola Tax:1570291
983 38859-38864 Species denotes Ebola Tax:1570291
990 39270-39275 Species denotes Ebola Tax:1570291
991 39443-39451 Species denotes SARS-CoV Tax:694009
992 39554-39567 Species denotes coronaviruses Tax:11118
993 39166-39174 Disease denotes COVID-19 MESH:C000657245
994 39280-39283 Disease denotes HIV MESH:D015658
995 39347-39350 Disease denotes HIV MESH:D015658
998 39658-39669 Species denotes coronavirus Tax:11118
999 39962-39983 Disease denotes coronavirus infection MESH:D018352

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 430-440 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T2 462-475 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T3 580-593 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T4 723-732 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T5 796-800 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T6 828-832 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T7 1315-1318 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T8 2120-2128 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T9 2190-2200 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T10 2217-2230 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T11 2420-2422 Body_part denotes Ag http://purl.org/sig/ont/fma/fma61898
T12 2463-2465 Body_part denotes Ag http://purl.org/sig/ont/fma/fma61898
T13 2553-2558 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 2573-2575 Body_part denotes Ag http://purl.org/sig/ont/fma/fma61898
T15 2613-2623 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T16 2764-2768 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T17 2782-2796 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T18 2815-2819 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T19 2858-2872 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T20 2891-2895 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T21 3342-3351 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T22 3443-3456 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T23 3443-3447 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T24 4219-4226 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 4506-4514 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T26 5841-5846 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T27 5888-5892 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T28 7238-7242 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T29 7613-7617 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T30 7996-8002 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T31 8077-8085 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T32 8141-8148 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 8167-8174 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 8187-8194 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 8311-8318 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 8343-8354 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T37 8390-8411 Body_part denotes transmembrane protein http://purl.org/sig/ont/fma/fma67858
T38 8670-8675 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39 8679-8686 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 8819-8826 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 8897-8904 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T42 9410-9421 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T43 9995-10002 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 10363-10375 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T45 10363-10367 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T46 10678-10683 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T47 10749-10754 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 11188-11199 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T49 11221-11228 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 11252-11264 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T51 11690-11697 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 12228-12237 Body_part denotes Cytoplasm http://purl.org/sig/ont/fma/fma66835
T53 12301-12309 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T54 12446-12452 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T55 12906-12914 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T56 13279-13283 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T57 13334-13342 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T58 13508-13520 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T59 13610-13617 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 13890-13904 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T61 13934-13948 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T62 14344-14355 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T63 14408-14415 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 14509-14517 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 14807-14814 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 15335-15343 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T67 15738-15743 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 15875-15879 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T69 16032-16045 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T70 16270-16278 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T71 16346-16353 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 16429-16439 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T73 16459-16466 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 16533-16544 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T75 16736-16744 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T76 17281-17288 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 17382-17390 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T78 17460-17467 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 17474-17482 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T80 17876-17879 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T81 19062-19065 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T82 19113-19120 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 19133-19137 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T84 19221-19237 Body_part denotes surface of cells http://purl.org/sig/ont/fma/fma67653
T85 19232-19237 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T86 19297-19304 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T87 19357-19364 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 19401-19408 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T89 19639-19646 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90 19762-19769 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T91 20450-20452 Body_part denotes V2 http://purl.org/sig/ont/fma/fma13443|http://purl.org/sig/ont/fma/fma68615
T93 21504-21512 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T94 22564-22572 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T95 22971-22978 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T96 23155-23162 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T97 23194-23205 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T98 23303-23315 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T99 23558-23562 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T100 23729-23733 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T101 23821-23831 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T102 24073-24076 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T103 24282-24285 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T104 24372-24375 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T105 24376-24384 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T106 24612-24620 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T107 24725-24733 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T108 24751-24757 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T109 25236-25242 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T110 25304-25312 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T111 25556-25562 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T112 25957-25965 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T113 26092-26097 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T114 26277-26284 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T115 26461-26469 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T116 26501-26511 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T117 26640-26650 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T118 26704-26711 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T119 27027-27035 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T120 27189-27197 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T121 27259-27267 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T122 27428-27436 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T123 27499-27507 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T124 27547-27555 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T125 27661-27669 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T126 27783-27789 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T127 27981-27989 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T128 28014-28022 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T129 28237-28245 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T130 28393-28401 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T131 28756-28764 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T132 28865-28877 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T133 28865-28869 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T134 29249-29256 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T135 29394-29401 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T136 29483-29505 Body_part denotes cytotoxic T-lymphocyte http://purl.org/sig/ont/fma/fma70573
T137 29493-29505 Body_part denotes T-lymphocyte http://purl.org/sig/ont/fma/fma62870
T138 29773-29776 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T139 29851-29854 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T140 30166-30170 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T141 30300-30308 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T142 30327-30339 Body_part denotes T lymphocyte http://purl.org/sig/ont/fma/fma62870
T143 30691-30698 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T144 30806-30811 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 31617-31621 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T146 31628-31632 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T147 31697-31705 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T148 31775-31783 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T149 31796-31800 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T150 31876-31879 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T151 31894-31899 Body_part denotes digit http://purl.org/sig/ont/fma/fma85518
T152 31913-31916 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T153 31926-31929 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T154 31939-31942 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T155 31954-31957 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T156 31974-31977 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T157 31996-32000 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T158 32180-32192 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T159 32301-32313 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T160 32471-32476 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T161 33160-33170 Body_part denotes Methionine http://purl.org/sig/ont/fma/fma82759
T162 33175-33183 Body_part denotes Tyrosine http://purl.org/sig/ont/fma/fma82768
T163 33215-33223 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T164 33276-33280 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T165 33402-33413 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T166 33421-33425 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 33530-33537 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T168 33545-33549 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T169 33581-33584 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T170 33762-33766 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T171 34555-34558 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T172 34780-34785 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T173 35109-35115 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T174 35254-35264 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T175 35930-35936 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T176 36091-36099 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T177 36824-36827 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T178 36924-36937 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T179 36955-36958 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T180 36964-36971 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T181 37246-37250 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T182 37381-37385 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T183 37417-37425 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T184 37928-37931 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T185 39038-39046 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T186 39280-39283 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T187 39347-39350 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T188 39527-39535 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T189 39710-39717 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 39754-39762 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 462-475 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T2 580-593 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T3 2217-2230 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T4 26092-26097 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T5 31894-31899 Body_part denotes digit http://purl.obolibrary.org/obo/UBERON_0002544
T6 37381-37385 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 162-186 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T2 188-196 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 928-936 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 960-968 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 1322-1346 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T6 1348-1356 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 1863-1871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1886-1894 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 2962-2977 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T10 2968-2977 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11 5403-5411 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 5413-5446 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T13 5731-5739 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 5744-5752 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 5864-5872 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 6030-6038 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 6657-6665 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 6843-6877 Disease denotes severe acute respiratory syndromes http://purl.obolibrary.org/obo/MONDO_0005091
T19 7470-7478 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 7708-7716 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 7736-7744 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 7785-7789 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 8908-8916 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 10258-10266 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 10418-10426 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 10427-10437 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T27 10510-10526 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T28 10866-10875 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 10963-10971 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 11008-11016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 11160-11168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 11268-11276 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 11546-11554 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 11587-11595 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 11701-11709 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 11721-11729 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 12050-12058 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 12063-12071 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 12103-12111 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 12146-12154 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 12510-12518 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 13053-13061 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 13237-13245 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 13416-13424 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 13569-13577 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 13621-13629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 13706-13714 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 13797-13805 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 14450-14458 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 15075-15083 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 15234-15242 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 15320-15328 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 15383-15391 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 15502-15510 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 15847-15855 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 16475-16483 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 16929-16937 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 17534-17542 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 17599-17607 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 17715-17723 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 17732-17741 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T62 17952-17970 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T63 17961-17970 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64 19270-19278 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 19283-19291 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 19431-19435 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 20046-20055 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 20355-20364 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T69 20655-20664 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 20965-20974 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T71 21855-21863 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T72 21898-21906 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 22144-22152 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 22184-22192 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 22209-22213 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 22359-22367 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 22423-22431 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 22438-22446 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T79 22511-22520 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T80 22530-22538 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 22543-22551 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 22912-22920 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 23050-23058 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 23133-23141 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 23166-23174 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 23292-23300 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 23391-23394 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T89 23515-23524 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90 23526-23534 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 23939-23954 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T92 23945-23954 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93 23961-23969 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 24502-24510 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 24803-24811 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 24917-24926 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T97 24928-24933 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T98 24937-24945 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 25050-25060 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T100 25351-25359 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 25905-25913 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 25971-25979 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 26045-26053 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 26056-26065 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T105 26073-26081 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 26117-26125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 26170-26178 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 26222-26230 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 26264-26272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T110 26381-26389 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 26423-26431 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 26599-26607 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 26684-26687 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T115 26810-26818 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T116 26823-26831 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 27053-27061 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 27079-27087 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T119 27581-27589 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 27635-27643 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T121 27744-27752 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 27826-27834 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 27906-27914 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 28371-28379 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T125 28493-28497 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 28585-28593 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 28631-28639 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T128 28678-28686 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 28690-28698 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T130 29044-29052 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 29113-29121 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 29205-29213 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 29260-29268 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T134 29327-29335 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 29405-29413 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T136 29423-29432 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T137 29545-29553 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T138 29660-29668 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T139 29673-29681 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 29873-29881 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 29885-29893 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 29947-29955 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 30058-30066 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 30209-30217 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 30438-30446 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 30449-30458 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T147 30477-30485 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 30566-30574 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T149 30735-30743 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T150 30923-30931 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 30970-30978 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 30999-31007 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T153 31201-31209 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 31354-31362 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 31367-31375 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T156 31484-31492 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T157 31519-31527 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T158 31541-31549 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 31645-31653 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T160 31709-31717 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T161 31764-31772 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T162 31943-31946 Disease denotes DRA http://purl.obolibrary.org/obo/MONDO_0019440
T163 32127-32135 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 32379-32387 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T165 32501-32509 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T166 32577-32585 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T167 32706-32714 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T168 32748-32756 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 32774-32782 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T170 32862-32870 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T171 32875-32883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 32909-32917 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 33099-33107 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 33907-33915 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T175 34065-34073 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T176 34092-34100 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 34169-34177 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T178 34259-34267 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T179 34310-34318 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T180 34584-34592 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T181 34676-34684 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T182 34902-34910 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T183 35098-35102 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T184 35174-35178 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 35489-35497 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T186 35501-35509 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T187 35907-35915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T188 36805-36814 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T189 36831-36839 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T190 36975-36983 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 37323-37331 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T192 37381-37393 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T193 37500-37509 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T194 37599-37608 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T195 37612-37620 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T196 37914-37923 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T197 38068-38076 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T198 38134-38142 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T199 38760-38765 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T200 38829-38834 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T201 38859-38864 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T202 39166-39174 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T203 39258-39262 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T204 39270-39275 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T205 39443-39451 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 39974-39983 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 91-103 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Homo sapiens
T2 131-136 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 137-147 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T4 241-251 http://purl.obolibrary.org/obo/UBERON_0001456 denotes are facing
T5 252-253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 385-397 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human beings
T7 430-435 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T8 462-475 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T9 540-547 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T10 580-593 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T11 763-771 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T12 1561-1568 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human's
T13 1626-1627 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 2021-2028 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T15 2181-2188 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T16 2190-2195 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 2201-2204 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 2217-2230 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T19 2274-2279 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T20 2326-2327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2345-2354 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T22 2391-2392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 2523-2526 http://purl.obolibrary.org/obo/CLO_0001686 denotes Ags
T24 2551-2558 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T25 2762-2768 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T26 2815-2819 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T27 2891-2895 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T28 3195-3196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 3293-3298 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T30 3342-3351 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T31 3431-3438 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T32 3443-3447 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T33 3448-3456 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T34 3666-3673 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T35 3963-3964 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 4576-4583 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T37 4795-4796 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 4814-4821 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T39 5067-5068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 5136-5142 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T41 5338-5339 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T42 5349-5354 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T43 5392-5393 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T44 5564-5567 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T45 5572-5575 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T46 5772-5773 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T47 5841-5846 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T48 5873-5876 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T49 5937-5942 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T50 5943-5946 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T51 5982-5985 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T52 6017-6023 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T53 6041-6044 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T54 6045-6049 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T55 6100-6107 http://purl.obolibrary.org/obo/NCBITaxon_9669 denotes ferrets
T56 6121-6128 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T57 6135-6136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 6180-6183 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T59 6200-6204 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T60 6225-6230 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 6257-6263 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T62 6290-6295 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T63 6312-6317 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T64 6487-6494 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T65 6572-6579 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T66 6779-6784 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T67 6802-6807 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T68 6982-6983 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 7077-7083 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T70 7123-7128 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T71 7188-7190 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T72 7203-7206 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T73 7307-7314 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T74 7349-7355 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T75 7357-7358 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T76 7404-7408 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T77 7559-7564 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T78 7607-7623 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T79 7646-7651 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T80 7672-7678 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T81 7842-7845 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T82 7846-7853 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T83 7893-7900 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T84 7906-7907 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 8132-8140 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T86 8359-8360 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 8445-8446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 8474-8476 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T89 8490-8491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 8646-8655 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T91 8670-8675 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T92 8687-8690 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T93 8691-8692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 8717-8718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 8827-8830 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T96 8831-8832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 8981-8983 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T98 8994-8996 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T99 9046-9048 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T100 9046-9048 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T101 9059-9061 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T102 9084-9092 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T103 9129-9137 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T104 9139-9141 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T105 9142-9157 http://purl.obolibrary.org/obo/OBI_0100026 denotes is organized in
T106 9142-9157 http://purl.obolibrary.org/obo/UBERON_0000468 denotes is organized in
T107 9180-9181 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T108 9220-9221 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 9252-9254 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T110 9325-9327 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T111 9509-9511 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T112 9554-9562 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T113 9582-9583 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 9611-9613 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T115 9611-9613 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T116 9634-9642 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T117 9695-9697 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T118 9716-9718 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T119 9863-9864 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 10025-10030 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T121 10107-10115 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T122 10347-10367 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity on the cell
T123 10455-10457 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T124 10640-10647 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T125 10678-10683 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 10749-10754 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T127 10800-10802 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T128 10901-10903 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T129 11027-11029 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T130 11375-11377 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T131 11469-11471 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T132 11469-11471 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T133 11518-11519 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 12162-12168 http://purl.obolibrary.org/obo/SO_0000418 denotes Signal
T135 12169-12176 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T136 12189-12196 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T137 12224-12226 http://purl.obolibrary.org/obo/PR_000005794 denotes CP
T138 12250-12255 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 12351-12353 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T140 12556-12561 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T141 12563-12565 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T142 12595-12596 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 12824-12825 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 12883-12885 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T145 12890-12893 http://purl.obolibrary.org/obo/CLO_0054064 denotes 491
T146 12900-12905 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T147 12947-12949 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T148 12984-12985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 13067-13069 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T150 13304-13306 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T151 13317-13322 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T152 13379-13381 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T153 13455-13460 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 13633-13635 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T155 13728-13730 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T156 13748-13749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T157 13884-13889 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T158 13905-13910 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T159 13925-13933 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes by human
T160 13949-13954 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T161 13983-13985 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T162 13998-14000 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T163 14077-14080 http://purl.obolibrary.org/obo/CLO_0001435 denotes 5E4
T164 14120-14122 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T165 14141-14146 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T166 14214-14216 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T167 14359-14361 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T168 14500-14502 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T169 14506-14508 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T170 14506-14508 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T171 14531-14533 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T172 14693-14698 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T173 14804-14806 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T174 14830-14832 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T175 14882-14884 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T176 14951-14953 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T177 15124-15126 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T178 15187-15189 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T179 15315-15317 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T180 15329-15334 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T181 15354-15355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 15454-15456 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T183 15481-15484 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T184 15557-15565 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T185 15595-15597 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T186 15628-15633 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T187 15706-15711 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T188 15730-15735 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T189 15736-15743 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T190 15798-15806 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T191 15900-15902 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T192 15916-15918 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T193 15916-15918 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T194 16189-16191 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T195 16189-16191 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T196 16233-16240 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T197 16343-16345 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T198 16343-16345 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T199 16472-16474 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T200 16612-16614 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T201 16612-16614 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T202 16653-16654 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T203 16655-16662 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T204 16674-16676 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T205 16711-16719 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T206 16721-16723 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T207 16760-16762 http://purl.obolibrary.org/obo/CLO_0002988 denotes F9
T208 16760-16762 http://purl.obolibrary.org/obo/CLO_0050537 denotes F9
T209 16760-16762 http://purl.obolibrary.org/obo/CLO_0050539 denotes F9
T210 16871-16873 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T211 16871-16873 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T212 16992-16999 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T213 17011-17016 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T214 17049-17053 http://purl.obolibrary.org/obo/CLO_0052881 denotes 2B12
T215 17060-17063 http://purl.obolibrary.org/obo/CLO_0054001 denotes 4F9
T216 17070-17073 http://purl.obolibrary.org/obo/CLO_0052893 denotes 6C9
T217 17369-17370 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T218 17371-17376 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T219 17409-17410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 17440-17442 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T221 17457-17459 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T222 17457-17459 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T223 17515-17525 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T224 17608-17610 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T225 17608-17610 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T226 17972-17974 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T227 18022-18023 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 18033-18038 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T229 18188-18190 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T230 18202-18207 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T231 18241-18242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 18320-18324 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T233 18373-18379 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T234 18432-18435 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T235 18436-18443 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T236 18509-18516 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T237 18574-18575 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 18576-18579 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T239 18580-18585 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T240 18589-18595 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T241 18640-18645 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T242 18710-18716 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T243 18732-18739 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T244 18774-18780 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T245 18829-18830 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 18848-18853 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T247 18889-18892 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T248 18894-18899 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T249 18904-18909 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camel
T250 19006-19007 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 19133-19137 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T252 19232-19237 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T253 19471-19473 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T254 19501-19509 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T255 19527-19529 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T256 19527-19529 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T257 19541-19542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 19559-19566 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T259 19924-19926 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T260 19938-19940 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T261 20077-20079 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T262 20118-20119 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 20155-20157 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T264 20202-20206 http://purl.obolibrary.org/obo/CLO_0001329 denotes 3B11
T265 20280-20282 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T266 20680-20685 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T267 20747-20756 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T268 21060-21063 http://purl.obolibrary.org/obo/CLO_0001258 denotes 2E6
T269 21261-21263 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T270 21296-21301 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T271 21321-21323 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T272 21346-21355 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T273 21377-21382 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T274 21473-21475 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T275 21760-21763 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T276 21787-21792 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T277 21819-21831 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human beings
T278 21984-21985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 22197-22200 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T280 22318-22319 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T281 22450-22451 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 22521-22528 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T283 22561-22562 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 22682-22692 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T285 23078-23079 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T286 23102-23107 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T287 23111-23116 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T288 23231-23233 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T289 23269-23270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T290 23345-23347 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T291 23400-23401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T292 23479-23480 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T293 23558-23562 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T294 23595-23597 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T295 23653-23655 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T296 23653-23655 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T297 23690-23695 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 23729-23733 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T299 23790-23791 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 23888-23895 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T301 23939-23944 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T302 23956-23958 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T303 24394-24400 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T304 24429-24433 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T305 24429-24433 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T306 24567-24568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 24603-24604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T308 24665-24666 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T309 24751-24757 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T310 24833-24836 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T311 24842-24848 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T312 24866-24872 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T313 24901-24908 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T314 24990-24995 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T315 25236-25242 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T316 25402-25405 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T317 25436-25441 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T318 25556-25562 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T319 25568-25569 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 25841-25842 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T321 26030-26036 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T322 26661-26663 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T323 26713-26715 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T324 26775-26777 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T325 26885-26888 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T326 27166-27167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T327 27525-27526 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 27783-27789 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T329 27851-27852 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 28226-28227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T331 28369-28370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 28426-28430 http://purl.obolibrary.org/obo/CLO_0001692 denotes a kd
T333 28524-28526 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T334 28602-28604 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T335 28608-28609 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T336 28664-28666 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T337 28701-28704 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T338 28744-28749 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T339 28787-28794 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T340 28865-28869 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T341 28909-28917 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T342 29030-29032 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T343 29030-29032 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T344 29056-29058 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T345 29158-29162 http://purl.obolibrary.org/obo/CLO_0001165 denotes 1G10
T346 29191-29193 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T347 29191-29193 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T348 29313-29315 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T349 29313-29315 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T350 29346-29347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T351 29363-29365 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T352 29516-29518 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T353 29554-29556 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T354 29554-29556 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T355 29688-29689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T356 29717-29721 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T357 29812-29817 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T358 29909-29912 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T359 30073-30074 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T360 30159-30162 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T361 30164-30170 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T362 30536-30541 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T363 30625-30630 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T364 30806-30811 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T365 30847-30855 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptides
T366 30892-30899 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T367 31054-31062 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T368 31278-31285 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T369 31428-31429 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 31440-31443 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T371 31606-31607 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 31615-31621 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T373 31626-31632 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T374 31721-31723 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T375 31794-31800 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T376 31830-31832 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T377 31894-31899 http://www.ebi.ac.uk/efo/EFO_0000881 denotes digit
T378 31917-31918 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T379 31930-31931 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T380 31994-32000 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T381 32225-32228 http://purl.obolibrary.org/obo/CLO_0054064 denotes 491
T382 32351-32352 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T383 32469-32476 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T384 32482-32483 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T385 32652-32653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 32986-32991 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T387 33033-33035 http://purl.obolibrary.org/obo/CLO_0002147 denotes C7
T388 33033-33035 http://purl.obolibrary.org/obo/CLO_0051562 denotes C7
T389 33076-33077 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T390 33274-33280 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T391 33419-33425 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T392 33543-33549 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T393 33565-33567 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T394 33664-33672 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T395 33684-33692 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T396 33753-33754 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T397 33760-33766 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T398 33919-33920 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T399 33935-33944 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T400 34133-34140 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T401 34211-34219 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T402 34420-34425 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T403 34431-34433 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T404 34479-34487 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T405 34559-34564 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T406 34691-34692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T407 34778-34785 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T408 35116-35119 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T409 35120-35121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T410 35356-35357 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T411 35667-35668 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T412 35889-35901 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human beings
T413 35930-35936 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T414 35999-36002 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T415 36115-36116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T416 36138-36143 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T417 36155-36161 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T418 36314-36318 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T419 36392-36397 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T420 36442-36445 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T421 36719-36720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T422 36791-36792 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T423 36815-36822 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T424 36915-36916 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T425 36917-36922 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T426 37075-37076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T427 37117-37120 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T428 37381-37385 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T429 37381-37385 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T430 37450-37453 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T431 37813-37814 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T432 37823-37826 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T433 37866-37871 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T434 37932-37939 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T435 38223-38226 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T436 38386-38387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 38433-38434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T438 38435-38440 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T439 38486-38487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T440 39060-39061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T441 39062-39067 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T442 39083-39084 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T443 39133-39138 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T444 39242-39249 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T445 39402-39407 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T446 39818-39826 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T447 39828-39829 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T448 39844-39847 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 2410-2418 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T2 2420-2422 Chemical denotes Ag http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141|http://purl.obolibrary.org/obo/CHEBI_59132
T5 2463-2465 Chemical denotes Ag http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141|http://purl.obolibrary.org/obo/CHEBI_59132
T8 2573-2575 Chemical denotes Ag http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141|http://purl.obolibrary.org/obo/CHEBI_59132
T11 2701-2710 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T12 3770-3778 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T13 3873-3880 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T14 4075-4082 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T15 4151-4158 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T16 4176-4183 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T17 4208-4215 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T18 4219-4226 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 4730-4739 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T20 4797-4802 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T21 7129-7140 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T22 8077-8085 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T23 8141-8148 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 8167-8174 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 8187-8194 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26 8231-8236 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T27 8240-8248 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T28 8311-8318 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T29 8343-8354 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T30 8343-8348 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T31 8349-8354 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T32 8404-8411 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 8679-8686 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34 8819-8826 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 8897-8904 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T36 9046-9048 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T37 9410-9421 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T38 9410-9415 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T39 9416-9421 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T40 9611-9613 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T41 9634-9642 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T42 9995-10002 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 10669-10677 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T44 11188-11199 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T45 11188-11193 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T46 11194-11199 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T47 11221-11228 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 11252-11264 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T49 11469-11471 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T50 11690-11697 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 12158-12160 Chemical denotes SP http://purl.obolibrary.org/obo/CHEBI_74820
T52 12169-12176 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T53 12178-12180 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T54 12189-12196 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T55 12198-12200 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T57 12224-12226 Chemical denotes CP http://purl.obolibrary.org/obo/CHEBI_3380|http://purl.obolibrary.org/obo/CHEBI_73461
T59 12343-12350 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T60 12446-12452 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T62 12475-12482 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T63 12650-12657 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T64 12875-12882 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T65 12986-12990 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T67 13371-13378 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T68 13508-13520 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T69 13610-13617 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 13720-13727 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T71 14205-14212 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T72 14344-14355 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T73 14344-14349 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T74 14350-14355 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T75 14408-14415 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 14506-14508 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T77 14509-14517 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T78 14807-14814 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 14822-14829 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T80 14874-14881 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T81 15116-15123 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T82 15179-15186 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T83 15254-15258 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T85 15295-15299 Chemical denotes R162 http://purl.obolibrary.org/obo/CHEBI_85885
T86 15916-15918 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T87 16032-16045 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T88 16189-16191 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T89 16270-16278 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T90 16343-16345 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T91 16346-16353 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T92 16429-16439 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T93 16429-16434 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T94 16435-16439 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T95 16459-16466 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T96 16533-16544 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T97 16533-16538 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T98 16539-16544 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T99 16612-16614 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T100 16655-16662 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T101 16736-16744 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T102 16805-16808 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T105 16816-16819 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T107 16828-16831 Chemical denotes Pro http://purl.obolibrary.org/obo/CHEBI_50342
T108 16840-16843 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T110 16871-16873 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T111 17281-17288 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T112 17431-17438 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T113 17457-17459 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T114 17460-17467 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 17608-17610 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T116 17895-17904 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867
T117 19066-19070 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T118 19113-19120 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 19297-19304 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 19357-19364 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T121 19401-19408 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T122 19527-19529 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T123 19559-19566 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T124 19639-19646 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 19762-19769 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T126 20069-20076 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T127 21079-21086 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T128 22234-22236 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T129 22327-22331 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T130 22639-22649 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T131 22650-22661 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T132 22730-22739 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T133 22971-22978 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T134 23155-23162 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 23194-23205 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T136 23194-23199 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T137 23200-23205 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T138 23303-23315 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T139 23653-23655 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T140 23807-23814 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T141 23888-23895 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T142 24429-24433 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T143 25957-25965 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T144 26277-26284 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T145 26470-26477 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T146 26501-26511 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T147 26501-26506 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T148 26507-26511 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T149 26640-26650 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T150 26640-26645 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T151 26646-26650 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T152 26704-26711 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T153 27005-27012 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T154 27036-27043 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T155 27198-27205 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T156 27259-27267 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T157 27360-27367 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T158 27499-27507 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T159 28338-28347 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T160 28447-28454 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T161 28619-28626 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T162 29030-29032 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T163 29191-29193 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T164 29249-29256 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T165 29313-29315 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T166 29354-29361 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T167 29394-29401 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T168 29445-29452 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T169 29554-29556 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T170 30691-30698 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T171 30892-30899 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T172 31054-31062 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T173 31278-31285 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T174 31456-31463 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T175 31697-31705 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T176 31724-31731 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T177 31775-31783 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T178 32041-32048 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T179 32180-32192 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T180 32200-32207 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T181 32301-32313 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T182 32666-32673 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T183 33037-33040 Chemical denotes C14 http://purl.obolibrary.org/obo/CHEBI_28875
T184 33160-33170 Chemical denotes Methionine http://purl.obolibrary.org/obo/CHEBI_16643|http://purl.obolibrary.org/obo/CHEBI_16811
T186 33175-33183 Chemical denotes Tyrosine http://purl.obolibrary.org/obo/CHEBI_17895|http://purl.obolibrary.org/obo/CHEBI_18186
T188 33402-33413 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T189 33402-33407 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T190 33408-33413 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T191 33530-33537 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T192 33664-33672 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T193 33684-33692 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T194 35062-35067 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T195 35254-35264 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T196 35254-35259 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T197 35260-35264 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T198 35669-35677 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T199 35711-35719 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T200 36887-36896 Chemical denotes immunogen http://purl.obolibrary.org/obo/CHEBI_60816
T201 36924-36937 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T202 36964-36971 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T203 37082-37089 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T204 37112-37116 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T205 39030-39037 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T206 39710-39717 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T207 39818-39826 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 22564-22578 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T2 37381-37393 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 580-603 http://purl.obolibrary.org/obo/GO_0002376 denotes immune system processes
T2 676-682 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T3 893-901 http://purl.obolibrary.org/obo/GO_0007612 denotes Learning
T4 2345-2354 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T5 2762-2780 http://purl.obolibrary.org/obo/GO_0030183 denotes B-cell development
T6 2764-2780 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T7 2962-2977 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 2996-3013 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T9 2996-3013 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T10 3299-3310 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T11 3352-3363 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T12 3517-3543 http://purl.obolibrary.org/obo/GO_0051641 denotes intracellular localization
T13 3531-3543 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T14 4321-4330 http://purl.obolibrary.org/obo/GO_0007585 denotes breathing
T15 4506-4525 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T16 8859-8866 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T17 9084-9099 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T18 9379-9392 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T19 10510-10526 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T20 10762-10767 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T21 11527-11542 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T22 29626-29651 http://purl.obolibrary.org/obo/GO_0002456 denotes cellular immune responses
T23 29626-29651 http://purl.obolibrary.org/obo/GO_0002449 denotes cellular immune responses
T24 29626-29651 http://purl.obolibrary.org/obo/GO_0002443 denotes cellular immune responses
T25 30790-30805 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host
T26 32360-32375 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T27 32462-32468 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T28 32941-32949 http://purl.obolibrary.org/obo/GO_0007612 denotes learning
T29 34629-34646 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T30 34629-34646 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T31 35202-35209 http://purl.obolibrary.org/obo/GO_0042056 denotes attract
T32 37032-37047 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T33 37681-37698 http://purl.obolibrary.org/obo/GO_0006955 denotes immunity response
T34 39301-39309 http://purl.obolibrary.org/obo/GO_0007612 denotes learning

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 14020-14023 GlycoEpitope denotes 3A7 http://www.glycoepitope.jp/epitopes/AN0057
T2 14047-14050 GlycoEpitope denotes 4E2 http://www.glycoepitope.jp/epitopes/AN0611
T3 14057-14060 GlycoEpitope denotes 5A5 http://www.glycoepitope.jp/epitopes/AN0206
T4 29158-29162 GlycoEpitope denotes 1G10 http://www.glycoepitope.jp/epitopes/AN0438

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-24 Sentence denotes Coronaviruses pandemics:
T2 25-58 Sentence denotes Can neutralizing antibodies help?
T3 60-68 Sentence denotes Abstract
T4 69-198 Sentence denotes For the first time in Homo sapiens history, possibly, most of human activities is stopped by coronavirus disease 2019 (COVID-19).
T5 199-325 Sentence denotes Nearly eight billion people of this world are facing a great challenge, maybe not “to be or not to be” yet, but unpredictable.
T6 326-425 Sentence denotes What happens to other major pandemics in the past, and how human beings went through these hurdles?
T7 426-548 Sentence denotes The human body is equipped with the immune system that can recognize, respond and fight against pathogens such as viruses.
T8 549-690 Sentence denotes Following the innate response, immune system processes the adaptive response by which each pathogen is encoded and recorded in memory system.
T9 691-801 Sentence denotes The humoral reaction containing cytokines and antibodies is expected to activate when the pathogens come back.
T10 802-892 Sentence denotes Exploiting this nature of body protection, neutralizing antibodies have been investigated.
T11 893-1041 Sentence denotes Learning from past, in parallel to SARS-CoV-2, other coronaviruses SARS-CoV and MERS-CoV who caused previous pandemics, are recalled in this review.
T12 1042-1154 Sentence denotes We here propose insights of origin and characteristics and perspective for the future of antibodies development.
T13 1156-1174 Sentence denotes Graphical abstract
T14 1176-1191 Sentence denotes 1 Introduction
T15 1192-1483 Sentence denotes In full social distancing crisis, far from lab work, in looking anxiously at the red dots growing every day in the graphic map of coronavirus disease 2019 (COVID-19) pandemic [1], we wonder how were the other major pandemics and how antibodies, natural or artificial, can fight the diseases.
T16 1484-1610 Sentence denotes Several pandemics have occurred throughout history, some had more effects on human's life and/or on economics than the others.
T17 1611-1684 Sentence denotes As scientists, a key step in vaccines research is to learn from the past.
T18 1685-1776 Sentence denotes By that mean, what we are doing now might be cornerstone preparing us for future pandemics.
T19 1777-1938 Sentence denotes In this review, we look for the diversity and variability of coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, which cause pandemics from 21th century.
T20 1939-2103 Sentence denotes The origins, impacts and molecular structure with insights of vulnerable sites of viruses who are targets of antibodies and its humoral responses will be described.
T21 2105-2145 Sentence denotes 2 Overview of antibody and immunization
T22 2146-2259 Sentence denotes In response to pathogens including viruses, human body has evolved its immune system to protect it from invasion.
T23 2260-2428 Sentence denotes Following the virus invasion, antibodies (Abs) are produced after a series of immune signaling and these Abs are able to recognize a diverse array of antigens (Ag) [2].
T24 2429-2527 Sentence denotes More specifically, the paratopes (Ag-binding sites) of Abs bind epitopes on virion-associated Ags.
T25 2528-2612 Sentence denotes During an Ab response, B-cells which express Ag receptors are clonally expanded [3].
T26 2613-2742 Sentence denotes Antibodies structurally are composed of heavy (μ, α, γ, δ, ε) chains that are linked by disulfide bonds with light chains (κ, λ).
T27 2743-2914 Sentence denotes In the progress of B-cell development, immunoglobulin heavy (IgH) chain gene recombination typically occurs before immunoglobulin light (IgL) chain gene recombination [4].
T28 2915-3020 Sentence denotes Neutralizing antibodies (nAbs) can inhibit the viral infection via following the viral replication cycle.
T29 3021-3122 Sentence denotes Attachment is the first critical step blocked by Abs by interfering with the virion-receptor binding.
T30 3123-3233 Sentence denotes Moreover, Abs may induce the aggregation of viral particles which cause a reduction of individual penetration.
T31 3234-3364 Sentence denotes In post-attachment step, Abs on the virion possibly dampen virus endocytosis internalization leading to the lysosomal degradation.
T32 3365-3457 Sentence denotes The Abs also block fusion of virion when they intercalate between viruses and cell membrane.
T33 3458-3562 Sentence denotes The next stage of interference is to uncoat or appropriate intracellular localization of core or capsid.
T34 3563-3709 Sentence denotes Lastly, Abs might bind virion surface then inhibit the metabolic events that blocks the replication of viruses even after internalization [3,5,6].
T35 3710-3835 Sentence denotes The approach to nAbs design relies on the identification of antigens; in other words, the epitopes are the central of quests.
T36 3836-3998 Sentence denotes However, the variable regions of the antigen induce the largest fraction of the antibodies whereas broadly nAbs represent only a minor proportion of the response.
T37 3999-4131 Sentence denotes The major challenges related to both sides were previously described: viral antigen and the generation of antibodies to these sites.
T38 4132-4495 Sentence denotes In the detail, the antigen concerns are (1) epitope masking or shielding by glycans or protein loops; (2) transient exposure during the entry process or via other mechanisms such as viral “breathing;” (3) the size of conserved epitopes is small resulting in the limitation of interaction, (4) epitopes are constrainedly accessible, (5) the mutability of epitopes.
T39 4496-4758 Sentence denotes Regarding antibody production, (1) the need for extensive somatic mutations and focused evolution; (2) the use of specific germline allelic variants and HCDR3s of particular length and structure; and (3) the molecular mimicry of host molecules are mentioned [6].
T40 4760-4776 Sentence denotes 3 Coronaviruses
T41 4777-4897 Sentence denotes Coronaviruses are a group of related viruses in the family Coronaviridae and subfamily Coronavirinae, order Nidovirales.
T42 4898-5045 Sentence denotes In the subfamily Coronavirinae, coronaviruses include 4 genres: alphacoronavirus, betacoronavirus, gammacoronavirus and deltacoronavirus (Fig. 1 ).
T43 5046-5147 Sentence denotes Coronaviruses infect a wide variety of hosts including many species of birds, mammals and humans [7].
T44 5148-5281 Sentence denotes Alphacoronaviruses and betacoronaviruses circulate among mammals, gammacoronaviruses and deltacoronaviruses infect birds and mammals.
T45 5282-5630 Sentence denotes Within betacoronaviruses, there are 4 lineages: lineage A contains human coronaviruses HKU1 and OC43, lineage B to which SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) belongs, lineage C belongs to MERS-CoV (Middle East Respiratory Coronavirus Syndrome) and the lineage D has the bat coronaviruses HKU4 and HKU5 who are close to MERS-CoV.
T46 5631-5730 Sentence denotes Fig. 1 Isolates of coronaviruses discussed in this review and their receptors, host and reservoirs.
T47 5731-5795 Sentence denotes SARS-CoV and SARS-CoV-2 from the lineage B use ACE2 as receptor.
T48 5796-5863 Sentence denotes MERS-CoV from the lineage C enters into host cells by binding DPP4.
T49 5864-6029 Sentence denotes SARS-CoV has the masked palm civets as an intermediate host in which the virus has adapted from the Chinese Horseshoe bat reservoir to ultimately infect humans [13].
T50 6030-6170 Sentence denotes SARS-CoV-2 has bats and pangolins as natural reservoir and can infect ferrets or domestics animals, with a high susceptibility in cats [14].
T51 6171-6301 Sentence denotes MERS-CoV has the origin from bats [15] but maybe this virus had an adaptation through camels before its emergence into human [16].
T52 6302-6477 Sentence denotes The first human coronaviruses 229E (HCoV-229E) and OC43 (HCoV-OC43) were isolated in the 1960s and are now classified respectively as alphacoronaviruses and betacoronaviruses.
T53 6478-6638 Sentence denotes As these viruses were not very pathogenic and often associated with colds [8], this family of viruses attracted little interest from scientists until the 2000s.
T54 6639-6796 Sentence denotes In November 2002, SARS-CoV, first reported in Guangdong province, China, became the first highly pathogenic coronavirus that emerged in the human population.
T55 6797-7045 Sentence denotes This virus was responsible for an epidemic of severe acute respiratory syndromes that started in China before spreading rapidly over the world with around 8000 infected people and with a mortality rate of around 10%, depending on patients' age [9].
T56 7046-7199 Sentence denotes However, this coronavirus from animal origin was initially unable to use the human angiotensin 2 converting enzyme (ACE2) as receptor [[10], [11], [12]].
T57 7200-7356 Sentence denotes It has been suggested that the masked palm civet (Paguma larvata) may be an intermediate host in which the viruses have adapted to ultimately infect humans.
T58 7357-7479 Sentence denotes A recent study suggests that Chinese Horseshoe bats in the family Rhinolophidae may be the natural reservoir for SARS-CoV.
T59 7480-7703 Sentence denotes One of these two viral isolates in this study, WIV1, was able to recognize the human ACE2 receptor and to replicate in certain human cell lines, suggesting that this virus can directly infect humans without adaptation [13].
T60 7705-7735 Sentence denotes 4 SARS-CoV: from 2002 to 2003
T61 7736-7854 Sentence denotes SARS-CoV, first reported in 2002, belongs to the SARS-related coronavirus species that also includes many bat viruses.
T62 7855-7938 Sentence denotes Coronaviruses are spherical enveloped viruses with a diameter of 80 to 120 nm [17].
T63 7939-8059 Sentence denotes The viral capsid formed by the nucleoprotein (N) and the genome is contained in the envelope and is of helical symmetry.
T64 8060-8205 Sentence denotes Three structural proteins are embedded on the surface of particles, the membrane protein (M), the envelope protein (E) and the protein spike (S).
T65 8206-8304 Sentence denotes They give this aspect of crown in electron microscopy that inspired the name of this viral family.
T66 8305-8478 Sentence denotes The S protein of coronaviruses (~1255 amino acids) is a highly N-glycosylated type I transmembrane protein, from 180 to 200 kDa, that plays a major role in viral entry [18].
T67 8479-8676 Sentence denotes It insures a double function in viral entry by binding the cellular receptor before conformational changes and proceeding to the fusion of the viral envelope with the membranes of the target cells.
T68 8677-8816 Sentence denotes S protein has a long N-terminal domain, a short C-terminal domain and assembles into homotrimers on the surface of the viral particle [19].
T69 8817-8894 Sentence denotes S protein has a decisive role in cellular tropism and for pathogenicity [20].
T70 8895-9138 Sentence denotes S protein of SARS-CoV is composed of two functionally distinct subunits: the globular S1 subunit (~aa 12–680) allows receptor recognition, whereas the S2 subunit (~aa 681–1255) facilitates membrane fusion and anchors S into the viral membrane.
T71 9139-9184 Sentence denotes S1 is organized in four distinct domains A–D.
T72 9185-9342 Sentence denotes Domains S1A and S1B may be used as a receptor-binding domain (RBD, aa 318–510) containing the highly conserved receptor-binding motif (RBM, aa 424–494) [21].
T73 9343-9513 Sentence denotes Moreover, RBD contains 3 functional glycosylation sites located at amino acids 318, 330 and 357, which are necessary for S expression but do not affect ACE2 binding [22].
T74 9514-9610 Sentence denotes S1B forms an extended loop on the viral membrane-distal side and is a hypervariable region [20].
T75 9611-9780 Sentence denotes S2 contains the fusion peptides (FP1 and FP2) [23], two heptad repeat regions (HR1, aa ~889–972 and HR2, aa ~1142–1193) and the well conserved transmembrane domain [24].
T76 9781-9919 Sentence denotes The mechanism of interactions with peptidases (aminopeptidase APN, ACE2, DPP4) as a cellular receptor for most coronaviruses is not known.
T77 9920-10067 Sentence denotes Indeed, the binding of coronaviruses to their receptor is not enough and S protein on the surface of the virus must undergo proteolytic maturation.
T78 10068-10242 Sentence denotes Coronaviruses do not use the catalytic activity of peptidases serving as receptors for this maturation but enter after the action of proteases located close to the receptors.
T79 10243-10443 Sentence denotes The binding of SARS-CoV to its ACE2 receptor is followed by internalization and decrease in ACE2 enzyme activity on the cell surface, which may partly explain the severity of SARS-CoV infections [25].
T80 10445-10474 Sentence denotes 4.1 Anti-S1 & RBD antibodies
T81 10475-10605 Sentence denotes Neutralizing Abs can fight against viral infections by blocking binding to cellular receptors or by interfering with viral fusion.
T82 10606-10795 Sentence denotes Besides, in the case of enveloped viruses, the Abs can recruit effector cells or the complement, thus allowing the destruction of the infected cells or the lysis of the viral particles [6].
T83 10796-10876 Sentence denotes The S1 domain contains most of the epitopes recognized by nAbs during infection.
T84 10877-11044 Sentence denotes The RBD located in this S1 domain would be the most important target for nAbs against SARS-CoV, MERS-CoV and the novel coronavirus SARS-CoV-2 [[26], [27], [28], [29]].
T85 11045-11152 Sentence denotes More specifically, certain secondary structures such as extended loops seem to be particularly immunogenic.
T86 11153-11229 Sentence denotes RBD of SARS-CoV is composed of 193 amino acids (N318-V510) within S protein.
T87 11230-11560 Sentence denotes Five regions on the S glycoprotein of SARS-CoV (residues 274–306, 510–586, 587–628, 784–803 and 870–893), in which three first regions belong to S1 subunit in the CTD2 and CTD3 (C-terminal domain) and two later belong to HR1 domain of the S2 subunit, were predicted to be associated with a robust immune response to SARS-CoV [30].
T88 11561-11680 Sentence denotes Several specific-nAbs for SARS-CoV were discovered; unfortunately none of them are under clinical trial [31] (Fig. 2 ).
T89 11681-11781 Sentence denotes Fig. 2 S protein of SARS-CoV, MERS-CoV, SARS-CoV-2 with its subdomains are the target of antibodies.
T90 11782-12022 Sentence denotes The antibodies cited in this review have different origins or techniques, and some of them have specific targets such as the receptor binding domain (RBD) containing the receptor binding motif (RBM), the heptad repeat regions (HR1 and HR2).
T91 12023-12074 Sentence denotes Some antibodies could bind SARS-CoV and SARS-CoV-2.
T92 12075-12092 Sentence denotes Background color:
T93 12093-12157 Sentence denotes Black for SARS-CoV, dark grey for MERS-CoV, grey for SARS-CoV-2.
T94 12158-12161 Sentence denotes SP:
T95 12162-12181 Sentence denotes Signal peptide, FP:
T96 12182-12201 Sentence denotes Fusion peptide, TM:
T97 12202-12227 Sentence denotes Transmembrane domain, CP:
T98 12228-12245 Sentence denotes Cytoplasm domain.
T99 12246-12463 Sentence denotes The human single-chain variable region fragment (scFv) antibody 80R blocked ACE-RBD interaction (epitope aa 324–503) [32] but some 80R-escape variants were found with the mutations mostly locating at lysine D480 [33].
T100 12464-12567 Sentence denotes The target epitope of 80R is not conserved in SARS-CoV-2 then it does not affect this novel virus [34].
T101 12568-12697 Sentence denotes Another nAb generated from a non-immune scFv library, named 256, could bind to an epitope of RBD but did not inhibit RBD binding.
T102 12698-12769 Sentence denotes 256 is weak but specific to D480A-muted strains of 80R-escape variants.
T103 12770-13308 Sentence denotes Some engineered broad nAbs, fm6 and fm39, also showed a high affinity to D480A-muted strains [33]. m396 (epitope aa 482–491) from human antibody fab library was cross-reactive [35] and used the D95 of m396 to form a salt bridge with R395 or an electrostatic interaction with D408 of SARS-CoV RBD [34]. m396 potently neutralized GD03 strain isolated from the second outbreak which resisted neutralization by 80R and S3.1. m396 also neutralized isolates from the first SARS-CoV outbreak (Urbani, Tor2) and from palm civets (SZ3, SZ16) [36].
T104 13309-13526 Sentence denotes Another human monoclonal antibody from scFv libraries CR3014 (epitope aa 318–510) showed potent effects on SARS-CoV neutralization; however, this virus can escape CR3014 upon P426L mutation in the S glycoprotein [37].
T105 13527-13637 Sentence denotes Same as 80R, m396 and CR3014 RBD-specific SARS-CoV antibodies failed to bind the S protein of SARS-CoV-2 [34].
T106 13638-13855 Sentence denotes CR3022, always from scFv libraries, could bind noncompetitively the SARS-CoV RBD (epitope aa 318–510) and had a synergistic neutralizing effect with CR3014 on SARS-CoV, even with the escaped P426L-muted variants [37].
T107 13856-13997 Sentence denotes By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found.
T108 13998-14176 Sentence denotes 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor.
T109 14177-14315 Sentence denotes The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding.
T110 14316-14421 Sentence denotes Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39].
T111 14422-14586 Sentence denotes Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40].
T112 14587-14673 Sentence denotes The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants.
T113 14674-14754 Sentence denotes Other neutralizing human monoclonal Abs from transgenic mice were also reported.
T114 14755-14841 Sentence denotes Ab 201 interfered with ACE2 binding by targeting S1 protein at the epitope aa 490–510.
T115 14842-14955 Sentence denotes In contrast to 201, Ab 68 bound epitope aa 130–150 at the N-terminal of RBD but did not affect ACE2 binding [41].
T116 14956-15089 Sentence denotes F26 family of monoclonal Abs generated from mice (F26G9, F26G10, F26G18 and F26G19) showed neutralizing effect against SARS-CoV [42].
T117 15090-15170 Sentence denotes F26G18 binding RBD at the epitope aa 460–476 showed the most potent effect [43].
T118 15171-15319 Sentence denotes F26G19 (epitope aa 486–492 on RBD [44]) or 80R could also bind SARS-CoV by forming salt bridge R426 (RBD)-D56 or D480 (RBD)-R162, respectively [34].
T119 15320-15458 Sentence denotes SARS-CoV mouse antibody 240CD had a nanomolar affinity for the SARS-CoV-2 RBD but did not significantly block ACE-2 receptor binding [45].
T120 15459-15599 Sentence denotes As 240CD, CR3022 also has high affinity to SARS-CoV-2 and moreover, CR3022 had cross-neutralizing activity with this novel coronavirus [34].
T121 15600-15758 Sentence denotes The effects of neutralizing human monoclonal antibodies, S3.1, S215.13 [46] and S230.15, from Epstein-Bar virus transformation of human B cells were observed.
T122 15759-15904 Sentence denotes As m396, S230.15 had potent inhibitory activity against isolates from the first, second SARS-CoV outbreaks and from palm civets (SZ3, SZ16) [36].
T123 15906-15929 Sentence denotes 4.2 Anti-S2 antibodies
T124 15930-16108 Sentence denotes In contrast to RBD, the fusion domains are more difficult to access due to the tight folding of viral glycoproteins or the excessively transient exposure during the fusion stage.
T125 16109-16169 Sentence denotes This is why few epitopes are described in these regions [6].
T126 16170-16338 Sentence denotes Interestingly, the S2 specific mAbs can neutralize pseudotyped viruses which expressing different S proteins containing RBD sequences of various clinical isolates [47].
T127 16339-16374 Sentence denotes The S2 protein is highly conserved.
T128 16375-16502 Sentence denotes No mutation in HR1 was reported in an analysis of the amino acid sequences of the S protein from 94 SARS-CoV clinical isolates.
T129 16503-16606 Sentence denotes Only few mutations in HR2, at amino acids K1163 or Q1183 for example, were observed in this study [47].
T130 16607-16652 Sentence denotes Some S2 epitopes inducing nAbs were reported.
T131 16653-16725 Sentence denotes A peptide containing aa 1055–1192 can elicit neutralizing activity [48].
T132 16726-16947 Sentence denotes Two other proteins Trx-F3 and Trx-F9 containing linear antigenic determinants (Leu 803 to Ala 828 and Pro 1061 to Ser 1093, respectively) on the S2 domain were identified by using sera from convalescent SARS-CoV patients.
T133 16948-17005 Sentence denotes Trx-F3 was capable of inducing nAbs in some animals [49].
T134 17006-17178 Sentence denotes Some human mAbs anti-HR1 (1F8, 1D12, 2A12, 2B12, 4A4, 4F9, 5C3, 6C9, 6H2) and anti-HR2 (1E10, 2D2, 2D6, 3A11, 3E10, 3H11, 5B9, 5B10, 5D7, 5E9, 5G8, 5G9, 6H1) were reported.
T135 17179-17368 Sentence denotes With these Abs, the authors showed that the combination of HmAbs targeting different regions of the S protein would likely increase the broad neutralization against different isolates [47].
T136 17369-17468 Sentence denotes A human scFv antibody, named B1, showed a high affinity to an epitope (aa 1023–1189) on S2 protein.
T137 17469-17557 Sentence denotes This antibody also showed potent neutralizing activities against SARS-CoV in vitro [50].
T138 17558-17660 Sentence denotes B1, 1F8 and 5E9 nAbs against epitopes on SARS-CoV S2 also showed effectiveness in neutralization [51].
T139 17661-17755 Sentence denotes The protective immunity by the time in patients after SARS-CoV natural infection was observed.
T140 17756-17871 Sentence denotes After 6 years, the humoral immunity continuously decreased and eventually disappeared in most infected individuals.
T141 17872-17976 Sentence denotes The IgG Ab could be an indicator of neutralizing Ab for the humoral response to SARS-CoV infection [52].
T142 17978-18011 Sentence denotes 5 MERS-CoV: from 2012 to present
T143 18012-18174 Sentence denotes MERS-CoV, a zoonotic virus, belonging to lineage C in the genre betacoronavirus of the family Coronaviridae, caused the Middle East respiratory syndrome, in 2012.
T144 18175-18272 Sentence denotes As of August 11, 2016, the virus had infected 1791 patients, with a mortality rate of 35.6% [53].
T145 18273-18405 Sentence denotes The natural reservoir of MERS-CoV is assumedly bats whereas intermediate host is possibly dromedary camels [[54], [55], [56], [57]].
T146 18406-18547 Sentence denotes BtCoV-HKU4 and BtCoV-HKU5 bat viruses have been shown to be the closest phylogenetically even if these viruses are not direct ancestors [15].
T147 18548-18717 Sentence denotes The first transmission of a bat virus to camels for an adaptation before its emergence into human was suggested. nAbs anti-MERS-CoV could accordingly be found in camels.
T148 18718-18862 Sentence denotes Moreover, the viruses circulating in dromedaries and in humans are very close suggesting that the dromedary is a reservoir of the virus [58,59].
T149 18863-18979 Sentence denotes The genomic structures of bat, human and camel MERS-CoVs are similar but their genomic sequences are different [16].
T150 18980-19088 Sentence denotes Structurally, MERS-CoV is a spherical, enveloped, single-stranded, positive sense RNA beta-coronavirus [60].
T151 19089-19294 Sentence denotes MERS-CoV utilizes its S protein to mediates cell internalization via binding with the receptor dipeptidyl peptidase 4 (DPP4) on the surface of cells instead of the receptor ACE2 of SARS-CoV and SARS-CoV-2.
T152 19295-19370 Sentence denotes S protein is therefore the most exposed and immunogenic viral protein [61].
T153 19371-19631 Sentence denotes The association of MERS-CoV S protein is similar to that of SARS-CoVs including: the distal subunit S1 containing the RBD and the membrane-anchored subunit S2 containing a putative fusion peptide, transmembrane domain and two heptad repeat regions HR1 and HR2.
T154 19632-19709 Sentence denotes This S protein is also the target to develop nAbs, particularly the RBD [62].
T155 19710-19841 Sentence denotes Using the fragment containing residues 358–588 of S protein, the neutralization against MERS-CoV of induced Abs were observed [63].
T156 19842-19965 Sentence denotes Other studies, also approaching RBD, reported the generated Abs with the epitopes aa 377–662 or aa 377–588 of MERS-CoV RBD.
T157 19966-20064 Sentence denotes The latter elicited the strongest effect which effectively neutralized MERS-CoV infection [64,65].
T158 20065-20111 Sentence denotes The epitope aa 736–761 also induced nAbs [66].
T159 20112-20328 Sentence denotes Using a novel panning strategy, seven anti-S1 scFvs Abs, named 1E9, 1F8, 3A1, 3B12, 3C12, 3B11, and M14D3, which bind one or several of these three different epitopes (aa 21–358, 349–751 and 349–590) were identified.
T160 20329-20400 Sentence denotes They neutralized MERS-CoV infection at nanomolar of concentration [67].
T161 20401-20534 Sentence denotes Other Abs, such as MERS-4 and its variant MERS-4 V2, were intriguingly discovered to bind RBD and compete with DPP4 but from outside.
T162 20535-20673 Sentence denotes MERS-4 Fab and MERS-4V2 scFv interact with β5-β6, β6-β7, and β7-β8 loops of RBD resulting in the inhibition of MERS-CoV infection [68,69].
T163 20674-20980 Sentence denotes Three human monoclonal Abs, m336, m337, and m338 bind RBD of MERS-CoV at extremely low concentration, 4.2, 9.3, and 15 nM, respectively. m336, that neutralized 50% of both pseudotyped and live MERS-CoV at 0.005 and 0.07 μg/mL, respectively, suggested the prophylaxis and therapy of MERS-CoV infection [70].
T164 20981-21174 Sentence denotes In another study, using MERS-RBD to immunize mice, two monoclonal nAbs 4C2 and 2E6 recognizing an epitope that partially overlaps the receptor-binding footprint in MERS-CoV RBD were identified.
T165 21175-21265 Sentence denotes The 4C2 could further reduce the number of viral particles in MERS-CoV infected mice [71].
T166 21266-21629 Sentence denotes Recently, other nAbs, such as human mAbs or Fabs (MERS-27, MERS-GD27, or MCA1), humanized mAbs (hMS-1, 4C2 h), mouse mAbs (Mersmab1, 4C2, or D12), single-domain antibodies (nanobodies Nbs) HCAb-83 or NbMS10-Fc and transchromosomic cattle antibody SAB-301 recognizing epitopes on the RBD have been demonstrated to neutralize pseudotyped and/or live MERS-CoVs [31].
T167 21630-21680 Sentence denotes Only SAB-301 is under phase I clinical trial [72].
T168 21681-21850 Sentence denotes Despite the efforts of scientists to find anti-MERS-CoV antibodies, no vaccine has been found yet and the virus continues to circulate in human beings and other species.
T169 21852-21887 Sentence denotes 6 SARS-CoV-2: from 2019 to present
T170 21888-22118 Sentence denotes The novel SARS-CoV-2 coronavirus, first appeared in Wuhan, China, in December 2019, is creating a pandemic over the world with the number of confirmed cases reached 3,529,408, of which 248,025 were dead up to the 4th May 2020 [1].
T171 22119-22294 Sentence denotes Phylogenetic analysis of SARS-CoV-2 demonstrated similarity with SARS-CoV and bat-derived SARS-like coronaviruses (SL-CoVs) with 79.6% and 88% sequence identity, respectively.
T172 22295-22358 Sentence denotes They belong to lineage B of the beta coronavirus genus [73,74].
T173 22359-22437 Sentence denotes SARS-CoV-2 seems to be more contagious but less pathogenic than SARS-CoV [75].
T174 22438-22494 Sentence denotes COVID-19 is a self-limiting disease in >80% of patients.
T175 22495-22605 Sentence denotes Same as Spanish influenza viruses, SARS-CoV and SARS-CoV-2 induce a “cytokine storm” but to different degrees.
T176 22606-22770 Sentence denotes The difference of some conserved interferon antagonists and of inflammasome activators explains their abilities to modulate antiviral and proinflammatory responses.
T177 22771-22911 Sentence denotes Along with the race of finding therapeutic treatment, nAbs and vaccine development are also important to control the spread in the long run.
T178 22912-23152 Sentence denotes SARS-CoV-2 entries the host via the binding of its spike S protein to the ACE2 receptor - sharing receptor, but with higher affinity than SARS-CoV S [76], suggesting a basis for the greater human-to-human transmission of SARS-CoV-2 [51,77].
T179 23153-23331 Sentence denotes S protein of SARS-CoV-2 composed of 1273 amino acids [76] uses its N-terminal S1 subunit to bind ACE2 receptor with a better affinity than SARS-CoV S glycoprotein for entry [78].
T180 23332-23432 Sentence denotes Effectively, S1 subunit divides into an N-terminal domain (NTD) and a receptor-binding domain (RBD).
T181 23433-23507 Sentence denotes The latter is necessary for viral binding and a potential target for nAbs.
T182 23508-23742 Sentence denotes During infection, SARS-CoV-2 first binds the host cell through interaction between its S1-RBD and ACE2, triggering conformational changes in the S2 subunit that is indispensable for virus fusion and entry into the target cell [79,80].
T183 23743-23820 Sentence denotes Some recent studies also confirmed that RBD is a conformational epitope [78].
T184 23821-23960 Sentence denotes Antibodies binding RBD may sterically hinder binding to the nearby peptide S14P5 of ACE2 receptor, thereby abolishing virus infection [34].
T185 23961-24174 Sentence denotes SARS-CoV-2 nAbs could be detected in patients from 10 to 15 days after symptoms onset and the positive rate for IgG reached close to 100% around 20 days [81,82] with the highest level during day 31–40 since onset.
T186 24175-24268 Sentence denotes Some patients (5.7%) had neutralizing Abs titers under the detectable level (ID50: <40) [83].
T187 24269-24359 Sentence denotes The level of IgG antibodies was different between gender, age and clinical classification.
T188 24360-24448 Sentence denotes The average IgG antibody level in female patients was higher than in male patients [84].
T189 24449-24552 Sentence denotes Patient over 40 years old developed higher levels of SARS-CoV-2 specific nAbs than the younger persons.
T190 24553-24632 Sentence denotes Patients with a worse clinical classification had a higher antibody titer [83].
T191 24633-24712 Sentence denotes This remark is useful to select a research candidate and to save research time.
T192 24713-24849 Sentence denotes The passive antibody therapy, such as plasma fusion containing polyclonal antibodies from COVID-19 neutralized patients has been tested.
T193 24850-24977 Sentence denotes This method was tested as an option to treat other viruses such as influenza, Ebola or SARS-CoV [[85], [86], [87], [88], [89]].
T194 24978-25088 Sentence denotes The lack of human sera, and the possibility of contamination with other infectious agents limit this strategy.
T195 25089-25194 Sentence denotes However, several groups have reported some positive results demonstrating the potential of this approach.
T196 25195-25395 Sentence denotes After one dose of 200 mL of convalescent plasma derived from recently recovered donors with the neutralizing antibody titers above 1:640, the patients with SARS-CoV-2 positive revealed an improvement.
T197 25396-25473 Sentence denotes Among ten patients, seven patients were virus-negative post transfusion [90].
T198 25474-25653 Sentence denotes Whereas in another study, among 5 patients received transfusion with convalescent plasma with a neutralization titer >40, 3 have been discharged from the hospital (length of stay:
T199 25654-25740 Sentence denotes 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion [91].
T200 25741-25859 Sentence denotes More studies might brighter this approach but evaluation in clinical trials are also still far from a bold conclusion.
T201 25861-25924 Sentence denotes 6.1 Effect of cross-reactive antibodies on SARS-CoV-2 pandemic
T202 25925-26091 Sentence denotes Due to the high similarity of S proteins from SARS-CoV and MERS-CoV [73], their specific cross-nAbs were tested against SARS-CoV-2 infection in the COVID-19 outbreak.
T203 26092-26236 Sentence denotes Serum Abs from recovered SARS-CoV patients could efficiently cross-neutralize SARS-CoV-2 but with lower efficiency as compared to SARS-CoV [92].
T204 26237-26320 Sentence denotes Cross-reactive Abs against SARS-CoV-2 S protein mostly target non-RBD regions [93].
T205 26321-26496 Sentence denotes Using simulation technique, the binding of five Abs against SARS-CoV, six Abs anti-MERS-CoV to RBD of SARS-CoV-2 was predicted with Rosetta antibody-antigen docking protocols.
T206 26497-26610 Sentence denotes The amino acid position 445–449 (VGGNY) and 470–486 (TEIYQAGSTPCNGVEGF) were found to be conserved in SARS-CoV-2.
T207 26611-26779 Sentence denotes Moreover, in addition to the amino acid positions 71–77 (GTNGTKR) in the NTD region of the S protein, aa 445–449 and 470–486 are potential for further development [94].
T208 26780-26872 Sentence denotes The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues.
T209 26873-26941 Sentence denotes This change has an important impact on the cross-reactivity of nAbs.
T210 26942-27022 Sentence denotes This difference was observed using bioinformatic approaches of epitope analysis.
T211 27023-27088 Sentence denotes The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV.
T212 27089-27292 Sentence denotes Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic.
T213 27293-27474 Sentence denotes The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions.
T214 27475-27565 Sentence denotes The divergence of spike proteins is considered as a major change in the antibody epitopes.
T215 27566-27660 Sentence denotes The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95].
T216 27661-27712 Sentence denotes Antibody response to RBD is viral species-specific.
T217 27713-27847 Sentence denotes Effectively, none of the found SARS-CoV-2 antibodies nor the infected plasma cross-reacted with RBDs from either SARS-CoV or MERS-CoV.
T218 27848-27951 Sentence denotes In a study, 206 monoclonal antibodies specific to the RBD SARS-CoV-2 were identified in eight patients.
T219 27952-28104 Sentence denotes These mAbs are different in: antibody heavy and light chains, antibody clones, CDR3 length… which lead to different binding and neutralizing capacities.
T220 28105-28196 Sentence denotes ACE2 is out-competed with almost 100% efficacity by some mAbs such as P2B-2F6 and P2C-1F11.
T221 28197-28360 Sentence denotes Interestingly the latter and a moderate antibody P2C-1C10 seems to target the different epitopes, and they could be combined for synergistic antiviral effect [96].
T222 28361-28528 Sentence denotes CR3022, a SARS-CoV RBD-specific antibody, can bind strongly with a kd of 6.3 nM to an epitope on RBD that does not overlap with the SARS-Cov-2 ACE-2 binding site [34].
T223 28529-28601 Sentence denotes Despite its strong binding, CR3022 could not neutralize SARS-CoV-2 [97].
T224 28602-28659 Sentence denotes S1 is a specific antigen for SARS-CoV-2 diagnostics [98].
T225 28660-28739 Sentence denotes The S1 subunit of SARS-CoV or SARS-CoV-2 has four core domains S1A through S1D.
T226 28740-29000 Sentence denotes The human 47D11 antibody binds the S1B of both viruses, without competing with S1B binding to ACE2 receptor expressed at the cell surface, and showed cross-neutralizing activity by an unknown mechanism that is different from receptor binding interference [99].
T227 29001-29124 Sentence denotes An immunogenic domain in the S2 subunit of SARS-CoV S (aa 1029–1192) was highly conserved in several strains of SARS-CoV-2.
T228 29125-29271 Sentence denotes Four murine monoclonal Abs, 1A9, 1G10, 2B2 and 4B12, against this S2 subunit of SARS-CoV can also cross-reactive with the S protein of SARS-CoV-2.
T229 29272-29439 Sentence denotes Interestingly, 1A9 can strongly bind the S2 subunit of SARS-CoV-2 through a novel epitope (aa 1111–1130) and can detect S protein in SARS-CoV-2 during infection [100].
T230 29440-29571 Sentence denotes This epitope also overlaps with one of two cytotoxic T-lymphocyte epitopes (aa 884–891 and 1116–1123) of SARS-CoV S2 subunit [101].
T231 29572-29684 Sentence denotes 1A9 is therefore suggested to induce both humoral and cellular immune responses against SARS-CoV and SARS-CoV-2.
T232 29685-29914 Sentence denotes In a serologic cross-reactivity test, Khan et al. found out that 4 out of 5 showed high IgG seroreactivity across the 4 common human coronaviruses but all showed low IgG seroreactivity to SARS-CoV-2, SARS-CoV, and MERS-CoV [102].
T233 29915-30118 Sentence denotes The weak cross-immunity against SARS-CoV-2 from others betacoronaviruses, such as HCoV-OC43 and HCoV-HKU1, could restraint the transmission of SARS-CoV-2 but a resurgence is possible in the future [103].
T234 30119-30273 Sentence denotes Moreover, spike- and non-spike specific CD4+ T cell responses were detectable not only in SARS-CoV-2 infected patients but also in uninfected individuals.
T235 30274-30465 Sentence denotes If there is an absence of antibody cross-reactivity, T lymphocyte cross-reactivity present in 50% of cases will be responsible for the epidemiological evolution of SARS-CoV-2 infection [104].
T236 30467-30507 Sentence denotes 6.2 Anti-SARS-CoV-2 specific antibodies
T237 30508-30596 Sentence denotes Up to this moment, only few tests of specific Abs against SARS-CoV-2 have been reported.
T238 30597-30699 Sentence denotes 311mab-31B5 and 311mab-32D4 human monoclonal Abs could strongly and specifically bind the RBD protein.
T239 30700-30846 Sentence denotes These mAbs could efficiently block SARS-CoV-2-ACE2 interaction and neutralize pseudovirus entry into host cells ectopically expressing ACE2 [105].
T240 30847-31090 Sentence denotes Peptides S14P5 and S21P2 in the two distinct peptide pools S14 and S21 from SARS-CoV-2 S library were strongly detected in COVID-19 patients but not in SARS-CoV patients by using pools of overlapping linear peptides and functional assays [78].
T241 31091-31227 Sentence denotes With the data from antibodies depletion assays, researchers indicated that S14P5 and S21P2 were necessary for SARS-CoV-2 neutralization.
T242 31228-31387 Sentence denotes Moreover, pool S51 contains very conserved fusion peptide in coronavirus [106,107] and is partially overlapped in the sera of SARS-CoV and SARS-CoV-2 patients.
T243 31388-31464 Sentence denotes These results suggested that S51 may be a potential pan-coronavirus epitope.
T244 31465-31582 Sentence denotes Sera from recalled SARS-CoV patients could neutralize SARS-CoV, but not the SARS-CoV-2 pseudotyped lentiviruses [78].
T245 31583-31810 Sentence denotes In an effort to screen a set of B cell and T cell epitopes of SARS-CoV toward to the spike S and nucleocapsid (N) proteins of SARS-CoV-2, 27 epitope-sequences were identical within SARS-CoV-2 proteins among 115 T cell epitopes.
T246 31811-31989 Sentence denotes However, 19 out of 27 epitopes are associated with five distinct MHC alleles (at 4-digit resolution): HLA-A*02:01, HLA-B*40:01, HLA-DRA*01:01, HLA-DRB1*07:01, and HLA-DRB1*04:01.
T247 31990-32144 Sentence denotes For B cell epitopes, they found 49 identical match epitope-sequences that have potential for developing effective vaccines to combat the SARS-CoV-2 [108].
T248 32145-32395 Sentence denotes Based on the sequence of the spike glycoprotein, seven epitope residue/regions (491–505, 558–562, 703–704, 793–794, 810, 914, and 1140–1146) in the surface glycoprotein were predicted to be associated with a robust immune response to SARS-CoV-2 [30].
T249 32396-32451 Sentence denotes Other candidate epitopes need to be confirmed [95,108].
T250 32452-32621 Sentence denotes Using the memory B cells from a survivor who was SARS-CoV infected in 2003, one nAb anti-RBD named S309 was found to bind to SARS-CoV-2 without interfering ACE2 binding.
T251 32622-32717 Sentence denotes Besides, S309 could recognize a N343-glycan epitope that is distant from the RBM of SARS-CoV-2.
T252 32718-32818 Sentence denotes Interestingly, N343-glycan of SARS-CoV-2 corresponds to SARS-CoV N330 and they are highly conserved.
T253 32819-32926 Sentence denotes S309 potently neutralized both pseudotyped SARS-CoV and SARS-CoV-2 and also the authentic SARS-CoV-2 [109].
T254 32927-33110 Sentence denotes Using machine learning approaches with the data from other virus outbreaks, some synthetic nAbs named C3, C7, C14, C17, C18, Co1, Co2 and Co4 showed a potential to against SARS-CoV-2.
T255 33111-33245 Sentence denotes The authors also confirmed that the mutations of Methionine and Tyrosine could increase the affinity of antibody-target binding [110].
T256 33246-33381 Sentence denotes 19 potential immunogenicity B-cell epitopes, including 2 epitopes located within the RBD region were reported using in silico analysis.
T257 33382-33414 Sentence denotes 17 of them have >14 amino acids.
T258 33415-33538 Sentence denotes The B-cell epitopes which had highest score in this study is the 1052-FPQSAPH-1058 located at position 1052aa of S protein.
T259 33539-33635 Sentence denotes 499 T-cell epitopes bound 34 most popular HLA alleles in the Chinese population were also found.
T260 33636-33797 Sentence denotes Around 30 candidate vaccine peptides in which 5 peptides located within the RBD region and 17 of them contained both B- and T-cell epitopes, were designed [111].
T261 33798-33918 Sentence denotes These vaccine candidates are theoretically able to induce either specific humoral or cellular immune against SARS-CoV-2.
T262 33919-34046 Sentence denotes A panel of five humanized single domain antibodies (sdAbs) or nanobodies, 1E2, 2F2, 3F11, 4D8 and 5F8, was recently discovered.
T263 34047-34178 Sentence denotes These sdAbs bound SARS-CoV-2 tightly but not SARS-CoV, except for 5F8 could bind both viruses but with weaker affinity to SARS-CoV.
T264 34179-34270 Sentence denotes They also showed neutralization activity against both pseudotyped and authentic SARS-CoV-2.
T265 34271-34386 Sentence denotes 1E2, 3F11 and 4D8 completely prevented SARS-CoV-2 RBD-ACE2 binding but this effect of 2F2 and 5F8 was only partial.
T266 34387-34512 Sentence denotes Interestingly, the fusion of the human IgG1 Fc to these sdAbs improved their neutralization activity by 10- to 80-fold [112].
T267 34513-34653 Sentence denotes Due to the lack of repairing mechanism of RNA virus replicase complex, SARS-CoV-2 mutations frequently occur during viral replication [111].
T268 34654-34786 Sentence denotes The genetic drifts of SARS-CoV-2 are a selective evolution toward less immunogenicity for host immune surveillance by T- or B-cells.
T269 34787-34861 Sentence denotes The latter appearing strains are less immunogenic than earlier ones [113].
T270 34862-34920 Sentence denotes Antigenic drift is also reported in the COVID-19 pandemic.
T271 34921-35090 Sentence denotes The highly prevalent 23403A > G (p.D614G) variant in the European population may result in vaccine mismatches with little protection to that group of patients [114,115].
T272 35091-35246 Sentence denotes Though SARS-COV-2 genome has a much lower mutation rate and genetic diversity than SARS, some of its mutations attract the special attention of scientists.
T273 35247-35409 Sentence denotes Single amino acid mutation R408I in RBD can reduce the affinity of ACE2 receptor binding [115] that leads to a low or ineffective vaccine for the future epidemic.
T274 35410-35510 Sentence denotes Effectively, sequence alignment showed that this 408R is strictly conserved in SARS-CoV-2, SARS-CoV.
T275 35511-35652 Sentence denotes 408R located at the interface between RBD and ACE2, but positioned relatively far away from ACE2, does not have direct interaction with ACE2.
T276 35653-35705 Sentence denotes 408R can form a hydrogen bond with the 90 N of ACE2.
T277 35706-35803 Sentence denotes This hydrogen bond is suggested to contribute to the high binding affinity of ACE2 binding [115].
T278 35805-35818 Sentence denotes 7 Discussion
T279 35819-35916 Sentence denotes Science, with new advances, somehow might find the therapy to protect human beings from COVID-19.
T280 35917-36057 Sentence denotes Among these, plasma therapy composing of antibodies and humoral immune components has been doing great and being one of the first solutions.
T281 36058-36175 Sentence denotes Because of that, the quest of an antibody always becomes a “must-do-first” when human population facing new pandemic.
T282 36176-36276 Sentence denotes However, only one lesson could be obvious is we can never get the answer for every pandemic at ones.
T283 36277-36412 Sentence denotes Some coronaviruses can infect birds, bats and other species, some are phylogenetically similar to known pathogenic human coronaviruses.
T284 36413-36576 Sentence denotes The search for the reservoir has resulted in the vast expansion of the library of known coronaviruses which suggests that additional emergence events are possible.
T285 36577-36660 Sentence denotes Pandemics will create the urgent need for vaccines around the world simultaneously.
T286 36661-36778 Sentence denotes But it is not because of this urgency that we can license a vaccine when its benefits and side effects are not clear.
T287 36779-36864 Sentence denotes Researching a vaccine for influenza viruses, HIV or SARS-CoV-2 is always challenging.
T288 36865-37097 Sentence denotes Firstly, although the immunogen for protection of a virus, glycoproteins gp120 or gp41 of HIV or S protein of SARS-CoV-2 for example, can be quickly detected, but the immune response needs to be optimized with a good antigen design.
T289 37098-37269 Sentence denotes Secondly, any drug has side effects immediately or in long-term, directly by the composition of the medication or indirectly by the response of the body to the medication.
T290 37270-37470 Sentence denotes Pre-clinical experiences with vaccine candidates for SARS-CoV and MERS-CoV are typical examples in aggravating lung disease, either directly or by antibody-dependent enhancement [[116], [117], [118]].
T291 37471-37712 Sentence denotes Thirdly, in natural acquired infection, the time point of the detection of nAbs can be easily observed, from 10 to 14 days post-infection in SARS-CoV-2 case for example [119,120], but the potential duration of immunity response is not clear.
T292 37713-37797 Sentence denotes Therefore, the use of singe-dose or several doses of vaccines needs to be confirmed.
T293 37798-37905 Sentence denotes Moreover, once a vaccine has been approved, that does not mean that virus research and monitoring can stop.
T294 37906-38041 Sentence denotes Indeed, influenza and HIV viruses have been reported to have high mutations, making it difficult to find broadly neutralizing vaccines.
T295 38042-38173 Sentence denotes In the actual pandemic of SARS-CoV-2, drift variants have been reported and that can affect COVID-19 vaccine development [114,115].
T296 38174-38228 Sentence denotes No vaccine is available against any coronavirus [121].
T297 38229-38362 Sentence denotes Monoclonal antibodies cocktails including multiple epitopes targeting Abs could be taken into account to broaden spectrum of therapy.
T298 38363-38415 Sentence denotes Vaccine development is a long and expensive process.
T299 38416-38498 Sentence denotes From identifying a virus to producing vaccines to market, it takes us a few years.
T300 38499-38719 Sentence denotes If pandemic gets end before vaccines are approved, the research of vaccine candidates under development need to be continued and ready for clinical trials, in order to get emergency authorization when an outbreak recurs.
T301 38720-38858 Sentence denotes This statement draws on experience from Ebola pandemic in which vaccine was still under development when the Ebola outbreak ended in 2016.
T302 38859-38998 Sentence denotes Ebola vaccine is recently approved [[122], [123], [124]] and already used in the recent outbreak in the Democratic Republic of Congo [125].
T303 38999-39158 Sentence denotes Studying and understanding the antigen-antibody mechanism of a virus can be used as a precondition to accelerate the studying another virus during an outbreak.
T304 39159-39284 Sentence denotes In the COVID-19 pandemic, some nAbs studies were based on the research of previous viruses such as SARS, MERS, Ebola and HIV.
T305 39285-39472 Sentence denotes Through machine learning approaches with the data composed of HIV gp41-antibodies complexes and of 13 more different virus types, some potential nAbs against SARS-CoV-19 were found [110].
T306 39473-39637 Sentence denotes This case shows the usefulness of this review of host-antibody interactions from coronaviruses pandemics for young or mature scientists working on vaccine research.
T307 39638-39827 Sentence denotes The key findings in coronavirus antibodies investigation could reveal S protein and its subunits as major frame for antibody generation in which RBD seems to be the most efficient peptides.
T308 39828-39895 Sentence denotes A lot of effort has been tried but still plenty of gaps to fill up.
T309 39896-39984 Sentence denotes Other approaches and therapies are also needed to protect us from coronavirus infection.
T310 39986-40001 Sentence denotes Acknowledgments
T311 40002-40090 Sentence denotes We would like to thank Dr. Thi-Ngoc-Anh Nguyen and Dr. Bruno Beaumelle for their advice.
T312 40092-40099 Sentence denotes Funding
T313 40100-40222 Sentence denotes This review did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

2_test

Id Subject Object Predicate Lexical cue
32450171-27784796-66454436 2425-2426 27784796 denotes 2
32450171-12185262-66454437 2609-2610 12185262 denotes 3
32450171-24441474-66454438 2911-2912 24441474 denotes 4
32450171-12185262-66454439 3702-3703 12185262 denotes 3
32450171-4617423-66454440 5144-5145 4617423 denotes 7
32450171-24172901-66454441 6025-6027 24172901 denotes 13
32450171-25211075-66454442 6206-6208 25211075 denotes 15
32450171-30531947-66454443 6297-6299 30531947 denotes 16
32450171-15577937-66454444 7042-7043 15577937 denotes 9
32450171-16169905-66454445 7182-7184 16169905 denotes 10
32450171-19788804-66454446 7194-7196 19788804 denotes 12
32450171-24172901-66454447 7699-7701 24172901 denotes 13
32450171-19321428-66454448 8474-8476 19321428 denotes 18
32450171-2170676-66454449 8812-8814 2170676 denotes 19
32450171-16122388-66454450 9509-9511 16122388 denotes 22
32450171-27030273-66454451 9658-9660 27030273 denotes 23
32450171-15161975-66454452 9776-9778 15161975 denotes 24
32450171-24762977-66454453 10439-10441 24762977 denotes 25
32450171-15163706-66454454 11021-11023 15163706 denotes 26
32450171-27936982-66454455 11027-11029 27936982 denotes 27
32450171-32183941-66454456 11556-11558 32183941 denotes 30
32450171-15857975-66454457 12364-12366 15857975 denotes 32
32450171-32065055-66454458 12563-12565 32065055 denotes 34
32450171-16597622-66454459 12947-12949 16597622 denotes 35
32450171-32065055-66454460 13067-13069 32065055 denotes 34
32450171-17620608-66454461 13304-13306 17620608 denotes 36
32450171-32065055-66454462 13633-13635 32065055 denotes 34
32450171-19748648-66454463 14015-14017 19748648 denotes 38
32450171-15313178-66454464 14417-14419 15313178 denotes 39
32450171-19748648-66454465 14579-14581 19748648 denotes 38
32450171-17161858-66454466 14582-14584 17161858 denotes 40
32450171-15655773-66454467 14951-14953 15655773 denotes 41
32450171-15234813-66454468 15085-15087 15234813 denotes 42
32450171-20168090-66454469 15166-15168 20168090 denotes 43
32450171-19324051-66454470 15206-15208 19324051 denotes 44
32450171-32065055-66454471 15315-15317 32065055 denotes 34
32450171-32065055-66454472 15595-15597 32065055 denotes 34
32450171-15247913-66454473 15672-15674 15247913 denotes 46
32450171-17620608-66454474 15900-15902 17620608 denotes 36
32450171-15731223-66454475 16721-16723 15731223 denotes 48
32450171-15194770-66454476 17001-17003 15194770 denotes 49
32450171-15939399-66454477 17553-17555 15939399 denotes 50
32450171-32226289-66454478 17656-17658 32226289 denotes 51
32450171-21576510-66454479 17972-17974 21576510 denotes 52
32450171-27576010-66454480 18268-18270 27576010 denotes 53
32450171-26414077-66454481 18382-18384 26414077 denotes 54
32450171-23622767-66454482 18388-18390 23622767 denotes 55
32450171-24206838-66454483 18394-18396 24206838 denotes 56
32450171-23831647-66454484 18400-18402 23831647 denotes 57
32450171-25211075-66454485 18543-18545 25211075 denotes 15
32450171-23933067-66454486 18855-18857 23933067 denotes 58
32450171-25810418-66454487 18858-18860 25810418 denotes 59
32450171-30531947-66454488 18975-18977 30531947 denotes 16
32450171-23075143-66454489 19084-19086 23075143 denotes 60
32450171-27083424-66454490 19366-19368 27083424 denotes 61
32450171-23835475-66454491 19705-19707 23835475 denotes 62
32450171-23785207-66454492 19837-19839 23785207 denotes 63
32450171-23824801-66454493 20057-20059 23824801 denotes 64
32450171-25387086-66454494 20107-20109 25387086 denotes 66
32450171-29996104-66454495 20669-20671 29996104 denotes 69
32450171-24789777-66454496 20976-20978 24789777 denotes 70
32450171-26391698-66454497 21261-21263 26391698 denotes 71
32450171-32015507-66454498 22351-22353 32015507 denotes 73
32450171-32007145-66454499 22354-22356 32007145 denotes 74
32450171-32190290-66454500 22433-22435 32190290 denotes 75
32450171-32226289-66454501 23145-23147 32226289 denotes 51
32450171-19198616-66454502 23735-23737 19198616 denotes 79
32450171-27936982-66454503 23738-23740 27936982 denotes 80
32450171-32065055-66454504 23956-23958 32065055 denotes 34
32450171-12777656-66454505 24948-24950 12777656 denotes 85
32450171-17914053-66454506 24954-24956 17914053 denotes 86
32450171-26735992-66454507 24960-24962 26735992 denotes 87
32450171-15214887-66454508 24966-24968 15214887 denotes 88
32450171-15616839-66454509 24972-24974 15616839 denotes 89
32450171-32253318-66454510 25469-25471 32253318 denotes 90
32450171-32015507-66454511 25994-25996 32015507 denotes 73
32450171-32065055-66454512 28524-28526 32065055 denotes 34
32450171-19475608-66454513 29566-29569 19475608 denotes 101
32450171-19439480-66454514 31302-31305 19439480 denotes 106
32450171-32183941-66454515 32391-32393 32183941 denotes 30
32450171-18941225-66454516 37457-37460 18941225 denotes 117
32450171-32196410-66454517 37645-37648 32196410 denotes 120
32450171-28017403-66454518 38896-38899 28017403 denotes 122
32450171-30685246-66454519 38903-38906 30685246 denotes 123
32450171-27686015-66454520 38910-38913 27686015 denotes 124
32450171-31141654-66454521 38993-38996 31141654 denotes 125