PMC:7243768 / 9791-13336 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"4.1 SARS-CoV – cardiovascular risk\nIt was reported that SARS induced myocardial infarction and acute coronary syndrome [31,32]. A small group of 75 patients infected with SARS had shown that 2 of the five patients died due to acute myocardial infarction [32]. In another study which was conducted among 46 patients infected with SARS indicated that there were no significant changes in the initial stages of infection and, after 30 days, didn't show any risks related to the cardiovascular system. In another study conducted on 121 patients, it was reported that patients had other comorbidities such as cardiovascular diseases, hypotension, and transient cardiomegaly, particularly tachycardia and transient paroxysmal atrial fibrillation and most importantly tachycardia [33] (represented in Table 1 ).\nTable 1 Differentiating SARS-CoV, MERS-CoV, and SARS-CoV-2 based on the impact of manifestations posed by them at various organ levels.\nTarget SARS-CoV MERS-CoV SARS-CoV-2\nACE2 receptor DPP4 receptor ACE2 receptor\n1. Heart Hypotension, transient cardiomegaly, tachycardia, transient paroxysmal atrial fibrillation, myocardial infarction, acute coronary syndrome Elevated troponin levels, a chronic severe 3-vessel disease with no acute vessel closure characterized by coronary angiography Decreased levels of ACE2 receptor and increased troponin, resulting in cardiac arrest and cardiac injury.\n2. Lungs Hepatization, severe lung consolidation, edema with pleural effusion, mucopurulent material in the tracheobronchial tree, focal hemorrhage, alveolar and septal fibrosis, edema, alveolar hemorrhage, fibrin exudation in alveolar spaces, hyaline membrane formation, and extreme bronchiolar injury indicate the acute phase. Acute respiratory distress syndrome, septic shock, the mild upper respiratory illness may result in swiftly growing pneumonitis, respiratory failure Severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, edema, multinucleated giant cells, protruding hyaline membranes, and proteinaceous exudate.\n3. Kidney Acute renal impairment – Proteinuria, hematuria, acute kidney injury (AKI)\n4. Liver Hepatitis, liver injury characterized by elevated ALT, and AST levels Disintegrated death of hepatocytes in the hepatic sinus, penetration of large amounts of activated macrophages and Kupffer cells, elevated pro-inflammatory cytokine responses, and lobular lymphocytes infiltrate, mild cellular hydropic degeneration in hepatic parenchyma and mild portal tract and liver damage indicated by elevated ALT and AST levels. Liver injury characterized by elevated ALT, GGT, and AST levels. Decreased bilirubin levels.\n5. Gastrointestinal tract – – Viral load found in the cytoplasm of epithelia of duodenum and rectum, nausea, and diarrhea.\n6. Central nervous system Vision-related issues, the chemotactic attraction of immune cells by the infected brain cells, the presence of a chemokine called Mig found in the patient's brain Fever, vomiting, confusion and ataxia, bilateral basal ganglia, deep white matter, large area of hypodensity in the proximal half of the corpus callosum up to the mid part of his body and interval multiple patchy hypodensities bilaterally in the periventricular, acute infarction, and bilaterally in the deep watershed and the parasagittal region as well as scattered foci in the cortical and subcortical regions of the temporal and parietal lobes Nausea, vomiting, and 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