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PMC:7243768 / 65179-67167 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2546 28-32 Gene denotes ACE2 Gene:59272
2547 5-15 Species denotes SARS-CoV-2 Tax:2697049
2565 42-46 Gene denotes ACE2 Gene:59272
2566 82-85 Gene denotes Ang Gene:283
2567 92-100 Gene denotes Ang (1–7 Gene:284
2568 153-157 Gene denotes ACE2 Gene:59272
2569 406-410 Gene denotes ACE2 Gene:59272
2570 497-501 Gene denotes ACE2 Gene:59272
2571 620-624 Gene denotes ACE2 Gene:59272
2572 744-748 Gene denotes ACE2 Gene:59272
2573 782-786 Gene denotes ACE2 Gene:59272
2574 978-982 Gene denotes ACE2 Gene:59272
2575 373-383 Species denotes SARS-CoV-2 Tax:2697049
2576 444-451 Species denotes patient Tax:9606
2577 563-573 Species denotes SARS-CoV-2 Tax:2697049
2578 594-599 Species denotes human Tax:9606
2579 804-814 Species denotes SARS-CoV-2 Tax:2697049
2580 431-443 Disease denotes hypertension MESH:D006973
2581 911-919 Disease denotes COVID-19 MESH:C000657245
2593 1946-1950 Gene denotes ACE2 Gene:59272
2594 1108-1128 Species denotes African green monkey Tax:9534
2595 1202-1212 Species denotes SARS-CoV-2 Tax:2697049
2596 1613-1623 Species denotes SARS-CoV-2 Tax:2697049
2597 1102-1106 Disease denotes ARDS MESH:D012128
2598 1188-1196 Disease denotes infected MESH:D007239
2599 1223-1231 Disease denotes infected MESH:D007239
2600 1323-1332 Disease denotes infection MESH:D007239
2601 1599-1607 Disease denotes infected MESH:D007239
2602 1795-1810 Disease denotes CoV-2 infection MESH:C000657245
2603 1907-1922 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T533 116-121 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T534 229-244 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T535 466-471 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T536 1129-1135 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T537 1144-1148 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T538 1494-1514 Body_part denotes embryonic stem cells http://purl.org/sig/ont/fma/fma82841
T539 1509-1514 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T540 1523-1529 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T541 1570-1575 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T542 1779-1784 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T543 1962-1967 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T262 116-121 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T263 466-471 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T264 1129-1135 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T265 1523-1529 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T266 1962-1967 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T779 5-13 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T780 5-9 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T781 373-381 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T782 373-377 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T783 431-443 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T784 563-571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T785 563-567 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T786 804-812 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T787 804-808 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T788 911-919 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T789 1102-1106 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T790 1202-1210 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T791 1202-1206 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T792 1323-1343 Disease denotes infection, the viral http://purl.obolibrary.org/obo/MONDO_0005108
T793 1323-1332 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T794 1613-1621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T795 1613-1617 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T796 1790-1798 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T797 1790-1794 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T798 1801-1810 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T799 1907-1922 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T800 1913-1922 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T807 116-121 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T808 116-121 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T809 173-183 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranous
T810 229-235 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T811 236-244 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T812 305-306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T813 466-471 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T814 466-471 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T815 594-599 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T816 771-781 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranous
T817 881-882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T818 1059-1062 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T819 1080-1081 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T820 1122-1128 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T821 1129-1135 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T822 1129-1135 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T823 1129-1135 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T824 1144-1153 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T825 1163-1167 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T826 1163-1167 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T827 1385-1386 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T828 1504-1514 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T829 1523-1529 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T830 1523-1529 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T831 1523-1529 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T832 1570-1575 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T833 1669-1670 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T834 1779-1784 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T835 1861-1862 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T836 1962-1967 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T837 1962-1967 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85195 86-88 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T85 694-696 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T2639 1026-1028 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T139 67-78 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T140 139-151 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T141 1007-1018 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T142 1338-1355 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T143 1338-1355 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T144 1648-1665 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T145 1648-1665 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T146 1907-1922 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T482 0-41 Sentence denotes 7.2 SARS-CoV-2 and soluble ACE2 receptor
T483 42-152 Sentence denotes ACE2 is required for the degradation of Ang II to Ang (1–7), reducing the blood pressure through vasodilation.
T484 153-334 Sentence denotes ACE2 exists as both membranous forms, which are found to be anchored to the plasma membrane and the soluble form, circulating in the bloodstream but at a lower proportion [151,152].
T485 335-481 Sentence denotes Besides serving as an entry point for SARS-CoV-2, the higher levels of ACE2 are required by the hypertension patient to reduce the blood pressure.
T486 482-574 Sentence denotes Therefore, the ACE2 levels need to be maintained besides inhibiting the entry of SARS-CoV-2.
T487 575-920 Sentence denotes Thus, the usage of human recombinant soluble ACE2 (hrsACE2) which exhibited positive results in the phase I and phased II clinical trials to elevate the soluble form of ACE2that competes with the membranous ACE2 for binding with SARS-CoV-2 and inhibits the viral entry and replication can be considered as a therapeutic option to treat COVID-19.
T488 921-1039 Sentence denotes Besides inhibiting the viral entry, it also sustains the ACE2 levels required for the degradation of Ang II [153,154].
T489 1040-1107 Sentence denotes Currently, hrsACE2 has been approved as a treatment option of ARDS.
T490 1108-1213 Sentence denotes African green monkey kidney derived cell line; namely, Vero E6 was cultured and infected with SARS-CoV-2.
T491 1214-1312 Sentence denotes Then the infected culture was added with hrsACE2 to estimate the therapeutic potential of hrsACE2.
T492 1313-1462 Sentence denotes 15 h post-infection, the viral replication was found to be inhibited in a dose-dependent manner with reference to the concentration of hrsACE2 added.
T493 1463-1693 Sentence denotes The addition of hrsACE2 to the embryonic stem cells derived kidney organoids comprised of proximal tubular cells and podocytes clusters infected with SARS-CoV-2 had shown to reduce the viral replication in a dose-dependent manner.
T494 1694-1821 Sentence denotes No studies support the in-vivo and the therapeutic roles of hrsACE2 on the pulmonary cells upon SARS-CoV-2 infection [153,155].
T495 1822-1988 Sentence denotes Therefore, the usage of hrsACE2 can be a potential therapeutic option to inhibit the viral infection besides preserving the ACE2 levels and blood pressure in control.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T317 431-443 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
32450165-26552008-66451125 325-328 26552008 denotes 151
32450165-19948988-66451126 329-332 19948988 denotes 152
32450165-32354636-66451127 1030-1033 32354636 denotes 153
32450165-32167153-66451128 1034-1037 32167153 denotes 154
32450165-32354636-66451129 1812-1815 32354636 denotes 153
32450165-17482553-66451130 1816-1819 17482553 denotes 155