PMC:7243768 / 49870-51041 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"The ACE2 receptors are also widely distributed in the superficial parts such as conjunctiva and cornea inferior parts such as iris, ciliary body, aqueous humor, trabecular meshwork, retina, and non-pigmented ciliary epithelium of the ocular globe which is mentioned out to be the intraocular renin-angiotensin system. Therefore, the distribution of ACE2 and TMPRSS2 protein must be taken into consideration to study the passage of infection through the ocular route [116]. Also, there is a chance for the virus to enter into the nasal cavity, which causes respiratory illness and the digestive system through the lacrimal canaliculi aided by the effectiveness of the tear film [117,118]. Out of 38 COVID-19 positive patients, 12 exhibited clinical manifestations, which include chemosis, epiphora, increased secretions, conjunctivitis, and conjunctival hyperemia. Researchers reported that patients exhibiting ocular symptoms would have elevated neutrophilic and lymphocytic counts, elated procalcitonin, lactate dehydrogenase, and C-reactive protein levels than those without ocular manifestations. The patients with ocular manifestations exhibited severe illness 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