PMC:7243768 / 47062-49068
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1729 | 83-88 | Gene | denotes | ACE-2 | Gene:59272 |
| 1730 | 385-389 | Gene | denotes | TRIF | Gene:148022 |
| 1731 | 943-946 | Gene | denotes | CD8 | Gene:925 |
| 1732 | 1034-1037 | Gene | denotes | CD4 | Gene:920 |
| 1733 | 1043-1046 | Gene | denotes | CD8 | Gene:925 |
| 1734 | 1242-1247 | Gene | denotes | IL-1β | Gene:3552 |
| 1735 | 1249-1253 | Gene | denotes | IL-6 | Gene:3569 |
| 1736 | 1255-1260 | Gene | denotes | TNF-α | Gene:7124 |
| 1737 | 1262-1266 | Gene | denotes | IL-8 | Gene:3576 |
| 1738 | 1268-1273 | Gene | denotes | IL-21 | Gene:59067 |
| 1739 | 1275-1279 | Gene | denotes | CCL2 | Gene:6347 |
| 1740 | 1281-1285 | Gene | denotes | CCL3 | Gene:6348 |
| 1741 | 1287-1291 | Gene | denotes | CCL5 | Gene:6352 |
| 1742 | 1293-1299 | Gene | denotes | CXCL10 | Gene:3627 |
| 1743 | 1301-1306 | Gene | denotes | TNF-β | Gene:7124 |
| 1744 | 1312-1317 | Gene | denotes | MCP-1 | Gene:6347 |
| 1745 | 1751-1756 | Gene | denotes | IL-10 | Gene:3586 |
| 1746 | 1885-1889 | Gene | denotes | IL-4 | Gene:3565 |
| 1747 | 1997-2000 | Gene | denotes | Th1 | Gene:51497 |
| 1748 | 1770-1773 | Gene | denotes | Th1 | Gene:51497 |
| 1749 | 1444-1447 | Gene | denotes | Th1 | Gene:51497 |
| 1750 | 896-899 | Gene | denotes | CD8 | Gene:925 |
| 1751 | 7-17 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1752 | 980-988 | Species | denotes | SARS-CoV | Tax:694009 |
| 1753 | 1407-1416 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 1754 | 667-675 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1755 | 967-976 | Disease | denotes | infection | MESH:D007239 |
| 1756 | 995-1003 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1757 | 1004-1013 | Disease | denotes | infection | MESH:D007239 |
| 1758 | 1131-1143 | Disease | denotes | inflammation | MESH:D007249 |
| 1759 | 1689-1694 | Disease | denotes | death | MESH:D003643 |
| 1760 | 1717-1728 | Disease | denotes | lymphopenia | MESH:D008231 |
| 1761 | 1856-1864 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1762 | 1865-1871 | Disease | denotes | sepsis | MESH:D018805 |
| 1763 | 1948-1956 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T429 | 39-43 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T430 | 138-153 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T431 | 298-306 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T432 | 419-424 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T433 | 454-462 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T434 | 484-488 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T435 | 521-525 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T436 | 573-599 | Body_part | denotes | antigen presentation cells | http://purl.org/sig/ont/fma/fma273565 |
| T437 | 594-599 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T438 | 688-698 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T439 | 699-704 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T440 | 730-734 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T441 | 797-802 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T442 | 833-842 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T443 | 902-907 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T444 | 950-955 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T445 | 1048-1052 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T446 | 1083-1091 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T447 | 1105-1110 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T448 | 1181-1189 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T449 | 1210-1219 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T450 | 1224-1233 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T451 | 1242-1246 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T452 | 1335-1341 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T453 | 1363-1367 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T454 | 1396-1403 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T455 | 1461-1474 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T456 | 1491-1498 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T457 | 1586-1593 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T458 | 1637-1641 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T459 | 1684-1688 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T460 | 1817-1830 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T223 | 484-488 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T224 | 1335-1341 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T225 | 1363-1367 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T226 | 1461-1474 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T227 | 1817-1830 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T533 | 7-15 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T534 | 7-11 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T535 | 667-675 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T536 | 967-976 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T537 | 980-988 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T538 | 980-984 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T539 | 995-1003 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T540 | 1004-1013 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T541 | 1131-1143 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T542 | 1342-1348 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T543 | 1407-1411 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T544 | 1717-1728 | Disease | denotes | lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T545 | 1856-1864 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T546 | 1948-1956 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T653 | 39-43 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T654 | 138-144 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T655 | 145-153 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T656 | 162-167 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T657 | 321-330 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T658 | 335-344 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T659 | 369-371 | http://purl.obolibrary.org/obo/CLO_0007074 | denotes | kB |
| T660 | 369-371 | http://purl.obolibrary.org/obo/CLO_0051988 | denotes | kB |
| T661 | 419-424 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T662 | 433-438 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T663 | 439-448 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T664 | 499-504 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T665 | 521-525 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T666 | 594-599 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T667 | 699-704 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T668 | 728-734 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T669 | 764-774 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T670 | 795-802 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T671 | 882-892 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T672 | 896-899 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T673 | 900-907 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T674 | 943-946 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T675 | 948-955 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T676 | 1024-1025 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T677 | 1034-1037 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T678 | 1043-1046 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T679 | 1048-1052 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T680 | 1105-1110 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T681 | 1262-1266 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T682 | 1430-1440 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T683 | 1461-1474 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T684 | 1553-1562 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T685 | 1617-1627 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T686 | 1635-1641 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cell |
| T687 | 1665-1675 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T688 | 1684-1688 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T689 | 1817-1830 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T690 | 1890-1893 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T253 | 298-306 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T254 | 366-368 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T257 | 531-538 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T258 | 573-580 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T259 | 601-604 | Chemical | denotes | APC | http://purl.obolibrary.org/obo/CHEBI_80551 |
| T260 | 1242-1244 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T262 | 1249-1251 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T264 | 1262-1264 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T266 | 1268-1270 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T268 | 1293-1299 | Chemical | denotes | CXCL10 | http://purl.obolibrary.org/obo/CHEBI_138157 |
| T269 | 1312-1315 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T271 | 1396-1403 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T272 | 1491-1498 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T273 | 1586-1593 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T274 | 1751-1753 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T276 | 1885-1887 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T89 | 281-290 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T90 | 335-352 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T91 | 335-344 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T92 | 531-546 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen present |
| T93 | 573-593 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen presentation |
| T94 | 1131-1143 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T95 | 1665-1694 | http://purl.obolibrary.org/obo/GO_0071888 | denotes | activation-induced cell death |
| T96 | 1684-1694 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T97 | 1703-1712 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T98 | 1703-1712 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T99 | 1777-1796 | http://purl.obolibrary.org/obo/GO_0042092 | denotes | Th2 immune response |
| T100 | 1781-1796 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T331 | 0-89 | Sentence | denotes | Fig. 2 SARS-CoV-2 enters into the host cell via binding with the cellular receptor ACE-2. |
| T332 | 90-168 | Sentence | denotes | It undergoes the fusion with the joining of the plasma membrane and the virus. |
| T333 | 169-307 | Sentence | denotes | Then it undergoes the process of the proteolytic cleavage; further, it will undergo replication and lead to the formation of the proteins. |
| T334 | 308-390 | Sentence | denotes | This process activates the signaling pathway, such as the NF-kB pathway, via TRIF. |
| T335 | 391-470 | Sentence | denotes | The interaction between the cells and the virus activates many cytokine storms. |
| T336 | 471-666 | Sentence | denotes | On the other hand, once the virus enters into the cell, the antigen present in that would undergo the antigen presentation cells (APC); further, this stimulates the humoral and cellular immunity. |
| T337 | 667-843 | Sentence | denotes | COVID-19 infects the macrophage cells, which presents to the T cell, further, which leads to the activation, differentiation of T-cells, along with the production of cytokines. |
| T338 | 844-908 | Sentence | denotes | This shows the negative action on the activation of CD8 T cells. |
| T339 | 909-989 | Sentence | denotes | Thus the mediator produced by the CD8+ T cells clears the infection of SARS-CoV. |
| T340 | 990-1144 | Sentence | denotes | Upon COVID-19 infection, there is a reduced CD4+ and CD8+ cell level, further increasing the cytokine level in the cells, which triggers the inflammation. |
| T341 | 1145-1349 | Sentence | denotes | This mediates the production of the cytokine storm via secreting chemokine and cytokines such as IL-1β, IL-6, TNF-α, IL-8, IL-21, CCL2, CCL3, CCL5, CXCL10, TNF-β, and MCP-1 and triggers the tissue injury. |
| T342 | 1350-1510 | Sentence | denotes | On the other hand, based on the weight of the protein of SARS-CoV2, there is an activation of Th1/Th17 (boosts immune system) when the spike protein is >70 kDa. |
| T343 | 1511-1872 | Sentence | denotes | In case of the Th2 (anti-inflammatory) is activated by the majority of the protein with <70 kDa, then the activation of the B-cell receptor, which causes activation-induced cell death such as apoptosis and lymphopenia which is by releasing IL-10, shifting of Th1 to Th2 immune response, suppression of the immune system and further leads to the COVID-19 sepsis. |
| T344 | 1873-1918 | Sentence | denotes | The role of IL-4 has not been elucidated yet. |
| T345 | 1919-2006 | Sentence | denotes | It remains unanswerable upon COVID-19 condition with the mechanism of Th2 and Th1/Th17. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T215 | 454-469 | Phenotype | denotes | cytokine storms | http://purl.obolibrary.org/obo/HP_0033041 |
| T216 | 1181-1195 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T217 | 1717-1728 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
| T218 | 1865-1871 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |