PMC:7243768 / 41781-42844
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1611 | 5-15 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1624 | 272-282 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1625 | 567-575 | Species | denotes | patients | Tax:9606 |
| 1626 | 651-661 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1627 | 382-394 | Disease | denotes | inflammation | MESH:D007249 |
| 1628 | 399-412 | Disease | denotes | demyelination | MESH:D003711 |
| 1629 | 548-556 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1630 | 557-566 | Disease | denotes | infection | MESH:D007239 |
| 1631 | 584-590 | Disease | denotes | nausea | MESH:D009325 |
| 1632 | 592-600 | Disease | denotes | vomiting | MESH:D014839 |
| 1633 | 606-614 | Disease | denotes | headache | MESH:D006261 |
| 1634 | 839-854 | Disease | denotes | viral infection | MESH:D001102 |
| 1635 | 895-914 | Disease | denotes | respiratory illness | MESH:D012140 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T358 | 16-19 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T359 | 89-103 | Body_part | denotes | nervous system | http://purl.org/sig/ont/fma/fma7157 |
| T360 | 150-155 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T361 | 194-201 | Body_part | denotes | neurons | http://purl.org/sig/ont/fma/fma54527 |
| T362 | 321-326 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T363 | 445-450 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T364 | 483-488 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T365 | 489-494 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T366 | 695-700 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T367 | 701-706 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T368 | 790-795 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T369 | 796-801 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T370 | 828-833 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T371 | 1030-1052 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T372 | 1054-1057 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T195 | 16-19 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T196 | 89-103 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T197 | 299-313 | Body_part | denotes | olfactory lobe | http://purl.obolibrary.org/obo/UBERON_0005366 |
| T198 | 309-313 | Body_part | denotes | lobe | http://purl.obolibrary.org/obo/UBERON_3010752 |
| T199 | 321-326 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T200 | 445-450 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T201 | 483-502 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T202 | 483-488 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T203 | 489-494 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T204 | 695-714 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T205 | 695-700 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T206 | 701-706 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T207 | 790-809 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T208 | 790-795 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T209 | 796-801 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T210 | 828-833 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T211 | 1030-1052 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T212 | 1038-1052 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T213 | 1054-1057 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T494 | 5-13 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T495 | 5-9 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T496 | 272-280 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T497 | 272-276 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T498 | 382-394 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T499 | 548-556 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T500 | 557-566 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T501 | 651-659 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T502 | 651-655 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T503 | 839-854 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T504 | 845-854 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T576 | 16-19 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T577 | 16-19 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T578 | 16-19 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T579 | 150-155 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T580 | 167-172 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T581 | 228-229 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T582 | 321-326 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T583 | 321-326 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T584 | 445-450 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T585 | 445-450 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T586 | 483-488 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T587 | 483-488 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T588 | 489-494 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T589 | 489-494 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T590 | 695-700 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T591 | 695-700 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T592 | 701-706 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T593 | 701-706 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T594 | 760-761 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T595 | 790-795 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T596 | 790-795 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T597 | 796-801 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T598 | 796-801 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T599 | 828-833 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T600 | 828-833 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T601 | 956-961 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T602 | 1030-1052 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T603 | 1030-1052 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T604 | 1030-1052 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
| T605 | 1054-1057 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T606 | 1054-1057 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T607 | 1054-1057 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T207 | 746-751 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T60 | 382-394 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T61 | 839-854 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T288 | 0-24 | Sentence | denotes | 6.7 SARS-CoV-2-CNS risk |
| T289 | 25-162 | Sentence | denotes | Mathew reported that it might be due to the obstructions in the nervous system, which may restrict the entry of air into the lungs [108]. |
| T290 | 163-227 | Sentence | denotes | The virus enters the medullary neurons during the latency phase. |
| T291 | 228-413 | Sentence | denotes | A possible mechanism explained was that the SARS-CoV-2 might enter the olfactory lobe of the brain through nasal chambers upon inhalation and may lead to inflammation and demyelination. |
| T292 | 414-503 | Sentence | denotes | Later, it spreads to the whole brain due to its ability to cross the blood-brain barrier. |
| T293 | 504-640 | Sentence | denotes | Some neurological symptoms exhibited by the COVID-19 infection patients include nausea, vomiting, and headache (represented in Table 1). |
| T294 | 641-855 | Sentence | denotes | Since the SARS-CoV-2 possess the ability to cross the blood-brain barrier, it is important to design the drugs in such a way that they can cross the blood-brain barrier and scavenges the brain from viral infection. |
| T295 | 856-1063 | Sentence | denotes | Also, it is essential to note that the respiratory illness accompanies neurological invasion by the virus, therapeutic care must be taken to prevent the viral entry into the central nervous system (CNS) [7]. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T205 | 399-412 | Phenotype | denotes | demyelination | http://purl.obolibrary.org/obo/HP_0011096 |
| T206 | 584-600 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T207 | 606-614 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T208 | 895-914 | Phenotype | denotes | respiratory illness | http://purl.obolibrary.org/obo/HP_0002086 |