PMC:7243768 / 39292-41779 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"6.6 SARS-CoV-2-lung injury\nIt was possible to study the lung pathology of COVID-19 patients diagnosed with COVID-19 retrospectively after undergoing lung lobectomy surgery for adenocarcinoma. Also, the patients didn't present pneumonia at the time of surgery, indicating the initial stages of COVID-19. A female patient who was 80 years old was hospitalized due to an irregularly shaped solid nodule in the right middle lobe. On a postoperative day 1, a CT scan was performed, which indicated a few clinical manifestations. Later, the patient was presented with increased leucocytes, decreased lymphocytic count, chest tightness, wheezing, dry cough, and difficulty in breathing. Later findings confirmed that SARS-CoV-2 infected her from a patient in the same room who was already affected. Another patient who was 73 years old and had a medical history of hypertension from 20 years who underwent surgery for adenocarcinoma was discharged on the 6th-day post-operation. On postoperative day 9, the patient exhibited chest tightness, muscle pain, dry cough, and decreased lymphocytic count. His CT-scan findings revealed for viral pneumonia, and he was also tested positive for the 20,189-nC0V test. He was admitted to the infectious disease ward. After, 20 days he was discharged as he recovered. Histopathological findings showed focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, edema, multinucleated giant cells, protruding hyaline membranes, and proteinaceous exudates [106] (represented in Table 1).\nThe patients, who are recovered from COVID-19, have a possibility of chronic lung damage. Out of 70 COVID-19 pneumonia patients, 66 patients have lung damage in a different manner, which was determined by CT. This damage is in a diverse range; in the alveoli, there is a hardened tissue with the dense clumps which block the vessels in the tiny air sacs, which absorb the oxygen and cause tissue lesions. This tissue lesion acts as a sign of the long-term lung disease. Similar reports have been found in both the SARS CoV and MERS. The patients admitted with lung pneumonia shows damage in both the lungs. The CT scan of the COVID-19 patients indicates that there is a tissue lesion found over the alveoli and which can develop into the scars. There are \u003e2.9 million people have COVID-19 disease worldwide, according to April 27. 80% of the patients are having a high risk of problems, such as from breathing to respiratory failure 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