PMC:7243768 / 38088-39290
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1505 | 95-99 | Gene | denotes | ACE2 | Gene:59272 |
| 1506 | 210-214 | Gene | denotes | ACE2 | Gene:59272 |
| 1507 | 449-453 | Gene | denotes | ACE2 | Gene:59272 |
| 1508 | 0-8 | Species | denotes | SARS-CoV | Tax:694009 |
| 1509 | 13-23 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1510 | 707-715 | Species | denotes | patients | Tax:9606 |
| 1511 | 1019-1028 | Chemical | denotes | lopinavir | MESH:D061466 |
| 1512 | 247-259 | Disease | denotes | liver injury | MESH:D017093 |
| 1513 | 274-294 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 1514 | 508-528 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 1515 | 542-554 | Disease | denotes | liver injury | MESH:D017093 |
| 1516 | 626-640 | Disease | denotes | hepatic injury | MESH:D056486 |
| 1517 | 687-706 | Disease | denotes | SARS-CoV-2 infected | MESH:C000657245 |
| 1518 | 787-796 | Disease | denotes | steatosis | MESH:D005234 |
| 1519 | 818-830 | Disease | denotes | liver damage | MESH:D056486 |
| 1520 | 879-899 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 1521 | 927-939 | Disease | denotes | liver injury | MESH:D017093 |
| 1522 | 1045-1059 | Disease | denotes | hepatic damage | MESH:D056486 |
| 1523 | 1090-1102 | Disease | denotes | liver injury | MESH:D017093 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T319 | 78-82 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T320 | 136-141 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T321 | 149-154 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T322 | 165-174 | Body_part | denotes | bile duct | http://purl.org/sig/ont/fma/fma9706 |
| T323 | 175-180 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T324 | 185-196 | Body_part | denotes | hepatocytes | http://purl.org/sig/ont/fma/fma14515 |
| T325 | 247-252 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T326 | 306-315 | Body_part | denotes | bile duct | http://purl.org/sig/ont/fma/fma9706 |
| T327 | 316-332 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T328 | 327-332 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T329 | 394-405 | Body_part | denotes | hepatocytes | http://purl.org/sig/ont/fma/fma14515 |
| T330 | 470-479 | Body_part | denotes | bile duct | http://purl.org/sig/ont/fma/fma9706 |
| T331 | 480-485 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T332 | 542-547 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T333 | 581-592 | Body_part | denotes | hepatocytes | http://purl.org/sig/ont/fma/fma14515 |
| T334 | 818-823 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T335 | 927-932 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T336 | 1090-1095 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T166 | 165-174 | Body_part | denotes | bile duct | http://purl.obolibrary.org/obo/UBERON_0002394 |
| T167 | 165-169 | Body_part | denotes | bile | http://purl.obolibrary.org/obo/UBERON_0001970 |
| T168 | 170-174 | Body_part | denotes | duct | http://purl.obolibrary.org/obo/UBERON_0000058 |
| T169 | 247-252 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T170 | 306-315 | Body_part | denotes | bile duct | http://purl.obolibrary.org/obo/UBERON_0002394 |
| T171 | 306-310 | Body_part | denotes | bile | http://purl.obolibrary.org/obo/UBERON_0001970 |
| T172 | 311-315 | Body_part | denotes | duct | http://purl.obolibrary.org/obo/UBERON_0000058 |
| T173 | 470-479 | Body_part | denotes | bile duct | http://purl.obolibrary.org/obo/UBERON_0002394 |
| T174 | 470-474 | Body_part | denotes | bile | http://purl.obolibrary.org/obo/UBERON_0001970 |
| T175 | 475-479 | Body_part | denotes | duct | http://purl.obolibrary.org/obo/UBERON_0000058 |
| T176 | 542-547 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T177 | 818-823 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T178 | 927-932 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T179 | 1090-1095 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T445 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T446 | 0-4 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T447 | 13-21 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T448 | 13-17 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T449 | 253-259 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T450 | 274-282 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T451 | 274-278 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T452 | 285-294 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T453 | 508-516 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T454 | 508-512 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T455 | 519-528 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T456 | 548-554 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T457 | 634-640 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T458 | 687-695 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T459 | 687-691 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T460 | 879-887 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T461 | 879-883 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T462 | 890-899 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T463 | 933-939 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T464 | 1096-1102 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T508 | 78-82 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T509 | 136-141 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T510 | 149-154 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T511 | 165-174 | http://purl.obolibrary.org/obo/UBERON_0002394 | denotes | bile duct |
| T512 | 175-180 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T513 | 247-252 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T514 | 247-252 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T515 | 306-315 | http://purl.obolibrary.org/obo/UBERON_0002394 | denotes | bile duct |
| T516 | 316-326 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T517 | 327-332 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T518 | 432-433 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T519 | 470-479 | http://purl.obolibrary.org/obo/UBERON_0002394 | denotes | bile duct |
| T520 | 480-485 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T521 | 542-547 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T522 | 542-547 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T523 | 749-757 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T524 | 818-823 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T525 | 818-823 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T526 | 927-932 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T527 | 927-932 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T528 | 957-958 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T529 | 1061-1064 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
| T530 | 1090-1095 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T531 | 1090-1095 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T532 | 1117-1122 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T204 | 1019-1028 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T205 | 1143-1148 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T55 | 58-82 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into the host cell |
| T56 | 349-365 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T57 | 374-386 | http://purl.obolibrary.org/obo/GO_0031099 | denotes | regeneration |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T257 | 0-109 | Sentence | denotes | SARS-CoV and SARS-CoV-2 share the similarity in making an entry into the host cell through the ACE2 receptor. |
| T258 | 110-301 | Sentence | denotes | In addition to the type 2 cells in the lungs, both the bile duct cells and hepatocytes also express ACE2, which might be the reason that liver injury occurs during SARS-CoV-2 infection [103]. |
| T259 | 302-412 | Sentence | denotes | The bile duct epithelial cells are involved in immune responses and the regeneration of the hepatocytes [104]. |
| T260 | 413-646 | Sentence | denotes | Besides possessing a high number of ACE2 on its surface, bile duct cells are more prone to the SARS-CoV-2 infection resulting in liver injury, which indicates that the hepatocytes are not directly involved in the hepatic injury [37]. |
| T261 | 647-803 | Sentence | denotes | The histopathological manifestations of SARS-CoV-2 infected patients revealed mild lobular and portal activity and restrained microvascular steatosis [105]. |
| T262 | 804-900 | Sentence | denotes | The degree of liver damage is directly proportional to the severity of the SARS-CoV-2 infection. |
| T263 | 901-956 | Sentence | denotes | Still, the reason for the liver injury remains elusive. |
| T264 | 957-1066 | Sentence | denotes | A recent study reported that the use of anti-viral medication lopinavir might result in hepatic damage [102]. |
| T265 | 1067-1202 | Sentence | denotes | Therefore, whether the liver injury is due to the virus entry or due to the drugs used as anti-viral medication needs to be elucidated. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T189 | 787-796 | Phenotype | denotes | steatosis | http://purl.obolibrary.org/obo/HP_0001397 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32450165-30850822-66451089 | 407-410 | 30850822 | denotes | 104 |
| 32450165-32170806-66451090 | 642-644 | 32170806 | denotes | 37 |