PMC:7243768 / 24582-26640 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"5.4 MERS-CoV-CNS risk\nA report presented 3 cases that were infected by MERS-CoV and exhibited abnormal neurological findings along with other predisposed co-morbid conditions. A 74 years old patient with co-morbid medical conditions, including dyslipidemia, diabetes, and hypertension, exhibited fever, vomiting, confusion, and ataxia three days later. Computerized tomography exhibited no acute changes whereas presented chronic lacunar strokes. The chest radiograph revealed infiltration in the mid-right lung zone. Decreased motor activity on the left side was observed. He was tested positive for MERS-CoV exhibiting respiratory illness, and then he was admitted to ICU. On day 24, after hospitalization, his medical condition improved confirmed by tracheostomy, which confirmed an improvement in the respiratory status of the patient. The CSF examination revealed lymphopenia and was tested negative for MERS-CoV-2 RT-PCR. In 57 years old patient infected with MERS-CoV exhibited neurological findings apart from other cardiovascular abnormalities. The neurological findings include bilateral basal ganglia, deep white matter, a large area of hypodensity in the proximal half of the corpus callosum up to the mid part of his body, and interval multiple patchy hypodensities bilaterally in the periventricular. MRI examination revealed occipital lobes with a restriction on the diffusion-weighted images (DWI) consistent with acute infarction, and bilaterally in the deep watershed and the parasagittal region scattered foci in the cortical and subcortical regions of the temporal and parietal lobes (represented in Table 1).\nThe patient experienced multiple cardiac arrests, severe shock, and acute kidney injury and eventually expired. Forty-five-year-old patients with acute kidney injury, diabetes, and hypertension were tested positive for MERS-CoV, and CT scan findings revealed no acute abnormalities but exhibited similar findings consistent with encephalitis. The patient exhibited lymphocytopenia and was tested negative after a few days 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