PMC:7243768 / 18782-19632 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"720","span":{"begin":301,"end":308},"obj":"Gene"},{"id":"721","span":{"begin":366,"end":379},"obj":"Gene"},{"id":"722","span":{"begin":381,"end":385},"obj":"Gene"},{"id":"723","span":{"begin":391,"end":412},"obj":"Gene"},{"id":"724","span":{"begin":414,"end":417},"obj":"Gene"},{"id":"725","span":{"begin":504,"end":508},"obj":"Gene"},{"id":"726","span":{"begin":511,"end":539},"obj":"Gene"},{"id":"727","span":{"begin":541,"end":545},"obj":"Gene"},{"id":"728","span":{"begin":548,"end":576},"obj":"Gene"},{"id":"729","span":{"begin":578,"end":582},"obj":"Gene"},{"id":"730","span":{"begin":588,"end":612},"obj":"Gene"},{"id":"731","span":{"begin":613,"end":619},"obj":"Gene"},{"id":"732","span":{"begin":737,"end":740},"obj":"Gene"},{"id":"733","span":{"begin":813,"end":817},"obj":"Gene"},{"id":"734","span":{"begin":819,"end":823},"obj":"Gene"},{"id":"735","span":{"begin":825,"end":829},"obj":"Gene"},{"id":"736","span":{"begin":835,"end":841},"obj":"Gene"},{"id":"737","span":{"begin":4,"end":9},"obj":"Species"},{"id":"738","span":{"begin":10,"end":23},"obj":"Species"},{"id":"739","span":{"begin":659,"end":667},"obj":"Species"},{"id":"740","span":{"begin":787,"end":795},"obj":"Species"},{"id":"741","span":{"begin":43,"end":58},"obj":"Disease"},{"id":"742","span":{"begin":188,"end":199},"obj":"Disease"},{"id":"743","span":{"begin":224,"end":233},"obj":"Disease"},{"id":"744","span":{"begin":641,"end":649},"obj":"Disease"},{"id":"745","span":{"begin":769,"end":777},"obj":"Disease"}],"attributes":[{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Gene:3440"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"Gene:3569"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"Gene:3569"},{"id":"A723","pred":"tao:has_database_id","subj":"723","obj":"Gene:7124"},{"id":"A724","pred":"tao:has_database_id","subj":"724","obj":"Gene:7124"},{"id":"A725","pred":"tao:has_database_id","subj":"725","obj":"Gene:6347"},{"id":"A726","pred":"tao:has_database_id","subj":"726","obj":"Gene:6348"},{"id":"A727","pred":"tao:has_database_id","subj":"727","obj":"Gene:6348"},{"id":"A728","pred":"tao:has_database_id","subj":"728","obj":"Gene:6352"},{"id":"A729","pred":"tao:has_database_id","subj":"729","obj":"Gene:6352"},{"id":"A730","pred":"tao:has_database_id","subj":"730","obj":"Gene:3627"},{"id":"A731","pred":"tao:has_database_id","subj":"731","obj":"Gene:3627"},{"id":"A732","pred":"tao:has_database_id","subj":"732","obj":"Gene:3439"},{"id":"A733","pred":"tao:has_database_id","subj":"733","obj":"Gene:6347"},{"id":"A734","pred":"tao:has_database_id","subj":"734","obj":"Gene:6348"},{"id":"A735","pred":"tao:has_database_id","subj":"735","obj":"Gene:6352"},{"id":"A736","pred":"tao:has_database_id","subj":"736","obj":"Gene:3627"},{"id":"A737","pred":"tao:has_database_id","subj":"737","obj":"Tax:9606"},{"id":"A738","pred":"tao:has_database_id","subj":"738","obj":"Tax:11118"},{"id":"A739","pred":"tao:has_database_id","subj":"739","obj":"Tax:694009"},{"id":"A740","pred":"tao:has_database_id","subj":"740","obj":"Tax:694009"},{"id":"A741","pred":"tao:has_database_id","subj":"741","obj":"MESH:D001102"},{"id":"A742","pred":"tao:has_database_id","subj":"742","obj":"MESH:D055370"},{"id":"A743","pred":"tao:has_database_id","subj":"743","obj":"MESH:D007239"},{"id":"A744","pred":"tao:has_database_id","subj":"744","obj":"MESH:D007239"},{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T173","span":{"begin":96,"end":101},"obj":"Body_part"},{"id":"T174","span":{"begin":150,"end":158},"obj":"Body_part"},{"id":"T175","span":{"begin":188,"end":192},"obj":"Body_part"},{"id":"T176","span":{"begin":270,"end":279},"obj":"Body_part"},{"id":"T177","span":{"begin":348,"end":357},"obj":"Body_part"},{"id":"T178","span":{"begin":366,"end":379},"obj":"Body_part"},{"id":"T179","span":{"begin":366,"end":377},"obj":"Body_part"},{"id":"T180","span":{"begin":456,"end":465},"obj":"Body_part"},{"id":"T181","span":{"begin":484,"end":493},"obj":"Body_part"},{"id":"T182","span":{"begin":521,"end":530},"obj":"Body_part"},{"id":"T183","span":{"begin":558,"end":567},"obj":"Body_part"},{"id":"T184","span":{"begin":600,"end":609},"obj":"Body_part"},{"id":"T185","span":{"begin":630,"end":640},"obj":"Body_part"},{"id":"T186","span":{"begin":723,"end":732},"obj":"Body_part"},{"id":"T187","span":{"begin":752,"end":768},"obj":"Body_part"},{"id":"T188","span":{"begin":763,"end":768},"obj":"Body_part"}],"attributes":[{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma264829"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T96","span":{"begin":188,"end":192},"obj":"Body_part"}],"attributes":[{"id":"A96","pred":"uberon_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T240","span":{"begin":43,"end":58},"obj":"Disease"},{"id":"T241","span":{"begin":49,"end":58},"obj":"Disease"},{"id":"T242","span":{"begin":193,"end":199},"obj":"Disease"},{"id":"T243","span":{"begin":224,"end":233},"obj":"Disease"},{"id":"T244","span":{"begin":391,"end":396},"obj":"Disease"},{"id":"T245","span":{"begin":659,"end":667},"obj":"Disease"},{"id":"T246","span":{"begin":659,"end":663},"obj":"Disease"},{"id":"T247","span":{"begin":787,"end":795},"obj":"Disease"},{"id":"T248","span":{"begin":787,"end":791},"obj":"Disease"}],"attributes":[{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T285","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T286","span":{"begin":96,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T287","span":{"begin":188,"end":192},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T288","span":{"begin":188,"end":192},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T289","span":{"begin":366,"end":379},"obj":"http://purl.obolibrary.org/obo/PR_000001393"},{"id":"T290","span":{"begin":590,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0009645"},{"id":"T291","span":{"begin":590,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0050824"},{"id":"T292","span":{"begin":752,"end":762},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T293","span":{"begin":763,"end":768},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T78","span":{"begin":381,"end":383},"obj":"Chemical"},{"id":"T80","span":{"begin":588,"end":612},"obj":"Chemical"},{"id":"T81","span":{"begin":613,"end":619},"obj":"Chemical"},{"id":"T82","span":{"begin":835,"end":841},"obj":"Chemical"}],"attributes":[{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A79","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":43,"end":58},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T27","span":{"begin":397,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T28","span":{"begin":397,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T29","span":{"begin":397,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T30","span":{"begin":397,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T131","span":{"begin":0,"end":218},"obj":"Sentence"},{"id":"T132","span":{"begin":219,"end":629},"obj":"Sentence"},{"id":"T133","span":{"begin":630,"end":741},"obj":"Sentence"},{"id":"T134","span":{"begin":742,"end":850},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T98","span":{"begin":150,"end":164},"obj":"Phenotype"},{"id":"T99","span":{"begin":391,"end":396},"obj":"Phenotype"}],"attributes":[{"id":"A98","pred":"hp_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A99","pred":"hp_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}

{"project":"2_test","denotations":[{"id":"32450165-15919935-66451044","span":{"begin":622,"end":624},"obj":"15919935"},{"id":"32450165-15860669-66451045","span":{"begin":625,"end":627},"obj":"15860669"},{"id":"32450165-15860669-66451046","span":{"begin":843,"end":845},"obj":"15860669"},{"id":"32450165-16501078-66451047","span":{"begin":846,"end":848},"obj":"16501078"}],"text":"The human coronaviruses connected with the viral infection, highly infiltration of inflammatory cells, an enhanced level of the pro-inflammatory, and cytokine storm response, resulting in lung injury at an acute level. This infection reduces the level of the anti-viral cytokines such as interferons (IFN-α/β); upregulation of the pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF) and upregulation of the inflammatory cytokines such as C—C Motif Chemokine Ligand 2 (CCL2), C—C Motif Chemokine Ligand 3 (CCL3), C—C Motif Chemokine Ligand 5 (CCL5) and C-X-C motif chemokine 10(CXCL10) [55,56]. Macrophage infected with the SARS-CoV showed an elevated level of the other pro-inflammatory cytokines and IFN. Also, the epithelial cells infected with the SARS-CoV have an enhanced CCL2, CCL3, CCL5, and CXCL10 [56,57]."}