PMC:7241115 / 2285-3830 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7241115","sourcedb":"PMC","sourceid":"7241115","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7241115","text":"Introduction\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and mortality worldwide [1–5]. The evidence pertaining to the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) has been emerging rapidly [2–7]. However, few studies have evaluated the duration of viral shedding, which has important implications for guiding the clinical decisions regarding isolation precautions and antiviral treatment in patients with COVID-19 [7, 8]. Factors associated with prolonged duration of viral shedding remain elusive. A recent randomised controlled trial showed that lopinavir/ritonavir (LPV/r) treatment could not provide additional benefits beyond standard-of-care (including in relation to viral shedding) in hospitalised severely ill patients with COVID-19 [9]. However, a post hoc subgroup analysis found that earlier administration of LPV/r treatment accelerated the clinical recovery and reduced mortality [9]. Therefore, it remains crucial to determine whether adding LPV/r treatment could influence the duration of SARS-CoV-2 RNA shedding in non-critically ill patients and whether an earlier administration of LPV/r could shorten the duration of viral shedding.\nThus, this study sought to assess the risk factors associated with prolonged viral shedding and the potential impact of earlier administration of LPV/r treatment on the duration of viral shedding in hospitalised non-critically ill patients with SARS-CoV-2 infection between 31 January and 9 March 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