PMC:7239603 / 26368-27524 JSONTXT

{"project":"0_colil","denotations":[{"id":"32031602-7853886-6102","span":{"begin":995,"end":997},"obj":"7853886"},{"id":"32031602-25108304-6103","span":{"begin":999,"end":1001},"obj":"25108304"}],"text":"Porcine hearts have a wide septal muscle shelf near the right cusp, which could change the geometry in the aortic annulus. However, the porcine model is an acknowledged and widely used model with low interindividual variation, which facilitates assessment of surgical procedures. Due to the close proximity of the left coronary artery to the myocardium in pigs, the Dacron ring was not closed. The difference observed between the 2 interventions could be caused by ventricular fatigue; however, there was no observed difference in LV dP/dt between the 2 groups, which is a measure of ventricular performance. Our animal model is a healthy acute model, which defrays conclusions on the long-term effects of an annuloplasty ring in patients. Nonetheless, the effect of the annuloplasty on stress distribution and geometry is new insight and should be confirmed in long-term studies. In pigs, the aortic annulus is larger than the STJ; however, in humans the STJ is larger than the aortic annulus [24, 25]. This would result in a larger STJ ring compared with the ring at the aortic annulus, and therefore a different STJ/annulus ratio would apply for humans."}

{"project":"TEST0","denotations":[{"id":"32031602-114-120-6102","span":{"begin":995,"end":997},"obj":"[\"7853886\"]"},{"id":"32031602-118-124-6103","span":{"begin":999,"end":1001},"obj":"[\"25108304\"]"}],"text":"Porcine hearts have a wide septal muscle shelf near the right cusp, which could change the geometry in the aortic annulus. However, the porcine model is an acknowledged and widely used model with low interindividual variation, which facilitates assessment of surgical procedures. Due to the close proximity of the left coronary artery to the myocardium in pigs, the Dacron ring was not closed. The difference observed between the 2 interventions could be caused by ventricular fatigue; however, there was no observed difference in LV dP/dt between the 2 groups, which is a measure of ventricular performance. Our animal model is a healthy acute model, which defrays conclusions on the long-term effects of an annuloplasty ring in patients. Nonetheless, the effect of the annuloplasty on stress distribution and geometry is new insight and should be confirmed in long-term studies. In pigs, the aortic annulus is larger than the STJ; however, in humans the STJ is larger than the aortic annulus [24, 25]. This would result in a larger STJ ring compared with the ring at the aortic annulus, and therefore a different STJ/annulus ratio would apply for humans."}

{"project":"2_test","denotations":[{"id":"32031602-7853886-28904415","span":{"begin":995,"end":997},"obj":"7853886"},{"id":"32031602-25108304-28904416","span":{"begin":999,"end":1001},"obj":"25108304"}],"text":"Porcine hearts have a wide septal muscle shelf near the right cusp, which could change the geometry in the aortic annulus. However, the porcine model is an acknowledged and widely used model with low interindividual variation, which facilitates assessment of surgical procedures. Due to the close proximity of the left coronary artery to the myocardium in pigs, the Dacron ring was not closed. The difference observed between the 2 interventions could be caused by ventricular fatigue; however, there was no observed difference in LV dP/dt between the 2 groups, which is a measure of ventricular performance. Our animal model is a healthy acute model, which defrays conclusions on the long-term effects of an annuloplasty ring in patients. Nonetheless, the effect of the annuloplasty on stress distribution and geometry is new insight and should be confirmed in long-term studies. In pigs, the aortic annulus is larger than the STJ; however, in humans the STJ is larger than the aortic annulus [24, 25]. This would result in a larger STJ ring compared with the ring at the aortic annulus, and therefore a different STJ/annulus ratio would apply for humans."}

{"project":"MyTest","denotations":[{"id":"32031602-7853886-28904415","span":{"begin":995,"end":997},"obj":"7853886"},{"id":"32031602-25108304-28904416","span":{"begin":999,"end":1001},"obj":"25108304"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Porcine hearts have a wide septal muscle shelf near the right cusp, which could change the geometry in the aortic annulus. However, the porcine model is an acknowledged and widely used model with low interindividual variation, which facilitates assessment of surgical procedures. Due to the close proximity of the left coronary artery to the myocardium in pigs, the Dacron ring was not closed. The difference observed between the 2 interventions could be caused by ventricular fatigue; however, there was no observed difference in LV dP/dt between the 2 groups, which is a measure of ventricular performance. Our animal model is a healthy acute model, which defrays conclusions on the long-term effects of an annuloplasty ring in patients. Nonetheless, the effect of the annuloplasty on stress distribution and geometry is new insight and should be confirmed in long-term studies. In pigs, the aortic annulus is larger than the STJ; however, in humans the STJ is larger than the aortic annulus [24, 25]. This would result in a larger STJ ring compared with the ring at the aortic annulus, and therefore a different STJ/annulus ratio would apply for humans."}

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