PMC:7239603 / 21740-22907 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7239603","sourcedb":"PMC","sourceid":"7239603","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7239603","text":"In the aortic annulus, the highest stresses were found in the LR segment and the lowest stresses in the LN segment. Grande et al. [21] investigated 9 human homografts and the stress variations occurring in the aortic root with a finite element model. They found the highest stresses in the right coronary sinus and NC, and the lowest stresses in the left sinus. The authors concluded that the low stresses at the NC might be due to an absent coronary ostium, which relieves the blood pressure loading in the aortic root. The radial stresses in the current study, were, however, measured upstream of the aortic valve, thus the pressure relief of a coronary ostium would not apply to these measurements. The heterogenicity in the measured stresses is most likely caused by differences in tissue composition. The aortic annulus consists of not only muscular tissue as part of the interventricular septum but also fibrous tissue as part of the anterior leaflet of the mitral valve. We have previously found that the native aortic annulus is heterogeneous in both force distribution and dynamics throughout the cardiac cycle, which confirms the results in this study 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