PMC:7239183 / 117-1632
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T2 | 199-206 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T3 | 378-385 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T4 | 406-413 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T5 | 548-555 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T6 | 594-599 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T7 | 715-722 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T8 | 838-845 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T9 | 918-925 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T10 | 1181-1193 | Body_part | denotes | glycopeptide | http://purl.org/sig/ont/fma/fma82784 |
| T11 | 1300-1307 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T12 | 1363-1370 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 66-74 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T3 | 929-937 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 254-262 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T2 | 304-305 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 424-426 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T4 | 431-433 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T5 | 431-433 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T6 | 459-461 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T7 | 565-567 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T8 | 572-574 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T9 | 572-574 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T10 | 588-599 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T11 | 854-856 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T12 | 886-889 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T13 | 1078-1080 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T14 | 1486-1487 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T2 | 199-206 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T3 | 378-385 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T4 | 406-413 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T5 | 431-433 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T6 | 548-555 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T7 | 572-574 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T8 | 715-722 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T9 | 838-845 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T10 | 918-925 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T11 | 1044-1053 | Chemical | denotes | O-glycans | http://purl.obolibrary.org/obo/CHEBI_59521 |
| T12 | 1046-1053 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T13 | 1181-1193 | Chemical | denotes | glycopeptide | http://purl.obolibrary.org/obo/CHEBI_24396 |
| T14 | 1300-1307 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T15 | 1363-1370 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-docs
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 254-269 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 351-366 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 472-487 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 474-487 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 517-530 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 682-697 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 684-697 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 762-777 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 764-777 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 870-885 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 872-885 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1008-1023 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1010-1023 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1105-1121 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1108-1121 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1273-1286 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 254-269 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 351-366 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 472-487 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 474-487 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 517-530 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 682-697 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 684-697 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 762-777 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 764-777 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 870-885 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 872-885 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1008-1023 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1010-1023 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1105-1121 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1108-1121 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1273-1286 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-172 | Sentence | denotes | The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities. |
| T5 | 173-367 | Sentence | denotes | The coronavirus spike (S) protein, which facilitates viral attachment, entry and membrane fusion is heavily glycosylated and plays a critical role in the elicitation of the host immune response. |
| T6 | 368-494 | Sentence | denotes | The spike protein is comprised of two protein subunits (S1 and S2), which together possess 22 potential N-glycosylation sites. |
| T7 | 495-642 | Sentence | denotes | Herein, we report the glycosylation mapping on spike protein subunits S1 and S2 expressed on human cells through high resolution mass spectrometry. |
| T8 | 643-857 | Sentence | denotes | We have characterized the quantitative N-glycosylation profile on spike protein and interestingly, observed unexpected O-glycosylation modifications on the receptor binding domain (RBD) of spike protein subunit S1. |
| T9 | 858-1081 | Sentence | denotes | Even though O-glycosylation has been predicted on the spike protein of SARS-CoV-2, this is the first report of experimental data for both the site of O-glycosylation and identity of the O-glycans attached on the subunit S1. |
| T10 | 1082-1308 | Sentence | denotes | Our data on the N- and O- glycosylation is strengthened by extensive manual interpretation of each glycopeptide spectra in addition to using bioinformatics tools to confirm the complexity of glycosylation in the spike protein. |
| T11 | 1309-1515 | Sentence | denotes | The elucidation of the glycan repertoire on the spike protein provides insights into the viral binding studies and more importantly, propels research towards the development of a suitable vaccine candidate. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 25 | 372-377 | Gene | denotes | spike | Gene:43740568 |
| 26 | 542-547 | Gene | denotes | spike | Gene:43740568 |
| 27 | 709-714 | Gene | denotes | spike | Gene:43740568 |
| 28 | 832-837 | Gene | denotes | spike | Gene:43740568 |
| 29 | 912-917 | Gene | denotes | spike | Gene:43740568 |
| 30 | 1294-1299 | Gene | denotes | spike | Gene:43740568 |
| 31 | 1357-1362 | Gene | denotes | spike | Gene:43740568 |
| 32 | 29-46 | Species | denotes | novel coronavirus | Tax:2697049 |
| 33 | 66-76 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 34 | 177-188 | Species | denotes | coronavirus | Tax:11118 |
| 35 | 588-593 | Species | denotes | human | Tax:9606 |
| 36 | 929-939 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 37 | 472-473 | Chemical | denotes | N | MESH:D009584 |
| 38 | 682-683 | Chemical | denotes | N | MESH:D009584 |
| 39 | 1044-1053 | Chemical | denotes | O-glycans | |
| 40 | 1098-1099 | Chemical | denotes | N | MESH:D009584 |
| 41 | 1181-1193 | Chemical | denotes | glycopeptide | MESH:D006020 |
| 42 | 1332-1338 | Chemical | denotes | glycan | MESH:D011134 |
| 43 | 160-171 | Disease | denotes | mortalities | MESH:D003643 |