PMC:7239183 / 108-1632
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T2 | 208-215 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T3 | 387-394 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T4 | 415-422 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T5 | 557-564 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T6 | 603-608 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T7 | 724-731 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T8 | 847-854 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T9 | 927-934 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T10 | 1190-1202 | Body_part | denotes | glycopeptide | http://purl.org/sig/ont/fma/fma82784 |
| T11 | 1309-1316 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T12 | 1372-1379 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 75-83 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T3 | 938-946 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 263-271 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T2 | 313-314 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 433-435 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T4 | 440-442 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T5 | 440-442 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T6 | 468-470 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T7 | 574-576 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T8 | 581-583 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T9 | 581-583 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T10 | 597-608 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T11 | 863-865 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T12 | 895-898 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T13 | 1087-1089 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T14 | 1495-1496 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T2 | 208-215 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T3 | 387-394 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T4 | 415-422 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T5 | 440-442 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T6 | 557-564 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T7 | 581-583 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T8 | 724-731 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T9 | 847-854 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T10 | 927-934 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T11 | 1053-1062 | Chemical | denotes | O-glycans | http://purl.obolibrary.org/obo/CHEBI_59521 |
| T12 | 1055-1062 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T13 | 1190-1202 | Chemical | denotes | glycopeptide | http://purl.obolibrary.org/obo/CHEBI_24396 |
| T14 | 1309-1316 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T15 | 1372-1379 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-docs
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 263-278 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 360-375 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 481-496 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 483-496 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 526-539 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 691-706 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 693-706 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 771-786 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 773-786 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 879-894 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 881-894 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1017-1032 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1019-1032 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1114-1130 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1117-1130 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1282-1295 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 263-278 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 360-375 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 481-496 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 483-496 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 526-539 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 691-706 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 693-706 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 771-786 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 773-786 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 879-894 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 881-894 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1017-1032 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1019-1032 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1114-1130 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1117-1130 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1282-1295 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-8 | Sentence | denotes | Abstract |
| T4 | 9-181 | Sentence | denotes | The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities. |
| T5 | 182-376 | Sentence | denotes | The coronavirus spike (S) protein, which facilitates viral attachment, entry and membrane fusion is heavily glycosylated and plays a critical role in the elicitation of the host immune response. |
| T6 | 377-503 | Sentence | denotes | The spike protein is comprised of two protein subunits (S1 and S2), which together possess 22 potential N-glycosylation sites. |
| T7 | 504-651 | Sentence | denotes | Herein, we report the glycosylation mapping on spike protein subunits S1 and S2 expressed on human cells through high resolution mass spectrometry. |
| T8 | 652-866 | Sentence | denotes | We have characterized the quantitative N-glycosylation profile on spike protein and interestingly, observed unexpected O-glycosylation modifications on the receptor binding domain (RBD) of spike protein subunit S1. |
| T9 | 867-1090 | Sentence | denotes | Even though O-glycosylation has been predicted on the spike protein of SARS-CoV-2, this is the first report of experimental data for both the site of O-glycosylation and identity of the O-glycans attached on the subunit S1. |
| T10 | 1091-1317 | Sentence | denotes | Our data on the N- and O- glycosylation is strengthened by extensive manual interpretation of each glycopeptide spectra in addition to using bioinformatics tools to confirm the complexity of glycosylation in the spike protein. |
| T11 | 1318-1524 | Sentence | denotes | The elucidation of the glycan repertoire on the spike protein provides insights into the viral binding studies and more importantly, propels research towards the development of a suitable vaccine candidate. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 25 | 381-386 | Gene | denotes | spike | Gene:43740568 |
| 26 | 551-556 | Gene | denotes | spike | Gene:43740568 |
| 27 | 718-723 | Gene | denotes | spike | Gene:43740568 |
| 28 | 841-846 | Gene | denotes | spike | Gene:43740568 |
| 29 | 921-926 | Gene | denotes | spike | Gene:43740568 |
| 30 | 1303-1308 | Gene | denotes | spike | Gene:43740568 |
| 31 | 1366-1371 | Gene | denotes | spike | Gene:43740568 |
| 32 | 38-55 | Species | denotes | novel coronavirus | Tax:2697049 |
| 33 | 75-85 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 34 | 186-197 | Species | denotes | coronavirus | Tax:11118 |
| 35 | 597-602 | Species | denotes | human | Tax:9606 |
| 36 | 938-948 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 37 | 481-482 | Chemical | denotes | N | MESH:D009584 |
| 38 | 691-692 | Chemical | denotes | N | MESH:D009584 |
| 39 | 1053-1062 | Chemical | denotes | O-glycans | |
| 40 | 1107-1108 | Chemical | denotes | N | MESH:D009584 |
| 41 | 1190-1202 | Chemical | denotes | glycopeptide | MESH:D006020 |
| 42 | 1341-1347 | Chemical | denotes | glycan | MESH:D011134 |
| 43 | 169-180 | Disease | denotes | mortalities | MESH:D003643 |