PMC:7239183
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 58-65 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T2 | 316-323 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T3 | 495-502 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T4 | 523-530 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T5 | 665-672 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T6 | 711-716 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T7 | 832-839 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T8 | 955-962 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T9 | 1035-1042 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T10 | 1298-1310 | Body_part | denotes | glycopeptide | http://purl.org/sig/ont/fma/fma82784 |
| T11 | 1417-1424 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T12 | 1480-1487 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 87-95 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T2 | 183-191 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T3 | 1046-1054 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 371-379 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T2 | 421-422 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 541-543 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T4 | 548-550 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T5 | 548-550 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T6 | 576-578 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T7 | 682-684 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T8 | 689-691 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T9 | 689-691 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T10 | 705-716 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T11 | 971-973 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T12 | 1003-1006 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T13 | 1195-1197 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T14 | 1603-1604 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 58-65 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T2 | 316-323 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T3 | 495-502 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T4 | 523-530 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T5 | 548-550 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T6 | 665-672 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T7 | 689-691 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T8 | 832-839 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T9 | 955-962 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T10 | 1035-1042 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T11 | 1161-1170 | Chemical | denotes | O-glycans | http://purl.obolibrary.org/obo/CHEBI_59521 |
| T12 | 1163-1170 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T13 | 1298-1310 | Chemical | denotes | glycopeptide | http://purl.obolibrary.org/obo/CHEBI_24396 |
| T14 | 1417-1424 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T15 | 1480-1487 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-docs
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-36 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T2 | 23-36 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T3 | 371-386 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 468-483 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 589-604 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 591-604 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 634-647 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 799-814 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 801-814 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 879-894 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 881-894 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 987-1002 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 989-1002 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1125-1140 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1127-1140 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1222-1238 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1225-1238 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1390-1403 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-36 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T2 | 23-36 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T3 | 371-386 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T4 | 468-483 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T5 | 589-604 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T6 | 591-604 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T7 | 634-647 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T8 | 799-814 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T9 | 801-814 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T10 | 879-894 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T11 | 881-894 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T12 | 987-1002 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T13 | 989-1002 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T14 | 1125-1140 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O-glycosylation |
| T15 | 1127-1140 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 1222-1238 | http://purl.obolibrary.org/obo/GO_0006493 | denotes | O- glycosylation |
| T17 | 1225-1238 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T18 | 1390-1403 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-97 | Sentence | denotes | Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 |
| T2 | 99-107 | Sentence | denotes | Abstract |
| T3 | 108-116 | Sentence | denotes | Abstract |
| T4 | 117-289 | Sentence | denotes | The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities. |
| T5 | 290-484 | Sentence | denotes | The coronavirus spike (S) protein, which facilitates viral attachment, entry and membrane fusion is heavily glycosylated and plays a critical role in the elicitation of the host immune response. |
| T6 | 485-611 | Sentence | denotes | The spike protein is comprised of two protein subunits (S1 and S2), which together possess 22 potential N-glycosylation sites. |
| T7 | 612-759 | Sentence | denotes | Herein, we report the glycosylation mapping on spike protein subunits S1 and S2 expressed on human cells through high resolution mass spectrometry. |
| T8 | 760-974 | Sentence | denotes | We have characterized the quantitative N-glycosylation profile on spike protein and interestingly, observed unexpected O-glycosylation modifications on the receptor binding domain (RBD) of spike protein subunit S1. |
| T9 | 975-1198 | Sentence | denotes | Even though O-glycosylation has been predicted on the spike protein of SARS-CoV-2, this is the first report of experimental data for both the site of O-glycosylation and identity of the O-glycans attached on the subunit S1. |
| T10 | 1199-1425 | Sentence | denotes | Our data on the N- and O- glycosylation is strengthened by extensive manual interpretation of each glycopeptide spectra in addition to using bioinformatics tools to confirm the complexity of glycosylation in the spike protein. |
| T11 | 1426-1632 | Sentence | denotes | The elucidation of the glycan repertoire on the spike protein provides insights into the viral binding studies and more importantly, propels research towards the development of a suitable vaccine candidate. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3 | 52-57 | Gene | denotes | spike | Gene:43740568 |
| 4 | 69-86 | Species | denotes | novel coronavirus | Tax:2697049 |
| 5 | 13-14 | Chemical | denotes | N | MESH:D009584 |
| 25 | 489-494 | Gene | denotes | spike | Gene:43740568 |
| 26 | 659-664 | Gene | denotes | spike | Gene:43740568 |
| 27 | 826-831 | Gene | denotes | spike | Gene:43740568 |
| 28 | 949-954 | Gene | denotes | spike | Gene:43740568 |
| 29 | 1029-1034 | Gene | denotes | spike | Gene:43740568 |
| 30 | 1411-1416 | Gene | denotes | spike | Gene:43740568 |
| 31 | 1474-1479 | Gene | denotes | spike | Gene:43740568 |
| 32 | 146-163 | Species | denotes | novel coronavirus | Tax:2697049 |
| 33 | 183-193 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 34 | 294-305 | Species | denotes | coronavirus | Tax:11118 |
| 35 | 705-710 | Species | denotes | human | Tax:9606 |
| 36 | 1046-1056 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 37 | 589-590 | Chemical | denotes | N | MESH:D009584 |
| 38 | 799-800 | Chemical | denotes | N | MESH:D009584 |
| 39 | 1161-1170 | Chemical | denotes | O-glycans | |
| 40 | 1215-1216 | Chemical | denotes | N | MESH:D009584 |
| 41 | 1298-1310 | Chemical | denotes | glycopeptide | MESH:D006020 |
| 42 | 1449-1455 | Chemical | denotes | glycan | MESH:D011134 |
| 43 | 277-288 | Disease | denotes | mortalities | MESH:D003643 |