PMC:7239011 / 3505-4254 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"136","span":{"begin":338,"end":358},"obj":"Species"},{"id":"137","span":{"begin":376,"end":382},"obj":"Species"},{"id":"138","span":{"begin":470,"end":476},"obj":"Species"},{"id":"139","span":{"begin":401,"end":413},"obj":"Chemical"},{"id":"140","span":{"begin":524,"end":536},"obj":"Chemical"},{"id":"141","span":{"begin":565,"end":568},"obj":"Chemical"},{"id":"142","span":{"begin":576,"end":582},"obj":"Chemical"},{"id":"143","span":{"begin":628,"end":639},"obj":"Chemical"},{"id":"144","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"145","span":{"begin":58,"end":72},"obj":"Disease"},{"id":"146","span":{"begin":261,"end":270},"obj":"Disease"},{"id":"147","span":{"begin":452,"end":461},"obj":"Disease"}],"attributes":[{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"Tax:197"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"Tax:197"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"Tax:197"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:D005732"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:D005732"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:D005677"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:D005732"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"MESH:C000657245"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"MESH:D011115"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"MESH:D007239"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T13","span":{"begin":140,"end":156},"obj":"Body_part"},{"id":"T14","span":{"begin":208,"end":220},"obj":"Body_part"},{"id":"T15","span":{"begin":208,"end":212},"obj":"Body_part"},{"id":"T16","span":{"begin":401,"end":413},"obj":"Body_part"},{"id":"T17","span":{"begin":488,"end":496},"obj":"Body_part"},{"id":"T18","span":{"begin":524,"end":536},"obj":"Body_part"},{"id":"T19","span":{"begin":628,"end":639},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma65239"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T11","span":{"begin":151,"end":156},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0001021"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":58,"end":72},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001271"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T63","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"T64","span":{"begin":20,"end":23},"obj":"Disease"},{"id":"T65","span":{"begin":58,"end":72},"obj":"Disease"},{"id":"T66","span":{"begin":76,"end":79},"obj":"Disease"},{"id":"T67","span":{"begin":261,"end":270},"obj":"Disease"},{"id":"T68","span":{"begin":368,"end":371},"obj":"Disease"},{"id":"T69","span":{"begin":452,"end":461},"obj":"Disease"},{"id":"T70","span":{"begin":679,"end":683},"obj":"Disease"},{"id":"T71","span":{"begin":685,"end":690},"obj":"Disease"},{"id":"T72","span":{"begin":710,"end":725},"obj":"Disease"},{"id":"T73","span":{"begin":722,"end":725},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0001824"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0020349"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0020348"},{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0016493"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T17","span":{"begin":24,"end":27},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T18","span":{"begin":28,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T19","span":{"begin":140,"end":156},"obj":"http://purl.obolibrary.org/obo/UBERON_0001021"},{"id":"T20","span":{"begin":208,"end":212},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T21","span":{"begin":224,"end":232},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T22","span":{"begin":555,"end":563},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":401,"end":413},"obj":"Chemical"},{"id":"T9","span":{"begin":414,"end":421},"obj":"Chemical"},{"id":"T10","span":{"begin":524,"end":536},"obj":"Chemical"},{"id":"T11","span":{"begin":565,"end":568},"obj":"Chemical"},{"id":"T14","span":{"begin":570,"end":574},"obj":"Chemical"},{"id":"T16","span":{"begin":583,"end":587},"obj":"Chemical"},{"id":"T18","span":{"begin":589,"end":593},"obj":"Chemical"},{"id":"T19","span":{"begin":598,"end":602},"obj":"Chemical"},{"id":"T20","span":{"begin":628,"end":639},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A12","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A13","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_18163"},{"id":"A15","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_82607"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_18163"},{"id":"A17","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_82607"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_28175"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_27515"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":40,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T2","span":{"begin":497,"end":506},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T20","span":{"begin":0,"end":53},"obj":"Sentence"},{"id":"T21","span":{"begin":54,"end":271},"obj":"Sentence"},{"id":"T22","span":{"begin":272,"end":372},"obj":"Sentence"},{"id":"T23","span":{"begin":373,"end":440},"obj":"Sentence"},{"id":"T24","span":{"begin":441,"end":604},"obj":"Sentence"},{"id":"T25","span":{"begin":605,"end":749},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":565,"end":568},"obj":"GlycoEpitope"},{"id":"T2","span":{"begin":570,"end":574},"obj":"GlycoEpitope"},{"id":"T3","span":{"begin":576,"end":587},"obj":"GlycoEpitope"},{"id":"T4","span":{"begin":583,"end":587},"obj":"GlycoEpitope"},{"id":"T5","span":{"begin":589,"end":593},"obj":"GlycoEpitope"},{"id":"T6","span":{"begin":598,"end":602},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0056"},{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0058"},{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0056"},{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/EP0059"},{"id":"A6","pred":"glyco_epitope_db_id","subj":"T6","obj":"http://www.glycoepitope.jp/epitopes/EP0069"}],"text":"Is COVID-19-related GBS has a different pathogenesis? The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection. This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS. C. jejuni expresses various gangliosides antigen on its outer core. Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b). Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000)."}