PMC:7228307 / 6589-7000 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"93","span":{"begin":37,"end":44},"obj":"Gene"},{"id":"97","span":{"begin":60,"end":68},"obj":"Chemical"},{"id":"98","span":{"begin":160,"end":164},"obj":"Chemical"},{"id":"100","span":{"begin":321,"end":324},"obj":"Disease"}],"attributes":[{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Gene:2213"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D014443"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:D011125"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T50","span":{"begin":60,"end":68},"obj":"Body_part"},{"id":"T51","span":{"begin":214,"end":218},"obj":"Body_part"}],"attributes":[{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T97","span":{"begin":37,"end":39},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T98","span":{"begin":172,"end":181},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T99","span":{"begin":214,"end":218},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T100","span":{"begin":385,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T101","span":{"begin":388,"end":390},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T102","span":{"begin":396,"end":397},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T24","span":{"begin":60,"end":68},"obj":"Chemical"},{"id":"T25","span":{"begin":321,"end":324},"obj":"Chemical"}],"attributes":[{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_80551"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T38","span":{"begin":214,"end":218},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T39","span":{"begin":338,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T5","span":{"begin":60,"end":68},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"100","span":{"begin":321,"end":324},"obj":"Disease"},{"id":"93","span":{"begin":37,"end":44},"obj":"Gene"},{"id":"97","span":{"begin":60,"end":68},"obj":"Chemical"},{"id":"98","span":{"begin":160,"end":164},"obj":"Chemical"}],"attributes":[{"id":"A100","pred":"pubann:denotes","subj":"100","obj":"MESH:D011125"},{"id":"A93","pred":"pubann:denotes","subj":"93","obj":"Gene:2213"},{"id":"A97","pred":"pubann:denotes","subj":"97","obj":"MESH:D014443"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T33","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1","span":{"begin":321,"end":324},"obj":"Protein"}],"attributes":[{"id":"A1","pred":"uniprot_id","subj":"T1","obj":"https://www.uniprot.org/uniprot/P0C1F2"},{"id":"A2","pred":"uniprot_id","subj":"T1","obj":"https://www.uniprot.org/uniprot/P01532"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T50","span":{"begin":60,"end":68},"obj":"Body_part"},{"id":"T51","span":{"begin":214,"end":218},"obj":"Body_part"}],"attributes":[{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T18","span":{"begin":14,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":129,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":172,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":338,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T18","span":{"begin":14,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":129,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":172,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":338,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":14,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":129,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":172,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":338,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}

{"project":"LitCovid-sentences","denotations":[{"id":"T33","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role."}