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PMC:7228307 / 58420-58930 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1197 93-100 Gene denotes FcγRIIb Gene:2213
1198 225-232 Gene denotes FcγRIIb Gene:2213
1199 12-16 Gene denotes FcγR Gene:2213

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T978 12-14 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T979 81-82 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T980 93-95 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T981 225-227 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T982 338-346 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T80667 270-277 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T94340 417-424 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T17986 481-491 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T165 0-3 DT denotes The
T166 4-8 NN denotes role
T167 9-11 IN denotes of
T168 12-16 NN denotes FcγR
T169 17-19 IN denotes in
T170 20-23 DT denotes the
T171 24-30 NN denotes action
T172 31-33 IN denotes of
T173 34-39 DT denotes these
T174 40-45 NNS denotes types
T175 46-48 IN denotes of
T176 49-53 NNS denotes mAbs
T177 54-61 VBZ denotes appears
T178 62-64 TO denotes to
T179 65-67 VB denotes be
T180 68-77 RB denotes primarily
T181 78-80 IN denotes as
T182 81-82 DT denotes a
T183 83-91 NN denotes scaffold
T184 93-100 NN denotes FcγRIIb
T185 101-103 VBZ denotes is
T186 104-109 RB denotes often
T187 110-113 DT denotes the
T188 114-125 JJ denotes predominate
T189 126-134 NN denotes receptor
T190 135-143 VBN denotes involved
T191 144-147 CC denotes and
T192 148-151 DT denotes the
T193 152-158 NN denotes extent
T194 159-161 IN denotes of
T195 162-165 PRP-DOLLAR- denotes its
T196 166-177 NN denotes involvement
T197 178-180 VBZ denotes is
T198 181-188 JJ denotes complex
T199 190-192 IN denotes In
T200 193-196 DT denotes the
T201 197-201 NN denotes case
T202 202-204 IN denotes of
T203 205-209 NN denotes CD40
T204 209-210 -COMMA- denotes ,
T205 211-214 DT denotes the
T206 215-221 NN denotes degree
T207 222-224 IN denotes of
T208 225-232 NN denotes FcγRIIb
T209 233-244 NN denotes scaffolding
T210 245-252 NN denotes potency
T211 253-255 VBZ denotes is
T212 256-262 VBN denotes linked
T213 263-265 TO denotes to
T214 266-269 DT denotes the
T215 270-277 NN denotes epitope
T216 278-286 NN denotes location
T217 287-289 IN denotes of
T218 290-293 DT denotes the
T219 294-303 VBG denotes targeting
T220 304-307 NN denotes mAb
T221 308-312 IN denotes with
T222 313-320 JJR denotes greater
T223 321-328 NN denotes potency
T224 329-333 VBN denotes seen
T225 334-337 IN denotes for
T226 338-346 NN denotes membrane
T227 347-355 JJ denotes proximal
T228 356-367 NN denotes epitopes.43
T229 367-368 -COMMA- denotes ,
T230 369-372 CD denotes 117
T231 373-375 PRP denotes It
T232 376-378 VBZ denotes is
T233 379-383 RB denotes also
T234 384-394 JJ denotes noteworthy
T235 395-399 IN denotes that
T236 400-409 VBG denotes depending
T237 410-412 IN denotes on
T238 413-416 DT denotes the
T239 417-424 NN denotes epitope
T240 425-433 NN denotes location
T241 433-434 -COMMA- denotes ,
T242 435-438 DT denotes the
T243 439-450 NN denotes scaffolding
T244 451-453 IN denotes of
T245 454-463 NN denotes anti‐CD40
T246 464-468 NNS denotes mAbs
T247 469-472 MD denotes may
T248 473-480 VB denotes convert
T249 481-491 NN denotes antagonist
T250 492-496 NNS denotes mAbs
T251 497-499 TO denotes to
T252 500-509 JJ denotes agonistic
R166 T166 T165 arg1Of role,The
R167 T166 T167 arg1Of role,of
R168 T168 T167 arg2Of FcγR,of
R169 T166 T169 arg1Of role,in
R170 T171 T169 arg2Of action,in
R171 T171 T170 arg1Of action,the
R172 T171 T172 arg1Of action,of
R173 T174 T172 arg2Of types,of
R174 T174 T173 arg1Of types,these
R175 T174 T175 arg1Of types,of
R176 T176 T175 arg2Of mAbs,of
R177 T166 T177 arg1Of role,appears
R178 T179 T177 arg2Of be,appears
R179 T179 T178 arg1Of be,to
R180 T166 T179 arg1Of role,be
R181 T181 T179 arg2Of as,be
R182 T181 T180 arg1Of as,primarily
R183 T166 T181 arg1Of role,as
R184 T183 T181 arg2Of scaffold,as
R185 T183 T182 arg1Of scaffold,a
R186 T184 T185 arg1Of FcγRIIb,is
R187 T189 T185 arg2Of receptor,is
R188 T185 T186 arg1Of is,often
R189 T189 T187 arg1Of receptor,the
R190 T189 T188 arg1Of receptor,predominate
R191 T189 T190 arg2Of receptor,involved
R192 T185 T191 arg1Of is,and
R193 T197 T191 arg2Of is,and
R194 T193 T192 arg1Of extent,the
R195 T193 T194 arg1Of extent,of
R196 T196 T194 arg2Of involvement,of
R197 T196 T195 arg1Of involvement,its
R198 T193 T197 arg1Of extent,is
R199 T198 T197 arg2Of complex,is
R200 T193 T198 arg1Of extent,complex
R201 T212 T199 arg1Of linked,In
R202 T201 T199 arg2Of case,In
R203 T201 T200 arg1Of case,the
R204 T201 T202 arg1Of case,of
R205 T203 T202 arg2Of CD40,of
R206 T212 T204 arg1Of linked,","
R207 T206 T205 arg1Of degree,the
R208 T206 T207 arg1Of degree,of
R209 T210 T207 arg2Of potency,of
R210 T210 T208 arg1Of potency,FcγRIIb
R211 T210 T209 arg1Of potency,scaffolding
R212 T206 T211 arg1Of degree,is
R213 T212 T211 arg2Of linked,is
R214 T232 T211 modOf is,is
R215 T206 T212 arg2Of degree,linked
R216 T212 T213 arg1Of linked,to
R217 T216 T213 arg2Of location,to
R218 T216 T214 arg1Of location,the
R219 T216 T215 arg1Of location,epitope
R220 T216 T217 arg1Of location,of
R221 T219 T217 arg2Of targeting,of
R222 T219 T218 arg1Of targeting,the
R223 T218 T219 arg1Of the,targeting
R224 T220 T219 arg2Of mAb,targeting
R225 T219 T221 arg1Of targeting,with
R226 T223 T221 arg2Of potency,with
R227 T223 T222 arg1Of potency,greater
R228 T223 T224 arg2Of potency,seen
R229 T224 T225 arg1Of seen,for
R230 T228 T225 arg2Of epitopes.43,for
R231 T228 T226 arg1Of epitopes.43,membrane
R232 T228 T227 arg1Of epitopes.43,proximal
R233 T216 T229 arg1Of location,","
R234 T230 T229 arg2Of 117,","
R235 T248 T231 arg1Of convert,It
R236 T248 T232 arg1Of convert,is
R237 T234 T232 arg2Of noteworthy,is
R238 T232 T233 arg1Of is,also
R239 T248 T234 arg1Of convert,noteworthy
R240 T248 T235 arg1Of convert,that
R241 T248 T236 arg1Of convert,depending
R242 T237 T236 arg2Of on,depending
R243 T240 T237 arg2Of location,on
R244 T240 T238 arg1Of location,the
R245 T240 T239 arg1Of location,epitope
R246 T248 T241 arg1Of convert,","
R247 T243 T242 arg1Of scaffolding,the
R248 T243 T244 arg1Of scaffolding,of
R249 T246 T244 arg2Of mAbs,of
R250 T246 T245 arg1Of mAbs,anti‐CD40
R251 T243 T247 arg1Of scaffolding,may
R252 T248 T247 arg2Of convert,may
R253 T243 T248 arg1Of scaffolding,convert
R254 T250 T248 arg2Of mAbs,convert
R255 T250 T249 arg1Of mAbs,antagonist
R256 T248 T251 arg1Of convert,to
R257 T252 T251 arg2Of agonistic,to

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1197 93-100 Gene denotes FcγRIIb Gene:2213
1198 225-232 Gene denotes FcγRIIb Gene:2213
1199 12-16 Gene denotes FcγR Gene:2213

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T324 0-92 Sentence denotes The role of FcγR in the action of these types of mAbs appears to be primarily as a scaffold.
T325 93-189 Sentence denotes FcγRIIb is often the predominate receptor involved and the extent of its involvement is complex.
T326 190-510 Sentence denotes In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic.

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T773 205-209 Protein denotes CD40 https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9
T799 459-463 Protein denotes CD40 https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T25 347-355 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T324 0-92 Sentence denotes The role of FcγR in the action of these types of mAbs appears to be primarily as a scaffold.
T325 93-189 Sentence denotes FcγRIIb is often the predominate receptor involved and the extent of its involvement is complex.
T326 190-510 Sentence denotes In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic.